Abnormal expression of long non ‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs
This study focused on the association of LINC01270 and computed tomography (CT) signs with glioma development, to evaluate their potential in the early detection of glioma. Serum LINC01270 was evaluated in glioma patients and healthy individuals using PCR. The involvement of LINC01270 in glioma onset and development was evaluated by ROC and chi‑square test. The association of LINC01270 with the CT signs and their combined effects in the diagnosis in glioma were also estimated. Serum LINC01270 was significantly elevated in glioma patients, which was closely associated with patients' advanced WHO grades and lower KPS. Both...
Source: Acta Neurobiologiae Experimentalis - April 8, 2024 Category: Neurology Authors: Ying Liu Yuntao Zhang Yongjun E Xianglin Zhang Heji Ma Furen Dong Source Type: research
Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report
We report a rare case of HLH... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 8, 2024 Category: Infectious Diseases Authors: Chia Hua Chang and Chih-Chuan Kao Tags: Case Report Source Type: research
Synergistic efficacy of repetitive peripheral magnetic stimulation on central intermittent theta burst stimulation for upper limb function in patients with stroke: a double-blinded, randomized controlled trial
Non-invasive techniques such as central intermittent theta burst stimulation (iTBS) and repetitive peripheral magnetic stimulation (rPMS) have shown promise in improving motor function for patients with stroke... (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - April 8, 2024 Category: Rehabilitation Authors: Chi-Shou Chang, Chia-Ling Chen, Rou-Shayn Chen, Hsieh-Ching Chen, Chung-Yao Chen, Chia-Ying Chung, Katie Pei-Hsuan Wu, Ching-Yi Wu and Keh-chung Lin Tags: Research Source Type: research
Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness
In this study, we in... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - April 8, 2024 Category: Nanotechnology Authors: Hoang Linh Bui, Yun-Han Su, Chia-Jung Yang, Chun-Jen Huang and Jui-Yang Lai Tags: Research Source Type: research
Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination
Vaccine. 2024 Apr 6:S0264-410X(24)00425-0. doi: 10.1016/j.vaccine.2024.04.011. Online ahead of print.ABSTRACTHeterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 follo...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Chia-Yin Chong Kai-Qian Kam Jinyan Zhang Antonio Bertoletti Smrithi Hariharaputran Rehena Sultana Rupini Piragasam Yun-Yan Mah Chee-Wah Tan Linfa Wang Chee-Fu Yung Source Type: research
Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination
Vaccine. 2024 Apr 6:S0264-410X(24)00425-0. doi: 10.1016/j.vaccine.2024.04.011. Online ahead of print.ABSTRACTHeterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 follo...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Chia-Yin Chong Kai-Qian Kam Jinyan Zhang Antonio Bertoletti Smrithi Hariharaputran Rehena Sultana Rupini Piragasam Yun-Yan Mah Chee-Wah Tan Linfa Wang Chee-Fu Yung Source Type: research
Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination
Vaccine. 2024 Apr 6:S0264-410X(24)00425-0. doi: 10.1016/j.vaccine.2024.04.011. Online ahead of print.ABSTRACTHeterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 follo...
Source: Vaccine - April 7, 2024 Category: Allergy & Immunology Authors: Chia-Yin Chong Kai-Qian Kam Jinyan Zhang Antonio Bertoletti Smrithi Hariharaputran Rehena Sultana Rupini Piragasam Yun-Yan Mah Chee-Wah Tan Linfa Wang Chee-Fu Yung Source Type: research
Pilot-scale production of a highly efficacious and stable monoglycosylated influenza split virus vaccine
In conclusion, this study provides efficacy and safety profiles of IVR-190mg for further clinical study and shows that this vaccine without a glycan shield has great potential to be safe and protective against H1N1 variants.PMID:38582606 | DOI:10.1016/j.vaccine.2023.11.038 (Source: Vaccine)
Source: Vaccine - April 6, 2024 Category: Allergy & Immunology Authors: Chia-Ying Wu Shao-En Kao Yung-Chieh Tseng Jen-Tzu Hou Li-Yang Wu Juine-Ruey Chen Source Type: research
Layer-by-layer assembly of quercetin-loaded zein/ γPGA/low-molecular-weight chitosan/fucoidan nanosystem for targeting inflamed blood vessels
