Botulinum toxin: a new differential diagnosis for a lytic bone lesion
ConclusionsOur search of the literature failed to identify any previous cases of this occurring. However, as the popularity of this cosmetic procedure only increases, we believe that this represents an important possible differential for isolated lytic lesion after administration of “Botox” injection. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 24, 2024 Category: General Medicine Source Type: research
Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells
This study evaluated the role of Wnt16 during surface-mediated osteoblastic differentiation of MSCs in vitro and osseointegration in vivo. MSCs were cultured on Ti substrates with different surface properties and non-canonical Wnt expression was determined. Subsequently, MSCs were cultured on Ti substrates +/-Wnt16 (100 ng/mL) and anti-Wnt16 antibodies (2 μg/mL). Wnt16 expression was increased in cells grown on microrough surfaces that were processed to be hydrophilic and have nanoscale roughness. However, treatment MSCs on these surfaces with exogenous rhWnt16b increased total DNA content and osteoprotegerin production, ...
Source: Annals of Biomedical Engineering - March 22, 2024 Category: Biomedical Engineering Authors: Michael B Berger Kyla Bosh Jingyao Deng Thomas W Jacobs D Joshua Cohen Barbara D Boyan Zvi Schwartz Source Type: research
Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and I κB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing
This study was designed to investigate the effects of BTXA on macrophages polarization during the early stage of skin repair. A skin defect model was established on the dorsal skin of SD rats. BTXA was intracutaneous injected into the edge of wound immediately as the model was established. Histological examinations were performed on scar samples. Raw 264.7 was selected as the cell model of recruited circulating macrophages, and was induced for M1 polarization by LPS. Identify the signaling pathways that primarily regulated M1 polarization and respond to BTXA treatment. Application of BTXA at early stage of injury significa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Yan-Ping Zou Xiao-Feng Shan Jia-Xuan Qiu Lin-Na Wang Ruo-Lan Xiang Zhi-Gang Cai Source Type: research
Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells
This study evaluated the role of Wnt16 during surface-mediated osteoblastic differentiation of MSCs in vitro and osseointegration in vivo. MSCs were cultured on Ti substrates with different surface properties and non-canonical Wnt expression was determined. Subsequently, MSCs were cultured on Ti substrates +/-Wnt16 (100 ng/mL) and anti-Wnt16 antibodies (2 μg/mL). Wnt16 expression was increased in cells grown on microrough surfaces that were processed to be hydrophilic and have nanoscale roughness. However, treatment MSCs on these surfaces with exogenous rhWnt16b increased total DNA content and osteoprotegerin production, ...
Source: Annals of Biomedical Engineering - March 22, 2024 Category: Biomedical Engineering Authors: Michael B Berger Kyla Bosh Jingyao Deng Thomas W Jacobs D Joshua Cohen Barbara D Boyan Zvi Schwartz Source Type: research
Botulinum toxin type A inhibits M1 macrophage polarization by deactivation of JAK2/STAT1 and I κB/NFκB pathway and contributes to scar alleviation in aseptic skin wound healing
This study was designed to investigate the effects of BTXA on macrophages polarization during the early stage of skin repair. A skin defect model was established on the dorsal skin of SD rats. BTXA was intracutaneous injected into the edge of wound immediately as the model was established. Histological examinations were performed on scar samples. Raw 264.7 was selected as the cell model of recruited circulating macrophages, and was induced for M1 polarization by LPS. Identify the signaling pathways that primarily regulated M1 polarization and respond to BTXA treatment. Application of BTXA at early stage of injury significa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2024 Category: Drugs & Pharmacology Authors: Yan-Ping Zou Xiao-Feng Shan Jia-Xuan Qiu Lin-Na Wang Ruo-Lan Xiang Zhi-Gang Cai Source Type: research
Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells
This study evaluated the role of Wnt16 during surface-mediated osteoblastic differentiation of MSCs in vitro and osseointegration in vivo. MSCs were cultured on Ti substrates with different surface properties and non-canonical Wnt expression was determined. Subsequently, MSCs were cultured on Ti substrates +/-Wnt16 (100 ng/mL) and anti-Wnt16 antibodies (2 μg/mL). Wnt16 expression was increased in cells grown on microrough surfaces that were processed to be hydrophilic and have nanoscale roughness. However, treatment MSCs on these surfaces with exogenous rhWnt16b increased total DNA content and osteoprotegerin production, ...
Source: Annals of Biomedical Engineering - March 22, 2024 Category: Biomedical Engineering Authors: Michael B Berger Kyla Bosh Jingyao Deng Thomas W Jacobs D Joshua Cohen Barbara D Boyan Zvi Schwartz Source Type: research
Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells
This study evaluated the role of Wnt16 during surface-mediated osteoblastic differentiation of MSCs in vitro and osseointegration in vivo. MSCs were cultured on Ti substrates with different surface properties and non-canonical Wnt expression was determined. Subsequently, MSCs were cultured on Ti substrates +/-Wnt16 (100 ng/mL) and anti-Wnt16 antibodies (2 μg/mL). Wnt16 expression was increased in cells grown on microrough surfaces that were processed to be hydrophilic and have nanoscale roughness. However, treatment MSCs on these surfaces with exogenous rhWnt16b increased total DNA content and osteoprotegerin production, ...
