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Ceftriaxone-Resistant Gonorrhea - China, 2022
MMWR Morb Mortal Wkly Rep. 2024 Mar 28;73(12):255-259. doi: 10.15585/mmwr.mm7312a2.ABSTRACTGonorrhea is a widespread sexually transmitted infection; in 2022, China reported 96,313 cases of gonorrhea, making it the fourth most common notifiable infectious disease in the country after viral hepatitis, pulmonary tuberculosis, and syphilis. The rise in prevalence in antimicrobial-resistant strains, particularly the international spread of ceftriaxone-resistant clones, poses a formidable challenge to gonorrhea control. The China Gonococcal Resistance Surveillance Program (China-GRSP), established in 1987 and covering 19 of 34 p...
Source: MMWR Morb Mortal Wkl... - March 28, 2024 Category: Epidemiology Authors: Xiaoyu Zhu Yue Xi Xiangdong Gong Shaochun Chen Source Type: research

Tetralogy of Fallot complicated by multiple cerebral abscesses in a child: a case report
ConclusionA comprehensive strategy involving medications, surgical drainage, and early neurosurgical consultation is vital in treating brain abscesses in uncorrected TOF. Early identification of the pathogen, appropriate antibiotic therapy, and vigilant follow-up through clinical assessments and imaging are crucial, potentially spanning a 4 –8-week treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 28, 2024 Category: General Medicine Source Type: research

Surgical Site Infections in Trauma Exploratory Laparotomies Preoperative Ceftriaxone and Metronidazole Versus Cefoxitin
Am Surg. 2024 Mar 27:31348241241695. doi: 10.1177/00031348241241695. Online ahead of print.ABSTRACTSurgical site infections (SSIs) remain a significant cause of morbidity and mortality in patients undergoing traumatic exploratory laparotomy. The goal of this study was to compare antibiotic usage and subsequent outcomes in patients undergoing traumatic exploratory laparotomy. A retrospective chart analysis and a chi-square test of independence were performed to examine the relation between preoperative cefoxitin versus ceftriaxone and metronidazole and the rate of SSI development. 323 patients were analyzed, 111 patients re...
Source: The American Surgeon - March 27, 2024 Category: Surgery Authors: Miles W Reese Brendan J Roess John M Hepner Raymond L Hogge Ricardo Rendel Michael T Martyak Ishraq K Kabir Tuan M Nguyen Kristen N Snyder Julia A Heaton Source Type: research

Case report: A rare case of skin abscess caused by coinfection of Actinobaculum schaalii and Actinomyces turicensis
Skin abscess is one of the most common infections of the skin and soft tissues. However, anaerobic bacteria are infrequently identified as the causative agents of this particular form of abscess. In this case, a 34-year-old pregnant woman was diagnosed with a skin abscess with the use of ultrasonography. The microbiological analysis results of the purulent fluid revealed the coinfection of Actinobaculum schaalii and Actinomyces turicensis. The patient was first treated empirically with 3 days of cefathiamidine, which resulted in no symptom improvement. Subsequently, a surgical procedure involving incision and draining was ...
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research

Effects of antibiotics ceftriaxone and levofloxacin on the growth of Protophormia terraenovae (Diptera: Calliphoridae)
In this study the effects of different concentrations of antibiotics levofloxacin and ceftriaxone on maggot development, weight, length, and mortality were examined. The maggot length and weight were significantly increased by therapeutical doses of levofloxacin and ceftriaxone. The maggot development time was significantly decreased in every levofloxacin treatment compared to the control. The time to start pupation was significantly increased in the control compared to the antibiotic treatments. Levofloxacin significantly increased the survivability of the maggots. Every levofloxacin treatment significantly improved the r...
Source: Forensic Science, Medicine, and Pathology - March 26, 2024 Category: Forensic Medicine Source Type: research

An Unusual Case of Non-typhoidal Salmonella Bacteremia Causing Life-Threatening Aortitis
Cureus. 2024 Feb 21;16(2):e54645. doi: 10.7759/cureus.54645. eCollection 2024 Feb.ABSTRACTNon-typhoidal Salmonella typically presents with gastroenteritis. However, an invasive Salmonella infection, which may be typically seen in immunocompromised patients, has a propensity for aortic involvement, especially in patients with risk factors for atherosclerosis. Here we present a 60-year-old female with multiple comorbid conditions and currently on immunosuppressants for rheumatoid arthritis, who presented with nausea, vomiting, and fever of three weeks duration and was found to have Salmonella bacteremia. Blood cultures were ...
Source: Atherosclerosis - March 25, 2024 Category: Cardiology Authors: Fawwad A Ansari Stefan Gafoor Mubashira Aftab Zola Nlandu Source Type: research

Be aware of the risks of nephrotoxicity when prescribing amoxicillin and third-generation cephalosporins
AbstractAmoxicillin and third-generation cephalosporins are widely used in the prevention and treatment of established infections. These broad-spectrum antibiotics are mainly excreted via urine and are considered relatively safe. However, several reports have indicated that substantial nephrotoxicity (e.g. acute interstitial nephritis and crystal nephropathy) occurs with amoxicillin and several cases of nephrotoxicity have been reported with ceftriaxone. While corticosteroids have been shown to improve kidney function in some patients with acute interstitial nephritis, close monitoring of kidney function for acute kidney i...
Source: Drugs and Therapy Perspectives - March 21, 2024 Category: Drugs & Pharmacology Source Type: research

A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019 –2020
ConclusionPediatric PM is more common in children aged 3 months to < 3 years old. Intracranial complications mostly occur in children < 1 year of age with fever being the most common clinical manifestations and subdural effusion and (or) empyema and hydrocephalus being the most common complications, respectively. CSF non-culture methods can facilitate improving the detection rate of pathogenic bacteria. More than 10% of PM children had adverse outcomes. S. pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol. (Source: Frontiers in cellular...
Source: Frontiers in cellular and infection microbiology - March 15, 2024 Category: Microbiology Source Type: research

Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review
This report details a rare and severe case of ceftriaxone-induced severe immune hemolytic anemia (IHA), hemolytic crisis, myocardial injury, liver injury, renal calculi, and cholecystolithiasis in a previously healthy 3-year-old child. The child, treated for bronchitis, experienced sudden pallor, limb stiffness, and altered consciousness following the fifth day of ceftriaxone infusion, with hemoglobin (Hb) levels precipitously dropping to 21 g/L. Immediate cessation of ceftriaxone and the administration of oxygen therapy, blood transfusion, intravenous immunoglobulin (IVIG), and corticosteroids led to a gradual recovery. ...
Source: Frontiers in Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Source Type: research

Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research