6143 —Botulinum toxin type A treatment for Raynaud’s phenomenon: Experience and 3-year follow-up
Introduction: Raynaud ’s phenomenon consists of vasospastic disease of the digital arteries after exposure to cold or stress and may appear in isolation or in the context of a systemic disease. When severe, it causes an important reduction in a patient’s quality of life. The available treatments do not always offer g ood results, making it necessary to look for therapeutic alternatives. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Botulinum toxin type A for the treatment of localized recalcitrant chronic pruritus
Background: Chronic pruritus is a common condition that carries a significant burden of disease and can be localized to certain body regions, such as in lichen simplex chronicus, post-burn pruritus, and multiple forms of neuropathic itch. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Subject satisfaction demonstrated for two on-label injection volumes of abobotulinumtoxinA when used to treat moderate to severe glabellar lines
In this study, we evaluated both on-label injection volumes in subjects with moderate to severe GLs at maximum frown and asked them to complete questionnaires before and after treatment to assess treatment satisfaction and health-related quality of life subject-reported outcomes, which is the focus of this report. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Two phase 3, randomized, double-blind, placebo-controlled, multicenter trials to evaluate the efficacy and safety of daxibotulinumtoxinA for injection to treat moderate to severe glabellar lines (SAKURA 1 and 2)
Objective and purpose: Injectable daxibotulinumtoxinA (RT002; investigational) is a purified 150 kDa botulinum toxin type A devoid of accessory proteins in a lyophilized powder containing a proprietary peptide. Phase 2 data (BELMONT study) show that 40 U daxibotulinumtoxinA is associated with a greater response rate and a significantly longer duration of response (median 23.6 weeks) compared with 20 U onabotulinumtoxinA, as well as a favorable risk-benefit profile (ClinicalTrials.gov NCT02303002). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

An Algorithm Using Botox Injections for Facial Scar Improvement in Fitzpatrick Type IV–VI Skin
Source: Plastic and Reconstructive Surgery Global Open - August 1, 2018 Category: Cosmetic Surgery Tags: Original Article Source Type: research

S093: pneumatic balloon dilation for palliation of recurrent symptoms of achalasia after esophagomyotomy
ConclusionSerial PBD is safe and effective in treatment of recurrent symptoms of achalasia after esophagomyotomy. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - July 31, 2018 Category: Surgery Source Type: research

Effect of botulinum toxin type A on the healing of facial skin biopsies - series of cases
Abstract: Several reports have demonstrated difficulties and lack of agreement in the histopathological diagnosis of particular melanocytic lesions, with problems in their management. A histogenetic approach to the study of these lesions originated the following classification: 1. superficial atypical proliferation significance; 2. melanocytic tumor of uncertain potential; 3. pigmented epithelioid melanocitoma of uncertain potential; 4. microinvasive radial growth phase of uncertain potential. The terminology remains controversial, reflecting the uncertainty of the diagnosis and the biological potential of these atypical m...
Source: Anais Brasileiros de Dermatologia - July 30, 2018 Category: Dermatology Source Type: research

Topical Botulinum Toxin Type A Liposomal Cream for Primary Axillary Hyperhidrosis: A Double-Blind, Randomized, Split-Site, Vehicle-Controlled Study
CONCLUSION Topical BTX-A liposomal cream pharmaceutically enhances drug delivery, is painless, cost-effective, and overall an innovative treatment of PAH. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - July 25, 2018 Category: Dermatology Tags: Original Article Source Type: research

A Randomized, Placebo-Controlled, Double-Blind, Prospective Clinical Trial of Botulinum Toxin Type A in Prevention of Hypertrophic Scar Development in Median Sternotomy Wound
AbstractBackgroundLinear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar. Botulinum toxin type A (BTA) is widely used in cosmetic surgery and has been shown to improve scar quality recently. The aim of this study was to evaluate the efficacy of BTA injected in the early postoperative of median sternotomy on preventing scar formation.MethodsIn this prospective randomized controlled trial, 19 consecutive patients who underwent median sternotomy were enrolled. The median sternotomy wound in each patient was divided into the upper half and the lower half...
Source: Aesthetic Plastic Surgery - July 17, 2018 Category: Cosmetic Surgery Source Type: research

