Botulinum toxin treatment of freezing of gait in Parkinson's disease patients as reflected in functional magnetic resonance imaging of leg movement.
CONCLUSION: Alleviation of the FOG in PD patients by botulinum toxin seems to be reflected in the functional participation of the cerebellum and its projections as seen by fMRI. PMID: 27179579 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - May 19, 2016 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Re: Comparison of Short Term Outcomes of Sacral Nerve Stimulation and Intradetrusor Injection of OnabotulinumtoxinA (Botox) in Women with Refractory Overactive Bladder
R. Singh, S. A. El Nashar, E. C. Trabuco, C. J. Klingele, J. B. Gebhart and J. A. Occhino (Source: The Journal of Urology)
Source: The Journal of Urology - May 18, 2016 Category: Urology & Nephrology Authors: Alan J. Wein Tags: Urological Survey Source Type: research

A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm
To characterize satisfaction with current standard-of-care botulinum neurotoxin type A (BoNT/A) treatment for blepharospasm, we performed a cross-sectional, structured survey in subjects with blepharospasm who had received ≥2 BoNT/A cycles. Subjects were interviewed immediately before re-injection to evaluate treatment satisfaction, time course of treatment effects, preferred injection intervals, Jankovic Rating Scale (JRS), and Blepharospasm Disability Index (BSDI).Subjects’ (n=114) last treatment was onabotulinumtoxinA (n=78), incobotulinumtoxinA (n=35), or abobotulinumtoxinA (n=1). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - May 16, 2016 Category: Neurology Authors: John Fezza, John Burns, Julie Woodward, Daniel Truong, Thomas Hedges, Amit Verma Tags: Clinical Research Paper Source Type: research

Botulinum toxin type B for cervical dystonia.
CONCLUSIONS: A single BtB-treatment session is associated with a significant and clinically relevant reduction of cervical dystonia impairment including severity, disability and pain, and is well tolerated, when compared with placebo. However, BtB-treated patients are at an increased risk of dry mouth and dysphagia. There are no data from RCTs evaluating the effectiveness and safety of repeated BtB injection cycles. There are no RCT data to allow us to draw definitive conclusions on the optimal treatment intervals and doses, usefulness of guidance techniques for injection, and impact on quality of life. PMID: 27176573...
Source: Cochrane Database of Systematic Reviews - May 13, 2016 Category: Journals (General) Authors: Marques RE, Duarte GS, Rodrigues FB, Castelão M, Ferreira J, Sampaio C, Moore AP, Costa J Tags: Cochrane Database Syst Rev Source Type: research

Use of prophylactic antibiotics for intra ‐vesicle Botox® injection
ConclusionRoutine antibiotics use lowers the risk of UTI's in patients receiving intra‐vesicle botox. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - May 13, 2016 Category: Urology & Nephrology Authors: Mohammad Hassan Khan, Omer Baldo, Philip Koenig, Naeem Shaikh Tags: Letter to the Editor Source Type: research

Botox injections and monitoring neuromuscular blockade – a reminder
(Source: Anaesthesia)
Source: Anaesthesia - May 9, 2016 Category: Anesthesiology Authors: C. Cross Tags: Correspondence Source Type: research

The mechanism of the beneficial effect of botulinum toxin type A used in the treatment of temporomandibular joints dysfunction.
Abstract In the course of temporomandibular joint dysfunctions very often comes to excessive increase in tension of masticatory muscles, so main aim of the treatment is reduction of this hypertension of muscles. That why we use botulinum toxin type A, which is produced by Gram-positive Clostridium bacteria. There are six serotypes of the toxin: A, B, C, D, E, F, and G. The botulinum toxin type A was first isolated in 1920s. Today, botulinum toxin type A is used increasingly more often as an efficient and patient-friendly therapy in neurology, ophthalmology, neurology, urology and laryngology. The aim of the articl...
Source: Mini Reviews in Medicinal Chemistry - May 6, 2016 Category: Chemistry Authors: Malgorzata P, Piotr C, Edward K Tags: Mini Rev Med Chem Source Type: research