Source: Annals of Biomedical Engineering - March 22, 2024 Category: Biomedical Engineering Authors: Michael B Berger Kyla Bosh Jingyao Deng Thomas W Jacobs D Joshua Cohen Barbara D Boyan Zvi Schwartz Source Type: research
Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology
AbstractPre-proenkephalin 1 (Penk1) is a pro-neuropeptide that belongs to the typical opioid peptide ’s family, having analgesic properties. We previously foundPenk1 to be the most downregulated gene in a whole gene profiling analysis performed in osteoblasts subjected to microgravity as a model of mechanical unloading. In this work,Penk1 downregulation was confirmed in the bones of two in vivo models of mechanical unloading: tail-suspended and botulinum toxin A (botox)-injected mice. Consistently, in the sera from healthy volunteers subjected to bed rest, we observed an inverse correlation between PENK1 and bed rest dur...
Source: Calcified Tissue International - March 20, 2024 Category: Orthopaedics Source Type: research
Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center
AbstractPreoperative injection of Botulinum Toxin A (Botox) has been described as an adjunctive therapy to facilitate fascial closure of large hernia defects in abdominal wall reconstruction (AWR). The purpose of this study was to evaluate the impact of Botox injections on fascial closure and overall outcomes to further validate its role in AWR. A prospectively maintained database was retrospectively reviewed to identify all patients undergoing AWR at our institution between January 2014 and March 2022. Patients who did and did not receive preoperative Botox injections were analyzed and compared. A total of 426 patients we...
Source: Updates in Surgery - March 20, 2024 Category: Surgery Source Type: research
Mixed treatment for same ‐severe mixed urinary incontinence: A novel method
This study reports treatment of a MUI case in a 56-year-old, with a history of MUI of 7-year duration, which was persistent to pharmacological treatment, pelvic muscle training, biofeedback, and anti-incontinence surgery (Burch Colposuspension). PRP-Fibrin Glue-Stem Cell injection, Botox injection, and TVT were performed in a one surgery session. Patient was discharged with ability to urinate with acceptable amount of post void residue. After 3-month follow-up, patient was completely satisfied and happy. Further research is needed to substantiate the efficacy of these mixed treatments for MUI. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 8, 2024 Category: General Medicine Authors: Daryoush Hamidi Alamdari,
Armina Douzandeh,
Maliheh Keshvari Shirvan,
Behzad Narouie,
Negar Radpour Tags: CASE REPORT Source Type: research
Trigeminal Neuralgia after Hyaluronic Acid and Botox Injection
AbstractA rare case of trigeminal neuralgia following injections of Hyaluronic Acid and Botox was documented. In addressing the severe pain and swelling caused by the injection, a novel combination therapy was employed, notably including 5-fluorouracil. The significant improvement observed in this case not only provided clinical insights but also spurred further investigation into the underlying mechanisms linking trigeminal nerve damage to local dermal filler injections. The aim was to glean new medical perspectives and develop practical preventive strategies to mitigate such complications in future cases. This approach h...
Source: Aesthetic Plastic Surgery - March 1, 2024 Category: Cosmetic Surgery Source Type: research
Efficacy and Safety Analysis of Botox Application and Iatrogenic Botulism: Panacea or Peril?
This article aims to cover all these issues related to botulism and other adverse outcomes related to BoNT-A injection in light of the most recent literature.PMID:38409723 | DOI:10.2174/0113816128284720240212111926 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 27, 2024 Category: Drugs & Pharmacology Authors: Ozgur Karcioglu Canan Akman Ilknur Atnis Source Type: research
Intraarticular botulinum toxin type A versus corticosteroid or hyaluronic acid for painful knee osteoarthritis: A meta-analysis of head-to-head randomized controlled trials
Toxicon. 2024 Feb 22:107656. doi: 10.1016/j.toxicon.2024.107656. Online ahead of print.ABSTRACTIntraarticular botulinum toxin type A (BTA) has been shown to be effective for painful knee osteoarthritis (KOA), while the efficacy and safety of intraarticular BTA compared to corticosteroid and hyaluronic acid (HA) remains unknown. A meta-analysis was performed to compare. A search was conducted in Medline (PubMed), CENTER (Cochrane Library), Embase (Ovid), Web of Science, Wanfang, and CNKI to find head-to-head randomized controlled trials (RCTs) directly compare the efficacy and safety between intraarticular BTA and intraarti...
Source: Toxicon - February 24, 2024 Category: Toxicology Authors: Yinan Yang Guozheng Li Yuping Su Source Type: research
Intraarticular botulinum toxin type A versus corticosteroid or hyaluronic acid for painful knee osteoarthritis: A meta-analysis of head-to-head randomized controlled trials
Toxicon. 2024 Feb 22:107656. doi: 10.1016/j.toxicon.2024.107656. Online ahead of print.ABSTRACTIntraarticular botulinum toxin type A (BTA) has been shown to be effective for painful knee osteoarthritis (KOA), while the efficacy and safety of intraarticular BTA compared to corticosteroid and hyaluronic acid (HA) remains unknown. A meta-analysis was performed to compare. A search was conducted in Medline (PubMed), CENTER (Cochrane Library), Embase (Ovid), Web of Science, Wanfang, and CNKI to find head-to-head randomized controlled trials (RCTs) directly compare the efficacy and safety between intraarticular BTA and intraarti...
Source: Toxicon - February 24, 2024 Category: Toxicology Authors: Yinan Yang Guozheng Li Yuping Su Source Type: research