Combined effects of botulinum toxin type A and repetitive transcranial magnetic stimulation with intensive motor training immediately after injection in a patient with chronic stroke: A case report
Single case report. (Source: Journal of Hand Therapy)
Source: Journal of Hand Therapy - July 16, 2018 Category: Rehabilitation Authors: Yuichi Hirakawa, Soichiro Koyama, Shigeo Tanabe, Kazuya Takeda, Tetsuya Ueda, Ikuo Motoya, Hiroaki Sakurai, Yoshikiyo Kanada, Nobutoshi Kawamura, Mami Kawamura, Junji Nagata, Tetsuo Kanno Tags: Case Report Source Type: research

Botox Injection for Laryngeal Dysfunction in Alexander Disease
Alexander disease (AD) is a rare neurodegenerative disorder caused by mutations in the gene encoding the glial fibrillary acidic protein (GFAP).1 AD was first described in an infant in 19492,3 and characterized by the presence of Rosenthal fibers (RFs) —eosinophilic inclusions localized in astrocytic cytoplasms—found in perivascular, periventricular, and subpial spaces of the cerebral hemispheres, the cerebellum, and the brainstem.4 Brainstem involvement may cause otorhinolaryngologic manifestations, including dysphonia, dysphagia, tremulous v oice, nasal dysarthria, and palatal tremor (PT). (Source: Journal of Voice)
Source: Journal of Voice - July 15, 2018 Category: ENT & OMF Authors: Amy Rutt, Selmin Karatayli Ozgursoy Source Type: research

Unilateral whisker pad injection of botulinum toxin type a enhances spatial learning in mice
The central cholinergic nervous system plays an important role in cognition, with acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type A (BoNT/A), a potent poison secreted by Clostridium botulinum, is used widely for dystonia treatment and facial cosmesis. BoNT/A injection inhibits acetylcholine release in the neuromuscular junction through cleavage of synaptosomal-associated protein of 25 kDa in cholinergic terminals. Furthermore, beyond the injection site, BoNT/A undergoes retrograde transport and transcytosis to the central nervous system from peripheral cholinergic termina...
Source: NeuroReport - July 14, 2018 Category: Neurology Tags: Clinical Neuroscience Source Type: research

Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Cindy L. Amundsen, Yuko M. Komesu, Christopher Chermansky, W. Thomas Gregory, Deborah L. Myers, Emily F. Honeycutt, Sandip P. Vasavada, John N. Nguyen, Tracey S. Wilson, Heidi S. Harvie, Dennis Wallace, for the Pelvic Floor Disorders NetworkAbstractBackgroundUrgency urinary incontinence (UUI) is a chronic condition for which sacral neuromodulation (SNM) (InterStim/Medtronic) and onabotulinumtoxinA (BTX) (BotoxA/Allergan) are utilized. These therapies have not been compared over extended time.ObjectiveTo compare UUI episodes (UUIE) over 24 mo ...
Source: European Urology - July 11, 2018 Category: Urology & Nephrology Source Type: research

Extracorporeal Shock Waves versus Botulinum Toxin Type A in the Treatment of Post-Stroke Upper Limb Spasticity – A Randomized, Noninferiority Trial
To investigate whether extracorporeal shock wave therapy (ESWT) is noninferior to botulinum toxin type A (BoNT-A) for the treatment of post-stroke upper limb spasticity. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - July 3, 2018 Category: Rehabilitation Authors: Yah-Ting Wu, Hui-Kung Yu, Li-Ru Chen, Chih-Ning Chang, Yi-Min Chen, Gwo-Chi Hu Source Type: research