Overview of Botulinum Toxins for Aesthetic Uses
Botulinum toxin type A (BTA) can be used for facial aesthetics. The 3 currently available BTA types include onabotulinumtoxinA (Botox; Botox Cosmetic, Allergan, Irvine, CA), abobotulinumtoxinA (Dysport; Ipsen, Ltd, Berkshire, UK), and incobotulinumtoxinA (Xeomin; Merz Pharmaceuticals, Frankfurt, Germany). The mechanism of action and clinical uses for treatment of dynamic lines of the forehead, brow, glabella, lateral orbit, nose, and lips are presented, as well as treatment of masseter hypertrophy, platysmal bands, and improvements of the perioral region. Specific BTA injection sites and suggested doses are presented. (Sou...
Source: Clinics in Plastic Surgery - May 4, 2016 Category: Cosmetic Surgery Authors: Michael S. Gart, Karol A. Gutowski Source Type: research

The Use of Sonographically Guided Botulinum Toxin Type A (Dysport) Injections Into the Tensor Fasciae Latae for the Treatment of Lateral Patellofemoral Overload Syndrome
Background: Pain in the anterior and lateral parts of the knee during exercise is a common clinical problem for which current management strategies are often unsuccessful. Purpose: To investigate the effect of an ultrasound-guided botulinum toxin (BT) injection into the tensor fasciae latae (TFL), followed by physical therapy, in patients classified with lateral patellofemoral overload syndrome (LPOS) who failed to respond to conventional treatment. Study Design: Case series; Level of evidence, 4. Methods: A total of 45 patients (mean ± SD age, 32.4 ± 8.6 years) who met the inclusion criteria of (1) activi...
Source: The American Journal of Sports Medicine - May 2, 2016 Category: Sports Medicine Authors: Stephen, J. M., Urquhart, D. W. J., van Arkel, R. J., Ball, S., Jaggard, M. K. J., Lee, J. C., Church, J. S. Tags: Knee, patella, Physical therapy/Rehabilitation, Running Source Type: research

Botulinum Toxin Type A as Preoperative Treatment for Immediately Loaded Dental Implants Placed in Fresh Extraction Sockets for Full-Arch Restoration of Patients With Bruxism
Conclusions: The preoperative use of Botulinum toxin in patients with bruxism undergoing full-arch rehabilitation using immediately loaded dental implants placed in fresh extraction sockets seems to be a technique that deserves attention. Further long-term, large-scale randomized clinical trials will help to determine the additional benefit of this suggested treatment modality. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - May 1, 2016 Category: Surgery Tags: Clinical Studies Source Type: research

The therapeutic usage of botulinum toxin (Botox) in non-cosmetic head and neck conditions – an evidence based review
Publication date: Available online 30 April 2016 Source:Saudi Pharmaceutical Journal Author(s): Kamran Habib Awan Botulinum toxin (Botox) is an exotoxin produced from Clostridium botulinum. It blocks the release of acetylcholine from the cholinergic nerve end plates resulting in inactivity of the muscles or glands innervated. The efficacy of Botox in facial aesthetics is well established, however, recent literature has highlighted its utilization in multiple non-cosmetic medical and surgical conditions. The present article reviews the current evidence pertaining to Botox use in the non-cosmetic head and neck conditions....
Source: Saudi Pharmaceutical Journal - May 1, 2016 Category: Drugs & Pharmacology Source Type: research

