Work on Senolytic Rejuvenation Therapies Begins to Attract More Mainstream Notice
This popular science piece on the development of senolytic therapies capable of clearing harmful senescent cells from aging tissues is a cut above the average. It is important to see more publicity for this line of work. Not because it will aid the industry, but because the more attention that is given to the field, the faster that existing senolytic treatments such as the dasatinib and quercetin combination will become available through off-label prescription and physician networks. Tens of millions of patients with inflammatory age-related diseases caused in part by senescent cells, and the many cancer survivors with high burdens of senescent cells due to chemotherapy, and diabetics whose condition is mediated by senescent cells, and the obese whose visceral fat tissue spurs cellular senescence might benefit in the US alone, if they only knew that senolytics exist today. The choice on whether to try now or wait for more human data for dasatinib and quercetin (or fisetin, or piperlongumine, or other easily obtained senolytics) should be one that people are permitted to make, not one they remain ignorant of because nobody bothered to tell them that it exists. My one complaint about the content of this article is that the author does conspicuously fail to mention that it is possible to obtain access to the first senolytic treatments today, at very low cost, and that older people in the self-experimentation community are indeed choosing to do this. Imagine if in...
Authors: Fan Y, Wen X, Zhang Q, Wang F, Li Q, Li X, Guo Y Abstract This systematic review and meta-analysis aimed at evaluating the effect of traditional Chinese medicine (TCM) Bufei granule on stable chronic obstructive pulmonary disease (COPD). We retrieved data from PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials, CNKI, Wanfang, and WeiPu (VIP) for studies focusing on whether the TCM Bufei granule would be effective in treating stable COPD. No language restriction and blinding were used. All trials involved were examined based on the standards of the Cochrane Handbook, and Revi...
Authors: Wang Y, Liu P, Fang Y, Tian J, Li S, Xu J, Zhao F, Yin X, Zhang Q, Li Y Abstract Objective: To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time of colorectal cancer (hereinafter referred to as CRC). Methods: Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients were divided into TCM treatment group and control group according to whether the modified Anti-cancer Decoction II Formula was applied for more than six months. Propensity score matching (hereinafter referred to as PSM) was used to further balance the ...
Conclusions: The results demonstrated a favorable effect or tendency of meditative movements to improve blood glucose and blood lipid levels in patients with type 2 diabetes mellitus. The special effects of meditative movements in type 2 diabetes mellitus patients need further research. PMID: 32089725 [PubMed]
This study was therefore aimed to assess the in vitro bioactivities associated with the LP EO. The EO was separated by hydrodistillation from the aerial parts of LP plants and analyzed for its antioxidant, antimicrobial, anticholinesterase, and antilipase activities. GC-MS was used for phytochemical analysis. The chemical analysis of the EO composition revealed 25 constituents, of which carvacrol (65.27%) was the most abundant. EO exhibited strong antioxidant (IC50 0.16-0.18 μL/mL), antiacetylcholinesterase (IC50 0.9 μL/mL), antibutyrylcholinesterase (IC50 6.82 μL/mL), and antilipase (IC50 1.0...
In conclusion, findings from this retrospective cohort study indicated that integrated CHM and Western medicine could improve survival in patients with colorectal cancer. Additional research on integrating TCM with Western medicine to improve cancer survival is warranted. PMID: 32089722 [PubMed]
Publication date: Available online 25 February 2020Source: Annals of Medicine and SurgeryAuthor(s): Gabriella Garruti, Michele De Fazio, Palma Capuano, Gennaro Martinez, Maria T. Rotelli, Francesco Puglisi, Nicola Palasciano, Francesco Giorgino
Publication date: Available online 24 February 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Ming-Yue Duan, Ming Li, Hui Tian, Gen Tang, Yu-Cong Yang, Nian-Cai Peng
Publication date: Available online 26 February 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Awadhesh Kumar Singh, Ritu Singh
Publication date: Available online 26 February 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Mina Movahedian, Jessica Thomas, Jamal Rahmani, Cain C.T. Clark, Bahram Rashidkhani, Matin Ghanavati
Publication date: Available online 24 January 2020Source: Practical Radiation OncologyAuthor(s): Jordan M. Slagowski, Lauren E. Colbert, Irina M. Cazacu, Ben S. Singh, Rachael Martin, Eugene J. Koay, Cullen M. Taniguchi, Albert C. Koong, Manoop S. Bhutani, Joseph M. Herman, Sam Beddar
More News: Age-Related Macular Degeneration (AMD) | Amnesia | Biotechnology | Cancer | Cancer & Oncology | Chemotherapy | Chronic Leukemia | Chronic Obstructive Pulmonary | Clinical Trials | Diabetes | Eating Disorders & Weight Management | Emphysema | Endocrinology | Genetics | Geriatrics | Glaucoma | Leukemia | Men | Obesity | Osteoarthritis | Radiation Therapy | Research | Science | Study