The Value of Urinary BDNF Levels on Assessment of the Botulinum Toxin Type A Treatment for Neurogenic Detrusor Overactivity in Children with Myelodysplasia
Urinary cytokines are proposed to predict the urodynamic findings and outcome of intradetrusor botulinum neurotoxin type A injection (iBoNT-Ai) in children with myelodysplasia. The relationship between urinary brain-derived neurotrophic factor (BDNF) and neurogenic and non-neurogenic detrusor overactivity (NDOA) has been shown, as well. In this prospective study, we aimed to investigate the effect of iBoNT-Ai on urine BDNF levels in children with NDOA due to myelodysplasia. (Source: The Journal of Urology)
Source: The Journal of Urology - July 3, 2018 Category: Urology & Nephrology Authors: Cagri Akin Sekerci, Yiloren Tanidir, Tuncay Toprak, Banu Isbilen Basok, Ferruh Isman, Ferruh Simsek, Cem Akbal, Tufan Tarcan Source Type: research

Botox in reverse: a useful adjunct for acromial fractures.
PMID: 29968503 [PubMed - as supplied by publisher] (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - July 3, 2018 Category: Surgery Authors: Awad F, Smith CD Tags: Ann R Coll Surg Engl Source Type: research

Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study.
;dös Z, Kaňovský P Abstract Botulinum toxin type A (BoNT) is considered an effective therapeutic option in cervical dystonia (CD). The pathophysiology of CD and other focal dystonias has not yet been fully explained. Results from neurophysiological and imaging studies suggest a significant involvement of the basal ganglia and thalamus, and functional abnormalities in premotor and primary sensorimotor cortical areas are considered a crucial factor in the development of focal dystonias. Twelve BoNT-naïve patients with CD were examined with functional MRI during a skilled hand motor task; the examin...
Source: Experimental Brain Research - July 3, 2018 Category: Neuroscience Authors: Nevrlý M, Hluštík P, Hok P, Otruba P, Tüdös Z, Kaňovský P Tags: Exp Brain Res Source Type: research

Extracorporeal Shock Waves Versus Botulinum Toxin Type A in the Treatment of Poststroke Upper Limb Spasticity: A Randomized Noninferiority Trial
To investigate whether extracorporeal shock wave therapy (ESWT) is noninferior to botulinum toxin type A (BoNT-A) for the treatment of poststroke upper limb spasticity. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - July 3, 2018 Category: Rehabilitation Authors: Yah-Ting Wu, Hui-Kung Yu, Li-Ru Chen, Chih-Ning Chang, Yi-Min Chen, Gwo-Chi Hu Tags: Original research Source Type: research

Usefulness of laparoscopy for determining the location of transitional zone in patients with inconclusive barium enema for Hirschsprung’s disease: a prospective clinical trial
Conclusion Laparoscopy was found to be a useful diagnostic and therapeutic tool for such patients. (Source: Annals of Pediatric Surgery)
Source: Annals of Pediatric Surgery - July 1, 2018 Category: Surgery Tags: Original Articles Source Type: research

The application of W-plasty combined Botox-A injection in treating sunk scar on the face
This study was aimed to explore the effect of W-plasty combined Botox-A injection in improving appearance of scar. According to the inclusive and exclusive criteria, patients received W-plasty combined Botox-A injection (study group) or traditional (control group) scar repairment were enrolled in this study. After surgery, a follow-up ranged from 1 to 2 years was conducted. The effectiveness of surgery was assessed by visual analogue scale (VAS). A total of 38 patients were enrolled in this study, including 21 cases in the study group and 17 cases in the control group. There were no significant difference were identified...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Botulinum Toxin Type A: Evaluation of Onset and Satisfaction
With the increasing interest in nonsurgical cosmetic procedures, this research study sought to evaluate the onset of Botulinum toxin Type A (BoNTA) between naive and non-naive consumers and its effect on satisfaction. This single-blinded research study consisted of 15 adults with scheduled appointments for neurotoxin treatment of undesired glabellar lines. Participants completed pretreatment FACE-Q scales. Both the participant and the researcher rated pretreated glabellar lines with the Merz 5-point scale. Daily photographs of the treated area were taken by the participant and submitted to the researcher over a secure elec...
Source: Plastic Surgical Nursing - July 1, 2018 Category: Nursing Tags: Departments: Aesthetics Department Source Type: research

