GSE244844 ERa profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions [Hi-C]
Contributors : Stacey E Joosten ; Sebastian Gregoricchio ; Suzan Stelloo ; Elif Yap ıcı ; Chia-Chi F Huang ; Maria Donaldson Collier ; Tunc Morova ; Berkay Altintas ; Yongsoo Kim ; Sander Canisius ; Gozde Korkmaz ; Nathan Lack ; Michiel Vermeulen ; Sabine C Linn ; Wilbert ZwartSeries Type : OtherOrganism : Homo sapiensEstrogen Receptor alpha (ERa) is the main driver of luminal breast cancer development and progression, and represents the main drug target in patient care. ERa chromatin binding has been extensively studied in breast cancer cell lines and a number of human tumors, often focused on differential b...
Source: GEO: Gene Expression Omnibus - March 27, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE244840 ERa profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions [ChIP-seq]
Contributors : Stacey E Joosten ; Sebastian Gregoricchio ; Suzan Stelloo ; Elif Yap ıcı ; Chia-Chi F Huang ; Maria Donaldson Collier ; Tunc Morova ; Berkay Altintas ; Yongsoo Kim ; Sander Canisius ; Gozde Korkmaz ; Nathan Lack ; Michiel Vermeulen ; Sabine C Linn ; Wilbert ZwartSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEstrogen Receptor alpha (ERa) is the main driver of luminal breast cancer development and progression, and represents the main drug target in patient care. ERa chromatin binding has been extensively studied in breast cancer cell lines an...
Source: GEO: Gene Expression Omnibus - March 27, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Increased risk of aspiration pneumonia associated with endoscopic procedures among patients with Glucagon-like peptide-1 receptor agonist use
(Source: Gastroenterology)
Source: Gastroenterology - March 27, 2024 Category: Gastroenterology Authors: Yee Hui Yeo, Srinivas Gaddam, Wee Han Ng, Pin-Chia Huang, Gastrointestinal Motility and Metabolic Pharmacoepidemiology Group, Kevin Sheng-Kai Ma, Ali Rezaie Tags: Research Letter Source Type: research
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that ... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - March 27, 2024 Category: Biomedical Science Authors: I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu and Ping-Ning Hsu Tags: Research Source Type: research
Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
Angew Chem Int Ed Engl. 2024 Mar 26:e202401195. doi: 10.1002/anie.202401195. Online ahead of print.ABSTRACTThe cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur-containing amino lipids (SALs) of importance for biofilm formation and marine surface colonization processes. Despite their physiological importance and abundance, SALs have only been explored through genomic mining approaches and lipidomic studies based on mass spectrometry, which left the relative and absolute structures of SALs unresolved hindering progress in biochemical and functional investigati...
Source: Angewandte Chemie - March 26, 2024 Category: Chemistry Authors: D ávid Roman Philippe Meisinger Richard Guillonneau Chia-Chi Peng Lukas K Peltner Paul M Jordan Veit Haensch Sebastian G ötze Oliver Werz Christian Hertweck Yin Chen Christine Beemelmanns Source Type: research
Concurrent Atezolizumab Plus Bevacizumab and High-Dose External Beam Radiotherapy for Highly Advanced Hepatocellular Carcinoma
CONCLUSIONS: The concurrent high-dose external beam radiotherapy appears to safely enhance the effectiveness of atezolizumab plus bevacizumab for highly advanced patients with HCC. Further studies are warranted to confirm these findings.PMID:38530254 | DOI:10.1093/oncolo/oyae048 (Source: The Oncologist)
Source: The Oncologist - March 26, 2024 Category: Cancer & Oncology Authors: Chung-Wei Su Wei Teng Eric Yi-Liang Shen Bing-Shen Huang Po-Ting Lin Ming-Mo Hou Tsung-Han Wu Din-Li Tsan Chia-Hsun Hsieh Ching-Ting Wang Pei-Mei Chai Chun-Yen Lin Shi-Ming Lin Chen-Chun Lin Source Type: research
Structure Revision of a Widespread Marine Sulfonolipid Class Based on Isolation and Total Synthesis
Angew Chem Int Ed Engl. 2024 Mar 26:e202401195. doi: 10.1002/anie.202401195. Online ahead of print.ABSTRACTThe cosmopolitan marine Roseobacter clade is of global biogeochemical importance. Members of this clade produce sulfur-containing amino lipids (SALs) of importance for biofilm formation and marine surface colonization processes. Despite their physiological importance and abundance, SALs have only been explored through genomic mining approaches and lipidomic studies based on mass spectrometry, which left the relative and absolute structures of SALs unresolved hindering progress in biochemical and functional investigati...
Source: Angewandte Chemie - March 26, 2024 Category: Chemistry Authors: D ávid Roman Philippe Meisinger Richard Guillonneau Chia-Chi Peng Lukas K Peltner Paul M Jordan Veit Haensch Sebastian G ötze Oliver Werz Christian Hertweck Yin Chen Christine Beemelmanns Source Type: research
Direct evidence of time-dependent crystallization evolution of SAPO-34 and SAPO-20 zeolites directed by trimethylbenzylammonium hydroxide for microwave-assisted ethanolysis of furfuryl alcohol
New J. Chem., 2024, Advance Article DOI: 10.1039/D4NJ00875H, PaperGuanchen Wang, Najla AlMasoud, Taghrid S. Alomar, Yasmin Nadhirah Azman, Pedro Maireles-Torres, Stephen Chia, Joon Ching Juan, Tau Chuan Ling, Zeinhom M. El-Bahy, Eng-Poh Ng Time-dependent crystallization evolution for synthesizing SAPO34 and SAPO-20 zeolites from a very active hydrogel is followed and reported where the XRD, FTIR, TGA/DTG, SEM/EDX, N2 adsorption –desorption and TPD-NH3 techniques are used. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemis...
