Fight Aging! Newsletter, November 4th 2019
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and control mice during development. In contrast, we found that moderately reducing ACh has various effects on adult NMJs and muscle fibers. VKDHet mice have significantly larger NMJs and muscle fibers compared to age-matched control mice. They also present with reduced expression of the pro-atrophy gene, Foxo1, and have more satellite cells in skeletal muscles. These molecular and cellular features may partially explain the increased size of NMJs and muscle fibers. Thus, moderately reducing ACh may be a therapeutic strategy to prevent the loss of skeletal muscle mass that occurs with advancing age. Low Dose Quercetin as a Geroprotector in Mice https://www.fightaging.org/archives/2019/10/low-dose-quercetin-as-a-geroprotector-in-mice/ Quercetin is used in combination with dasatinib as a senolytic treatment capable of selectively destroying senescent ...
Thousands of Covid-19 patients have been treated with blood plasma outside of rigorous clinical trials — hampering research that would have shown whether the therapy worked.
Vaccines protecting against influenza, hepatitis B and rabies are less effective for obese people. As scientists develop a Covid-19 vaccine, experts say obesity could be an impediment, a sobering prospect for the US, where nearly half of all adults are obese.
A third US company has released study results showing its coronavirus vaccine is safe and elicits an immune response.
Stacey Nagy told CNN's Erin Burnett she wrote an obituary for her husband's coronavirus death where she blamed President Trump, Texas Gov. Abbott and those who do not wear masks because she felt a need to "put blame where it belonged."
SUPPLEMENTS could be used to improve the health of your heart, as well as to protect against high blood pressure symptoms and signs. Add these cheap garlic capsules to your diet to lower your risk of heart problems, including heart attacks and heart disease.
In this study, we investigated the potential effects of disocin on amyloid-β peptide (Aβ1-42) oligomers-treated HT22 cells. Aβ1-42 oligomers induced great neurotoxicity to HT22 cells as examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results of terminal deoxynucleoitidyl transferase-mediated deoxyuridine triphosphate biotin nich end labeling (TUNEL) staining and flow cytometry indicated that Aβ1-42 oligomers led to increased apoptosis and generation of reactive oxygen species (ROS) in HT22 cells. However, dioscin could remarkably inhibit the neurotoxicity induce...
Those suffering from cancer, heart conditions, strokes, diabetes and lung disease are among the worst affected by delays to their diagnosis and care, a survey of senior doctors reveals.
University of Leeds experts found heart attack admissions dropped by 40 per cent in April and May in England. They say it may have been an 'unintended consequence' of Stay At Home' slogan.
HOW TO live longer: Long life expectancy is something we would all like to strive for. According to studies, the timing of when you eat could be just as important as what you eat. Health experts advise a new way of eating which will help burn fat, improve memory, aid in a healthier heart, reduce the risk of disease and boost longevity.
Vaccine development normally takes years, if not decades. But scientific teams around the world are aiming to develop a COVID-19 vaccine in 12 to 18 months. Here’s how they’re speeding up the process and why they think a vaccine produced this fast will be just as safe as any other.
More News: Academia | Alopecia | Alzheimer's | Antidoxidants | Biochemistry | Bioflavonoids | Biology | Biotechnology | Bone Cancers | Brain | Brain Cancers | Breast Cancer | Cancer | Cancer & Oncology | Cancer Vaccines | Cardiology | Cardiomyopathy | Cardiovascular | Chemotherapy | Chronic Obstructive Pulmonary | Clinical Trials | Colon Cancer | Colorectal Cancer | Conferences | Cytology | Databases & Libraries | Dementia | Diabetes | Diabetes Type 2 | Diets | Economic Slowdown | Economy | Education | Endocrinology | Environmental Health | Esophagus Cancer | Eyes | Fruit | Gastroschisis Repair | Genetics | Heart | Heart Attack | Heart Disease | Heart Failure | Hypertension | Infectious Diseases | Influenza | Influenza Vaccine | Insulin | Laboratory Medicine | Liver | Lung Cancer | Minerals | Mitochondria | Molecular Biology | Nanotechnology | Neurology | Neuroscience | Nicotine | Nutrition | Oral Cancer | Orthopaedics | Osteoarthritis | Osteoporosis | Osteosarcoma | Parkinson's Disease | Pensions | Pharmaceuticals | Pneomococcal Vaccine | Pneumonia | Research | Science | Skin | Skin Biopsy | Sports Medicine | Statistics | Stem Cell Therapy | Stem Cells | Study | Toxicology | Translocation | Transplants | Tuberculosis | Universities & Medical Training | Urology & Nephrology | USA Health | Vaccines | Venture Capital | Veterinary Vaccinations | Vitamins