Opiates, antibiotics and botox should be harder to get online, GPhC proposes
Medicines including antibiotics and opiates could become more difficult to obtain online under proposals published by the General Pharmaceutical Council. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - June 26, 2018 Category: Drugs & Pharmacology Source Type: research

Intra-articular injection of botulinum toxin type A for shoulder pain in glenohumeral osteoarthritis: a case series summary and review of the literature
(Source: Journal of Pain Research)
Source: Journal of Pain Research - June 25, 2018 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Botulinum toxins for the prevention of migraine in adults.
CONCLUSIONS: In chronic migraine, botulinum toxin type A may reduce the number of migraine days per month by 2 days compared with placebo treatment. Non-serious adverse events were probably experienced by 60/100 participants in the treated group compared with 47/100 in the placebo group. For people with episodic migraine, we remain uncertain whether or not this treatment is effective because the quality of this limited evidence is very low. Better reporting of outcome measures in published trials would provide a more complete evidence base on which to draw conclusions. PMID: 29939406 [PubMed - as supplied by publisher...
Source: Cochrane Database of Systematic Reviews - June 25, 2018 Category: General Medicine Authors: Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A Tags: Cochrane Database Syst Rev Source Type: research

Botulinum toxin-B injection into the lacrimal gland and posterior cricoarytenoid muscle for the treatment of epiphora and abductor spasmodic dysphonia secondary to Parkinson's disease.
We describe a 53-year old male with Parkinson's disease who did not respond to BTX-A injections to either the lacrimal gland, for epiphora secondary to Parkinsonian-related blink lagophthalmos, or posterior cricoarytenoid (PCA) muscles for ABSD. Subsequent BTX type-B (BTX-B) injections into the lacrimal gland remarkably improved his epiphora. BTX-B injections into the PCA muscle also greatly improved his dysphonia. We describe the first reported case of (1) BTX-B injection into the lacrimal gland for epiphora, (2) use of Botox in treating epiphora due to blink lagophthalmos/reduced blink frequency secondary to Parkinson's ...
Source: Orbit - June 25, 2018 Category: Opthalmology Authors: Sachdev A, Costello D, Madge S Tags: Orbit Source Type: research

Cost-Effectiveness of Third-Line Therapies for Overactive Bladder
AbstractPurpose of ReviewWhile third-line therapies for overactive bladder and urgency urinary incontinence are well-described in guideline statements, there is little offered in guidance when it comes to selecting a particular intervention amongst these therapies for patients. Data regarding efficacy has a body of literature that takes sides on all fronts, making efficacy of these interventions a topic of continued debate. An ever-present factor for consideration also remains —cost of therapy. This review examines current data available for cost of third-line therapies.Recent FindingsIn this body of literature regar...
Source: Current Bladder Dysfunction Reports - June 22, 2018 Category: Urology & Nephrology Source Type: research

Botulinum Toxin Type A Overdoses: Analysis of the FDA Adverse Event Reporting System Database
AbstractIntroductionPublished literature on overdoses related to botulinum toxin A (BtxA) agents is scarce.ObjectiveThe aim of this study was to assess the BtxA drug class ’ respective agents for associations with overdose.MethodsUnited States Food and Drug Administration (FDA) adverse event reporting system (FAERS) database was utilized to search for overdoses. The analysis was conducted on data between second quarter 2014 and third quarter 2017. BtxA cases were included when they were considered the “Primary Suspect” drug. Overdose was defined as presence of ‘overdose’ being reported as an a...
Source: Clinical Drug Investigation - June 20, 2018 Category: Drugs & Pharmacology Source Type: research

