Long-term follow-up of a healthy man with endogenous Streptococcus anginosus endophthalmitis
We report the long-term follow-up of an immunocompetent patient who presented with slowly progressive endogenous endophthalmitis secondary toStreptococcus anginosus. A 46-year-old healthy man presented with a two-month history of right eye iritis. On examination, visual acuity was 20/60 with intraocular pressure of 6 mm Hg. There was a small layer of hypopyon with non-granulomatous anterior uveitis and vitritis. On funduscopy, fluffy white peripheral retinal and pre-retinal lesions were noted in superonasal periphery. The patient denied any present or past illness. Diagnostic pars plana vitrectomy was performe d. Culture...
Source: Journal of Ophthalmic Inflammation and Infection - February 1, 2024 Category: Opthalmology Source Type: research
SERS-based detection of the antibiotic ceftriaxone in spiked fresh plasma and microdialysate matrix by using silver-functionalized silicon nanowire substrates
Talanta. 2024 Jan 18;271:125697. doi: 10.1016/j.talanta.2024.125697. Online ahead of print.ABSTRACTTherapeutic drug monitoring (TDM) is an important tool in precision medicine as it allows estimating pharmacodynamic and pharmacokinetic effects of drugs in clinical settings. An accurate, fast and real-time determination of the drug concentrations in patients ensures fast decision-making processes at the bedside to optimize the clinical treatment. Surface-enhanced Raman spectroscopy (SERS), which is based on the application of metallic nanostructured substrates to amplify the inherent weak Raman signal, is a promising techni...
Source: Talanta - January 31, 2024 Category: Chemistry Authors: Chen Liu C élia Franceschini Susanne Weber Tony Dib Poting Liu Long Wu Edoardo Farnesi Wen-Shu Zhang Vladimir Sivakov Peter B Luppa J ürgen Popp Dana Cialla-May Source Type: research
Predicting valuable missense variants with AlphaMissense in a multiple pulmonary infection patient
Clinical course of the patient. Sulfamethoxazole and ceftriaxone (day 12 –17), linezolid (day 18), moxifloxacin (day 136–140), meropenem (day 141–161), faropenem and rifampicin (day 161). (A, B) Contrast-enhanced CT of the pulmonary at day 65. (C, D) Contrast-enhanced CT of the pulmonary at day 132. Key Clinical MessageAlphaMissense is proficient in predicting the clinical classification of missense variants. we utilized AlphaMissense to find disease-relevant variants within a polymicrobial pulmonary infection case. Exome sequencing was performed in this patient, and AlphaMissense and Phenolyzer were combined to inve...
Source: Clinical Case Reports - January 30, 2024 Category: General Medicine Authors: Tianyuan Wang,
Jindi Ma,
Yuan Shu,
Bao Hong,
Zhouhan Wang,
Yingfeng Lu,
Xiaopeng Yu,
Xi Huang,
Yimin Zhang Tags: CASE REPORT Source Type: research
Real world drug treatment models for pregnancy complicated with urinary tract infection in China from 2018 to 2022: a cross-section analysis
Conclusion: In the 5 years of research, the average age of patients who visit a doctor has not increased substantially, but the opportunity cost of female fertility has increased, which has severely impeded the fulfillment of fertility desires. The selection of medications is generally reasonable, and the dosage of the first-line cephalosporins recommended by the guidelines is relatively high in this study. The dosage of furantoin and fosfomycin, which are more prevalent in urinary tract infections, is however relatively low. In addition, some expensive pharmaceuticals may increase patients’ financial burden. On the pre...
Source: Frontiers in Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Source Type: research
Standardized risk-based antibiotic prophylaxis and adhesive film dressing for the prevention of wound infection following cochlear implantation
CONCLUSION: Standardized risk-based AP can avoid prolonged administration of antibiotics in selected patients. The film dressing permits continual examination and sufficient wound protection.PMID:38280932 | DOI:10.1007/s00106-024-01423-0 (Source: HNO)
Source: HNO - January 27, 2024 Category: ENT & OMF Authors: Stefan Lyutenski Susanne Wendt Anja Lieder Paul James Marc Bloching Source Type: research
Reported antibiotic use among patients in the multicenter ANDEMIA infectious diseases surveillance study in sub-saharan Africa
ConclusionsReported antibiotic use data from this multicenter study in sub-Saharan Africa revealed a high proportion of WHO Watch antibiotics. Differences in Watch antibiotic use were found by disease syndrome, country and health facility location, which calls for a more differentiated approach to antibiotic use interventions including further evaluation of accessibility and affordability of patient treatment. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - January 25, 2024 Category: Infectious Diseases Source Type: research
Antimicrobial stewardship capacity and antibiotic utilisation practices in the Cape Coast Teaching Hospital, Ghana: A point prevalence survey study
ConclusionsThere was high use of antibiotics within the hospital which needs addressing. Identified quality targets include developing surgical prophylaxis guidelines, reviewing “Watch” antibiotic prescribing, and assessing antibiotic durations for patients on two or more antibiotics. Organizational-level deficiencies were also identified that need addressing to help instigate ASPs. These can be addressed by developing local prescribing protocols and antibiotic stewards hip policies in this hospital and wider in Ghana and across Africa. (Source: PLoS One)
Source: PLoS One - January 25, 2024 Category: Biomedical Science Authors: Elizabeth Agyare Source Type: research
Determination of Capsule Types, Antibiotic Resistance Profiles and Phylogenetic Relationships of Group B Streptococcus Isolates Isolated from Patients Followed in Various Clinics and Polyclinics
In conclusion, it was thought that more studies should be conducted to show the prevalence of GBS capsule serotypes and patterns of antibiotic resistance.PMID:38263936 | DOI:10.5578/mb.20249901 (Source: Mikrobiyoloji Bulteni)
Source: Mikrobiyoloji Bulteni - January 24, 2024 Category: Microbiology Authors: Suna K ızılyıldırım T ülay Kandemir Berfin Sucu Fatih K öksal Source Type: research
