Ceftriaxone Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Intravenous push antibiotics in the emergency department: Education and implementation
CONCLUSION: Intravenous push antibiotics decrease the time from ordering to the start of administration and result in significant cost savings.PMID:38373159 | DOI:10.1093/ajhp/zxae039 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 19, 2024 Category: Drugs & Pharmacology Authors: Rachel E Brady Elizabeth L Giordullo Charles A Harvey Nicholas D Krabacher Alyssa M Penick Source Type: research

Is shorter antibiotic treatment duration increasing the risk of relapse in paediatric acute focal bacterial nephritis?
Scenario A 12-year-old girl presented with another episode of pyelonephritis. Her history was remarkable for multiple prior episodes of pyelonephritis over several months. Each episode was accompanied by flank pain and fever. Urine culture showed Escherichia coli on all occasions. Treatment for the first episodes was with oral cephalosporins for 10 days. Renal ultrasound did not show any abnormality of the urinary tract and the performed uroflow was normal. Underlying risk factors for recurrence of pyelonephritis such as bowel–bladder dysfunction and constipation were ruled out. A sufficient oral fluid intake as well...
Source: Archives of Disease in Childhood - February 19, 2024 Category: Pediatrics Authors: Vaezipour, N., Evers, K., Schmid, H., Ritz, N., Goischke, A. Tags: ADC Archimedes Source Type: research

Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner
In this study, we found that β-amyloid (Aβ) treatment induced hippocampal LTP impairment and AMPAR downregulation and ubiquitination. Cef pretreatment ameliorated Aβ-induced hippocampal LTP impairment, reduced AMPAR ubiquitination, and increased AMPAR expression, especially in the plasma memb rane, in Aβ-treated mice. Administration of USP46 siRNA and DHK (a specific blocker of glutamate transporter-1) significantly inhibited the above effects of Cef, suggesting a role for anti-AMPAR ubiquitination and upregulation of glutamate transporter-1 (GLT-1) in the Cef-induced improvements menti oned above. The above findings d...
Source: Molecular Neurobiology - February 19, 2024 Category: Neurology Source Type: research

A case of late-onset organizing pneumonia following COVID-19 infection in a post-kidney transplant patient
AbstractA 50-year-old man who had undergone a living-donor kidney transplant 12 years prior for chronic renal failure due to autosomal dominant polycystic kidney disease contracted coronavirus disease 19 (COVID-19). He had a positive antigen test, mild symptoms, sore throat, and fever of 37.9 ℃. The patient was treated with molnupiravir for 5 days, and the symptoms disapp eared 5 days after onset. However, 10 days after onset, he developed a fever of approximately 37 ℃ and a non-productive cough; 27 days after onset, the patient was hospitalized for anorexia and a worsening respiratory condition. The severe acu...
Source: CEN Case Reports - February 17, 2024 Category: Urology & Nephrology Source Type: research

Immune recovery uveitis in Whipple ’s disease: an unusual ocular presentation
ConclusionsThis case underlines the possibility of IRU complicating WD. Ophthalmologists, rheumatologists, and internists should be aware of this rare complication, particularly in the context of previous immunosuppressive therapy. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - February 13, 2024 Category: Opthalmology Source Type: research

Repurposing of non-steroidal anti-inflammatory drugs for combination therapies to combat multidrug-resistant S. aureus of bovine reproductive tract origin
In conclusion, MDRS. aureus resistance was mitigatedin-vitro through the combination of antibiotics (oxytetracycline, gentamicin) with NSAIDs (meloxicam, ketoprofen) that could be used to create therapeutic strategies for bovine reproductive issues. (Source: Veterinary Research Communications)
Source: Veterinary Research Communications - February 12, 2024 Category: Veterinary Research Source Type: research

Biochemical evaluation and ligand binding studies on glycerophosphodiester phosphodiesterase from Staphylococcus aureus using STD-NMR spectroscopy and molecular docking analysis
In this study, competent E. coli BL21(DE3)pLysS expression cells were used to express the GDPD enzyme from vancomycin-resistant Staphylococcus aureus (VRSA), which was then purified using size exclusion and anion exchange chromatography. The hydrolytic activity of GDPD was evaluated on the non-physiological substrate bis(p-nitrophenyl) phosphate (BpNPP), which indicated functional activity of the enzyme. 79 drugs were evaluated for their inhibitory potential against GDPD enzyme by the colorimetric assay. Out of 79 drugs, 13 drugs, including tenofovir (1), adenosine (2), clioquinol (11), bromazepam (12), lamotrigine (13), s...
Source: Bioorganic Chemistry - February 9, 2024 Category: Chemistry Authors: Uzma Salar None Atia-Tul-Wahab M Iqbal Choudhary Source Type: research

The Management of Gonorrhea in the Era of Emerging Antimicrobial Resistance: What Primary Care Clinicians Should Know
Med Clin North Am. 2024 Mar;108(2):279-296. doi: 10.1016/j.mcna.2023.08.015. Epub 2023 Sep 14.ABSTRACTGonorrhea rates continue to rise in the United States and Neisseria gonorrhoeae's propensity to develop resistance to all therapies used for treatment has complicated the management of gonorrhea. Ceftriaxone is the only remaining highly effective recommended regimen for gonococcal treatment and few new anti-gonococcal antimicrobials are being developed. The 2021 CDC STI Treatment Guidelines increased the dose of ceftriaxone to 500 mg (1 g if ≥ 150 kg) for uncomplicated infections. It is recommended that all clinicians sh...
Source: The Medical Clinics of North America - February 8, 2024 Category: General Medicine Authors: Laura A S Quilter Sancta B St Cyr Lindley A Barbee Source Type: research

Selection of Antibiotics as Prophylaxis for Close Contacts of Patients with Meningococcal Disease in Areas with Ciprofloxacin Resistance - United States, 2024
MMWR Morb Mortal Wkly Rep. 2024 Feb 8;73(5):99-103. doi: 10.15585/mmwr.mm7305a2.ABSTRACTMeningococcal disease, caused by the bacterium Neisseria meningitidis, is a rare but life-threatening illness that requires prompt antibiotic treatment for patients and antibiotic prophylaxis for their close contacts. Historically, N. meningitidis isolates in the United States have been largely susceptible to the antibiotics recommended for prophylaxis, including ciprofloxacin. Since 2019, however, the number of meningococcal disease cases caused by ciprofloxacin-resistant strains has increased. Antibiotic prophylaxis with ciprofloxacin...
Source: MMWR Morb Mortal Wkl... - February 8, 2024 Category: Epidemiology Authors: Isha Berry Amy B Rubis Rebecca L Howie Shalabh Sharma Daya Marasini Henju Marjuki Samuel Crowe Lucy A McNamara Source Type: research