Complications of botulinum toxin injections for treatment of esophageal motility disorders†
Summary In achalasia and spastic esophageal motility disorders, botulinum toxin (botox) injection is considered an effective and low‐risk procedure for short‐term symptom relief. It is mainly offered to medically high‐risk patients. However, no analysis of risks of botox injections has been performed. To determine the incidence and risk factors of procedure‐related complications after esophageal botox injections, we analyzed the records of all patients undergoing botox injection therapy for esophageal motility disorders at four university hospitals in Europe and North America between 2008 and 2014. Complications we...
Source: Diseases of the Esophagus - May 1, 2016 Category: Gastroenterology Authors: Froukje B. van Hoeij, Jan F. Tack, John E. Pandolfino, Joel M. Sternbach, Sabine Roman, André J. P. M. Smout, Albert J. Bredenoord Tags: Original Article Source Type: research

Botulinum toxin for foot dystonia in patients with Parkinson's disease having deep brain stimulation: A case series and a pilot study.
CONCLUSION: Botox injection significantly improved foot dystonia, pain and lower limb functional outcomes in patients with Parkinson's disease with deep brain stimulation. PMID: 27122065 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - April 30, 2016 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

A Quantitative Analysis of OnabotulinumtoxinA, AbobotulinumtoxinA, and IncobotulinumtoxinA: A Randomized, Double-Blind, Prospective Clinical Trial of Comparative Dynamic Strain Reduction
Conclusions: Using digital image correlation, the tested neuromodulators do not have equivalent strain reduction in the glabella at the doses used. These results confirm assertions of noninterchangeability. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - April 29, 2016 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Safety of Ultrasound-Guided Botulinum Toxin Injections for Sialorrhea as Performed by Pediatric Otolaryngologists
Conclusion Prior published data indicated 16% complication incidence with ultrasound-guided injection of botulinum toxin. Our study found a low complication rate (0.6%) with ultrasound-guided injections of botulinum toxin to manage sialorrhea, without cases of aspiration pneumonia or motor paralysis. Of 306 intraglandular injections, there were 2 cases of worsening baseline subjective dysphagia that self-resolved. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - April 29, 2016 Category: ENT & OMF Authors: Shariat-Madar, B., Chun, R. H., Sulman, C. G., Conley, S. F. Tags: Pediatric Otolaryngology Source Type: research

Interventional Treatment for Post-traumatic Headache
Abstract Post-traumatic headache (migraine) is the most common symptom of concussion and traumatic brain injury. An expert opinion-based review along with a literature review (PubMed) was conducted looking at known interventional procedures for post-traumatic headache using the keywords post-traumatic headache, post-traumatic migraine headache, concussion, mild traumatic brain injury, and traumatic brain injury and the following categories: mechanism, pathophysiology, treatment, physical therapy, neurostimulation, Botox@/Onabotulinum toxin, and surgical intervention. The results returned a total of 181 articles o...
Source: Current Pain and Headache Reports - April 29, 2016 Category: Neurology Source Type: research

Minithyrotomy with radiofrequency‐induced thermotherapy (RFITT) for the treatment of adductor spasmodic dysphonia
ConclusionMinithyrotomy RFITT is a feasible technique that shows encouraging long‐term results for the potential treatment of patients with ADSD. Level of EvidenceN/A. Laryngoscope, 2016 (Source: The Laryngoscope)
Source: The Laryngoscope - April 23, 2016 Category: ENT & OMF Authors: Shaun C. Desai, Andrea M. Park, Rebecca D. Chernock, Randal C. Paniello Tags: Laryngology Source Type: research

Minithyrotomy with radiofrequency ‐induced thermotherapy for the treatment of adductor spasmodic dysphonia
ConclusionMinithyrotomy RFITT is a feasible technique that shows encouraging long‐term results for the potential treatment of patients with ADSD. Level of EvidenceN/A. Laryngoscope, 126:2325–2329, 2016 (Source: The Laryngoscope)
Source: The Laryngoscope - April 23, 2016 Category: ENT & OMF Authors: Shaun C. Desai, Andrea M. Park, Rebecca D. Chernock, Randal C. Paniello Tags: Laryngology Source Type: research

