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Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Dissemination of IncC plasmids in Salmonella enterica serovar Thompson recovered from seafood and human diarrheic patients in China
In conclusion, to our knowledge, it is the first report of the co-existence of blaCMY-2, qnrS, and qepA in IncC plasmids, and the conjugational transfer contributed to their dissemination in S. Thompson. These findings underline further challenges for the prevention and treatment of Enterobacteriaceae infections posed by IncC plasmids bearing blaCMY-2, qnrS, and qepA.PMID:38653121 | DOI:10.1016/j.ijfoodmicro.2024.110708 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - April 23, 2024 Category: Food Science Authors: Zengfeng Zhang Dai Kuang Xuebin Xu Zeqiang Zhan Hao Ren Chunlei Shi Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children
CONCLUSION: The emergence of ceftriaxone-resistant H. influenzae with ceftriaxone MIC values of up to 0.75 mg/L was observed even in children in South Korea, with most associated with S385T and L389F substitutions. The N526K mutation alone does not significantly impact ceftriaxone resistance. Further large-scale studies are essential to investigate changes in antibiotic resistance patterns and factors influencing antibiotic resistance in H. influenzae isolated from pediatric patients in Korea.PMID:38651222 | PMC:PMC11035717 | DOI:10.3346/jkms.2024.39.e136 (Source: J Korean Med Sci)
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Sanghoon Lee Gahee Kim Jung Hwa Kim Mi-Na Kim Jina Lee Source Type: research

A Day Saved is a Life Saved: Direct Antimicrobial Susceptibility Testing from Positively Flagged Blood Culture Bottles and their Concordance with the Routine Method
CONCLUSION: Rapid dAST from positively flagged blood culture bottles proved to significantly reduce the TAT from the time of sample collection to the first availability of antimicrobial susceptibility report with excellent categorical agreement of > 95% using the conventional disc diffusion method. Results obtained were within the acceptance criteria set by U. S. Food and Drug Administration (FDA) guidelines of > 90% categorical agreement for a new method. We were able to obtain excellent concordance for colistin using the E-strip method. Performing dAST not only saves a "day", but its proper implementation would sav...
Source: Infectious Disorders Drug Targets - April 19, 2024 Category: Infectious Diseases Authors: Alisha Aggarwal Kumar S Abhishek Vibhor Tak Sukanya Mehrotra Venkat Goutham Nag Vidhi Jain Source Type: research

Unusual presentation of disseminated gonococcal infection
A 30-year-old homosexual man living with HIV and receiving virologically suppressive antiretroviral treatment presented to the emergency department with a 3-day history of pain in his left wrist accompanied by fever and chills. On examination, the left wrist showed redness, swelling, tenderness and decreased range of movement. The patient had no history of trauma, insect bites or scratches. Four weeks earlier, he had engaged in unprotected oral sex with a casual partner. Nucleic acid amplification tests (NAATs) for Chlamydia trachomatis and Neisseria gonorrhoea (Ng) were performed from oropharyngeal, anal and urine samples...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: AlHammadi, M., Schembri, A., Calleja, L., Padovese, V. Tags: PostScript Source Type: research

Minimum inhibitory concentrations of Neisseria gonorrhoeae strains in clients of the Amsterdam sexual health clinic with a Dutch versus an international sexual network
Conclusions For three cephalosporin antibiotics, we found Ng strains with slightly higher MICs in clients with partner(s) from Europe or Latin America and the Caribbean. International travel might contribute to the spread of Ng with lower susceptibility. More understanding of the emergence of AMR Ng is needed. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Teker, B., Schim van der Loeff, M., Hoornenborg, E., Boyd, A., Reedijk, S., van Dam, A., Jongen, V. W., de Vries, H. Tags: Original research Source Type: research

Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar
ConclusionsWe report a high rate of MDR and low-level ciprofloxacin resistantS. Typhi circulating in Zanzibar, belonging to genotype 4.3.1.1, which is widespread in Southeast Asia and African countries and associated with low-level ciprofloxacin resistance. Few therapeutic options are available for treatment of typhoid fever in the study setting. Surveillance of the prevalence, spread and antimicrobial susceptibility ofS. Typhi can guide treatment and control efforts. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Annette Onken Source Type: research

Six-year progression of medically treated infective aortitis
CONCLUSIONS: Infective aortitis with mycotic aneurysms is usually treated surgically due to the significant risk of rupture in the acute period. This case suggests that if the acute infective period is passed, the aneurysmal disease stabilises and does not progress.PMID:38626935 | DOI:10.1177/17085381241248724 (Source: Vascular)
Source: Vascular - April 16, 2024 Category: Surgery Authors: Daniel Zhang Arvind Dhas Lee Source Type: research