Miracle Sister: Stem Cells Saved Her Life
When leukemia took over young Elham’s health in 2014, her parents were devastated. At just 12 years-old, she would experience pain that no child her age should know. Lost and unsure of how to help their daughter, they didn’t realize that after many unsuccessful tries, their miracle would be what was growing inside of Elham’s mom’s belly. After undergoing three unsuccessful rounds of aggressive chemotherapy, Elham’s doctors suggested a second option for treatment: a bone marrow transplant, recommended for its hematopoietic stem cells which are known for their ability to replace diseased blood cells with new, healt...
Source: Cord Blood News - July 16, 2019 Category: Perinatology & Neonatology Authors: Maze Cord Blood Tags: Cord Blood stem cells Source Type: blogs

Carbon Dioxide-Based Cancer Cryoablation Probe for Low-Resource Regions
Undergraduate researchers at John Hopkins University have developed a cryoablation probe for breast cancer, which uses carbon dioxide instead of argon, making it more affordable and accessible for use in low resource regions.   Treatments for women with breast cancer are scarce in poorer places. In fact, survival rates can be as low as 12% for breast cancer patients in places such as The Gambia, compared with 90% in the United States. Treatments that are commonly used in wealthier countries, such as surgery or chemotherapy, are either too expensive or impractical in poorer and more remote regions, where women frequ...
Source: Medgadget - July 15, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Surgery Source Type: blogs

Fight Aging! Newsletter, July 15th 2019
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive t...
Source: Fight Aging! - July 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Both Extracellular Vesicles and Secreted Proteins can Spread Cellular Senescence
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive t...
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

OncoSenX Raises $3 Million to Adapt the Oisin Biotechnologies Platform to Cancer
Oisin Biotechnologies uses a form of programmable suicide gene therapy to target senescent cells for destruction. The therapy can be triggered by expression of specific genes inside a cell, and so beyond senescent cells there is a long, long list of possibly harmful cell populations in aging and disease that it would be beneficial to remove. The obvious first choice is cancerous cells with a mutation in one of the common cancer suppressor genes, such that the gene is expressed but not helping. Thus Oisin Biotechnologies spun out OncoSenX last year. The company is moving forward towards trials, and recently raised a seed ro...
Source: Fight Aging! - July 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs