Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXR α/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models
Biomed Pharmacother. 2024 Apr 13;174:116598. doi: 10.1016/j.biopha.2024.116598. Online ahead of print.ABSTRACTAngiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), and 8-prenylnaringenin (8-PN), with the potential to manage lipid metabolism. T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wan-Yun Gao Pei-Yi Chen Hao-Jen Hsu Je-Wen Liou Chia-Ling Wu Ming-Jiuan Wu Jui-Hung Yen Source Type: research
LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus
Int J Mol Sci. 2024 Apr 2;25(7):3963. doi: 10.3390/ijms25073963.ABSTRACTOral cancer ranks fourth among malignancies among Taiwanese men and is the eighth most common cancer among men worldwide in terms of general diagnosis. The purpose of the current study was to investigate how low-density lipoprotein receptor-related protein 1B (LDL receptor related protein 1B; LRP1B) gene polymorphisms affect oral squamous cell carcinoma (OSCC) risk and progression in individuals with diabetes mellitus (DM). Three LRP1B single-nucleotide polymorphisms (SNPs), including rs10496915, rs431809, and rs6742944, were evaluated in 311 OSCC case...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Liang-Cheng Chen Yu-Sheng Lo Hsin-Yu Ho Chia-Chieh Lin Yi-Ching Chuang Wei-Chen Chang Ming-Ju Hsieh Source Type: research
An optimization model for reducing thrombectomy center rotations while maintaining medical accessibility
CONCLUSION: Our optimization model supports reducing the number of daily rotating hospitals by half while preserving a balance between patient accessibility and alleviating strain on medical teams.PMID:38614907 | DOI:10.1016/j.jfma.2024.04.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 13, 2024 Category: General Medicine Authors: Ming-Ju Hsieh Chung-Jung Lin Yen-Heng Lin Ling-Chieh Kung Jiun-Yu Yu Chia-Wei Kuo Source Type: research
Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition
J Cell Mol Med. 2024 Apr;28(8):e18299. doi: 10.1111/jcmm.18299.ABSTRACTPulmonary fibrosis is a lung disorder affecting the lungs that involves the overexpressed extracellular matrix, scarring and stiffening of tissue. The repair of lung tissue after injury relies heavily on Type II alveolar epithelial cells (AEII), and repeated damage to these cells is a crucial factor in the development of pulmonary fibrosis. Studies have demonstrated that chronic exposure to PM2.5, a form of air pollution, leads to an increase in the incidence and severity of pulmonary fibrosis by stimulation of epithelial-mesenchymal transition (EMT) in...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Chia-Chia Chao Sheng-Yen Hsiao Wan-Chen Kao Pei-Chen Chiou Chieh-Chen Huang Mei-Ting Wang Po-Chun Chen Source Type: research
An optimization model for reducing thrombectomy center rotations while maintaining medical accessibility
CONCLUSION: Our optimization model supports reducing the number of daily rotating hospitals by half while preserving a balance between patient accessibility and alleviating strain on medical teams.PMID:38614907 | DOI:10.1016/j.jfma.2024.04.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 13, 2024 Category: General Medicine Authors: Ming-Ju Hsieh Chung-Jung Lin Yen-Heng Lin Ling-Chieh Kung Jiun-Yu Yu Chia-Wei Kuo Source Type: research
Defect Induced Structural Transition and Lipase Immobilizatoin in Mesoporous Aluminum Metal-Organic Frameworks
Chemistry. 2024 Apr 12:e202400603. doi: 10.1002/chem.202400603. Online ahead of print.ABSTRACTThe disorder to order and structural transformation are unique metal-organic framework (MOF) characters. How to adapt or control both behaviors in MOF is rarely studied. In this case, we demonstrate that our successful synthesis of [Al(OH)(PDA)]n (AlPDA-53-DEF, AlPDA-53-H, and AlPDA-68) with H2PDA = 4,4'-[1,4-phenylenebis(ethyne-2,1-diyl)]-di benzoic acid has illuminated the intricate world of Aluminum Metal-Organic Frameworks (Al-MOFs), offering profound insights into defect structures to order and transformations. AlPDA-53-DEF, ...
Source: Chemistry - April 13, 2024 Category: Chemistry Authors: Sivasankar Kulandaivel Chun-Chuen Yang Yi-Chun Yeh Chia-Her Lin Source Type: research
Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition
J Cell Mol Med. 2024 Apr;28(8):e18299. doi: 10.1111/jcmm.18299.ABSTRACTPulmonary fibrosis is a lung disorder affecting the lungs that involves the overexpressed extracellular matrix, scarring and stiffening of tissue. The repair of lung tissue after injury relies heavily on Type II alveolar epithelial cells (AEII), and repeated damage to these cells is a crucial factor in the development of pulmonary fibrosis. Studies have demonstrated that chronic exposure to PM2.5, a form of air pollution, leads to an increase in the incidence and severity of pulmonary fibrosis by stimulation of epithelial-mesenchymal transition (EMT) in...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Chia-Chia Chao Sheng-Yen Hsiao Wan-Chen Kao Pei-Chen Chiou Chieh-Chen Huang Mei-Ting Wang Po-Chun Chen Source Type: research
An optimization model for reducing thrombectomy center rotations while maintaining medical accessibility
CONCLUSION: Our optimization model supports reducing the number of daily rotating hospitals by half while preserving a balance between patient accessibility and alleviating strain on medical teams.PMID:38614907 | DOI:10.1016/j.jfma.2024.04.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 13, 2024 Category: General Medicine Authors: Ming-Ju Hsieh Chung-Jung Lin Yen-Heng Lin Ling-Chieh Kung Jiun-Yu Yu Chia-Wei Kuo Source Type: research
Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition
J Cell Mol Med. 2024 Apr;28(8):e18299. doi: 10.1111/jcmm.18299.ABSTRACTPulmonary fibrosis is a lung disorder affecting the lungs that involves the overexpressed extracellular matrix, scarring and stiffening of tissue. The repair of lung tissue after injury relies heavily on Type II alveolar epithelial cells (AEII), and repeated damage to these cells is a crucial factor in the development of pulmonary fibrosis. Studies have demonstrated that chronic exposure to PM2.5, a form of air pollution, leads to an increase in the incidence and severity of pulmonary fibrosis by stimulation of epithelial-mesenchymal transition (EMT) in...