OnabotulinumtoxinA in the treatment of refractory chronic cluster headache
ConclusionsEncouraging results for the treatment with BoNT-A in rCCH patients were observed in our study population. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - June 19, 2018 Category: Neurology Source Type: research

Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial
Conclusions Both treatments offered sustainable UUI improvement, and higher BTX dosing had low clean intermittent catheterization rates, but with UTI risk. SNM revision/removal rates were low due to standardized lead placement with strict treatment response definitions. Patient summary We compared a large group of US women with severe urgency urinary incontinence (UUI) who received sacral neuromodulation (InterStim) or onabotulinumtoxinA (Botox A) therapy during a 2-yr period. We found that both therapies had similar success in reducing UUI symptoms, and adverse events were low. However, women in the BotoxA group had highe...
Source: European Urology - June 13, 2018 Category: Urology & Nephrology Source Type: research

Botulinum toxin type A for the first-line treatment of Hailey-Hailey disease.
PMID: 29896862 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - June 13, 2018 Category: Dermatology Authors: Kothapalli A, Caccetta T Tags: Australas J Dermatol Source Type: research

Botulinum toxin type A for the first ‐line treatment of Hailey–Hailey disease
Australasian Journal of Dermatology, EarlyView. (Source: Australasian Journal of Dermatology)
Source: Australasian Journal of Dermatology - June 13, 2018 Category: Dermatology Authors: Anita Kothapalli , Tony Caccetta Source Type: research

Efficacy of 8 Different Drug Treatments for Patients With Trigeminal Neuralgia: A Network Meta-analysis
Conclusions: Among the 8 drugs investigated, all exhibited a capacity to alleviate TN more than the placebo except for pimozide and proparacaine. Moreover, LDC, BTX-A, and CBZ stood out for their high efficacy and could be recommended as the primary choice of treatment for TN. (Source: The Clinical Journal of Pain)
Source: The Clinical Journal of Pain - June 7, 2018 Category: Anesthesiology Tags: Review Articles Source Type: research

An objective method to assess the improvements of skin texture roughness after botulinum toxin type a treatment of crow's feet
Skin Research and Technology, EarlyView. (Source: Skin Research and Technology)
Source: Skin Research and Technology - June 6, 2018 Category: Dermatology Authors: M. Cavallini , M. Papagni , R. Gazzola Source Type: research

Ketamine-Associated Bladder Dysfunction —a Review of the Literature
AbstractPurpose of ReviewThe purpose of this review is to study the epidemiology, presentation, pathogenesis and management of ketamine cystitis and its complications.Recent FindingsRecent data suggest that the toxicity of ketamine can be due to direct cytotoxicity, independent of a NMDA receptor-mediated mechanism. Bladder barrier dysfunction, neurogenic inflammation with abnormal neurotransmission and immunological mechanisms have also been proposed, based on data from animal models and in vitro studies. Effects on the bladder are dependent on the dose and duration of ketamine use. Clinical studies have showed that the m...
Source: Current Bladder Dysfunction Reports - June 5, 2018 Category: Urology & Nephrology Source Type: research

Quality of Life and Voice Changes After a Single Injection in Patients With ADSD Over Time
In this study, patients with ADSD were followed after a single BT injection to track the changes in QOL and perceptual voice quality over a 6-month period. (Source: Journal of Voice)
Source: Journal of Voice - June 5, 2018 Category: ENT & OMF Authors: Maryam Faham, Farhad Torabinezhad, Thomas Murry, Payman Dabirmoghaddam, Jamileh Abolghasemi, Mohammad Kamali, Meysam Asgari Source Type: research

