Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone
Antimicrob Agents Chemother. 2024 Feb 27:e0166323. doi: 10.1128/aac.01663-23. Online ahead of print.ABSTRACTThe use of ceftriaxone, a highly protein-bound drug, in the setting of hypoalbuminemia may result in suboptimal drug exposure. Patients with obesity also exhibit higher absolute drug clearance. We aimed to evaluate the impact of hypoalbuminemia on clinical success among hospitalized adults with obesity who were treated with ceftriaxone. This retrospective review included adult inpatients with weight >100 kg or body mass index >40 kg/m2 who received ceftriaxone 2 g intravenously every 12 hours for at least 72 ho...
Source: Antimicrobial Agents and Chemotherapy - February 27, 2024 Category: Microbiology Authors: Kellie Arensman Hannan Evan Draper Kristin C Cole Jack Mc Hugh Christina G Rivera Omar Abu Saleh Source Type: research
Impact of hypoalbuminemia on clinical outcomes among patients with obesity treated with ceftriaxone
Antimicrob Agents Chemother. 2024 Feb 27:e0166323. doi: 10.1128/aac.01663-23. Online ahead of print.ABSTRACTThe use of ceftriaxone, a highly protein-bound drug, in the setting of hypoalbuminemia may result in suboptimal drug exposure. Patients with obesity also exhibit higher absolute drug clearance. We aimed to evaluate the impact of hypoalbuminemia on clinical success among hospitalized adults with obesity who were treated with ceftriaxone. This retrospective review included adult inpatients with weight >100 kg or body mass index >40 kg/m2 who received ceftriaxone 2 g intravenously every 12 hours for at least 72 ho...
Source: Antimicrobial Agents and Chemotherapy - February 27, 2024 Category: Microbiology Authors: Kellie Arensman Hannan Evan Draper Kristin C Cole Jack Mc Hugh Christina G Rivera Omar Abu Saleh Source Type: research
Rocephin-graphene oxide-silver nanocomposites: A versatile platform for biomedical applications
Microsc Res Tech. 2024 Feb 26. doi: 10.1002/jemt.24536. Online ahead of print.ABSTRACTFor many years, the synthesis of graphene oxide (GO) had involved exfoliating graphite flakes, and the methods applied were expensive and time-consuming. Thus, an attempt had been made to create an inventive, less expensive method for the synthesis of GO using unrefined, raw carbon-containing material. Modified Hummer's method was used to prepare GO from banana peel. In addition, the metallic silver nanocomposite was also synthesized along with laoding of drug Rocephin where they interact with each other through electrostatic hydrogen bon...
Source: Cell Research - February 26, 2024 Category: Cytology Authors: Humaira Kashif Muhammad Naeem Ahmed Muhammad Altaf Ihsan Ul Haq Anila Iqbal Sirajul Haq Source Type: research
Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of < em > Escherichia coli < /em > and < em > Klebsiella pneumoniae < /em > in Two Kenyan Facilities: A National Referral and a Level Five Hospital
CONCLUSIONS: The high proportion of ESBL-producing E. coli and K. pneumoniae isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.PMID:38384586 | P...
Source: International Journal of Microbiology - February 22, 2024 Category: Microbiology Authors: Sylvia M Maveke Gabriel O Aboge Laetitia W Kanja Alfred O Mainga Naftaly Gachau Beatrice W Muchira Gervason A Moriasi Source Type: research
Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.ABSTRACTBACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines.RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis?METHODS: We conducted a multicenter retrosp...
Source: Chest - February 22, 2024 Category: Respiratory Medicine Authors: Anthony D Bai Siddhartha Srivastava Genevi ève C Digby Vincent Girard Fahad Razak Amol A Verma Source Type: research
Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of < em > Escherichia coli < /em > and < em > Klebsiella pneumoniae < /em > in Two Kenyan Facilities: A National Referral and a Level Five Hospital
CONCLUSIONS: The high proportion of ESBL-producing E. coli and K. pneumoniae isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.PMID:38384586 | P...
Source: International Journal of Microbiology - February 22, 2024 Category: Microbiology Authors: Sylvia M Maveke Gabriel O Aboge Laetitia W Kanja Alfred O Mainga Naftaly Gachau Beatrice W Muchira Gervason A Moriasi Source Type: research
Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.ABSTRACTBACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines.RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis?METHODS: We conducted a multicenter retrosp...
Source: Chest - February 22, 2024 Category: Respiratory Medicine Authors: Anthony D Bai Siddhartha Srivastava Genevi ève C Digby Vincent Girard Fahad Razak Amol A Verma Source Type: research
Phenotypic and Genotypic Characterization of Extended Spectrum Beta-Lactamase-Producing Clinical Isolates of < em > Escherichia coli < /em > and < em > Klebsiella pneumoniae < /em > in Two Kenyan Facilities: A National Referral and a Level Five Hospital
CONCLUSIONS: The high proportion of ESBL-producing E. coli and K. pneumoniae isolates increases the utilization of last-resort antibiotics, jeopardizing antimicrobial chemotherapy. Furthermore, the antimicrobial resistance patterns exhibited towards extended-spectrum cephalosporins, beta-lactam/beta-lactamase inhibitor combinations, fluoroquinolones, and macrolides show the risk of co-resistance associated with ESBL-producing isolates responsible for MDR. Hence, there is a need for regular surveillance and implementation of infection prevention and control strategies and antimicrobial stewardship programs.PMID:38384586 | P...
Source: International Journal of Microbiology - February 22, 2024 Category: Microbiology Authors: Sylvia M Maveke Gabriel O Aboge Laetitia W Kanja Alfred O Mainga Naftaly Gachau Beatrice W Muchira Gervason A Moriasi Source Type: research
The prevalence and clinical context of antimicrobial resistance amongst medical inpatients at a referral hospital in Rwanda: a cohort study
ConclusionsThis cohort highlights high rates of resistance amongst Gram-negative organisms in Rwanda, including the presence of carbapenem resistance. Nonetheless, the detailed prescribing data also highlight the challenges of using routine laboratory data to infer broader AMR prevalence. The significant exposure to empiric broad-spectrum antibiotic therapy prior to culturing introduces a selection bias and risks over-estimating the burden of resistant organisms. Broadening access to microbiological services and active surveillance outside of teaching hospitals are essential to support national and international efforts to...
Source: Antimicrobial Resistance and Infection Control - February 22, 2024 Category: Infectious Diseases Source Type: research
Intravenous push antibiotics in the emergency department: Education and implementation
CONCLUSION: Intravenous push antibiotics decrease the time from ordering to the start of administration and result in significant cost savings.PMID:38373159 | DOI:10.1093/ajhp/zxae039 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 19, 2024 Category: Drugs & Pharmacology Authors: Rachel E Brady Elizabeth L Giordullo Charles A Harvey Nicholas D Krabacher Alyssa M Penick Source Type: research