Int J Biol Macromol. 2024 Apr 3:131369. doi: 10.1016/j.ijbiomac.2024.131369. Online ahead of print.ABSTRACTChitosan acts as a versatile carrier in polymeric nanoparticle (NP) for diverse drug administration routes. Delivery of antioxidants, such as quercetin (Qu) showcases potent antioxidant and anti-inflammatory properties for reduction of various cardiovascular diseases, but low water solubility limits uptake. To address this, we developed a novel layer-by-layer zein/gamma-polyglutamic acid (γPGA)/low-molecular-weight chitosan (LC)/fucoidan NP for encapsulating Qu and targeting inflamed vessel endothelial cells. We used...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Hsin-Ying Lu Fwu-Long Mi Chih-Ming Chou Chi Lin Yi-Yu Chen Cheng-Ying Chu Cheng-Yang Liu Yu-Lin Amy Lee Chun Che Shih Chia-Hsiung Cheng Source Type: research
Comparative transcriptomic analysis of Staphylococcus epidermidis associated with periprosthetic joint infection under in vivo and in vitro conditions
In conclusion, this study provides insights into phenotypic alterations employed by S epidermidis to adapt to infective and non-infected microenvironments, potentially informing future therapeutic targets for related infections.PMID:38579524 | DOI:10.1016/j.ijmm.2024.151620 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 5, 2024 Category: Microbiology Authors: Cody R Fisher Thao L Masters Stephen Johnson Kerryl E Greenwood-Quaintance Nicholas Chia Matthew P Abdel Robin Patel Source Type: research
Author Correction: Substrate and drug recognition mechanisms of SLC19A3
Cell Res. 2024 Apr 5. doi: 10.1038/s41422-024-00953-0. Online ahead of print.NO ABSTRACTPMID:38580846 | DOI:10.1038/s41422-024-00953-0 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Yu Dang Tianyi Zhang Shabareesh Pidathala Guopeng Wang Yijie Wang Nanhao Chen Chen Song Chia-Hsueh Lee Zhe Zhang Source Type: research
Layer-by-layer assembly of quercetin-loaded zein/ γPGA/low-molecular-weight chitosan/fucoidan nanosystem for targeting inflamed blood vessels
Int J Biol Macromol. 2024 Apr 3:131369. doi: 10.1016/j.ijbiomac.2024.131369. Online ahead of print.ABSTRACTChitosan acts as a versatile carrier in polymeric nanoparticle (NP) for diverse drug administration routes. Delivery of antioxidants, such as quercetin (Qu) showcases potent antioxidant and anti-inflammatory properties for reduction of various cardiovascular diseases, but low water solubility limits uptake. To address this, we developed a novel layer-by-layer zein/gamma-polyglutamic acid (γPGA)/low-molecular-weight chitosan (LC)/fucoidan NP for encapsulating Qu and targeting inflamed vessel endothelial cells. We used...
Source: International Journal of Biological Macromolecules - April 5, 2024 Category: Biochemistry Authors: Hsin-Ying Lu Fwu-Long Mi Chih-Ming Chou Chi Lin Yi-Yu Chen Cheng-Ying Chu Cheng-Yang Liu Yu-Lin Amy Lee Chun Che Shih Chia-Hsiung Cheng Source Type: research
Comparative transcriptomic analysis of Staphylococcus epidermidis associated with periprosthetic joint infection under in vivo and in vitro conditions
In conclusion, this study provides insights into phenotypic alterations employed by S epidermidis to adapt to infective and non-infected microenvironments, potentially informing future therapeutic targets for related infections.PMID:38579524 | DOI:10.1016/j.ijmm.2024.151620 (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - April 5, 2024 Category: Microbiology Authors: Cody R Fisher Thao L Masters Stephen Johnson Kerryl E Greenwood-Quaintance Nicholas Chia Matthew P Abdel Robin Patel Source Type: research
Author Correction: Substrate and drug recognition mechanisms of SLC19A3
Cell Res. 2024 Apr 5. doi: 10.1038/s41422-024-00953-0. Online ahead of print.NO ABSTRACTPMID:38580846 | DOI:10.1038/s41422-024-00953-0 (Source: Cell Research)
Source: Cell Research - April 5, 2024 Category: Cytology Authors: Yu Dang Tianyi Zhang Shabareesh Pidathala Guopeng Wang Yijie Wang Nanhao Chen Chen Song Chia-Hsueh Lee Zhe Zhang Source Type: research
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
Dev Cell. 2024 Mar 28:S1534-5807(24)00188-6. doi: 10.1016/j.devcel.2024.03.020. Online ahead of print.ABSTRACTTelomere dynamics are linked to aging hallmarks, and age-associated telomere loss fuels the development of epithelial cancers. In Apc-mutant mice, the onset of DNA damage associated with telomere dysfunction has been shown to accelerate adenoma initiation via unknown mechanisms. Here, we observed that Apc-mutant mice engineered to experience telomere dysfunction show accelerated adenoma formation resulting from augmented cell competition and clonal expansion. Mechanistically, telomere dysfunction induces the repres...
Source: Developmental Cell - April 4, 2024 Category: Cytology Authors: Kyle A LaBella Wen-Hao Hsu Jiexi Li Yutao Qi Yonghong Liu Jingjing Liu Chia-Chin Wu Yang Liu Zingzhi Song Yiyun Lin Jonathan M Blecher Shan Jiang Xiaoying Shang Jincheng Han Denise J Spring Jianhua Zhang Yan Xia Ronald A DePinho Source Type: research