Combined effects of robot-assisted gait training and botulinum toxin type A effect on spastic equinus foot in patients with chronic stroke: a pilot, single blind, randomized controlled trial.
CONCLUSIONS: Our preliminary findings support the hypothesis that robot-assisted gait training does not enhance the effect of botulinum toxin type A on spastic equinus foot in patients with chronic stroke. CLINICAL REHABILITATION IMPACT: Our observations should be taken into account in daily clinical rehabilitation practice in order to develop effective treatment protocols based on the enhancement of antispastic drugs effect. PMID: 27098300 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
Source: European Journal of Physical and Rehabilitation Medicine - April 21, 2016 Category: Rehabilitation Authors: Picelli A, Bacciga M, Melotti C, LA Marchina E, Verzini E, Ferrari F, Pontillo A, Corradi J, Tamburin S, Saltuari L, Corradini C, Waldner A, Smania N Tags: Eur J Phys Rehabil Med Source Type: research

Efficacy of Fissurectomy and Botox for Chronic Anal Fissure
No abstract available (Source: Diseases of the Colon and Rectum)
Source: Diseases of the Colon and Rectum - April 8, 2016 Category: Gastroenterology Tags: Web-Exclusive Content: Letters To The Editor Source Type: research

Assessment of intralesional injection of botulinum toxin type A injection for hypertrophic scars
Conclusion: Botulinum toxin type A is a novel and promising therapy for hypertrophic scars with few side effects. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - April 6, 2016 Category: Dermatology Authors: Alhasan M Elhefnawy Source Type: research

The use of onabotulinum toxin A (Botox ® ) in the treatment of chronic migraine at the Parma Headache Centre: a prospective observational study
Abstract Chronic migraine is a debilitating headache, whose treatment is often complicated by the concomitant overuse of symptomatic medication and by the poor efficacy of standard prophylactic treatments. The PREEMPT studies have demonstrated the efficacy and tolerability of onabotulinum toxin A (Botox®) in the treatment of this headache type. Data about its use in clinical practice are still scarce. Our study evaluated all subjects with chronic migraine who were treated with onabotulinum toxin A between February 2014 and November 2015 at the Parma Headache Centre. Botox was injected according to the PREEMPT ...
Source: Neurological Sciences - April 5, 2016 Category: Neurology Source Type: research

The effect of laser and botulinum toxin in the treatment of myofascial pain and mouth opening: A randomized clinical trial
This study conducted a randomized clinical trial in 15 patients, who sought care at the Dental Clinic of the University of Passo Fundo, in order to compare the use of low-level laser and botulinum toxin in the treatment of myofascial pain and whether they alter the mouth opening of patients with temporomandibular disorder. The patients were divided into two groups: the Laser group received low-level GaAlAs laser, 100mW of power at a wavelength of 830nm in continuous light emission; and the Toxin group received 30U of botulinum toxin type A (BTX-A) in the first session, and 15U after fifteen days. The assessments were perfo...
Source: Journal of Photochemistry and Photobiology B: Biology - April 4, 2016 Category: Speech Therapy Source Type: research

Transcranial Direct Current Stimulation and Transcutaneous Occipital Nerve Stimulation in Chronic Migraine: A Pilot-Comparison of Therapeutic and Electrophysiological Effects (I3.008)
Conclusions:Cathodal visual cortex tDCS and tONS may thus be interesting options for the non-invasive treatment of CM. The effect size seems close to that seen with Botox or topiramate, but it remains to be confirmed in a RCT. Only tONS was able to induce recordable changes in visual cortex responsivity. Supported by FP7-EUROHEADPAIN 602633Disclosure: Dr. Schoenen has nothing to disclose. Dr. D'Ostilio has nothing to disclose. Dr. Cosseddu has nothing to disclose. Dr. Nonis has nothing to disclose. Dr. Sava has nothing to disclose. Dr. Magis has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Schoenen, J., D'Ostilio, K., Cosseddu, A., Nonis, R., Sava, S., Magis, D. Tags: New and Emerging Therapeutic Options in Migraine and Other Headache Disorders Data Blitz Presentations Source Type: research

