Advocating for Senolytics to Prevent Accelerated Aging Resulting from Cancer Treatment
Chemotherapy and radiotherapy remain the presently dominant forms of cancer treatment. Immunotherapies are making slow inroads, but remain a minority of all treatments. Both chemotherapy and radiotherapy kill cells and force cells into senescence, cancerous cells and otherwise. They are a balance struck between killing the cancer and killing healthy tissue, and are are not pleasant at all for the patient. Cancer survivors have a significantly reduced life expectancy, as large as that resulting from life-long smoking, and evidence strongly suggests that this is due to a significantly increased burden of>senescent cells left...
Source: Fight Aging! - May 11, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Is it time to give up your annual mammogram?
If you dread your annual mammogram, you’re not alone. For many women, this breast cancer screening examination can be painful, stressful, and just an overall hassle.
You may wonder, are you old enough to give it up? If you’re over age 75, the answer is: maybe or maybe not. The fact is, breast cancer screening isn’t right for all older adults, but there’s no expert consensus on the right age to stop. This is mostly because scientific evidence in this area is lacking, says Dr. Kathryn Rexrode, associate professor of medicine at Harvard Medical School and chief of the Division of Women’s Health at Brigham and Women...
Source: Harvard Health Blog - May 1, 2020 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Breast Cancer Healthy Aging Managing your health care Screening Women's Health Source Type: blogs
New radiation therapies keep advanced prostate cancer in check
Treatments for prostate cancer are always evolving, and now research is pointing to new ways of treating a cancer that has just begun to spread, or metastasize, after initial surgery or radiation. Doctors usually give hormonal therapies in these cases to block testosterone, which is a hormone that makes the cancer grow faster. But newer evidence shows that treating the metastatic tumors directly with radiation can produce better results.
In March, researchers published the latest study that supports this approach. Based at Johns Hopkins University School of Medicine in Baltimore, the team used a method for delivering power...
Source: Harvard Health Blog - April 28, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs
Primary pericardial mesothelioma
Unlike the pleural mesothelioma, direct link to asbestosis in case of primary pericardial mesothelioma has not been established [1]. It is a very rare malignant tumour of the pericardium with around 150 cases reported. Yet it represents half of primary pericardial tumours. It is a malignancy of the mesothelial cells lining the visceral or parietal pericardium.
Majority of cases occur between fourth and seventh decade and a male preponderance has been noted. They can present with large pericardial effusions which can be fatal [2]. In general it is an aggressive disease with survival less than 6 months. In one case report, ...
Source: Cardiophile MD - April 27, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardio Oncology Source Type: blogs
The Noble Prize for a Life Well-Lived
In honor of a beautiful and affectionate cat.RIP, beloved MaxApril 19, 2003– April 24, 2020So much acrimony and confusion and death...In the true meaning of the word, Max lived a noble life.“But he was just a cat,” you say. Yes, that ' s true. But he was loving and kind and selfless until the very end. He was a wonderful companion, and a great source of comfort to me (especially after my partner died inOctober 2018).Max and SandraFeb. 2, 2017He was cherished by previous caretakers and human friends, who showered him with gifts.Christmas Eve, 2017Christmas Day, 2018But now he ' s gone and life continues, filled with a...
Source: The Neurocritic - April 26, 2020 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
Reinventing Clinical Decision Support
In our latest book,Reinventing Clinical Decision Support: Data Analytics, Artificial Intelligence, and Diagnostic Reasoning, Paul Cerrato and I explore the promise of artificial intelligence and machine learning for improving clinicians ’ ability to make more informed diagnostic and therapeutic decisions. Here’s an excerpt from Chapter 2:“AI is a once-in-a-generation transformative technology. As such, expect its impact to be on the scale of the advent of electricity or the Internet,” says Jean-Claude Saghbini, Wolters Kluwer Health.(1)“Artificial intelligence and machine learning are set to transform healthcare....
Source: Life as a Healthcare CIO - April 24, 2020 Category: Information Technology Source Type: blogs
Chemotherapy and hearing loss: Monitoring is essential
Treatment for cancer is a difficult time for patients and their families. While there are significant benefits of chemotherapy in treating and managing many types of cancers, some of the negative side effects may not always be so obvious. One of the potential negative effects of chemotherapy that you may not be aware of is hearing loss. Hearing loss caused by chemotherapy is generally considered a type of sudden hearing loss, so monitoring hearing before and after treatment with hearing tests is important.
How are chemotherapy and hearing loss connected?
Hearing loss as a potential side effect of chemotherapy is more likel...
Source: Harvard Health Blog - April 13, 2020 Category: Consumer Health News Authors: James Naples, MD Tags: Cancer Ear, nose, and throat Hearing Loss Source Type: blogs
“ Essential Oncology ” : The COVID Challenge
By CHADI NABHAN MD, MBA, FACP
One harsh Chicago winter, I remember calling a patient to cancel his appointment because we had deemed it too risky for patients to come in for routine visits—a major snowstorm made us rethink all non-essential appointments. Mr. Z was scheduled for his 3-month follow-up for an aggressive brain lymphoma that was diagnosed the prior year, during which he endured several rounds of intense chemotherapy. His discontent in hearing that his appointment was canceled was palpable; he confessed that he was very much looking forward to the visit so that he could greet the nurses, front-desk staff, ...
Source: The Health Care Blog - April 3, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Hospitals Medical Practice Physicians Chadi Nabhan Clinical Trials coronavirus drug dosing Oncology Pandemic Source Type: blogs
Is it safe to see the pediatrician for vaccines and medical visits?
We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on.
Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines?
The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing risks and...
Source: Harvard Health Blog - March 31, 2020 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Adolescent health Children's Health Health care Parenting Vaccines Source Type: blogs
Fight Aging! Newsletter, March 23rd 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - March 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Two Way Relationship Between Cellular Senescence and Cancer in Bone Marrow
Cells become senescent in response to a variety of circumstances. The vast majority are cases of replicative senescence, somatic cells reaching the Hayflick limit. Cell damage and toxic environments also produce senescence, and senescent cells are also created as a part of the wound healing process. A senescent cell ceases replication and begins to secrete inflammatory and pro-growth signals, altering the nearby extracellular matrix and behavior of surrounding cells - even encouraging them to become senescent as well.
Near all senescent cells last a short time only, as they self-destruct or are removed by the immune...
Source: Fight Aging! - March 20, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An infectious disease doctor answers your COVID-19 and coronavirus questions
Being a specialist in infectious diseases right now is an interesting experience. Added to the usual challenges of our everyday practice — caring for people receiving transplants or chemotherapy, those with HIV, surgical infections, tropical diseases, and others — we now must manage a deluge of coronavirus-related questions from friends, family, and colleagues. Here are […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 5, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/paul-sax" rel="tag" > Paul Sax, MD < /a > < /span > Tags: Conditions Infectious Disease Source Type: blogs
Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging.
Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration
https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signal...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
USP7 Inhibition Clears Up to Half of Irradiation Induced Senescent Cells From Mouse Tissues
Researchers here report on the discovery of a novel mechanism by which senescent cells can be selectively destroyed. Short-term senolytic treatments to date seem to cluster tightly into two categories: (a) largely ineffective, and (b) able to destroy between 25-50% of senescent cells in tissues. Few have achieved greater clearance so far, and few lie in between these two outcomes. In the present environment, of ample seed stage funding and enthusiasm for targeting senescent cells as a treatment for aging, it seems likely that someone will pick up this new approach for clinical development in the near future.
Altho...
Source: Fight Aging! - February 28, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
