Dear Newly Diagnosed: What We Wish We Knew
In today’s show, Gabe discusses what he could have done differently as a newly diagnosed bipolar patient that may have made his life a little easier. He and Lisa also discuss some common pitfalls a new patient may run into.
For example, what’s the problem when patients are told they need to be med-compliant at all costs? Should you be open at work about your illness? Join us to hear Gabe’s experiences and learn from his rookie mistakes (which actually ended up working out in the end anyway).
(Transcript Available Below)
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Source: World of Psychology - October 20, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Disorders General LifeHelper Mental Health and Wellness Not Crazy Podcast Treatment Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected.
This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivery of T Cell Progenitor Cells as an Approach to Thymic Regeneration
The thymus is a small organ in which thymocytes generated in the bone marrow mature to become T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age, its active tissue largely replaced by fat in most people by age 50 or so. Thereafter the adaptive immune system declines into immunosenescence and inflammaging, deprived of a sufficiently large supply of reinforcement cells. Given the importance of the immune system to health, in matters including tissue maintenance, resistance to infection, suppression of cancer, and more, regeneration of the thymus must be an important component of any serious e...
Source: Fight Aging! - October 7, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Theorizing on Cosmic Radiation as an Accelerator of Aging via Cellular Senescence
Researchers here suggest that some of the detrimental effects of prolonged space missions are mediated by an increased burden of senescent cells resulting from cosmic radiation exposure. Senescent cell accumulation is a feature of aging and cancer treatments such as chemotherapy, and contributes to the progression of age-related dysfunction and disease. Senescent cells secrete an inflammatory mix of signal molecules that disrupt nearby tissue structure, alter cell behavior, and rouse the immune system into a state of chronic inflammation. Even a small number of senescent cells can have outsized effects on tissue function d...
Source: Fight Aging! - September 24, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fasting Mimicking Diet Improves Chemotherapy Effectiveness and Reduces Side Effects
The fasting mimicking diet emerged from efforts to better define the dose-response curve for beneficial effects resulting from a reduced calorie intake. Fasting is beneficial, calorie restriction is beneficial, but where are the dividing lines? How much food can one eat and still obtain near all of the benefits of fasting? As a result of this work, the fasting mimicking diet has undergone clinical testing in cancer patients. Numerous benefits have been demonstrated, and the paper here is an example of the type. In this human trial, fasting mimicking reduced the negative short term impact of chemotherapy on health, and, fur...
Source: Fight Aging! - September 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Clearance of Senescent Cells Reverses the Peripheral Neuropathy Caused by Chemotherapy
A primary goal of chemotherapy is to force cancerous cells into programmed cell death or cellular senescence. Cellular senescence is a state of growth arrest that should normally be triggered by exactly the sort of damage and dysfunction exhibited by cancer cells, but cancer is characterized by a mutation-induced ability to bypass those restrictions. Chemotherapy remains the primary approach to cancer therapy, but chemotherapeutic agents are still at best only marginally discriminating. Treating cancer with chemotherapy has always been a fine balance between harming the cancer and harming the patient. Even in the best of o...
Source: Fight Aging! - September 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Clearing the misinformation surrounding medical cannabis
An excerpt from Medical Marijuana: A Clinical Handbook. Imagine two patients sitting in the waiting area of a clinic. The first is a man in his sunset years who has recently begun treatment for stage 2 lung cancer. His treatment involves the use of chemotherapy, which has significantly reduced his appetite and given him terrible […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 6, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/samoon-ahmad-and-kevin-hill" rel="tag" > Samoon Ahmad, MD and Kevin Hill, MD < /a > < /span > Tags: Meds Psychiatry Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stress Granules as a Therapeutic Target
Stress granules are a comparatively poorly understood portion of the processes that a cell uses to maintain its protein machinery and component structures. When cells are subject to mild stress or damage, whether it is due to radiation, heat, lack of nutrients, or other challenges, they upregulate the activity of both autophagy and the ubuiquitin-proteasome system. Autophagy involves flagging proteins and structures for disassembly, followed by transport to a lysosome packed with enzymes to break down molecules into component parts that can be reused. The ubuiquitin-proteasome system tags proteins with ubiquitin, allowing ...
Source: Fight Aging! - September 3, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Weekly Overseas Health IT Links – 29 August, 2020.
Here are a few I came across last week. Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment. ----- https://www.digitalhealth.net/2020/08/managing-the-uks-next-big-crisis-of-disrupted-cancer-care-and-diagnosis/ Managing the UK ’s ‘next big crisis’ of disrupted cancer care and diagnosis With a lot of medical care on hold during the coronavirus pandemic, Paul Landau, founder and CEO of digital cancer care company Careology, looks into how (this is) the U...
Source: Australian Health Information Technology - August 28, 2020 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Father Fatally Shoots Terminally Ill 11-Year-Old Daughter
Miami area 11-year-old Angela Ng was terminally ill and undergoing chemotherapy. But for reasons vaguely reminiscent of the infamous Robert Latimer case, Angela's father fatally shot her before turning the gun on himself. Unlike cases with adults,... (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 24, 2020 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Covid-19 rapid guideline: arranging planned care in hospitals and diagnostic services
National Institute for Health and Care Excellence - The purpose of this guideline is to help healthcare professionals deliver efficient planned care while minimising the risk of Covid-19 in the context of increasing or decreasing local prevalence. It also aims to help patients make decisions about their planned care. It is for adults, young people and children in hospitals and diagnostic settings. Planned care covers elective surgery (day surgery and inpatient stays), interventional procedures, diagnostics and imaging. It does not include services where people have ongoing outpatient and day-case procedures such as c...
Source: Health Management Specialist Library - July 29, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: Patient safety Source Type: blogs
Driving culture change in the pursuit of oncology value
Five years ago, if you asked oncologists at my practice to name the list price of a given chemotherapy agent, most wouldn ’t have known–unless they were executives, maybe. Pharmaceutical reps rarely talk about costs. The EMRs don ’t give list prices. And when we input drug orders back then, no cost analyses were offered. These days, […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 26, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mark-walshauser" rel="tag" > Mark Walshauser, MD < /a > < /span > Tags: Policy Oncology/Hematology Source Type: blogs
