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Molecules, Vol. 29, Pages 1748: Diverse Co(II) Coordination Polymers with the Same Mixed Ligands: Evaluation of Chemical Stability and Structural Transformation
er Chen Reactions of Co(OAc)2&middot;4H2O, N&sbquo;N&rsquo;-bis(3-pyridylmethyl)oxalamide (L) and 4,4&prime;-sulfonyldibenzoic acid (H2SDA) afforded four coordination polymers with the same mixed ligands, {[Co(L)(SDA)(H2O)2]&middot;H2O&middot;CH3OH}n, 1, {[Co(L)0.5(SDA)]&middot;2H2O&middot;0.5L}n, 2, {[Co(L)1.5(SDA)(H2O)]&middot;H2O}n, 3, and {[Co2(L)1.5(SDA)2(H2O)2]&middot;4H2O}n, 4, which have been structurally characterized using single-crystal X-ray crystallography. Complexes 1&ndash;4 are 2D layers, revealing topologies of sql,...
Source: Molecules - April 12, 2024 Category: Chemistry Authors: Chia-Yi Lee Yu-Hui Ye Song-Wei Wang Jhy-Der Chen Tags: Article Source Type: research

Disseminated Cryptococcus neoformans infection involving multiple bones and lung in an immunocompetent patient: a case report
Cryptococcal osteomyelitis is a rare and potentially serious condition, typically encountered in individuals with compromised immune systems. This case underscores the unusual occurrence of disseminated Crypto... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 12, 2024 Category: Infectious Diseases Authors: Yang-Ming Lee, Yuag-Meng Liu and Tsung-Chia Chen Tags: Case Report Source Type: research

Conventional and machine-learning based risk score for patients with early-stage hepatocellular carcinoma
CONCLUSIONS: Both the conventional Cox-based CATS-IF score and ML-based CATS-INF score effectively stratified patients with early-stage HCC into distinct prognostic groups, with the CATS-INF score showing slightly superior performance.PMID:38600872 | DOI:10.3350/cmh.2024.0103 (Source: Clinical and molecular hepatology)
Source: Clinical and molecular hepatology - April 11, 2024 Category: Gastroenterology Authors: Chun-Ting Ho Elise Chia-Hui Tan Pei-Chang Lee Chi-Jen Chu Yi-Hsiang Huang Teh-Ia Huo Yu-Hui Su Ming-Chih Hou Jaw-Ching Wu Chien-Wei Su Source Type: research

Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress
Cell Rep. 2024 Apr 10;43(4):114069. doi: 10.1016/j.celrep.2024.114069. Online ahead of print.ABSTRACTThe integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation of growth arrest and DNA damage-inducible 34 (GADD34), a stress-induced regulatory subunit of protein phosphatase 1 that mediates translation reactivation and stress recovery. Here, we uncover a novel ISR regulatory mechanism that post-transcriptionally controls the stability of PPP1R15...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Vera Magg Alessandro Manetto Katja Kopp Chia Ching Wu Mohsen Naghizadeh Doris Lindner Lucy Eke Julia Welsch Stefan M Kallenberger Johanna Schott Volker Haucke Nicolas Locker Georg Stoecklin Alessia Ruggieri Source Type: research

Transcriptomic analysis reveals Cilostazol's role in ameliorating cardiovascular disease: Inhibition of monocyte-to-macrophage differentiation and reduction of endothelial cell reactive oxygen species production
CONCLUSION: The findings offer a nuanced understanding of the advantages and mechanisms of cilostazol in CVD, uncovering novel therapeutic targets and strategies to enhance the clinical application of cilostazol and contributing to the broader implications of this therapy in cardiovascular health.PMID:38601627 | PMC:PMC11004659 | DOI:10.1016/j.heliyon.2024.e29194 (Source: Atherosclerosis)
Source: Atherosclerosis - April 11, 2024 Category: Cardiology Authors: Chia-Ning Fan Tsung-Neng Tsai Xin-Jie Lu Hsing-Fan Lai Chun-Hua Wang Yi-Lin Chiu Source Type: research

Intestinal obstruction secondary to peritoneal metastases: More harm than good with water-soluble contrast study?
Asian J Surg. 2024 Apr 10:S1015-9584(24)00590-6. doi: 10.1016/j.asjsur.2024.03.163. Online ahead of print.NO ABSTRACTPMID:38604855 | DOI:10.1016/j.asjsur.2024.03.163 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 11, 2024 Category: Surgery Authors: Joreen Wen Qi Neo Sachin Mathur Claramae Shulyn Chia Chin-Ann Johnny Ong Source Type: research

Proteomic profiling of tumor microenvironment and prognosis risk prediction in stage I lung adenocarcinoma
Lung cancer is the leading cause of cancer-related mortality worldwide [1]. With the popularity of low-dose computed tomography (CT) screening, more and more early-stage lung cancers were being diagnosed. Flores et al. found a stage shift from later to earlier stage disease among people with lung cancer over the last decade. From 2006 to 2016, stage I-II lung cancer diagnoses increased from 26.5  % to 31.2 %, and stage III-IV diagnoses decreased from 70.8 % to 66.1 % [2]. The majority of patients diagnosed with low-dose CT were in the earlier stage. (Source: Lung Cancer)
Source: Lung Cancer - April 11, 2024 Category: Cancer & Oncology Authors: Yueh-Feng Lu, Ya-Hsuan Chang, Yi-Ju Chen, Min-Shu Hsieh, Mong-Wei Lin, Hsao-Hsun Hsu, Chia-Li Han, Yu-Ju Chen, Sung-Liang Yu, Jin-Shing Chen, Hsuan-Yu Chen Source Type: research

Pharmacological interventions to improve sleep in people with Alzheimer's disease: a meta-analysis of randomized controlled trials
CONCLUSION: Although melatonin was the most investigated intervention, the evidence for its efficacy is inconclusive. On the other hand, trazodone and orexin receptor antagonists showed promising results; however, more RCTs are needed for definite answers.PMID:38597219 | DOI:10.1080/14737175.2024.2341004 (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - April 10, 2024 Category: Neurology Authors: Amy Bedward Jasmine Kaur Sadiyah Seedat Holly Donohue Chia Siang Kow Muhammad Kamran Rasheed Amaan Javed Syed Shahzad Hasan Source Type: research

Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging
Oncol Lett. 2024 Mar 26;27(5):234. doi: 10.3892/ol.2024.14367. eCollection 2024 May.ABSTRACTCurrent tools are insufficient for distinguishing patients with ovarian cancer from those with benign ovarian lesions before extensive surgery. The present study utilized a readily accessible platform employing a negative selection strategy, followed by flow cytometry, to enumerate circulating tumor cells (CTCs) in patients with ovarian cancer. These counts were compared with those from patients with benign ovarian lesions. CTC counts at baseline, before and after anticancer therapy, and across various clinical scenarios involving o...
Source: Oncology Letters - April 10, 2024 Category: Cancer & Oncology Authors: Yung-Chia Kuo Chi-Hsi Chuang Hsuan-Chih Kuo Cheng-Tao Lin Angel Chao Huei-Jean Huang Hung-Ming Wang Jason Chia-Hsun Hsieh Hung-Hsueh Chou Source Type: research