Bioremediation of trichloroethylene-contaminated groundwater using green carbon-releasing substrate with pH control capability
Environ Pollut. 2024 Mar 15:123768. doi: 10.1016/j.envpol.2024.123768. Online ahead of print.ABSTRACTIn this research, a sustainable substrate, termed green and long-lasting substrate (GLS), featuring a blend of emulsified substrate (ES) and modified rice husk ash (m-RHA) was devised. The primary objective was to facilitate the bioremediation of groundwater contaminated with trichloroethylene (TCE) using innovative GLS for slow carbon release and pH control. The GLS was concocted by homogenizing a mixture of soybean oil, surfactants (Simple Green™ and soya lecithin), and m-RHA, ensuring a gradual release of carbon source...
Source: Environmental Pollution - March 17, 2024 Category: Environmental Health Authors: Hsin-Chia Lee Ssu-Ching Chen Yih-Terng Sheu Chao-Ling Yao Kai-Hung Lo Chih-Ming Kao Source Type: research
Selective activation of IFN γ-ipilimumab enhances the therapeutic effect and safety of ipilimumab
CONCLUSION: IFNγ-ipilimumab improved the effectiveness of ipilimumab while reducing its side effects. It is likely that future immunotherapies would rely on such antibodies to activate local cancer cells or immune cells, thereby increasing the therapeutic effectiveness of cancer treatments and ensuring their safety.PMID:38493818 | DOI:10.1016/j.ijbiomac.2024.130945 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 17, 2024 Category: Biochemistry Authors: Yi-Jung Huang Kai-Wen Ho Tian-Lu Cheng Yen-Tseng Wang Shi-Wei Chao Bo-Cheng Huang Yu-Shu Chao Chia-Yu Lin Yun-Han Hsu Fang-Ming Chen Chih-Hung Chuang Source Type: research
Selective activation of IFN γ-ipilimumab enhances the therapeutic effect and safety of ipilimumab
CONCLUSION: IFNγ-ipilimumab improved the effectiveness of ipilimumab while reducing its side effects. It is likely that future immunotherapies would rely on such antibodies to activate local cancer cells or immune cells, thereby increasing the therapeutic effectiveness of cancer treatments and ensuring their safety.PMID:38493818 | DOI:10.1016/j.ijbiomac.2024.130945 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 17, 2024 Category: Biochemistry Authors: Yi-Jung Huang Kai-Wen Ho Tian-Lu Cheng Yen-Tseng Wang Shi-Wei Chao Bo-Cheng Huang Yu-Shu Chao Chia-Yu Lin Yun-Han Hsu Fang-Ming Chen Chih-Hung Chuang Source Type: research
Bioremediation of trichloroethylene-contaminated groundwater using green carbon-releasing substrate with pH control capability
Environ Pollut. 2024 Mar 15:123768. doi: 10.1016/j.envpol.2024.123768. Online ahead of print.ABSTRACTIn this research, a sustainable substrate, termed green and long-lasting substrate (GLS), featuring a blend of emulsified substrate (ES) and modified rice husk ash (m-RHA) was devised. The primary objective was to facilitate the bioremediation of groundwater contaminated with trichloroethylene (TCE) using innovative GLS for slow carbon release and pH control. The GLS was concocted by homogenizing a mixture of soybean oil, surfactants (Simple Green™ and soya lecithin), and m-RHA, ensuring a gradual release of carbon source...
Source: Environmental Pollution - March 17, 2024 Category: Environmental Health Authors: Hsin-Chia Lee Ssu-Ching Chen Yih-Terng Sheu Chao-Ling Yao Kai-Hung Lo Chih-Ming Kao Source Type: research
Decreased interleukin ‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice
ConclusionReduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 17, 2024 Category: Cancer & Oncology Authors: Jeng ‐Kai Jiang,
Chi‐Hung Lin,
Ting‐An Chang,
Liang‐Chuan Lo,
Chien‐Ping Lin,
Ruey‐Hwa Lu,
Chih‐Yung Yang Tags: RESEARCH ARTICLE Source Type: research
Direct C –H electrophilic borylation with (C6F5)2B–NTf2 to generate B–N dibenzo[a,h]pyrenes
Dalton Trans., 2024, Advance Article DOI: 10.1039/D4DT00469H, PaperTony Nguyen, Jason L. Dutton, Chia Yun Chang, Wen Zhou, Warren E. Piers A new borylation reagent is introduced for preparing B –N doped conjugated organic frameworksvia direct borylation of aryl substituted pyridines and naphthyridines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - March 15, 2024 Category: Chemistry Authors: Tony Nguyen Source Type: research
Social activity, physical exercise, and health ‐related quality of life among people with osteoarthritis in Canada
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - March 15, 2024 Category: Rheumatology Authors: Pin ‐Chia Huang,
Kevin Sheng‐Kai Ma Tags: LETTER TO THE EDITOR Source Type: research
Implementing virtual reality technology to teach medical college systemic anatomy: A pilot study
In conclusion, the VR anatomy instruction video strategy is feasible and helpful for large classes, but educators should consider VIMS when planning their use of this teaching approach. (Source: Anatomical Sciences Education)
Source: Anatomical Sciences Education - March 15, 2024 Category: Anatomy Authors: Meng ‐Lin Liao,
Chi‐Chuan Yeh,
June‐Horng Lue,
Ming‐Fong Chang Tags: RESEARCH REPORT Source Type: research
Comparative adherence of macitentan versus ambrisentan and bosentan in Australian patients with pulmonary arterial hypertension: a retrospective real-world database study
This study assessed the comparative adherence of these ERAs for PAH in Australian patients.Methods: This retrospective, observational study used data for adults with PAH from the Services Australia 10% Pharmaceuticals Benefits Scheme (PBS) dataset (01/2006-10/2020). The primary outcome was treatment adherence (ie, receiving ≥80% of ERA doses over 12 months). Secondary outcomes were time to treatment change (add-on or switch) and overall survival.Results: The study included 436 patients who took bosentan (n = 200), ambrisentan (n = 69), or macitentan (n = 167). Treatment adherence was significantly greater in patients who...
