JARO - Journal of the Association for Research in Otolaryngology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

FDA-Approved Tedizolid Phosphate Prevents Cisplatin-Induced Hearing Loss Without Decreasing Its Anti-tumor Effect
ConclusionCollectively, these results showed that FDA-approved Ted protected HCs from cisplatin-induced HC loss by inhibiting ERK phosphorylation, indicating its potential as a candidate for preventing cisplatin ototoxicity in clinical settings. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - April 15, 2024 Category: ENT & OMF Source Type: research

Hampshire Sheep as a Large-Animal Model for Cochlear Implantation
ConclusionsHampshire sheep appear to be a suitable large-animal model for CI electrode insertion via an extended facial recess approach without sacrificing the FN. In this small sample, Hampshire specimens had improved RWM visibility compared to Suffolk-Dorset. Thus, Hampshire sheep may be superior to other breeds for ease of cochlear implantation, with FN and facial recess anatomy more similar to humans. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - April 15, 2024 Category: ENT & OMF Source Type: research

Echolocating Bats Have Evolved Decreased Susceptibility to Noise-Induced Temporary Hearing Losses
AbstractGlenis Long championed the application of quantitative psychophysical methods to understand comparative hearing abilities across species. She contributed the first psychophysical studies of absolute and masked hearing sensitivities in an auditory specialist, the echolocating horseshoe bat. Her data demonstrated that this bat has hyperacute frequency discrimination in the 83-kHz range of its echolocation broadcast. This specialization facilitates the bat ’s use of Doppler shift compensation to separate echoes of fluttering insects from concurrent echoes of non-moving objects. In this review, we discuss another spe...
Source: JARO - Journal of the Association for Research in Otolaryngology - April 2, 2024 Category: ENT & OMF Source Type: research

Mechanical Effects of Medical Device Attachment to Human Tympanic Membrane
ConclusionThe findings of our study aid the development and optimization of new therapeutic devices, attached to the tympanic membrane, to have the least adverse effects on middle-ear vibrations. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - April 1, 2024 Category: ENT & OMF Source Type: research

Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective
AbstractTinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions. Tinnitus exhibits high per...
Source: JARO - Journal of the Association for Research in Otolaryngology - March 26, 2024 Category: ENT & OMF Source Type: research

A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2+ Progenitors in the Neonatal Mouse Inner Ear Organoids
ConclusionOur findings underscore a practical strategy for enhancing the generation of inner ear organoids with a low dose of rapamycin, achieved by enriching SOX2+ progenitors in an in vitro setting. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - March 12, 2024 Category: ENT & OMF Source Type: research

Pneumococcal Meningitis Induces Hearing Loss and Cochlear Ossification Modulated by Chemokine Receptors CX3CR1 and CCR2
ConclusionsPneumococcal meningitis can have devastating effects on cochlear structure and function, although not all mice experienced hearing loss or cochlear damage. Meningitis can result in rapid progression of hearing loss with fibrosis starting at four DPI and ossification within 2  weeks of infection detectable by light microscopy. The inflammatory response to bacterial meningitis is robust and can affect all three scalae. Our results suggest that CCR2 may assist in controlling infection and maintaining cochlear patency, as CCR2 knockout mice experienced more severe disease, more rapid hearing loss, and more advanced...
Source: JARO - Journal of the Association for Research in Otolaryngology - March 12, 2024 Category: ENT & OMF Source Type: research

Exploring the Use of Interleaved Stimuli to Measure Cochlear-Implant Excitation Patterns
ConclusionA method that is sensitive enough to reveal a modest broadening in RP  + 2 showed no evidence for sharpening with focussed stimulation. We also showed that although voltage recordings from the implant accurately predicted a broadening of the psychophysical excitation patterns with RP + 2, they wrongly predicted a strong sharpening with pTP + 2. We addition ally argue, based on our recent research, that the interleaved-masking method can usefully be applied to non-human species and objective measures of CI excitation patterns. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - March 8, 2024 Category: ENT & OMF Source Type: research

Swept Along: Measuring Otoacoustic Emissions Using Continuously Varying Stimuli
AbstractAt the 2004 Midwinter Meeting of the Association for Research in Otolaryngology, Glenis Long and her colleagues introduced a method for measuring distortion-product otoacoustic emissions (DPOAEs) using primary-tone stimuli whose instantaneous frequencies vary continuously with time. In contrast to standard OAE measurement methods, in which emissions are measured in the sinusoidal steady state using discrete tones of well-defined frequency, the swept-tone method sweeps across frequency, often at rates exceeding 1 oct/s. The resulting response waveforms are then analyzed using an appropriate filter (e.g., by least-sq...
Source: JARO - Journal of the Association for Research in Otolaryngology - February 26, 2024 Category: ENT & OMF Source Type: research

Measuring Optokinetic Reflex and Vestibulo-Ocular Reflex in Unilateral Vestibular Organ Damage Model of Zebrafish
This study confirmed that VOR and OKR were significantly reduced in zebrafish with unilateral and bilateral vestibular damage. Follow-up studies on unilateral vestibular disorders can be conducted using this tool. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - February 15, 2024 Category: ENT & OMF Source Type: research

Editorial: Views on  JARO 2023
(Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - February 12, 2024 Category: ENT & OMF Source Type: research

Inner Ear Organoids: Strengths and Limitations
AbstractInner ear organoids derived from differentiation of human pluripotent stem cells have recently gained momentum as tools to study inner ear development and developmental defects. An additional exciting aspect about this technology is represented by its  translational potential, specifically, the use of organoids to validate therapeutics for hearing and balance restoration on human/patient-specific cells. This latter aspect will be briefly discussed here including opportunities and current limitations. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - February 9, 2024 Category: ENT & OMF Source Type: research

Frequency-Following Responses in Sensorineural Hearing Loss: A Systematic Review
ConclusionPatients with SNHL may require more time for processing (speech) stimuli, reflected in prolonged latencies. However, the exact timing of this delay remains unclear. Additionally, when presenting longer stimuli ( ≥ 170 ms), patients with SNHL show difficulties tracking the F0 of (speech) stimuli. No definite conclusions could be drawn on changes in wave amplitude in the time domain and the TFS in the frequency domain. Patient characteristics, acquisition parameters, and FFR outcome parameters differed greatly across studies. Future studies should be performed in larger and carefully matched subject groups, us...
Source: JARO - Journal of the Association for Research in Otolaryngology - February 9, 2024 Category: ENT & OMF Source Type: research

A Systematic Review on the Genetic Contribution to Tinnitus
ConclusionsThe genetic contribution to tinnitus is starting to be revealed and it shows population-specific effects in European and Asian populations. The common allelic variants associated with tinnitus that showed replication are associated with noise-induced tinnitus. Although severe tinnitus has been associated with rare variants with large effect, their role on hearing or hyperacusis has not been established. (Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - February 9, 2024 Category: ENT & OMF Source Type: research

ARO ’s 47th Annual MidWinter Meeting in Anaheim 2024: podium and poster titles
(Source: JARO - Journal of the Association for Research in Otolaryngology)
Source: JARO - Journal of the Association for Research in Otolaryngology - February 3, 2024 Category: ENT & OMF Source Type: research