Clonal Mutation in Immune Cells Correlates with Epigenetic Age Acceleration
The nuclear DNA encoding near all of the protein machinery necessary to cell function is constantly damaged and constantly repaired. The repair mechanisms are highly efficient, and are backed up by numerous other systems intended to destroy cells that suffer particularly critical DNA damage, mutations that can lead to cancer or severe dysfunction. Nonetheless, damage accumulates. Near all of this damage is irrelevant, as it occurs randomly in single somatic cells with a limited life span, in genes that the cell isn't using. Unfortunately, there are ways for DNA damage to become significant.
The first is obviously ca...
Source: Fight Aging! - September 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Magnetically Controlled Microbots for Drug Delivery and Hyperthermia Therapy in Cancer
Researchers in Daegu Gyeongbuk Institute of Science and Technology in South Korea have developed biodegradable microrobots that can be magnetically controlled to deliver drugs and provide hyperthermia treatment at the site of a tumor.
This latest research effort attempts to provide a delivery option for two different therapy pypes by creating biodegradable microrobots that can be activated when they are in the vicinity of a tumor. The microrobots consist of a biodegradable polymer loaded with magnetic nanoparticles and an encapsulated chemotherapeutic drug.
Chemotherapy is currently plagued by serious side-effects, s...
Source: Medgadget - September 9, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Nanomedicine Oncology Source Type: blogs
Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with hig...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Gold Nanostars Help Design New Nanomedicines
Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more rotational and translational movement compared to nanoparticles that cannot target cancer cells effectively. This exciting development can be used to screen different nanoparticle formulations based on size, charge, shape, and targeting molecule to see if they are effectively targeting cancer cells in vitro in order to develop new more effective nanomedicine cancer therapies.
...
Source: Medgadget - August 27, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Medicine Nanomedicine Source Type: blogs
Cold Plasma to be Tested as Killer of Cancer Cells
Cold plasma is an unusual gaseous substance in which only the electrons are heated to thousands of degrees, with the rest of the material remaining at room temperature. Purdue University researchers have advanced this field and have helped to make it ready for clinical applications, since cold plasma has the ability to kill target cells while sparing nearby cells. In particular, Purdue researchers created one of the first practical cold plasma generators and tested how cold plasma affects biological tissues.
Now, a cold plasma device from US Medical Innovations, a company based in Takoma Park, Maryland, just won FDA...
Source: Medgadget - August 19, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Surgery Source Type: blogs
Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DigniCap Delta Hair Loss Prevention System for Chemo Now in U.S.
Dignitana, a company out of Lund, Sweden, won FDA clearance and is now distributing its DigniCap Delta scalp cooling system in the U.S. The University of California, San Francisco (UCSF) will be the first recipient in America of the fourth generation system that’s designed to prevent hair loss in patients undergoing chemotherapy to fight solid tumors.
The system pumps a cool liquid, carefully controlled thanks to a number of sensors, through a cap worn by patients undergoing chemo. Cooling the head constricts the blood vessels in the scalp, reducing the amount of chemo that can pass through. At the same time, the ...
Source: Medgadget - August 15, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Medicine Oncology Source Type: blogs
Targeting NKG2D Ligands on the Surface of Persistent Senescent Cells Enables their Destruction by the Immune System
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands...
Source: Fight Aging! - August 14, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Proposal to Improve Healthcare and Make It More Affordable
By STEVE ZECOLA
Americans spend about $3 trillion
per year on healthcare, or about $10,000 per person per year. Despite these
expenditures, Americans are worse off than their international counterparts
with respect to infant mortality, life expectancy and the prevalence of chronic
conditions.
In policy debates, Republicans
mostly prefer to let the marketplace devise the appropriate outcomes, but this
approach ignores the market failures that plague the industry.
On the other hand, Democrats propose
a variety of solutions such as “Medicare for All” which nationalizes all
healthcare insurance or, as a variant, ...
Source: The Health Care Blog - August 6, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy Medicare For All Source Type: blogs
As The Article Sub Says “Rumours Of The Death of the Fax Machine, It Seems, Are Greatly Exaggerated!
Despite the ADHA waging all-out war this appeared last week.Are GPs ready to let go of the fax? Zilla Efrat Zilla is a Sydney-based freelance journalist covering business, finance and practice management topics. 23rd July 2019Rumours of the death of the fax machine, it seems, are greatly exaggerated.It ’s been almost three years since the RACGP identified what it said was a new national priority to save patients’ lives by eliminating faxes and letters as the chosen means for doctors to communicate with each other about patient care.The safety stakes can be high. In 2015, a patient with Hodgkin lymphoma, Mettaloka Halwa...
Source: Australian Health Information Technology - August 1, 2019 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
New Biomaterial Improves Brain Cancer Survival in Rats
Researchers from the University of Nottingham have developed a new biomaterial that delivers chemotherapies to treat brain cancer. Their work demonstrates that their biodegradable paste led to increased survival compared to controls, and that half of all rats in a study were clear of any cancer as confirmed by laboratory tests. This exciting development may one day improve treatment options for glioblastoma patients, as well as those with other cancers.
Surgery is commonly performed to try to fight glioblastoma. Yet, one of the major challenges is that despite careful surgical removal of the tumor, some cancer cells may...
Source: Medgadget - July 24, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Neurosurgery Oncology Source Type: blogs
Alternative cancer therapies and the promise of false hope
How do you respond when patients with a good prognosis want to delay chemotherapy to try an anticancer diet for a few months or visit an unregulated clinic for unproven therapies? I’m asking because of an alarming finding of ASCO’s 2018 National Cancer Opinion Survey: “Nearly 4 in 10 Americans believe cancer can be cured solely […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 22, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/wendy-s-harpham" rel="tag" > Wendy S. Harpham, MD < /a > < /span > Tags: Physician Oncology/Hematology Source Type: blogs
Chemo Tester Identifies Which Formulation Works for Each Patient
Chemotherapy is challenging for patients, as it can be terribly brutal on their bodies, but also for physicians trying to figure out which medication to deliver. Now, a new device has been developed at Rutgers University that can test whether a given chemo agent works on a patient’s specific tumor.
The idea is that a tumor biopsy is used to seed the device. Chemo agents are then added to see whether they kill the patient’s tumor cells. This is measured using a special biosensor that relies on multifrequency impedance spectroscopy to test whether a cell is alive or dead. The sensor feeds its readings into an ...
Source: Medgadget - July 17, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Oncology Pathology Surgery Source Type: blogs
All Ears: Seeds of Breakthrough on Chemo Side Effect
The post All Ears: Seeds of Breakthrough on Chemo Side Effect appeared first on Johns Hopkins Nursing Magazine. (Source: Nursing Blogs at Johns Hopkins University)
Source: Nursing Blogs at Johns Hopkins University - July 16, 2019 Category: Nursing Authors: Editor Tags: Cells to Society acupressure auricular point pressure cancer chemotherapy ear neuropathy pain research seeds side effect vaccaria Source Type: blogs