Efficacy and Safety of Botulinum Toxin Type A in Treating Patients of Advanced Age with Idiopathic Trigeminal Neuralgia.
Abstract Objective: To assess the therapeutic efficacy and safety of botulinum toxin type A (BTX-A) for treating idiopathic trigeminal neuralgia (ITN) in patients ≥80 years old. Methods: Selected patients (n=43) with ITN, recruited from the neurology clinic and inpatient department of the Second Affiliated Hospital of Soochow University between August 2008 and February 2014, were grouped by age, one subset (n=14) ≥80 years old and another (n=29)
Source: Pain Research and Management - June 1, 2018 Category: Anesthesiology Authors: Liu J, Xu YY, Zhang QL, Luo WF Tags: Pain Res Manag Source Type: research

Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
ConclusionsWhen sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever. (Source: Neurology and Therapy)
Source: Neurology and Therapy - June 1, 2018 Category: Neurology Source Type: research

Levator ani syndrome: transperineal botox injections
(Source: Techniques in Coloproctology)
Source: Techniques in Coloproctology - May 31, 2018 Category: Surgery Source Type: research

Tu1143 PERORAL ENDOSCOPIC MYOTOMY VERSUS SURGICAL MYOTOMY FOR THE TREATMENT OF ACHALASIA: SYSTEMATIC REVIEW AND META-ANALYSIS
Achalasia is a rare neurodegenerative motility esophageal disorder characterized by failure of LES relaxation and non peristaltic contractions of the esophageal body. The main symptoms are dysphagia, weight loss, regurgitation, and chest pain. There are some kinds of treatments, that includes medication, botox injection, pneumatic dilatation and surgery. The gold standard treatment is laparoscopic Heller Myotomy (LHM), that has the best long term efficacy. In 2010, Inoue et al described a new kind of treatment, the peroral endoscopic myotomy (POEM), a procedure that has good results, comparable with heller procedure and is...
Source: Gastrointestinal Endoscopy - May 30, 2018 Category: Gastroenterology Authors: Rafael K. Martins, Wanderlei M. Bernardo, Eduardo T. Moura, Lara M. Coutinho, Galileu F. Farias, Antonio C. Madruga Neto, Aureo Delgado, Igor B. Ribeiro, Paulo Sakai, Rubens A. Sallum, Eduardo G. de Moura Tags: Tuesday abstract Source Type: research

[Laryngeal dystonia: novel forms of therapeutic administration of botulinum toxin by direct routes].
CONCLUSION: In our experience, transoral administration of botulinum toxin type A to treat laryngeal dystonia has proved to be a simple, quick, effective and safe technique. PMID: 29790569 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - May 24, 2018 Category: Neurology Authors: Lopez Del Val LJ, Sebastian-Cortes JM, Bellosta-Diago E, Santos-Lasaosa S, Vinueza-Buitron PR, Lois-Ortega Y, Valles-Varea H, Lopez-Garcia E Tags: Rev Neurol Source Type: research

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse
AbstractBone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogen...
Source: Osteoporosis International - May 18, 2018 Category: Orthopaedics Source Type: research

Posture-Dependent Dysphagia After Botulinum Toxin Type A Injection at Sternocleidomastoid in a Patient With Athetoid Cerebral Palsy
We report a unique case of posture-dependent dysphagia due to preactivation of the suprahyoid and infrahyoid muscles to compensate for impaired head stabilization by the weakened sternocleidomastoid muscle while swallowing. This case suggests a possible mechanism of dysphagia in patients with athetoid cerebral palsy. (Source: American Journal of Physical Medicine and Rehabilitation)
Source: American Journal of Physical Medicine and Rehabilitation - May 16, 2018 Category: Rehabilitation Tags: Case Report Source Type: research

Botulinum toxin type A for wrinkles: the least interesting use of this versatile protein
British Journal of Dermatology,Volume 178, Issue 5, Page 999-999, May 2018. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - May 16, 2018 Category: Dermatology Authors: D.M. Ozog Source Type: research