Source: Journal of Medical Economics - March 15, 2024 Category: Health Management Authors: Edmund Lau Eugene Kotlyar Yogeshwar Makanji Dae Young Yu Jin Yu Tan Jeremy Casorso Mahsa H Kouhkamari Sooyeol Lim David Bin-Chia Wu Paul Bloomfield Source Type: research
Mismatch repair enzymes regulate telomere recombination in Saccharomycescerevisiae
This study investigates the participation of MMR in telomere recombination. Our findings reveal that mutations in MMR genes activate type I recombination. Notably, among the MMR proteins, MutSα (Msh2 and Msh6) and MutLα (Mlh1 and Pms1) exerted the most pronounced effects on telomere recombination. We also found that yeast cells containing simple human telomeric TTAGGG DNA sequences preferentially utilize type II recombination to maintain their telomeres, highlighting the influence of the heterogeneous nature of yeast telomeric sequences on type II recombination. Furthermore, our observations indicate that MMR activity is...
Source: Biochemical and Biophysical Research communications - March 15, 2024 Category: Biochemistry Authors: Chia-Chun Liu Mathilde M M Capart Jing-Jer Lin Source Type: research
Identification of novel laccase from cyanobacterium Microcystis flos-aquae and enhanced azo dye bioremediation potential
This study introduces a cost-effective, enzyme-mediated bioremediation alternative using a novel laccase from the cyanobacteriumMicrocystis flos-aquae. This purified enzyme yielded 0.55 % (w/w)with significant activity at 40 °C and pH 4.00. Kinetic studies showed the dependence of M. flos-aquae laccase on Cu2+and its inhibition by EDTA and Fe2+. The efficacy of the enzyme was demonstrated through rapid decolorization of the azo dye Cibacron Brilliant Blue over a wide temperature and pH range. As this enzyme effectively decolorizes dyes across a broad temperature and pH range, it offers a promising solution for bioremediat...
Source: Bioresource Technology - March 15, 2024 Category: Biotechnology Authors: Muhammad Ayyub Muhammad Emmanuel Oluwadareus Balogun Abdullahi Balarabe Sallau Mathias Ahii Chia Mohammed Nasir Shuaibu Source Type: research
Comparative adherence of macitentan versus ambrisentan and bosentan in Australian patients with pulmonary arterial hypertension: a retrospective real-world database study
This study assessed the comparative adherence of these ERAs for PAH in Australian patients.Methods: This retrospective, observational study used data for adults with PAH from the Services Australia 10% Pharmaceuticals Benefits Scheme (PBS) dataset (01/2006-10/2020). The primary outcome was treatment adherence (ie, receiving ≥80% of ERA doses over 12 months). Secondary outcomes were time to treatment change (add-on or switch) and overall survival.Results: The study included 436 patients who took bosentan (n = 200), ambrisentan (n = 69), or macitentan (n = 167). Treatment adherence was significantly greater in patients who...
Source: Journal of Medical Economics - March 15, 2024 Category: Health Management Authors: Edmund Lau Eugene Kotlyar Yogeshwar Makanji Dae Young Yu Jin Yu Tan Jeremy Casorso Mahsa H Kouhkamari Sooyeol Lim David Bin-Chia Wu Paul Bloomfield Source Type: research
USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy
Cell Death & Differentiation, Published online: 15 March 2024; doi:10.1038/s41418-024-01277-7USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - March 15, 2024 Category: Cytology Authors: Ming-Jer Young Shao-An Wang Yung-Ching Chen Chia-Yu Liu Kai-Cheng Hsu Sin-Wei Tang Yau-Lin Tseng Yi-Ching Wang Shih-Min Lin Jan-Jong Hung Source Type: research
Assessment for 11q and other chromosomal aberrations in large B-cell/high-grade B cell lymphomas of germinal center phenotype lacking BCL2 expression
The aggressive B-cell lymphomas include multiple entities with differences in morphology, phenotype, molecular pathogenesis, and clinical behavior. Of the large B cell lymphomas within this category, those that show germinal center (GC) phenotype but lack BCL2 expression include (among others) diffuse large B cell lymphoma, not otherwise specified (DLBCL NOS), a proportion of cases of high-grade B cell lymphoma, NOS (HGBCL, NOS), and high-grade B cell lymphomas with 11q aberration (HGBL-11q, WHO 5th edition). (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - March 15, 2024 Category: Genetics & Stem Cells Authors: Chia-Chen Ho, Kikkeri Naresh, Yajuan Liu, Yu Wu, Ajay K Gopal, Ashley M Eckel Source Type: research
Comprehensive Genomic Characterization of Thyroid Cancers: Real-world Implementation and Impact on Clinical Decisions
With the introduction of targeted therapeutic options for advanced thyroid cancer, molecular characterization has become an important clinical tool for decision making. This is a real-world study to evaluate how next-generation sequencing (NGS) informs treatment decisions and clinical outcomes in advanced thyroid cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: F.T.H. Wu, S. Yip, F. Usman, S.Y. Sabag, C. Hughesman, T. Ng, D. Alex, K.E. Khoo, N.A. Bosma, J.J. Laskin, H.J. Lim, S. Chia, J. Ko-Leong, S. Pollard, D. Weymann, P. DeMarco, D.A. Regier, N. Chau, C. Ho Tags: 227 Source Type: research
