Trojan Horse Virus Makes Tumors Destroy Themselves
Researchers at the University of Zurich have developed a virus-based therapy that causes a tumor to destroy itself. They modified an adenovirus, which is a common virus that typically infects the respiratory tract and which is already widely used in medicine, to deliver genetic material that codes for an anti-cancer protein. In a sneaky move, the researchers designed the therapy so that the virus would infect tumor cells, forcing them to destroy themselves.
Cancer therapies are constantly evolving. Immunotherapies, which include antibodies that stimulate the immune system to destroy cancer cells, are the latest class of...
Source: Medgadget - May 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Materials Medicine Oncology Source Type: blogs
Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated.
Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth
https://www.fightaging.org/archi...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The COVID-19 pandemic vowels: adaptability, empathy, innovation, optimism, unity
It feels like the days when I could go to all-you-can-eat buffets, when I could actually catch a smile from a patient and when I could hug someone after a successful chemotherapy round were written in history books long ago. In some ways, I have spent over the last 13 months figuring out how toRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 14, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/ricardo-chujutalli-and-daniel-azzam" rel="tag" > Ricardo Chujutalli and Daniel Azzam < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
Standing on Your Own Two Feet …at the bottom of the abyss
My chemotherapy for Hodgkin’s lymphoma started just four weeks after I got the cancerous vertebrae removed from my lower back. They’d inserted a metal cage inserted in its place, to hold my back together. The doctor said this procedure would keep me from being in a wheelchair for the rest of my life. I had just turned 33 years old.
But there I was: back in a wheelchair. Already. Just two chemo infusions into the long process ahead of me and I was responding so poorly that my body could no longer walk. I was feeling vulnerable, scared and scarred. I was dropping weight and popping pain pills. It was a time of e...
Source: PickTheBrain | Motivation and Self Improvement - May 13, 2021 Category: Consumer Health News Authors: Kristi Nelson Tags: confidence creativity depression featured happiness philosophy psychology self-improvement cancer empowerment healing inspiration motivation Source Type: blogs
Reviewing Recent Work on the Mechanisms of Cellular Senescence
Impressive results have been produced in mice via clearance of senescent cells: rejuvenation, extension of life, and reversal of numerous different age-related conditions. This has provoked an increasing number of research groups to focus on the mechanisms of cellular senescence, in search of novel ways to identify and destroy these cells, or to suppress the senescence-associated secretory phenotype (SASP) that they produce. The secreted signal molecules of the SASP alter surrounding cell behavior and rouse the immune system to chronic inflammation. This is the means by which the comparatively small number of lingering sen...
Source: Fight Aging! - May 11, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 10th 2021
This study suggests that some of those changes contribute to age-related hypertension, providing yet another reason to put resources into the near term development of therapies that can reverse the aging of the gut microbiome, such as flagellin vaccination or fecal microbiota transplantation.
"Previous studies from our lab have shown that the composition of the gut microbiota in animal models of hypertension, such as the SHRSP (spontaneously hypertensive stroke-prone) rat model, is different from that in animals with normal blood pressure. Further, transplanting dysbiotic gut microbiota from a hypertensive animal ...
Source: Fight Aging! - May 9, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ABL1 Inhibition Increases Neural Stem Cell Activity in the Aging Brain
Putting stem cells back to work is the theme of a great of the research that takes place in the regenerative medicine community. Stem cells are responsible for producing a supply of daughter somatic cells, required to replace losses and maintain functional tissue. Stem cell activity throughout the body declines with age, however. Much of this decline is not caused by intrinsic cell and tissue damage that would prevent activity, but is rather an evolved reaction to the presence of that damage.
Suppressing stem cell activity likely serves to reduce cancer risk in later life. The more cell activity there is in a damage...
Source: Fight Aging! - May 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Calorie Restriction as an Adjuvant Cancer Treatment
Calorie restriction and intermittent fasting have been extensively studied in the context of aging, and most of the age-slowing interventions so far tested in animal studies are derived in some way from a knowledge of the stress response mechanisms triggered by a lowered calorie intake. The long term effects of calorie restriction and fasting in short-lived species are quite different from those in long-lived species: only the short-lived species exhibit a meaningful extension of life span, as much as 40% in mice. Yet the short-term effects on metabolism and cellular mechanisms are very similar. The beneficial response to ...
Source: Fight Aging! - April 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Implantable Pump Delivers Chemotherapy to Brain Tumors
Researchers at Linköping University, Sweden, and the Medical University of Graz, Austria have developed an electrical pump that can precisely deliver chemotherapeutic drugs into the brain. The technology is conceived as being implantable into brain tumor resection sites to deliver localized chemotherapy over extended periods. It is hoped that this approach can prevent tumor recurrence.
Unfortunately, brain tumor recurrence following surgical resection is all too common. It is difficult to remove all traces of the tumor without causing significant damage to healthy brain tissue, and therefore recurrence is inevitable fo...
Source: Medgadget - April 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurology Neurosurgery Oncology Source Type: blogs
Can some postmenopausal women with breast cancer skip chemotherapy?
Breast cancer remains the most common cancer among women. In the last two decades, the treatment of breast cancers has become personalized. This has been possible due to the subtyping of breast cancers. Breast cancers have been subtyped based on the receptors on the breast cancer cell. The most clinically significant receptors — those that have targeted therapies — are the estrogen and progesterone receptors and the human epidermal growth factor receptor 2 (HER2). Cancers that have the estrogen and progesterone receptors are termed hormone receptor (HR)-positive cancers.
The development of hormone therapy for HR-positi...
Source: Harvard Health Blog - April 15, 2021 Category: Consumer Health News Authors: Salewa T. Salewa Oseni, MD Tags: Cancer Medical Research Women's Health Source Type: blogs
Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders.
Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Non-Invasive Biomarker to Measure the Effectiveness of Senolytic Drugs
In this study, mice were given chemotherapy which induces widespread senescence, followed by a senolytic drug. The biomarker was only detected in the blood and urine of mice treated with both chemotherapy and the senolytic, but not with either on its own, confirming specificity for senolysis.
Link: https://www.buckinstitute.org/news/the-first-non-invasive-biomarker-to-track-and-verify-efficacy-of-senolytic-drugs/ (Source: Fight Aging!)
Source: Fight Aging! - April 8, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Accelerating the Development of Tests for Endometriosis and Cancer
NIGMS’ Small Business Technology Transfer (STTR) program works toward more effective methods for patient screening, diagnosis, and treatment.
Translating lab discoveries into health care products requires large investments of time and resources. Through the STTR Regional Technology Transfer Accelerator Hubs for IDeA States program, NIGMS helps researchers interested in transitioning their discoveries and/or inventions into products. Here are the stories of three researchers working with the XLerator Hub, which funds projects in the southeastern United States and Puerto Rico.
Ending Diagnostic Delays for Endomet...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 7, 2021 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness Cancer Diseases Profiles Scientific Process Source Type: blogs
Evaluation of the Surgical Specimen After Neoadjuvant Systemic Therapy
ConclusionPostneoadjuvant systemic therapy histopathological changes are complex, and careful systematic review of the specimen is required for accurate diagnosis and follow-up treatment. For pathological complete response to be used as an indicator of response to novel therapies, it is essential to have a standardized way in which residual disease is measured and reported. We designed the recommendations specifically for the clinical trial setting; however, they can be optionally incorporated into routine practice because, in our opinion, standardization is most effective when uniformly applied. Hopefully, such standardiz...
Source: Oncopathology - March 23, 2021 Category: Cancer & Oncology Tags: breast Breast Biopsy Procedure breast cancer Source Type: blogs