Treatment of Frontal Secondary Headache Attributed to Nerve Entrapment
This cohort study compares treatment outcomes of oral medication, botulinum toxin type A injections, and endoscopic decompression surgery in patients with frontal secondary headache attributed to supratrochlear nerve and supraorbital nerve entrapment. (Source: JAMA Facial Plastic Surgery)
Source: JAMA Facial Plastic Surgery - May 10, 2018 Category: Cosmetic Surgery Source Type: research

Alternatives to Biologics in Management of Knee Osteoarthritis: A Systematic Review
Conclusion: There is moderate supportive evidence for the effectiveness of prolotherapy in improving pain and function in both, short-term and long-term. Limited supporting evidence found for botulinum toxin type A, sodium bicarbonate and calcium gluconate, and low–molecular weight fraction of 5% human serum albumin in improving pain and function. There is conflicting evidence for the use of local anesthetic agents in patients with KOA. (Source: Sports Medicine and Arthroscopy Review)
Source: Sports Medicine and Arthroscopy Review - May 9, 2018 Category: Sports Medicine Tags: Review Articles Source Type: research

Duration of effectiveness of Botulinum toxin type A in excessive gingival display: a systematic review and meta-analysis
This study aimed to determine the duration of the effectiveness of botulinum toxin type A on a gummy smile. A systematic search was conducted using Medline (PubMed), Scopus, and Web of Science electronic databases, from 1970 to March 2017 with no language restriction; the search included studies evaluating adult patients with excessive gingival display who were treated with botulinum toxin and were followed-up for at least 3 months. OpenGrey and Clinical Trial Registry were also consulted. Quality assessment was applied to determine the level of evidence and bias, and a meta-analysis was performed. Of 2181 full texts, 71 w...
Source: Brazilian Oral Research - May 8, 2018 Category: Dentistry Source Type: research

Botulinum toxin injection to improve functional independence and to alleviate parenting stress in a child with advanced pantothenate kinase-associated neurodegeneration: A case report and literature review
We reported a 10-year-old female patient with advanced PKAN, manifesting as generalized dystonia and spasticity. Diagnosis: The patient was diagnosed with PKAN by a pediatric neurologist. Interventions: The patient received BoNT-A injection. Outcomes: The effect was obvious at four weeks after the injection, with an improvement of 25% in Barry-Albright Dystonia Scale and 4% in Functional Independence Measure for Children score. Furthermore, there was a 3.8% reduction in Parenting Stress Index Short Form score and 8.3% improvement in Pain and Impact of Disability domain in the score of Cerebral Palsy Quality of Lif...
Source: Medicine - May 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

054 Immunogenicity to botulinum neotoxins: Long term clinical relevance in aesthetic and therapeutic injections
Without any doubt, Botulinum Toxin is an amazing molecule with diverse clinical effects since the 1970S. The clinical use of Botulinum Toxin Type A and Type B (BONT-A and BONT-B) has revolutionized the practice of medicine over the past 30 years. The safety and effectiveness of injectable Botulinum Toxin have been well established in both aesthetic and medical indications. However to reach the desired endpoints and to maintain the efficacy, the frequency of injections is required. By increasing the numbers of patients without favorable therapeutic responses, a new concern has re-emerged on the immunoresistance and loss of ...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: M. Shiri, Z. Shiri, F. Bahrami, S. Shiri, G. Ebrahimi, H. Shiri, B. Shiri, M. Bahrami Tags: Adaptive and Auto-Immunity Source Type: research

333 Influence of social media on cosmetic procedure interest
Social media is increasingly cited in plastic surgeon surveys as a reason for undergoing cosmetic procedures, especially non-invasive procedures like onabotulinumtoxinA (Botox) and dermal fillers. We explored trends between social media usage and public interest in cosmetic procedures, as well as how these effects differ by procedure and by specialty (dermatology or plastic surgery). Google Trends was queried for search terms and compared with aggregate user data from Instagram and Facebook. Search terms were the brand names of medications, as these are how the general public knows the medications. (Source: Journal of Inve...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: C. Moreno, Z. Hopkins, A. Secrest Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research