The characterization and comorbidities of heterozygous Bardet-Biedl syndrome carriers
Conclusion: We found that aside from the association with overweight and obesity, heterozygous BBS mutations did not appear to increase the predisposition of individuals to comorbidities and metabolic diseases. To gain a more comprehensive understanding of the genetic susceptibility associated with Bardet-Biedl Syndrome (BBS), further research is warranted.PMID:38617006 | PMC:PMC11008491 | DOI:10.7150/ijms.92766 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Meng-Hua Li I-Chieh Chen Hui-Wen Yang Hsin-Chien Yen Yung-Chieh Huang Chia-Chi Hsu Yi-Ming Chen Yu-Yuan Ke Source Type: research
Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma
CONCLUSION: The risk score model derived from proteomic profiling of tumor microenvironment can be used to predict recurrence risk and prognosis of stage I LUAD.PMID:38621342 | DOI:10.1016/j.lungcan.2024.107791 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Yueh-Feng Lu Ya-Hsuan Chang Yi-Ju Chen Min-Shu Hsieh Mong-Wei Lin Hsao-Hsun Hsu Chia-Li Han Yu-Ju Chen Sung-Liang Yu Jin-Shing Chen Hsuan-Yu Chen Source Type: research
The characterization and comorbidities of heterozygous Bardet-Biedl syndrome carriers
Conclusion: We found that aside from the association with overweight and obesity, heterozygous BBS mutations did not appear to increase the predisposition of individuals to comorbidities and metabolic diseases. To gain a more comprehensive understanding of the genetic susceptibility associated with Bardet-Biedl Syndrome (BBS), further research is warranted.PMID:38617006 | PMC:PMC11008491 | DOI:10.7150/ijms.92766 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Meng-Hua Li I-Chieh Chen Hui-Wen Yang Hsin-Chien Yen Yung-Chieh Huang Chia-Chi Hsu Yi-Ming Chen Yu-Yuan Ke Source Type: research
Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma
CONCLUSION: The risk score model derived from proteomic profiling of tumor microenvironment can be used to predict recurrence risk and prognosis of stage I LUAD.PMID:38621342 | DOI:10.1016/j.lungcan.2024.107791 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - April 15, 2024 Category: Genetics & Stem Cells Authors: Yueh-Feng Lu Ya-Hsuan Chang Yi-Ju Chen Min-Shu Hsieh Mong-Wei Lin Hsao-Hsun Hsu Chia-Li Han Yu-Ju Chen Sung-Liang Yu Jin-Shing Chen Hsuan-Yu Chen Source Type: research
The characterization and comorbidities of heterozygous Bardet-Biedl syndrome carriers
Conclusion: We found that aside from the association with overweight and obesity, heterozygous BBS mutations did not appear to increase the predisposition of individuals to comorbidities and metabolic diseases. To gain a more comprehensive understanding of the genetic susceptibility associated with Bardet-Biedl Syndrome (BBS), further research is warranted.PMID:38617006 | PMC:PMC11008491 | DOI:10.7150/ijms.92766 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - April 15, 2024 Category: Biomedical Science Authors: Meng-Hua Li I-Chieh Chen Hui-Wen Yang Hsin-Chien Yen Yung-Chieh Huang Chia-Chi Hsu Yi-Ming Chen Yu-Yuan Ke Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Since the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pancreatic cancer cell-of-origin, analysis of single -cell datasets revealed that the ECM shapes an alternate route ...
Source: American Journal of Pathology - April 15, 2024 Category: Pathology Authors: Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael, W. Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang, Po-Hsien Huan Tags: Regular Article Source Type: research
Letter Regarding: “Mesh Type With Ventral Hernia Repair: A Systematic Review and Meta-Analysis of Randomized Trials”
We read the article by Siddiqui et al. titled “Mesh Type With Ventral Hernia Repair: A Systematic Review and Meta-Analysis of Randomized Trials” published in the Journal of Surgical Research with great interest.1 The authors performed a meta-analysis to compare the outcomes of biologic versus synthetic meshes for ventral hernia repair. Their analysis included four randomized controlled trials with a total of 758 patients, demonstrating significantly higher rates of major complications, hernia recurrence, and surgical site occurrences with the use of biological mesh than with synthetic mesh. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - April 15, 2024 Category: Surgery Authors: Kuo-Chuan Hung, Chia-Li Kao, Wei-Cheng Liu, I-Wen Chen Tags: Letter to the editor Source Type: research
Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXR α/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models
Biomed Pharmacother. 2024 Apr 13;174:116598. doi: 10.1016/j.biopha.2024.116598. Online ahead of print.ABSTRACTAngiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), and 8-prenylnaringenin (8-PN), with the potential to manage lipid metabolism. T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wan-Yun Gao Pei-Yi Chen Hao-Jen Hsu Je-Wen Liou Chia-Ling Wu Ming-Jiuan Wu Jui-Hung Yen Source Type: research
Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXR α/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models
Biomed Pharmacother. 2024 Apr 13;174:116598. doi: 10.1016/j.biopha.2024.116598. Online ahead of print.ABSTRACTAngiopoietin-like 3 (ANGPTL3) acts as an inhibitor of lipoprotein lipase (LPL), impeding the breakdown of triglyceride-rich lipoproteins (TGRLs) in circulation. Targeting ANGPTL3 is considered a novel strategy for improving dyslipidemia and atherosclerotic cardiovascular diseases (ASCVD). Hops (Humulus lupulus L.) contain several bioactive prenylflavonoids, including xanthohumol (Xan), isoxanthohumol (Isoxan), 6-prenylnaringenin (6-PN), and 8-prenylnaringenin (8-PN), with the potential to manage lipid metabolism. T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2024 Category: Drugs & Pharmacology Authors: Wan-Yun Gao Pei-Yi Chen Hao-Jen Hsu Je-Wen Liou Chia-Ling Wu Ming-Jiuan Wu Jui-Hung Yen Source Type: research
LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus
Int J Mol Sci. 2024 Apr 2;25(7):3963. doi: 10.3390/ijms25073963.ABSTRACTOral cancer ranks fourth among malignancies among Taiwanese men and is the eighth most common cancer among men worldwide in terms of general diagnosis. The purpose of the current study was to investigate how low-density lipoprotein receptor-related protein 1B (LDL receptor related protein 1B; LRP1B) gene polymorphisms affect oral squamous cell carcinoma (OSCC) risk and progression in individuals with diabetes mellitus (DM). Three LRP1B single-nucleotide polymorphisms (SNPs), including rs10496915, rs431809, and rs6742944, were evaluated in 311 OSCC case...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Liang-Cheng Chen Yu-Sheng Lo Hsin-Yu Ho Chia-Chieh Lin Yi-Ching Chuang Wei-Chen Chang Ming-Ju Hsieh Source Type: research
An optimization model for reducing thrombectomy center rotations while maintaining medical accessibility
CONCLUSION: Our optimization model supports reducing the number of daily rotating hospitals by half while preserving a balance between patient accessibility and alleviating strain on medical teams.PMID:38614907 | DOI:10.1016/j.jfma.2024.04.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 13, 2024 Category: General Medicine Authors: Ming-Ju Hsieh Chung-Jung Lin Yen-Heng Lin Ling-Chieh Kung Jiun-Yu Yu Chia-Wei Kuo Source Type: research
Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition
J Cell Mol Med. 2024 Apr;28(8):e18299. doi: 10.1111/jcmm.18299.ABSTRACTPulmonary fibrosis is a lung disorder affecting the lungs that involves the overexpressed extracellular matrix, scarring and stiffening of tissue. The repair of lung tissue after injury relies heavily on Type II alveolar epithelial cells (AEII), and repeated damage to these cells is a crucial factor in the development of pulmonary fibrosis. Studies have demonstrated that chronic exposure to PM2.5, a form of air pollution, leads to an increase in the incidence and severity of pulmonary fibrosis by stimulation of epithelial-mesenchymal transition (EMT) in...
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Chia-Chia Chao Sheng-Yen Hsiao Wan-Chen Kao Pei-Chen Chiou Chieh-Chen Huang Mei-Ting Wang Po-Chun Chen Source Type: research
An optimization model for reducing thrombectomy center rotations while maintaining medical accessibility
CONCLUSION: Our optimization model supports reducing the number of daily rotating hospitals by half while preserving a balance between patient accessibility and alleviating strain on medical teams.PMID:38614907 | DOI:10.1016/j.jfma.2024.04.007 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - April 13, 2024 Category: General Medicine Authors: Ming-Ju Hsieh Chung-Jung Lin Yen-Heng Lin Ling-Chieh Kung Jiun-Yu Yu Chia-Wei Kuo Source Type: research
Defect Induced Structural Transition and Lipase Immobilizatoin in Mesoporous Aluminum Metal-Organic Frameworks
Chemistry. 2024 Apr 12:e202400603. doi: 10.1002/chem.202400603. Online ahead of print.ABSTRACTThe disorder to order and structural transformation are unique metal-organic framework (MOF) characters. How to adapt or control both behaviors in MOF is rarely studied. In this case, we demonstrate that our successful synthesis of [Al(OH)(PDA)]n (AlPDA-53-DEF, AlPDA-53-H, and AlPDA-68) with H2PDA = 4,4'-[1,4-phenylenebis(ethyne-2,1-diyl)]-di benzoic acid has illuminated the intricate world of Aluminum Metal-Organic Frameworks (Al-MOFs), offering profound insights into defect structures to order and transformations. AlPDA-53-DEF, ...
Source: Chemistry - April 13, 2024 Category: Chemistry Authors: Sivasankar Kulandaivel Chun-Chuen Yang Yi-Chun Yeh Chia-Her Lin Source Type: research
