Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
T Cell Immunotherapy an Improvement Over Checkpoint Inhibition
Researchers here report on the results of a phase III trial of tumor infiltrating leukocyte (TIL) therapy for melanoma. A patient's T cells are multiplied outside the body and then injected, along with chemotherapy beforehand to clear existing T cell populations, and IL-2 delivery afterwards to promote replication of the delivered T cells. It has meaningful side-effects, as do other cancer immunotherapies, but the outcome is an improvement over the present standard approach of checkpoint inhibition for melanoma. Even as better approaches to cancer therapy are in development, such as those based on interference in telomere ...
Source: Fight Aging! - December 14, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Age-Related Mitochondrial DNA Mutation Does Not Appear to Influence Cancer, and Vice Versa
Mitochondria have their own genome, and damage to this mitochondrial DNA is thought to be involved in aging. Some forms of mitochondrial DNA damage can result in mitochondria that are both dysfunctional and have a selection advantage over their unmutated peers, allowing them to overtake a cell, turning it into an exporter of harmful oxidative molecules. Cancer is an age-related condition, in the sense that the risk of suffering cancer grows with age, but this interesting paper provides evidence to suggest that there is little to no mechanistic link between mitochondrial DNA damage and cancer.
Mitochondria are smal...
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A woman in her 20s with syncope
Written by Destiny Folk MD, with edits by Meyers, peer reviewed by Smith and GrauerA woman in her late 20s with a past medical history of cervical cancer status post chemotherapy and radiation therapy presented to the emergency department for shortness of breath, chest tightness, and two episodes of syncope.Her initial vital signs revealed a temp of 97.7F, HR 125, RR 20, BP 115/90, and an oxygen saturation of 95% on room air. Upon arrival, she did not appear in acute distress. She was noted to be tachycardic and her heart sounds were distant on physical exam. She had a normal respiratory effort, and her lungs were clear to...
Source: Dr. Smith's ECG Blog - November 28, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
mTOR in the Enhancement of Cancer Treatment Outcomes via Calorie Restriction
Calorie restriction, and related approaches such as protein restriction, tend to improve the outcomes for cancer patients, making cancers more vulnerable to therapies by reducing the normally rampant replication of cancer cells. Here, researchers explore the role of mTOR signaling in the mechanisms underlying this effect, finding the link between dietary intake of amino acids and mTOR activity in cell growth. Manipulating these mechanisms isn't enough on its own to deal with cancer, but there is a lot to be said for low cost improvements to the odds of success for patients undertaking any form of cancer therapy.
R...
Source: Fight Aging! - November 25, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Forgiveness
Mrs. Dalai was the love of my life, and I had the great honor of sharing the past 36 years with her. I will miss her more than I can possibly describe. She was often a contradiction in terms. She could be shy, she could be brash. She was retiring, she was outgoing. She felt the presence of God, but she didn ’t much like dealing with religion. She was easy to love, and she could be hard to love. But we loved her anyway. Mrs. Dalai and I met on a blind date on July 19, 1986. For me, it was love at first sight. For her, it took a little longer. She didn’t know what to do with me. She kept telling me to go away, and I kept...
Source: Dalai's PACS Blog - November 24, 2022 Category: Radiology Source Type: blogs
Learning About Medication Success at #HLTH2022 from Synapse Medicine
One of the great things about the HLTH 2022 conference is you get a wide range of topics across every part of healthcare. For example, I attended a session on Medication Success that was presented by Franck Tricot, VP, Strategic Partnerships at Synapse Medicine. Tricot gave us a really interesting view into what it takes to do medications properly in healthcare. I live tweeted what was shared. Check out my summary below to learn how you can better manage medications in your organization.
Let’s get this party started. Time to learn about Medication Success with @SynapseMed at the #HLTH2022 tech talk stage. pi...
Source: EMR and HIPAA - November 21, 2022 Category: Information Technology Authors: John Lynn Tags: Clinical EMR-EHR Health IT Company Healthcare IT Hospital - Health System Franck Tricot Healthcare Scene Featured Hlth HLTH 2022 Medication Reconiliation Medication Success Synapse Medicine Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Better Understanding the Outcome of Destroying and Rebuilding the Immune System
The use of chemotherapy to destroy as much of the peripheral immune system as possible, followed by some form of stem cell transplant to rebuild it, has been used for some years as a way to treat multiple sclerosis. In this autoimmune condition, the problem resides in the immune memory, and getting rid of that memory is the solution. The only approach currently demonstrated to work is this somewhat drastic treatment, and the balance of risk and cost means that it is only used for severe diseases such as multiple sclerosis. But in principle, clearance and restoration of the immune system could solve a great many of the issu...
Source: Fight Aging! - November 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Making Tumors Tastier for the Immune System
Researchers at The University of Texas MD Anderson Cancer Center have developed a nanotechnology platform that can make cancer cells more vulnerable to immune attack in the body. The researchers call their system the bispecific tumor-transforming nanoconjugate (BiTN) platform.
The idea is to make solid tumors more appealing for the immune system by attaching a molecule that acts as an “eat me” signal to white blood cells. This molecule is called signaling lymphocytic activation molecule family member 7 (SLAMF7) receptor and is more commonly found on cancer cells in blood cancers, which explains the relative success...
Source: Medgadget - November 15, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine Oncology MDAndersonNews Source Type: blogs
Which chemotherapeutic agent is well known to cause coronary vasospasm?
5-fluorouracil is well known to cause coronary vasospasm. 5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrhythmia or even sudden death can occur in up to 5% of patients. Vascular toxicity occurs generally within 72 hours of the...
Source: Cardiophile MD - November 13, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
What is pericardial effusion – Cardiology Basics
What is pericardial effusion – Cardiology Basics
Pericardial effusion is collection of fluid between the visceral and parietal layers of the pericardium. If the amount of pericardial fluid is large or there is a rapid increase in the amount of pericardial fluid, compression of the heart prevents its proper filling. This reduces cardiac output and causes hypotension and is known as cardiac tamponade.
Cardiac tamponade needs urgent pericardial aspiration or surgical drainage if the fluid is very thick. Very thick fluid can be there in purulent bacterial pericarditis. Sometimes it can be a hemopericardium due to bleedin...
Source: Cardiophile MD - October 24, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
About That Cancer Moonshot
BY KIM BELLARD
Joe Biden hates cancer. He led the Cancer Moonshot in the Obama Administration, and, as President, he reignited it, vowing to cut death rates in half over the next 25 years. Last month, on the 60th anniversary of President Kennedy’s historic call for an actual moonshot, he vowed “to end cancer as we know it. And even cure cancers once and for all.”
But, as several recent studies show, cancer is still surprising us.
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Our body has its own defenses against cancer, such as T-cells, and great strides have been made in cancer therapies, including ...
Source: The Health Care Blog - October 6, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Research Cancer Cancer Progression Fungi John F. Kennedy Moonshot Source Type: blogs
About that Cancer Moonshot
By KIM BELLARD
Joe Biden hates cancer. He led the Cancer Moonshot in the Obama Administration, and, as President, he reignited it, vowing to cut death rates in half over the next 25 years. Last month, on the 60th anniversary of President Kennedy’s historic call for an actual moonshot, he vowed “to end cancer as we know it. And even cure cancers once and for all.”
But, as several recent studies show, cancer is still surprising us.
—————
Our body has its own defenses against cancer, such as T-cells, and great strides have been made in cancer therapies, includi...
Source: The Health Care Blog - October 6, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Public Health Biden Cancer Cancer Moonshot Source Type: blogs
