Fight Aging! Newsletter, September 16th 2019

In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without these genetic associations. Differences in blood LDL cholesterol and systolic blood pressure (the highest level that blood pressure reaches when the heart contracts), along with the number of cardiovascular events was compared between groups. A long-term reduction of 1 mmol/L low-density lipoprotein (LDL), or 'bad' cholesterol, in the blood with a 10 mmHg reduction in blood pressure led to an 80 percent lower lifetime risk of developing heart and circulatory disease. This combination also reduced the risk of death from these conditions by 67 percent. The team found that even small reductions can provide health benefits. A decrease of 0.3 mmol/L LDL cholesterol in the blood and 3 mmHg lower blood pressure was associated with a 50 percent lower lifetime risk of heart and circulatory disease. Association of Genetic Variants Related to Combined Expos...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSION: Ultrastructural changes in rat liver tissue in conditions of obstructive jaundice may be reversible after restoration of drainage. On the other hand, ultrastructural changes in renal tissue in cases of prolonged jaundice are irreversible even if the internal drainage is restored. KEY WORDS: Bile Duct, Liver, Kidney, Obstructive Jaundice. PMID: 31630139 [PubMed - as supplied by publisher]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Conclusion Cognitive rehabilitation is able to prolong the independence of the patient in performing activities of daily living and generate functional and structural changes. As a consequence of the finding of few studies that met the eligibility criteria, we also verified the need for more controlled studies and greater application control, considering the high risk of bias in the studies used.
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Conclusions Nuclear transcription receptors, cerebral cortex and hippocampus, microglia, and amyloid beta protein have shown significant importance in the pathogenesis of Alzheimer ’ s disease in this study.
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
RESUMO O fen ómeno hikikomori, forma de isolamento social grave e prolongado, constitui um desafio diagnóstico. A nível conceptual, alguns autores diferenciam o hikikomori em primário e secundário. Este último conceito é utilizado quando está presente comorbilidade que, pelo menos parcialmente, explique a síndrome, enquanto na ausência de diagnóstico psiquiátrico denomina- se “ hikikomori prim ário ” . Os autores apresentam um caso cl ínico português com as mesmas características sociodemográfica...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
His research brought an end to radical mastectomy, and he pioneered the design and implementation of large-scale multi-institutional randomized clinical trials.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Authors: Campos-Borges HC, Sanz-González SM, Zanón-Moreno V, Millán Salvador JM, Pinazo-Duran MD PMID: 31629562 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
This study assessed the effects of the incorporation of Lactobacillus acidophilus LA-05 or Bifidobacterium animalis ssp. lactis BB-12 in the content and bioaccessibility of phenolics in red pitaya pulp. The oxygen radical absorbance capacity (ORAC) of the dialyzed (bioaccessible) fraction of red pitaya pulp fermented by these probiotics was also assessed. After 48 h of cultivation in red pitaya pulp, the pH and sugar contents decreased, while organic acids and viable counts of the tested probiotics increased (p 
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 15 September 2019Source: Food Research InternationalAuthor(s): Qian Janice Wang, Charles SpenceAbstractWine colour carries a myriad of meanings regarding the provenance and expected sensory qualities of a wine. That meaning is presumably learnt through association, and part of a wine taster's skill comes from being able to decode information that can be discerned in subtle variations in the colour of the wine that they drink/evaluate. However, reliance on colour means that wine tasters, especially experts, often exhibit colour-induced olfactory biases. The present study assesses how wine ...
Source: Food Research International - Category: Food Science Source Type: research
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