Transcranial Direct Current Stimulation and Transcutaneous Occipital Nerve Stimulation in Chronic Migraine: A Pilot-Comparison of Therapeutic and Electrophysiological Effects (P2.200)
Conclusions:Cathodal visual cortex tDCS and tONS may thus be interesting options for the non-invasive treatment of CM. The effect size seems close to that seen with Botox or topiramate, but it remains to be confirmed in a RCT. Only tONS was able to induce recordable changes in visual cortex responsivity. Supported by FP7-EUROHEADPAIN 602633Disclosure: Dr. Schoenen has nothing to disclose. Dr. D'Ostilio has nothing to disclose. Dr. Cosseddu has nothing to disclose. Dr. Nonis has nothing to disclose. Dr. Sava has nothing to disclose. Dr. Magis has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Schoenen, J., D'Ostilio, K., Cosseddu, A., Nonis, R., Sava, S., Magis, D. Tags: Headache: Therapeutics Source Type: research

Methodologies, Patient Characteristics, and Treatment Results Between Registry Studies of Botulinum Toxin Type A in Cervical Dystonia (P1.035)
Conclusions: Patient characteristics and response patterns were generally similar across BoNT-A registries, supporting their individual effectiveness in CD.Disclosure: Dr. Trosch has received personal compensation for activities with Ipsen as a speaker and consultant. Dr. Comella has received personal compensation for activities with Ipsen, Merz, Allergan, Medtronic, Teva, US World Meds, Impax, Acadia, Acorda, Revance, Neurocrine, and Ultragenx Pharmaceuticals as a consultant. Dr. Comella has received research support Dr. Espay has received personal compensation as a consultant/scientific advisory board member for Abbvie, ...
Source: Neurology - April 4, 2016 Category: Neurology Authors: Espay, A., Comella, C., Trosch, R., Snyder, D., Marchese, D., Truong, D. Tags: Movement Disorders: Cervical Dystonia Source Type: research

Efficacy and Safety of a 2 mL Dilution of AbobotulinumtoxinA Compared with Placebo in Adult Patients with Cervical Dystonia (P1.029)
OBJECTIVE: To determine efficacy and safety of a 500 unit, 2 mL dilution of abobotulinumtoxinA (Dysport®) vs placebo in cervical dystonia (CD) patients. BACKGROUND: CD is characterized by involuntary cervical muscle contractions leading to sustained and painful head and neck postures. Botulinum toxin is FDA approved for the treatment of CD, and abobotulinumtoxinA is effectively administered in solutions up to 1 mL to affected muscles. Off-label 2 mL dilutions have been reported in the US and trials supporting this dilution would support dosing flexibility. METHODS: In this 12-week, phase 3b, double-blind study, CD pati...
Source: Neurology - April 4, 2016 Category: Neurology Authors: Lew, M., Snyder, D. Tags: Movement Disorders: Cervical Dystonia Source Type: research

Botulinum Toxin Type A in Severe Diabetic Neuropathy (P6.272)
Conclusion: Botulinum Toxin (A) is effective in sever diabetic neuropathy and may be an alternative way in management of severe diabetic neuropathy.Disclosure: Dr. Egila has nothing to disclose. Dr. Gomaa has nothing to disclose. Dr. Abd El-naby has nothing to disclose. Dr. Shehab-Eldin has nothing to disclose. (Source: Neurology)
Source: Neurology - April 4, 2016 Category: Neurology Authors: Gomaa, M., Egila, H., Abd El-naby, A., Shehab-Eldin, M. Tags: Pain and Palliative Care Source Type: research

