Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice.
Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - November 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Consume their Neighbors
The accumulation of lingering senescent cells is an important contributing cause of degenerative aging. In this intriguing report, researchers note that senescent cells resulting from chemotherapy treatment can consume neighboring cells in order to prolong their survival. This is most likely the case for senescent cells in general, whatever their origin. This cellular cannibalism is probably detrimental to tissue function to some small degree, but, since senescent cells are always a tiny minority of all cells, even in old tissues, it is nowhere near as detrimental as the inflammatory signaling profile that accompanies cell...
Source: Fight Aging! - October 31, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Vicodin Withdrawal: Symptoms, Timeline and Treatment
What is Vicodin and What Does It Do?
According to MedicineNet, Vicodin is a combination of Hydrocodone and Acetaminophen. Hydrocodone is a narcotic pain-reliever and a cough suppressant, similar to codeine. Hydrocodone blocks the receptors on nerve cells in the brain that give rise to the sensation of pain. Acetaminophen is a non-narcotic pain reliever and fever reducer. Acetaminophen works by elevating the threshold to pain. Essentially, in order for pain to be felt, s greater stimulation of the nerves responsible for the sensation of pain is necessary. It reduces fever through its action on the temperature-regulating ce...
Source: Cliffside Malibu - October 30, 2019 Category: Addiction Authors: Jaclyn Uloth Tags: Addiction Addiction Recovery Detox Resources for Alcohol and Drugs/Opiates Drug Rehab Information Drug Treatment anxiety in withdrawal vicodin withdrawal symptoms Source Type: blogs
Coaxial Electrospinning Creates Novel Contraceptive, Other Medical Devices
Electrospinning is a manufacturing technique that has recently been getting a lot of attention in medicine because it allows researchers to produce novel materials and devices. Essentially, a polymer is melted and squeezed through a nozzle and an electric field is used to pull and spin it into a mesh of very fine fiber. The material has a huge surface area, given its volume, and it can be combined with drugs and other devices, and used as a part of therapies in all sorts of ways.
There’s also a type of electrospinning called coaxial electrospinning, and it allows for two or more very different polymers to be spun ...
Source: Medgadget - October 28, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Materials Medicine Neurosurgery Ob/Gyn Oncology Source Type: blogs
Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health.
Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice
https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/
Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Displaced Nuclear DNA a Meaningful Cause of Chronic Inflammation in Aging?
Sterile inflammation arises without external cause, such as infection or injury, and chronic sterile inflammation is a characteristic of aging. Inflammatory signaling becomes constant and pronounced in tissues, and the immune system is constantly roused to action. Processes, such as regeneration from injury, that depend upon a clear cycle of inflammation that starts, progresses, and resolves are significantly disrupted. It is no exaggeration to say that the downstream consequences of chronic inflammation accelerate the progression of all of the common age-related conditions. It is of great importance in atherosclerosis and...
Source: Fight Aging! - October 11, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The SENS Research Foundation on the Beneficial Nature of Senolytic Therapies
The SENS Research Foundation should need no introduction to this audience, but, just in case, this is one of the few non-profit organizations dedicated to advancing the state of the art in rejuvenation research and development. The focus of the SENS Research Foundation staff is on unblocking lines of research that are presently moving too slowly, rather than on reinforcing success. The co-founder, Aubrey de Grey, assembled the Strategies for Engineered Negligible Senescence (SENS) going on twenty years ago. It was, and is, a synthesis of what is known in the research community regarding the root causes of aging. In the SEN...
Source: Fight Aging! - October 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Many Roles of Senescent Cells
Long-lived senescent cells accumulate with age, initially quite slowly as they are efficiently removed by the immune system when their own programmed cell death processes fail, but once the immune system starts to decline with age, the burden of cellular senescence ramps up dramatically. Senescent cells secrete a potent mix of signals known as a senescence-associated secretory phenotype (SASP). It spurs chronic inflammation, destructively remodels nearby tissue, encourages nearby cells to also become senescent, and causes all sorts of other issues as well. It is very harmful, and the more senescent cells there are, the wor...
Source: Fight Aging! - October 8, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Part 6 - Why Is Cancer Pain So Special?
by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Another Hand-Cr...
Source: Pallimed: A Hospice and Palliative Medicine Blog - October 6, 2019 Category: Palliative Care Tags: cancer opioids pain rosielle The profession Source Type: blogs
Fight Aging! Newsletter, September 30th 2019
In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
Source: Fight Aging! - September 29, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Implicated in Age-Related Changes in Blood Clotting
In this study, researchers validated the expression of some of the specific factors in cultured cells and in mice, which were treated with doxorubicin, a widely-used chemotherapy drug which induces widespread senescence. Those mice showed increased blood clotting, similar to what happens in humans who undergo chemotherapy. "Conversely, when we selectively removed senescent cells in specially bred transgenic mice, the increased clotting caused by doxorubicin went away."
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells
Cellular senescence irreversibly arrests cell...
Source: Fight Aging! - September 25, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
How Are Hospitals Supposed to Reduce Readmissions? | Part I
By KIP SULLIVAN
The notion that hospital readmission rates are a “quality” measure reached the status of conventional wisdom by the late 2000s. In their 2007 and 2008 reports to Congress, the Medicare Payment Advisory Commission (MedPAC) recommended that Congress authorize a program that would punish hospitals for “excess readmissions” of Medicare fee-for-service (FFS) enrollees. In 2010, Congress accepted MedPAC’s recommendation and, in Section 3025 of the Affordable Care Act (ACA) (p. 328), ordered the Centers for Medicare and Medicaid Services (CMS) to start the Hospital Readmissions Reduction Program (HRRP...
Source: The Health Care Blog - September 24, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medicare ACA Affordable Care Act hospital readmissions Hospital Readmissions Reduction Program HRRP Kip Sullivan Medicaid MedPAC Source Type: blogs
My Ironic Journey as an SLP With ‘ Chemo Brain ’
I defeated breast cancer, but am still battling the cognitive changes left behind after two years of intense treatment. Eight surgeries, six chemotherapy treatments, 25 radiation appointments, and two bouts of infection changed my body forever.
I’m OK with that, because everything was done to keep me alive. All signs point to these efforts succeeding. But one remnant of the battle didn’t get left behind with the wigs and empty medicine bottles: chemo brain. “Chemo brain” is a common term used for the attention and memory issues often caused by cancer treatment—although these issues are thought to come fro...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - September 18, 2019 Category: Speech-Language Pathology Authors: Mary Ann Eller Tags: Health Care Private Practice Slider Speech-Language Pathology Cognitive Rehabilitation Source Type: blogs
The broader mission for hospice care
I remember it was raining outside when I told Ester she had metastatic stomach cancer. She cried, as her son sat silently holding one thin hand in two of his. After a while, she asked, how long did she have to live? I explained it depended on how well the chemotherapy worked. She smiled gently, […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 15, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/james-c-salwitz" rel="tag" > James C. Salwitz, MD < /a > < /span > Tags: Physician Palliative Care Source Type: blogs
Fight Aging! Newsletter, September 16th 2019
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial.
People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - September 15, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