Source: RSC - New J. Chem. latest articles - March 26, 2024 Category: Chemistry Authors: Guanchen Wang Source Type: research
A hierarchical fusion strategy of deep learning networks for detection and segmentation of hepatocellular carcinoma from computed tomography images
Automatic segmentation of hepatocellular carcinoma (HCC) on computed tomography (CT) scans is in urgent need to assist diagnosis and radiomics analysis. The aim of this study is to develop a deep learning base... (Source: Cancer Imaging)
Source: Cancer Imaging - March 26, 2024 Category: Radiology Authors: I-Cheng Lee, Yung-Ping Tsai, Yen-Cheng Lin, Ting-Chun Chen, Chia-Heng Yen, Nai-Chi Chiu, Hsuen-En Hwang, Chien-An Liu, Jia-Guan Huang, Rheun-Chuan Lee, Yee Chao, Shinn-Ying Ho and Yi-Hsiang Huang Tags: Research article Source Type: research
The splicing regulators RBM5 and RBM10 are subunits of the U2 snRNP engaged with intron branch sites on chromatin
Damianov et al. developed a method for the isolation of complexes derived from spliceosomes formed in vivo, applicable both in examining functions of spliceosomal factors and mapping of spliceosome assembly sites. They demonstrated that the splicing regulators RBM5 and RBM10 are U2 snRNP-associated factors r epressing exon inclusion following branch site selection. (Source: Molecular Cell)
Source: Molecular Cell - March 26, 2024 Category: Cytology Authors: Andrey Damianov, Chia-Ho Lin, Jeffrey Huang, Lin Zhou, Yasaman Jami-Alahmadi, Parham Peyda, James Wohlschlegel, Douglas L. Black Tags: Article Source Type: research
Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease
CONCLUSION: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.PMID:38525673 | DOI:10.1080/14787210.2024.2334052 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 25, 2024 Category: Infectious Diseases Authors: Chia-Chen Chen Chi-Ya Huang Jheng-Yan Wu Mei-Yuan Liu Min-Hsiang Chuang Ting-Hui Liu Ya-Wen Tsai Wan-Hsuan Hsu Po-Yu Huang Ming-Hui Chen Su-Yen Liu Mei-Chuan Lee Kuo-Chuan Hung Chih-Cheng Lai I-Ning Yang Source Type: research
Utility of molecular markers in predicting local control specific to lung cancer spine metastases treated with stereotactic body radiotherapy
CONCLUSION: We report a significant association of PD-L1 ≥ 50% status on improved LC rates from spine SBRT in NSCLC patients.PMID:38526757 | DOI:10.1007/s11060-024-04603-8 (Source: Cancer Control)
Source: Cancer Control - March 25, 2024 Category: Cancer & Oncology Authors: Dana Shor Alexander V Louie Kang Liang Zeng Ines B Menjak Eshetu G Atenafu None Chia-Lin Tseng Jay Detsky Jeremie Larouche Beibei Zhang Hany Soliman Sten Myrehaug Pejman Maralani David M Hwang Arjun Sahgal Hanbo Chen Source Type: research
Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana
J Food Drug Anal. 2023 Dec 15;31(4):739-771. doi: 10.38212/2224-6614.3483.ABSTRACTBoehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). ...
Source: Cancer Control - March 25, 2024 Category: Cancer & Oncology Authors: Ching-Yi Lu Zheng-Ying Huang Meng-Chin Chen Hui-Kang Liu Shoei-Sheng Lee Chia-Chuan Chang Source Type: research
A large language model-based generative natural language processing framework fine-tuned on clinical notes accurately extracts headache frequency from electronic health records
CONCLUSION: We developed a robust information extraction model based on a state-of-the-art large language model, a GPT-2 generative model that can extract headache frequency from EHR free-text clinical notes with high accuracy and R2 score. It overcame several challenges related to different ways clinicians document headache frequency that were not easily achieved by traditional NLP models. We also showed that GPT-2-based frameworks outperformed ClinicalBERT in terms of accuracy in extracting headache frequency from clinical notes. To facilitate research in the field, we released the GPT-2 generative model and inference co...
Source: Headache - March 25, 2024 Category: Neurology Authors: Chia-Chun Chiang Man Luo Gina Dumkrieger Shubham Trivedi Yi-Chieh Chen Chieh-Ju Chao Todd J Schwedt Abeed Sarker Imon Banerjee Source Type: research
Clinical effectiveness of oral antiviral agents for treating non-hospitalized COVID-19 patients with chronic kidney disease
CONCLUSION: Oral antiviral agents could be associated with lower rates of all-cause hospitalization or death among non-hospitalized COVID-19 patients with CKD.PMID:38525673 | DOI:10.1080/14787210.2024.2334052 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - March 25, 2024 Category: Infectious Diseases Authors: Chia-Chen Chen Chi-Ya Huang Jheng-Yan Wu Mei-Yuan Liu Min-Hsiang Chuang Ting-Hui Liu Ya-Wen Tsai Wan-Hsuan Hsu Po-Yu Huang Ming-Hui Chen Su-Yen Liu Mei-Chuan Lee Kuo-Chuan Hung Chih-Cheng Lai I-Ning Yang Source Type: research
