Unusual presentation of disseminated gonococcal infection
A 30-year-old homosexual man living with HIV and receiving virologically suppressive antiretroviral treatment presented to the emergency department with a 3-day history of pain in his left wrist accompanied by fever and chills. On examination, the left wrist showed redness, swelling, tenderness and decreased range of movement. The patient had no history of trauma, insect bites or scratches. Four weeks earlier, he had engaged in unprotected oral sex with a casual partner. Nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoea (Ng) were performed from oropharyngeal, anal and urine samples...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: AlHammadi, M., Schembri, A., Calleja, L., Padovese, V. Tags: PostScript Source Type: research
Minimum inhibitory concentrations of Neisseria gonorrhoeae strains in clients of the Amsterdam sexual health clinic with a Dutch versus an international sexual network
Conclusions
For three cephalosporin antibiotics, we found Ng strains with slightly higher MICs in clients with partner(s) from Europe or Latin America and the Caribbean. International travel might contribute to the spread of Ng with lower susceptibility. More understanding of the emergence of AMR Ng is needed. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Teker, B., Schim van der Loeff, M., Hoornenborg, E., Boyd, A., Reedijk, S., van Dam, A., Jongen, V. W., de Vries, H. Tags: Original research Source Type: research
Predominance of multidrug-resistant < i > Salmonella < /i > Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar
ConclusionsWe report a high rate of MDR and low-level ciprofloxacin resistantS. Typhi circulating in Zanzibar, belonging to genotype 4.3.1.1, which is widespread in Southeast Asia and African countries and associated with low-level ciprofloxacin resistance. Few therapeutic options are available for treatment of typhoid fever in the study setting. Surveillance of the prevalence, spread and antimicrobial susceptibility ofS. Typhi can guide treatment and control efforts. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Annette Onken Source Type: research
Six-year progression of medically treated infective aortitis
CONCLUSIONS: Infective aortitis with mycotic aneurysms is usually treated surgically due to the significant risk of rupture in the acute period. This case suggests that if the acute infective period is passed, the aneurysmal disease stabilises and does not progress.PMID:38626935 | DOI:10.1177/17085381241248724 (Source: Vascular)
Source: Vascular - April 16, 2024 Category: Surgery Authors: Daniel Zhang Arvind Dhas Lee Source Type: research
Six-year progression of medically treated infective aortitis
CONCLUSIONS: Infective aortitis with mycotic aneurysms is usually treated surgically due to the significant risk of rupture in the acute period. This case suggests that if the acute infective period is passed, the aneurysmal disease stabilises and does not progress.PMID:38626935 | DOI:10.1177/17085381241248724 (Source: Vascular)
Source: Vascular - April 16, 2024 Category: Surgery Authors: Daniel Zhang Arvind Dhas Lee Source Type: research
Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis
ConclusionsFindings recommend that leptospirosis patients be treated with antibiotics, which significantly reduced the leptospirosis defervescence time. Cephalosporins, doxycycline, and penicillin are suggested, and azithromycin may be a suitable alternative for drug-resistant cases.Systematic review registrationPROSPERO CRD42022354938. (Source: Systematic Reviews)
Source: Systematic Reviews - April 16, 2024 Category: International Medicine & Public Health Source Type: research
GSE261757 High-throughput Fitness Experiments Reveal Specific Vulnerabilities of Human-Adapted Salmonella During Stress and Infection- Barseq3 (LB, ceftriaxone, ciprofloxacin, azithromycin)
Contributors : Benjamin X Wang ; Denise M MonackSeries Type : OtherOrganism : Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 ; Salmonella enterica subsp. enterica serovar Typhi str. Ty2 ; Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 ; Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74Salmonella enterica is comprised of genetically distinct “serovars”, that together provide an intriguing model for exploring the genetic basis of pathogen evolution. While the genomes of numerous Salmonella isolates with broad variations in host range and human disease manifes...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Other Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150 Salmonella enterica subsp. enterica serovar Typhi str. Ty2 Salmonella enterica subsp. enterica serovar Typhimurium str. D23580 Salmonella enterica subsp. enterica serovar Source Type: research
Machine Learning Exploration of the Relationship Between Drugs and the Blood –Brain Barrier: Guiding Molecular Modification
