Antibiotics for treatment of leptospirosis
CONCLUSIONS: As the certainty of evidence is very low, we do not know if antibiotics provide little to no effect on all-cause mortality, serious adverse events, or adverse events considered non-serious. There is a lack of definitive rigorous data from randomised trials to support the use of antibiotics for treating leptospirosis infection, and the absence of trials reporting data on clinically relevant outcomes further adds to this limitation.PMID:38483092 | PMC:PMC10938876 | DOI:10.1002/14651858.CD014960.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - March 14, 2024 Category: General Medicine Authors: Tin Zar Win Su Myat Han Tansy Edwards Hsu Thinzar Maung David M Brett-Major Chris Smith Nathaniel Lee Source Type: research
Molecular typing of clinical multidrug-resistant Klebsiella pneumoniae isolates
CONCLUSION: Both PCR-typing methods with phenotypic patterns can be useful for the epidemiological typing of K. pneumoniae isolates with the highest performance in discriminating isolates.PMID:38478145 | DOI:10.1007/s11033-024-09278-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 13, 2024 Category: Molecular Biology Authors: Mehdi Kashefieh Habib Zeighami Hossein Samadi Kafil Pourya Gholizadeh Javid Sadeghi Mohammad Hossein Soroush Barhaghi Hamed Ebrahimzadeh Leylabadlo Reza Ghotaslou Source Type: research
Molecular typing of clinical multidrug-resistant Klebsiella pneumoniae isolates
CONCLUSION: Both PCR-typing methods with phenotypic patterns can be useful for the epidemiological typing of K. pneumoniae isolates with the highest performance in discriminating isolates.PMID:38478145 | DOI:10.1007/s11033-024-09278-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - March 13, 2024 Category: Molecular Biology Authors: Mehdi Kashefieh Habib Zeighami Hossein Samadi Kafil Pourya Gholizadeh Javid Sadeghi Mohammad Hossein Soroush Barhaghi Hamed Ebrahimzadeh Leylabadlo Reza Ghotaslou Source Type: research
Outpatient parenteral antimicrobial therapy (OPAT) in Germany: insights and clinical outcomes from the K-APAT cohort study
ConclusionThe study demonstrates that OPAT can be safely conducted in Germany. In preparation for its broader implementation, crucial next steps include creating medical guidelines, fostering interdisciplinary and inter-sectoral communication, as well as creating financial and structural regulations that facilitate and encourage the adoption of OPAT.Trial registration numberNCT04002453. (Source: Infection)
Source: Infection - March 13, 2024 Category: Infectious Diseases Source Type: research
Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2
ConclusionsPneumococcal meningitis can have devastating effects on cochlear structure and function, although not all mice experienced hearing loss or cochlear damage. Meningitis can result in rapid progression of hearing loss with fibrosis starting at four DPI and ossification within 2 weeks of infection detectable by light microscopy. The inflammatory response to bacterial meningitis is robust and can affect all three scalae. Our results suggest that CCR2 may assist in controlling infection and maintaining cochlear patency, as CCR2 knockout mice experienced more severe disease, more rapid hearing loss, and more advanced...
Source: JARO - Journal of the Association for Research in Otolaryngology - March 12, 2024 Category: ENT & OMF Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Antimicrobial susceptibilities of < em > Neisseria gonorrhoeae < /em > in Canada, 2021
CONCLUSION: The spread of antimicrobial-resistant gonorrhea is a significant public health concern. The continued regional and national surveillance of antimicrobial resistance in N. gonorrhoeae is essential in ensuring effective treatment therapies are recommended.PMID:38463902 | PMC:PMC10919915 | DOI:10.14745/ccdr.v49i09a05 (Source: Can Commun Dis Rep)
Source: Can Commun Dis Rep - March 11, 2024 Category: Infectious Diseases Authors: Pamela Sawatzky Brigitte Lefebvre Mathew Diggle Linda Hoang Jason Wong Samir Patel Paul Van Caessele Jessica Minion Richard Garceau Sarah Jeffrey David Haldane Lillian Lourenco Genevieve Gravel Michael Mulvey Irene Martin Source Type: research
Clinical and microbiological profile of Viridans group streptococcal bacteraemia; experience from South India
CONCLUSIONS: VGS are an important cause of bacteraemia and was associated with 19% mortality in our study. High rates of penicillin and ceftriaxone resistance are a reason of concern. Molecular diagnostics like matrix assisted laser desorption ionization-time of flight (MALDI-TOF) identification must be increasingly applied for species identification considering that a substantial number of isolates were not identified to species level.PMID:38456022 | PMC:PMC10917554 | DOI:10.53854/liim-3201-5 (Source: Infezioni in Medicina)
Source: Infezioni in Medicina - March 8, 2024 Category: Infectious Diseases Authors: Rajalakshmi Arjun Vettakkara Kandy Muhammed Niyas Febeena Hussain Sandeep Surendran Viji Mohan Source Type: research