Eight-Year Experience With Botulinum Toxin Type-A Injections for the Treatment of Nonneurogenic Overactive Bladder: Are Repeated Injections Worthwhile?
Authors: Kim SH, Habashy D, Pathan S, Tse V, Collins R, Chan L Abstract PURPOSE: To investigate the efficacy and safety of repeated botulinum toxin type-A (BTX-A) injections for patients with drug-refractory nonneurogenic overactive bladder (NNOAB) and explore factors predictive of outcome. METHODS: Data were collected from all patients receiving repeated BTX-A injections for drug-refractory NNOAB between 2004 and 2012. Trigone-sparing injections were administered under sedation with antibiotic prophylaxis. Patient characteristics including age, sex, preoperative urodynamics, injection number, BTX-A dose, compl...
Source: International Neurourology Journal - April 3, 2016 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Botulinum Toxin Type A
For the general dentist, the use of botulinum toxin type A (BTA) confers the ability to exert control over the soft tissues surrounding the mouth to better create a harmonious smile. The injection of BTA into the facial musculature requires a level of finesse to achieve the desired outcomes. A sound understanding of the toxin's mechanism of action and the ability to manage potential complications are also necessary, as the dentist administering BTA must be competent to the same level as other providers who have traditionally been the gatekeepers of such agents. (Source: Dental Clinics of North America)
Source: Dental Clinics of North America - April 1, 2016 Category: Dentistry Authors: Jared Miller, Earl Clarkson Source Type: research

Use of prophylactic antibiotics for intra‐vesicle Botox® injection
ConclusionRoutine antibiotics use lowers the risk of UTI's in patients receiving intra‐vesicle botox. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - April 1, 2016 Category: Urology & Nephrology Authors: Mohammad Hassan Khan, Omer Baldo, Philip Koenig, Naeem Shaikh Tags: Letter to the Editor Source Type: research

Intradetrusor injections of onabotulinum toxin A (Botox ®) 300 U or 200 U versus abobotulinum toxin A (Dysport®) 750 U in the management of neurogenic detrusor overactivity: A case control study
ConclusionsIntradetrusor injections of abobotulinum toxin 750 U for NDO provided better outcomes than injections of onabotulinum toxin 200 U. Success rates of abobotulinum toxin 750 U and onabotulinum toxin 300 U were similar but interval between injections tended to be longer with onabotulinum toxin 300 U. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - March 31, 2016 Category: Urology & Nephrology Authors: Benoit Peyronnet, Evelyne Castel ‐Lacanal, Mathieu Roumiguie, Lucie Even, Philippe Marque, Michel Soulié, Pascal Rischmann, Xavier Game Tags: Original Clinical Article Source Type: research

Per-Oral Pyloromyotomy (POP)
A growing body of literature supports the use of laparoscopic pyloroplasty as a minimally invasive treatment of refractory gastroparesis that has failed conservative measures and for benign gastric outlet obstruction. Endoscopic pyloric dilation, stent placement, and Botox have been described for similar indications, but often with transient or mixed results. Per-oral pyloromyotomy has recently been proposed as an endoscopic alternative to surgical pyloroplasty or pylormyotomy because it is less invasive by its nature and potentially more durable than current endoscopic treatments. (Source: Gastrointestinal Endoscopy Clinics of North America)
Source: Gastrointestinal Endoscopy Clinics of North America - March 30, 2016 Category: Gastroenterology Authors: Lee L. Swanstrom, Carter Lebaras Source Type: research

A Comparative Assessment of Three Formulations of Botulinum Toxin Type A for Facial Rhytides: A Systematic Review with Meta-Analyses
Conclusions: Evidence supporting benefits versus placebo of the different formulations was clear over time. Comparisons between active formulations were rare and typically based on single trials of small to moderate sample size. The data suggest some gains with high-dose onabotulinum toxin (relative to standard dose), whereas exploratory indirect comparisons between active formulations were largely associated with inconclusive findings. Future studies should undertake head-to-head comparisons of the different formulations and ensure longer follow-up to best inform the accumulating evidence base. CLINICAL QUESTION/LEVEL OF...
Source: Plastic and Reconstructive Surgery - March 30, 2016 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Mp67-01 preliminary evidence suggests periureteral botulinum toxin type a injection improves ureteral stone passage in the porcine model
We evaluated the use of periureteral injection of botulinum toxin type A (Botox®, BTX-A) to facilitate passage of ureteral stones in a porcine model. We believe that reducing detrusor muscle tone around the intramural ureter may facilitate passage of ureteral stones through the ureterovesical junction. (Source: The Journal of Urology)
Source: The Journal of Urology - March 28, 2016 Category: Urology & Nephrology Authors: Necole M Streeper, Stephen Y Nakada, Margaret L Wertheim, Sara L Best Tags: Stone Disease: Basic Research & Pathophysiology II Source Type: research