ConclusionsThe machine learning models developed can accurately predict BBB permeability, and many drug molecules are likely to have increased BBB penetration if the number of Hydrogen Bond Donors and Acceptors are reduced. These findings suggest that molecular modifications can enhance the efficacy of CNS drugs and provide practical strategies for drug design and development. This is particularly relevant for improving drug penetration of the BBB.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
Bartonella quintana pulmonary native valve endocarditis
AbstractBartonella quintana is a well-known cause of blood culture-negative endocarditis; however, pulmonary valve involvement is rare. The case of a 40-year-old African male who presented to the Emergency Department with chest pain, cardiac failure, and a 2-week history of fever is presented. Transoesophageal echocardiography confirmed an atrial septal defect, severe pulmonary insufficiency with large vegetations, severe mitral regurgitation due to anterior leaflet prolapse, and right ventricular dysfunction. Empirical antibiotic therapy was started, and urgent surgical intervention was decided. There were vegetations on ...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - April 10, 2024 Category: Cardiovascular & Thoracic Surgery Source Type: research
A Rare Case of Lemierre ’s Syndrome due to Veillonella Parvula: A Dangerous and Forgotten Complication of a Septic Condition
AbstractThis clinical case presents an unusual case of Lemierre ’s syndrome (LS) in a young woman of 38-year-old. She arrived in the Emergency Department with a high fever and pharyngology resistant to antibiotic therapy with clarithromycin, ceftriaxone, and cortisone for two weeks. At the blood sampling, there is a marked leucocytosis, and the advice of the o tolaryngologist is required given the strong pain in the throat. Due to the tonsillar abscess, a neck CT with a contrast medium is necessary for the otolaryngologist’s opinion. The CT shows thrombosis of the jugular vein and left subclavian, with thickening of so...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 2, 2024 Category: ENT & OMF Source Type: research
Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures
In conclusion, the use of ceftriaxone as monotherapy for antibiotic prophylaxis in lower extremity type III open fractures is not statistically different than the use of historic prophylactic regimens.PMID:38551626 | DOI:10.1177/00031348241241657 (Source: The American Surgeon)
Source: The American Surgeon - March 29, 2024 Category: Surgery Authors: Thomas W Robinson Corinne E Gautreaux Yann-Leei L Lee Maryann Mbaka Christopher M Kinnard Andrew C Bright Ashley Y Williams Nathan M Polite Thomas J Capasso Jon D Simmons Charles C Butts Source Type: research
Comparison of Cefazolin and Ceftriaxone Enterobacterales Susceptibilities for Inpatient Treatment of Urinary Tract Infections and Risk of Hospital-Onset Clostridioides difficile Infection
Clin Ther. 2024 Mar 28:S0149-2918(24)00066-3. doi: 10.1016/j.clinthera.2024.02.011. Online ahead of print.ABSTRACTPURPOSE: Urinary tract infection (UTI) is the second most common indication for antibiotic therapy among inpatients in the United States. Ceftriaxone, a third-generation cephalosporin, is habitually chosen to treat inpatient UTIs due to familiarity, cost, and perceived safety. However, third-generation cephalosporins increase the risk of health care facility-onset Clostridioides difficile infection (HOCDI) more than any other antibiotic group, while no statistical risk exists for first-generation cephalosporins...
Source: Clinical Therapeutics - March 29, 2024 Category: Drugs & Pharmacology Authors: Eric Wombwell Allison Rosa Source Type: research
Monotherapy Antibiotic Prophylaxis of Lower Extremity Long Bone Type III Open Fractures
In conclusion, the use of ceftriaxone as monotherapy for antibiotic prophylaxis in lower extremity type III open fractures is not statistically different than the use of historic prophylactic regimens.PMID:38551626 | DOI:10.1177/00031348241241657 (Source: The American Surgeon)
Source: The American Surgeon - March 29, 2024 Category: Surgery Authors: Thomas W Robinson Corinne E Gautreaux Yann-Leei L Lee Maryann Mbaka Christopher M Kinnard Andrew C Bright Ashley Y Williams Nathan M Polite Thomas J Capasso Jon D Simmons Charles C Butts Source Type: research
Comparison of Cefazolin and Ceftriaxone Enterobacterales Susceptibilities for Inpatient Treatment of Urinary Tract Infections and Risk of Hospital-Onset Clostridioides difficile Infection
Clin Ther. 2024 Mar 28:S0149-2918(24)00066-3. doi: 10.1016/j.clinthera.2024.02.011. Online ahead of print.ABSTRACTPURPOSE: Urinary tract infection (UTI) is the second most common indication for antibiotic therapy among inpatients in the United States. Ceftriaxone, a third-generation cephalosporin, is habitually chosen to treat inpatient UTIs due to familiarity, cost, and perceived safety. However, third-generation cephalosporins increase the risk of health care facility-onset Clostridioides difficile infection (HOCDI) more than any other antibiotic group, while no statistical risk exists for first-generation cephalosporins...
Source: Clinical Therapeutics - March 29, 2024 Category: Drugs & Pharmacology Authors: Eric Wombwell Allison Rosa Source Type: research
