The FDA ’s Culture: Should Safety Dominate All Practices?
By STEVEN ZECOLA
An organization’s culture is an internal set of shared values, attitudes and practices. The cohesiveness of the organizational culture will affect whether the entity will meet its vision, purpose, and goals.
One type of organizational culture is hierarchical in nature. Unlike a risk-taking culture, this structure features policy, process and precision. It is best suited for mature and stable organizations.
The disadvantage of a hierarchal culture is that its stability and control can turn into rigidity. In many cases, the organization develops a negative attitude towards ideas s...
Source: The Health Care Blog - August 26, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy FDA Parkinson's Disease Steven Zecola Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflam...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Worse Functional Decline with Age is Observed in Cancer Survivors
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories. (Source: Fight Aging!)
Source: Fight Aging! - August 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
If FDA Won ’t Rethink Rules on Off‐Label Drug Use, Courts Should
Walter OlsonAs Cato writershave longpointedout, the law takes a paradoxical stance toward so ‐called “off‐label” use of drugs approved for use by the Food and Drug Administration (FDA). On the one hand, it’s completely lawful for physicians to prescribe approved drugs for other than the FDA‐approved uses, and such uses are vital in everyday practice. Indeed, off‐la bel compounds oftenconstitute a “gold standard” of care in chemotherapy cancer treatments and other fields of medicine. On the other hand, the agency strictly prohibits makers of the compounds frompromoting such use, even when ...
Source: Cato-at-liberty - August 11, 2021 Category: American Health Authors: Walter Olson Source Type: blogs
Health Care You Do Not See
By KIM BELLARD
Within a mile from my home in one direction, there are two pharmacies and a primary care office. In another direction, there’s a multi-specialty physician practice, complete with lab and pharmacy. And in a third direction, an urgent care center. Widen the circle another mile, and there are more physician offices, a plethora of other health care professionals, another urgent care, a retail clinic, and an imaging center. Add a couple more miles and hospitals – plural – to start show up.
I’m not sure that’s a good thing.
Admittedly, not everyone has so many options.&nb...
Source: The Health Care Blog - August 10, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Kim Bellard Source Type: blogs
Should Your Parent Risk an Anesthesia Disaster or Forego Surgery?
Photo credit Niklas Hamann
Just last week a reader asked me whether she should try to sway her mother, who had colon cancer, toward surgery. Her mother, 87, was diagnosed with colon cancer and given the choice of surgery and chemotherapy or letting it alone. If she chose not to have surgery, she could still have chemotherapy and radiation, though she was told that treatment wasn't apt to help a great deal. As expected, the daughter was distraught. She was seeking help in determining what her responsibility to her mother is. The woman mentioned that her mother was mentally sharp, so I told her that, in my opinion......
Source: Minding Our Elders - August 10, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent T Cells in the Context of Cancer
Cells become senescent in response to potentially cancer-inducing stresses and damage, to tissue injury, or when they reach the Hayflick limit on cellular replication. Senescent cells cease to replicate and secrete pro-inflammatory, pro-growth signals. They are cleared by the immune system or via programmed cell death mechanisms. Their presence is beneficial in the short term, an important part of the panoply of mechanisms devoted to, separately, cancer suppression and regeneration. When senescent cells begin to linger, however, their secretions become highly disruptive to normal tissue function. Senescent cell accumulatio...
Source: Fight Aging! - August 4, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, August 2nd 2021
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants experienced sign...
Source: Fight Aging! - August 1, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Peptide Coated Nanoparticles as a Basis for a Non-Invasive Test for Cancer
A reliable, low-cost means of early detection of cancer would be of great benefit. Approaches to the treatment are advancing to the point at which very early stage cancer has a high rate of survival, and the side-effects of treatments for early stage cancer are becoming less onerous. In the ideal world, a yearly physical would include a low-cost cancer screen that robustly detects even small volumes of cancerous tissue. Various approaches are under development, such as those based on identification of signal molecules in the bloodstream. The alternative approach noted here, based on the use of engineered nanoparticles, is ...
Source: Fight Aging! - July 27, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Oscillating Magnetic Field Shrinks Glioblastoma Tumor
At the Houston Methodist Neurological Institute, researchers have developed a device that generates a magnetic field and used it to successfully shrink a glioblastoma tumor in a patient volunteer. The device is worn on the head each day during treatment, and uses an oscillating magnetic field to disrupt biochemical processes in cancer cells. While the technique is in its infancy, this first-in-human test of this particular type of device shows promise, and could herald the first steps in a new non-invasive treatment modality.
Glioblastoma is a brain cancer with a very poor prognosis, and which nearly always proves fatal...
Source: Medgadget - July 26, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery Oncology Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting Senescent Cells to Reverse the Aging of the Kidneys
Senescent cells accumulate with age and cause a wide range of pathologies. They contribute in some way to near all of the common, ultimately fatal age-related conditions. Senescent cells secrete a mix of signals that produces chronic inflammation, disrupts tissue maintenance to encourage fibrosis, and changes the behavior of other cells for the worse in numerous ways. It is the signaling that allows the comparatively small fraction of senescent cells in any given aged tissue to cause such widespread harm.
Destroying senescent cells in a targeted fashion via the use of senolytic therapies has shown great promise in a...
Source: Fight Aging! - May 28, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Off Our Chests: No Secrets Left Behind
By CHADI NABHAN
She was a successful corporate lawyer turned professional volunteer and a housewife.
He was a charismatic, successful, and world-renowned researcher in gastrointestinal oncology. He was jealous of all breast cancer research funding and had declared that disease his nemesis.
They were married; life was becoming a routine, and borderline predictable. Both appeared to have lost some appreciation of each other and their sacrifices.
Then, she saw a lump, and was diagnosed with breast cancer. Not any breast cancer, but triple negative breast cancer. The kind that is aggressive and potentially lethal. ...
Source: The Health Care Blog - May 27, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Physicians Book Review Breast cancer Chadi Nabhan illness narratives John Marshall Liza Marshall Off Our Chests triple negative breast cancer Source Type: blogs
Doctors now must provide patients their health data, online and on demand
Last summer, Anna Ramsey suffered a flare-up of juvenile dermatomyositis, a rare autoimmune condition, posing a terrifying prospect for the Los Angeles resident: She might have to undergo chemotherapy, further compromising her immune system during a pandemic. After an agonizing three-day wait, the results of a blood test came back in her online patient portalRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - May 22, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/sarah-kwon" rel="tag" > Sarah Kwon < /a > < /span > Tags: Policy Health IT Source Type: blogs