Mp17-12 serial botulinum toxin injections offer durable results for neurogenic bladder: 4 year urodynamic outcomes
We report on urodynamic (UDS) outcomes at mean 44 months after initiating serial BTxA injections. (Source: The Journal of Urology)
Source: The Journal of Urology - March 28, 2016 Category: Urology & Nephrology Authors: Alexandra Rehfuss, Gabriel Leinwand, Paul Feustel, Elise De Tags: Urodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Neurogenic Voiding Dysfunction Source Type: research

Prevention of esophageal strictures after endoscopic submucosal dissection with the injection of botulinum toxin type A
Use of endoscopic submucosal dissection (ESD) for management of widespread superficial esophageal squamous carcinoma is closely associated with esophageal stenosis. We aimed to investigate the efficacy and feasibility of endoscopic injection of botulinum toxin type A (BTX-A) for preventing esophageal strictures after ESD for superficial esophageal squamous carcinoma. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 28, 2016 Category: Gastroenterology Authors: Jing Wen, Zhongsheng Lu, Enqiang Linghu, Yunsheng Yang, Jing Yang, Shufang Wang, Bin Yan, Jie Song, Xiaodong Zhou, Xiangdong Wang, Ke Meng, Yan Dou, Qingsen Liu Source Type: research

Anatomocosmetic implication rules of the corrugator supercilii muscle for youthful eye appearance
Abstract The dynamic balance of the eyebrows is maintained by the frontal muscle which acts as a brow elevator, and the brow depressors include corrugator supercilii muscle (CSM), procerus, depressor supercilii, and orbicularis oculi muscles. The glabellar rhytids might appear as a result of negative emotions, such as anger, anxiety, fatigue, fear, or disapproval. For youthful and calmer eyes, CSM may restore the muscle balance more safely and effectively for the treatments of forehead rejuvenation. In 50 cadaver hemibrows, CSM was dissected to investigate the location, position, muscle patterns, and its relations...
Source: Surgical and Radiologic Anatomy - March 28, 2016 Category: Anatomy Source Type: research

Prevention of esophageal strictures after endoscopic submucosal dissection with the injection of botulinum toxin type A
The use of endoscopic submucosal dissection (ESD) for management of widespread superficial esophageal squamous carcinoma is closely associated with esophageal stenosis. We investigated the efficacy and feasibility of endoscopic injection of botulinum toxin type A (BTX-A) for preventing esophageal strictures after ESD for superficial esophageal squamous carcinoma. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 28, 2016 Category: Gastroenterology Authors: Jing Wen, Zhongsheng Lu, Enqiang Linghu, Yunsheng Yang, Jing Yang, Shufang Wang, Bin Yan, Jie Song, Xiaodong Zhou, Xiangdong Wang, Ke Meng, Yan Dou, Qingsen Liu Tags: Original article Source Type: research

Efficacy and Safety of Single Botulinum Toxin Type A (Botox®) Injection for Relief of Upper Trapezius Myofascial Trigger Point: A Randomized, Double-Blind, Placebo-Controlled Study.
CONCLUSION: The efficacy in VAS reduction of a single 20 IU of Botulinum toxin type A (Botox®) injection was not different from 0.9% NaCl for myofascial trigger point at the upper trapezius muscle. However Botulinum toxin type A (Botox®) showed statistically significant more increased in pressure pain threshold at 6-week after injection without severe adverse effects. PMID: 27004309 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - March 24, 2016 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

