Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GTP Level Influences DNA Repair
Evidence suggests that enhanced DNA repair may act to slow the progression of aging. Researchers here note that increased levels of the metabolite guanosine triphosphate (GTP), a building block and energy source used in a variety of ways in the cell, can improve the pace of DNA repair. There are numerous ways by which GTP levels might be upregulated over the long term, but as researchers here note, the opposite is desirable in the case of cancer, in order to impair DNA repair and make cancerous cells more vulnerable to genotoxic therapies.
Researchers have long known that levels of nucleotides like GTP control how...
Source: Fight Aging! - November 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
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Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Clearance of Senescent Cells to Improve Heart Regeneration
Senescent cells accumulate with age in tissues throughout the body. Cells enter a senescent state constantly throughout life, largely the result of cells reaching the Hayflick limit on replication, but also due to stress, injury, and damage. A senescent cell ceases replication and instead produces a potent mix of pro-growth, pro-inflammatory signals. The primary purpose of senescence in an adult is to signal to the immune system that a cell needs to be removed, and potentially that the surrounding region of tissue requires further attention, such as in the case of an injury or toxic environment that is damaging other cells...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Imaging of Chromatin Structure as a Basis for an Aging Clock
Researchers here report a novel approach to building an aging clock, a system that can usefully measure biological age, the growing burden of damage and dysfunction. Epigenetic data, usually the status of DNA methylation at various sites on the genome, has been used to construct aging clocks in the past. Epigenetic changes of all sorts alter gene expression by altering the structure of chromatin, folded DNA in the cell nucleus, determining which regions and genes are exposed to transcriptional machinery. Thus why not directly assess changes in the structure of chromatin via microscopy imaging approaches? Researchers have n...
Source: Fight Aging! - October 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Mindful Body argues against mindlessly accepting age-related decline in cognition and health as inevitable
In 1979, Harvard researcher Ellen Langer invited elderly men to spend a week at a retreat designed to remind them of their younger days, surrounded by the art, music, food, games, décor, and more from the late 1950s. Afterward, the men were tested and found to have made significant gains in hearing, memory, dexterity, posture, and general well-being. It was as if being in a place signaling their younger days made them physiologically “younger.”
Maybe you, too, have had an experience where your mind seemed to affect your health. It turns out there’s a reason for that, according to Langer, author of the new book The M...
Source: SharpBrains - October 9, 2023 Category: Neuroscience Authors: Greater Good Science Center Tags: Brain/ Mental Health Education & Lifelong Learning anti-anxiety medication anti-depressants book cognition cognitive change cognitive-abilities Ellen Langer mind mindfulness-meditation mindlessly physiology placebo studies Th Source Type: blogs
Healthcare IT Regulations – What Needs to Be Added and What Needs to Be Removed
There are a lot of rules and regulations in place in the world of healthcare. These are put into place in order to protect patients and organizations. However, the world of healthcare is constantly changing and evolving as we come up with new ideas and solutions. Have the regulations done the same though? Or are there areas that are missing regulations? Or are there areas in healthcare where past regulations are now too restrictive and are holding us back?
In search of answers to these questions, we reached out to our incredibly beautiful Healthcare IT Today Community to see what areas they would add, remove, or update re...
Source: EMR and HIPAA - September 19, 2023 Category: Information Technology Authors: Grayson Miller Tags: Administration Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System LTPAC Regulations 1upHealth 4medica Amanda Heidemann Andrea Mazzoccoli Andrew Norden MD Bill Charnetski Cheryl Cheng Commur Source Type: blogs
Drug Delivery System for Ectopic Pregnancy
Researchers at Oregon State University have developed a drug delivery system that is intended to treat ectopic pregnancy. Often occurring in the fallopian tubes, ectopic pregnancies are non-viable and are the leading cause of maternal death in the first trimester. A drug called methotrexate can be administered to end the pregnancy, but can cause serious side-effects at the concentrations required. These researchers designed a nanoparticle delivery vehicle for methotrexate that can release its drug payload near where it is needed by responding to glutathione, a tripeptide that is present in high concentrations in placental ...
Source: Medgadget - August 22, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Ob/Gyn Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rutin Suppresses the SASP of Senescent Cells
Senescent cells accumulate with age and cause harm via a sustained, energetic production of signal molecules, the senescence-associated secretory phenotype (SASP), that disrupts tissue structure and function. In addition to the search for senolytic drugs that can selectively destroy senescent cells by pushing them into programmed cell death, researchers are also looking for senomorphic drugs that can suppress some or most of the SASP by interfering in its regulatory mechanisms. This seems to me a poor alternative to clearance of senescent cells, as a senomorphic drug must be taken continually, but nonetheless a great many ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Health misinformation ’ s deadly impact
Turning into vegetarians can cure COVID-19, birth control pills cause abortions, or eating ginger is 10,000 times more effective than chemotherapy at curing cancer were some casually trending health misinformation in the past year. But what is health misinformation, and why is it a serious public health concern? Health misinformation refers to health-related information that
Read more…
Health misinformation’s deadly impact originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 29, 2023 Category: General Medicine Authors: Neha Gour Tags: Policy Mainstream media Source Type: blogs
Cancer Treatment Increases Biological Age
The established non-surgical forms of cancer treatment, chemotherapy and radiotherapy, induce cellular senescence via stress and damage to cells. The target for these harmful effects is the cancer, but other cells are also inevitably stressed to the point of entering a senescent state. An increased burden of senescent cells in tissues throughout the body is a feature of aging. These cells directly contribute to dysfunction of tissues and organs via secreted signals, the senescence-associated secretory phenotype (SASP). When maintained over the long term, the SASP contributes to the onset and progression of age-related cond...
Source: Fight Aging! - July 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Sweet Spot of Health Care Cost Containment
BY BEN WHEATLEY
As health care continues to move in the direction of unaffordability, policy makers are considering a range of options to bring down health care costs. The Health Affairs Committee on Health Care Spending and Value has identified four broad areas for reform, including administrative savings, price regulation and supports for competition, spending growth targets, and value-based payment. These measures appropriately target health care’s supply side and the excesses that exist in the health care system.
In this blog, I would like to highlight another avenue for savings: one that focuses on the demand ...
Source: The Health Care Blog - July 19, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health Care Cost Containment Health care spending Source Type: blogs
Data Democracy! ‘Dr. Google’ (2023) Vs. ‘Every Man His Own Physician’ (1767)
BY MICHAEL MILLENSON
In the 18th-century, a pre-Google guide offered democratization of medical information
In 1767, as American colonists’ protestations against “taxation without representation” intensified, a Boston publisher reprinted a book by a British doctor seemingly tailor-made for the growing spirit of independence.
Talk about “democratization of health care information,” “participatory medicine” and “health citizens”! Every Man His Own Physician, by Dr. John Theobald, bore an impressive subtitle: Being a complete collection of efficacious and approved remedies for every disease...
Source: The Health Care Blog - July 7, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Democritization of Care Healthcare Michael Millenson Participatory medicine Source Type: blogs