Source: J Cell Mol Med - April 13, 2024 Category: Molecular Biology Authors: Chia-Chia Chao Sheng-Yen Hsiao Wan-Chen Kao Pei-Chen Chiou Chieh-Chen Huang Mei-Ting Wang Po-Chun Chen Source Type: research
Statin use, albuminuria, and mortality risk: re-evaluating C-reactive protein to albumin ratio in hypertensive patients based on NHANES data
(Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 13, 2024 Category: Nutrition Authors: Kuo-Chin Hung, Chia-Ter Chao Source Type: research
Outcomes after fertility ‐sparing surgery of early‐stage ovarian cancer: A nationwide population‐based study
ConclusionFSS can be a safe alternative procedure in selected young patients of Stage I EOC who have fertility desire. Endometrial biopsy before or during FSS and regular surveillance to detect recurrence are mandatory for ovarian cancer patients undergoing FSS. (Source: Cancer Medicine)
Source: Cancer Medicine - April 12, 2024 Category: Cancer & Oncology Authors: Chia ‐Yi Lee,
Chun‐Ju Chiang,
Yi‐Jou Tai,
Heng‐Cheng Hsu,
Yu‐Li Chen,
Ying‐Cheng Chiang,
Chia‐Ying Wu,
Wen‐Chung Lee,
Hsiao‐Lin Hwa,
Wen‐Fang Cheng Tags: RESEARCH ARTICLE Source Type: research
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Cell Stem Cell. 2024 Apr 4:S1934-5909(24)00092-4. doi: 10.1016/j.stem.2024.03.011. Online ahead of print.ABSTRACTAutonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and dysfunction in humans are vastly understudied due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void as a versatile platform. Here, we developed a differentiation paradigm detailing the derivation of func...
Source: Cell Stem Cell - April 12, 2024 Category: Stem Cells Authors: Hsueh-Fu Wu Kenyi Saito-Diaz Chia-Wei Huang Jessica L McAlpine Dong Eun Seo D Sumner Magruder Mohamed Ishan Harrison C Bergeron William H Delaney Fabio R Santori Smita Krishnaswamy Gerald W Hart Ya-Wen Chen Robert J Hogan Hong-Xiang Liu Natalia B Ivanova Source Type: research
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Cell Stem Cell. 2024 Apr 4:S1934-5909(24)00092-4. doi: 10.1016/j.stem.2024.03.011. Online ahead of print.ABSTRACTAutonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and dysfunction in humans are vastly understudied due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void as a versatile platform. Here, we developed a differentiation paradigm detailing the derivation of func...
Source: Cell Stem Cell - April 12, 2024 Category: Stem Cells Authors: Hsueh-Fu Wu Kenyi Saito-Diaz Chia-Wei Huang Jessica L McAlpine Dong Eun Seo D Sumner Magruder Mohamed Ishan Harrison C Bergeron William H Delaney Fabio R Santori Smita Krishnaswamy Gerald W Hart Ya-Wen Chen Robert J Hogan Hong-Xiang Liu Natalia B Ivanova Source Type: research
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Cell Stem Cell. 2024 Apr 4:S1934-5909(24)00092-4. doi: 10.1016/j.stem.2024.03.011. Online ahead of print.ABSTRACTAutonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and dysfunction in humans are vastly understudied due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void as a versatile platform. Here, we developed a differentiation paradigm detailing the derivation of func...
Source: Cell Stem Cell - April 12, 2024 Category: Stem Cells Authors: Hsueh-Fu Wu Kenyi Saito-Diaz Chia-Wei Huang Jessica L McAlpine Dong Eun Seo D Sumner Magruder Mohamed Ishan Harrison C Bergeron William H Delaney Fabio R Santori Smita Krishnaswamy Gerald W Hart Ya-Wen Chen Robert J Hogan Hong-Xiang Liu Natalia B Ivanova Source Type: research
Molecules, Vol. 29, Pages 1748: Diverse Co(II) Coordination Polymers with the Same Mixed Ligands: Evaluation of Chemical Stability and Structural Transformation
er Chen
Reactions of Co(OAc)2·4H2O, N‚N’-bis(3-pyridylmethyl)oxalamide (L) and 4,4′-sulfonyldibenzoic acid (H2SDA) afforded four coordination polymers with the same mixed ligands, {[Co(L)(SDA)(H2O)2]·H2O·CH3OH}n, 1, {[Co(L)0.5(SDA)]·2H2O·0.5L}n, 2, {[Co(L)1.5(SDA)(H2O)]·H2O}n, 3, and {[Co2(L)1.5(SDA)2(H2O)2]·4H2O}n, 4, which have been structurally characterized using single-crystal X-ray crystallography. Complexes 1–4 are 2D layers, revealing topologies of sql,...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Chia-Yi Lee Yu-Hui Ye Song-Wei Wang Jhy-Der Chen Tags: Article Source Type: research