The efficiency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache
Conclusions The intramuscular botulinum toxin type A injections have been an efficient method of treatment for masseter muscle pain in patients with temporomandibular joint dysfunction and tension-type headache. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - March 24, 2016 Category: Neurology Source Type: research

Prior treatment does not influence the performance or early outcome of per-oral endoscopic myotomy for achalasia
Abstract Introduction Per-oral endoscopic myotomy (POEM) is an emerging treatment for achalasia. Pneumatic dilation, botulinum toxin injection, and previous myotomy increase the difficulty of subsequent Heller myotomy, but their impact on POEM remains unknown. The purpose of this study was to compare patients who had undergone prior treatment for their achalasia to those undergoing POEM as an initial therapy. Methods and Procedures All patients undergoing POEM were entered into a prospective database from August 2012 to October 2014. Data coll...
Source: Surgical Endoscopy - March 23, 2016 Category: Surgery Source Type: research

Randomized, double-blind control trial of peri-articular hyaluronic acid: Botulinus toxin ve placebo injection in lateral epicondylosis
Purpose: To compare and describe the effects of peri-articular hyaluronic acid (HA) coadminsitered with botulinus toxin (HA + Botox) versus placebo in lateral epicondylosis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - March 20, 2016 Category: Rheumatology Authors: R.J. Petrella Source Type: research

Caregiver Satisfaction for Orthotic Management of a Severely Involved Child with Cerebral Palsy Seen at Age 7 Years and 19 Years
Conclusions: The primary caregiver is the key regulating factor in determining orthotic compliance outcomes. For an aging caregiver, with a young adult dependent in self-care, a daily wearing schedule may be an unrealistic goal. An alternative orthosis or wear schedule may be needed to assist with caregiver compliance. (Source: JPO Journal of Prosthetics and Orthotics)
Source: JPO Journal of Prosthetics and Orthotics - March 19, 2016 Category: Orthopaedics Tags: Case Report Source Type: research

The Efficacy of Botulinum Toxin for the Treatment of Trigeminal and Post-Herpetic Neuralgia: A Systematic Review with Meta-analyses
Conclusion While the studies had unclear or high risk of bias, moderate evidence regarding the efficacy of BoTN-A in treating TN and PHN was found. BoTN-A might be an alternative treatment to those patients who are either unable to manage their pain medically or would like adjunct therapy. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - March 16, 2016 Category: ENT & OMF Source Type: research

Healing of rotator cuff tendons using botulinum toxin A and immobilization in a rat model
We evaluated effects of botulinum toxin A (Botox) and cast immobilization on tendon healing in a rat model. Injection of Botox into rat supraspinatus was hypothesized to reduce muscle active force and improved... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - March 15, 2016 Category: Orthopaedics Authors: Mohit N. Gilotra, Michael J. Shorofsky, Jason A. Stein and Anand M. Murthi Source Type: research

The Efficacy of Botulinum Toxin for the Treatment of Trigeminal and Post-Herpetic Neuralgia: A Systematic Review with Meta-analyses
To evaluate the efficacy of a Botulinum toxin type A (BoTN-A) in treating trigeminal neuralgia (TN) and post-herpetic neuralgia (PHN). (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 14, 2016 Category: ENT & OMF Authors: Thomas Shackleton, Saravanan Ram, Misty Black, Jon Ryder, Glenn T. Clark, Reyes Enciso Source Type: research

The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses
To evaluate the efficacy of a botulinum toxin type A (BoTN-A) in treating trigeminal neuralgia (TN) and postherpetic neuralgia (PHN). (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 14, 2016 Category: ENT & OMF Authors: Thomas Shackleton, Saravanan Ram, Misty Black, Jon Ryder, Glenn T. Clark, Reyes Enciso Tags: Oral medicine Source Type: research