Part 6 - Why Is Cancer Pain So Special?

by Drew Rosielle (@drosielle)A Series of Observations on Opioids By a Palliative Doc Who Prescribes A Lot of Opioids But Also Has Questions.This is the 5th post in a series about opioids, with a focus on how my thinking about opioids has changed over the years. See also:Part 1 – Introduction, General Disclaimers, Hand-Wringing, and a Hand-Crafted Graph.Part 2 – We Were Wrong 20 years Ago, Our Current Response to the Opioid Crisis is Wrong, But We Should Still Be Helping Most of our Long-Term Patients Reduce Their Opioid DosesPart 3 – Opioids Have Ceiling Effects, High-Doses are Rarely Therapeutic, and Another Hand-Crafted GraphPart 4 – Everything We Were Taught About High Doses Was Wrong, And The Same Hand-Crafted GraphPart 5 – Why Do We Lump The Non-Cancer Pain Syndromes Together?This is Part 6, which asks the sort of inverse question toPart 5– Why Is Cancer Pain So Special?Why is cancer pain, in so many guidelines and organizational/public policies ‘exempted’ from the dosing and safety guidelines. This is not a rhetorical question – I have not actually ever read a coherent explanation as to why.One might reasonably assume there ’s all this research demonstrating the safety and efficacy of long-term opioid use in cancer patients. In reality, that research is non-existent.Guidelines like the CDC ’s accurately point out that there are essentially no data demonstrating the long term efficacy of opioids for &lsquo...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: cancer opioids pain rosielle The profession Source Type: blogs

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Publication date: Available online 23 September 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Vincent Laudenbach, Aude Charollais, Sophie Radi, Marie-Hélène Stumpf, Anne Vincent, Ingrid Kaltwasser, Tiphaine Tomczyk, Jacques Benichou, Philippe Leroux, Stéphane Marret
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
In this study, novel hollow gold nanoparticles (HGNPs) were used as drug carriers, and in order to improve the targeting ability of HGNPs to a lung tumor site, polyoxyethylene sorbitol oleate (PSO) was chosen here as a target ligand since it can be specifically recognized by the low-density lipoprotein (LDL) receptor which is usually over expressed on A549 lung cancer cells. In this way, a PSO-modified doxorubicin-loaded HGNP drug delivery system (PSO-HGNPs-DOX) was constructed and its physicochemical properties, photothermal conversion ability, and drug release of PSO-HGNPs-DOX was investigated. Further, the effects of tr...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
CONCLUSIONS: This method has wide-scale application prospects in the identification of metabolites. Considering that limited research has been conducted in this area, this study proposes metabolic pathways to further understand mechanisms of isochlorogenic acid A and the forms that are truly effective in vivo. PMID: 32964757 [PubMed - as supplied by publisher]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Authors: Hong D, Zhao HM Abstract Under the hydrothermal reaction condition, we prepared a new 3D Eu(III)-based coordination polymer (CP) [Eu(H2-DHBDC)0.5(DHBDC)0.5 (H2O)2]n·H2O (1, H4-DHBDC = 2,5-dihydroxy-1,4-terephthalic acid). Furthermore, we assessed the inhibitory influence on cervical cancer cells of this compound. Firstly, for testing the anti-viability of the compound against cervical cancer cells, the Cell Counting Kit-8 (CCK-8) assay was carried out. Then reactive oxygen species (ROS) detection kit was used to determine the ROS accumulation in the cervical cancer cells. Finally, after the Annexin ...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Authors: Marques E, Paluch Z, Boháč P, Slanař O, Běláček J, Hercogová J Abstract INTRODUCTION: Understanding how different comorbidities and epidemiological factors are related to psoriasis severity can help us estimating patients' clinical outcome. AIM: Establish possible prognostic factors of severe psoriasis. METHODS: Three groups of patients were included: 118 were on topical therapy, 83 used conventional systemic drugs and 112 were treated with biological agents. Based of the fact that patients on topical therapy have a lower grade of disease severity than patients treated syst...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Lam PH, Hon KL, Leung K, Leong KF, Li CK, Leung TF Abstract BACKGROUND: Atopic eczema (AE) is a common relapsing inflammatory skin disease in children which is often associated with chronicity and poor quality of life. Unlike atopic asthma, control of AE is seldom assessed in therapeutics. AIM: To investigate the utility of a Traffic Light Control (TLC) system as a measurement/assessment of self-perceived eczema control. METHODS: This is a prospectively study of all Chinese children (aged 6 to 18 years old) with eczema attending the paediatric dermatology clinic of a tertiary hospital from Jan to J...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Publication date: Available online 23 September 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Igor Łoniewski, Agata Misera, Karolina Skonieczna-Żydecka, Mariusz Kaczmarczyk, Karolina Kaźmierczak-Siedlecka, Błażej Misiak, Wojciech Marlicz, Jerzy Samochowiec
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
This initiative aims to support the development and testing of systems-level interventions targeting high-risk youth to reduce or prevent suicide and suicidal behavior in these populations. Populations identified with high suicide risk and high unmet service need include but are not limited to: youth in public service systems, racial/ethnic minority youth, sexual and gender minority (SGM) youth, rural youth, and youth with intersectional risk. Relevant settings include but are not limited to: education or training programs, housing programs, juvenile justice, and child welfare.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
The primary objective of this Funding Opportunity Announcement (FOA) is to advance translational research to better understand risk and resilience for suicide in the context of the Research Domain Criteria (RDoC) framework and the Positive Valence Systems (PVS) domain.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
This FOA seeks to encourage research addressing major gaps identified in the United States Preventive Services Task Force (USPSTF) recommendation statement concerning interventions to prevent perinatal depression.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
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