Re-examining the Optimal Use of Neuromodulators and the Changing Landscape: A Consensus Panel Update
Authors: Kaminer MS, Cox SE, Fagien S, Kaufman J, Lupo MP, Shamban A Abstract Since initial US Food and Drug Administration approval of botulinum toxin type A (BoNT-A) for aesthetic use in 2002, clinical evidence and experience with BoNT-A and understanding of facial anatomy have greatly increased, leading to rapid advances in treatment planning and implementation. BoNT-A use has expanded from the upper face to the midface, lower face, and neck, so that BoNT-A injection is the most common cosmetic procedure worldwide. Trends in facial aesthetics reflect growing patient diversity with respect to age, gender, and eth...
Source: Journal of Drugs in Dermatology - April 5, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Challenges in the management of anticoagulated patients with focal spasticity.
CONCLUSIONS: The Canadian consensus statements assist clinicians by providing a framework for consideration to navigate the challenges when injecting BoNTA in anticoagulated patients with spasticity. PMID: 32217235 [PubMed - as supplied by publisher] (Source: Toxicon)
Source: Toxicon - March 30, 2020 Category: Toxicology Authors: Boulias C, Ismail F, Phadke CP Tags: Toxicon Source Type: research

Comparison of the efficacy of intramuscular botulinum toxin type-A injection into the pectoralis major and the teres major muscles and suprascapular nerve block for hemiplegic shoulder pain: a prospective, double-blind, randomized, controlled trial
This study aims to investigate the effect of botulinum toxin-A (BoNT-A) injection into pectoralis major and teres major muscles and suprascapular nerve block (SSNB) on pain, range of motion (ROM), and upper extremity function for (hemiplegic shoulder pain) HSP, and to compare the effectiveness of these two methods.Materials and methodsSixty patients with HSP were randomly assigned into 2 groups. The Group 1 (n = 30) received BoNT-A injection into the pectoralis major and teres major, and the Group 2 (n = 30) received SSSB. Patients were evaluated just before the start of the study, and 2 and 6 ...
Source: Neurological Sciences - March 16, 2020 Category: Neurology Source Type: research

Comparison of botulinum toxin type A and aprotinin monotherapy with combination therapy in healing of burn wounds in an animal model.
Abstract Burns are one of the most common injuries that are complicated by many challenges including infection, severe inflammatory response, excessive expression of proteases, and scar formation. The aim of this study was to investigate the effect of botulinum toxin type A (BO) and aprotinin (AP) separately or in combination (BO-AP) in healing process. Four burn wounds were created in each rat and randomly filled with silver sulfadiazine (SSD), BO, AP and BO-AP. The rats were euthanized after 7, 14, and 28 days, and their harvested wound samples were evaluated by gross pathology, histopathology, gene express...
Source: Molecular Biology Reports - March 7, 2020 Category: Molecular Biology Authors: Oryan A, Alemzadeh E Tags: Mol Biol Rep Source Type: research

Migraine Treatment.
Abstract Migraine headaches affect more than 35 million Americans and are ranked the third-highest cause of disability worldwide, resulting in decreased quality of life and serious economic consequences. There are 4 types of migraine headaches: frontal, temporal, occipital, and rhinogenic. Each type has a well-described trigger site. Migraines headaches often are refractory to medical therapy and may respond well to botulinum toxin type A. Migraine surgery is another option to release trigger sites. A systematic review of the migraine surgery literature found an average success rate of 90%, with elimination or gre...
Source: Hand Surgery - March 4, 2020 Category: Surgery Authors: Olla D, Sawyer J, Sommer N, Moore JB Tags: Clin Plast Surg Source Type: research

Botulinum toxin type A for controlling bruxism assessed with computerized occlusal analysis: A pilot study
. (Source: Cranio - Journal of Craniomandibular and Sleep Practice)
Source: Cranio - Journal of Craniomandibular and Sleep Practice - March 3, 2020 Category: Sleep Medicine Authors: N ícea B. Pardo Robert B. Kerstein Mario C. J únior Leila S. Ferreira M árcio Abrahão Source Type: research

Local Injection of Botulinum Toxin Type A to Prevent Postoperative Scar
Background: Physical scars, especially those in the head and neck area, can cause emotional and psychological distress. Recent studies, have suggested that botulinum toxin type A (BTX-A), also known as Botox, may improve surgical scars by speeding up the wound healing process. Injection of BTX-A is generally considered a less invasive approach. Objectives: The purpose of this meta-analysis was to assess the efficacy and safety of BTX-A in the prevention of postoperative scars compared to placebo or no treatment. Materials and methods: Following databases were searched from inception to March 2019: Cochrane Library,...
Source: Journal of Craniofacial Surgery - March 1, 2020 Category: Surgery Tags: Original Articles Source Type: research

Parry-Romberg Syndrome With Hemimasticatory Spasm: A Rare Combination
In this study, a study of a young male patient with Parry-Romberg syndrome and hemimasticatory spasm on his left side was presented. Radiologic examinations showed severe atrophy limited to subcutaneous tissue and electromyography demonstrated as hemimasticatory spasm. Injection of botulinum toxin type A was applied for the treatment of hemimasticatory spasm and after 2 separated injections, the patient was significantly relieved from symptom. The theory of focal demyelination of the trigeminal nerve peripheral brunches is the possible link between hemifacial atrophy and hemimasticatory spasm, although the pathogenesis of ...
Source: Journal of Craniofacial Surgery - March 1, 2020 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Management of erectile dysfunction and LUTS/incontinence: the two most common, long-term side effects of prostate cancer treatment.
Authors: Shabataev V, Saadat SH, Elterman DS Abstract The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. While surgery is mostly associated with SUI and radiation mostly results in UUI, there can be an overlap. Incontinence rates after cryotherapy and high in...
Source: Canadian Journal of Urology - February 28, 2020 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

45: The first injection: Rates of urinary retention in women with urgency incontinence treated with intravesical onabotulinumtoxinA (Botox) injection
To describe rate and risks for symptomatic and asymptomatic urinary retention requiring catheterization in women undergoing initial intravesical onabotulinumtoxinA (Botox) injection for urgency urinary incontinence (UUI). (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 28, 2020 Category: OBGYN Authors: N.A. Squires, M.G. Mueller, C. Lewicky-Gaupp, S.A. Collins, K. Kenton, J. Geynisman-Tan Tags: Non-Oral Poster Source Type: research

Mouth Corner Lift with Botulinum Toxin Type A and Hyaluronic Acid Filler
Summary: An upturned mouth corner is associated with brightness, optimism, and friendliness, whereas a downturned mouth corner not only conveys negative feelings such as sadness, depression, and tiredness, but also makes a person appear years older than they are. Surgical approaches to the correction of a downturned mouth corner can result in predictable and long-lasting results. However, because of their fear of postsurgical scars and long downtimes, many patients are reluctant to undergo surgery involving the mouth corner. As a consequence, minimally invasive procedures have become increasingly popular in recent years....
Source: Plastic and Reconstructive Surgery - February 27, 2020 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review
ConclusionsChronic hand pain is a prevalent and serious condition and can cause significant morbidity and disability and interferes with independence and activities of daily living. Conservative treatment remains the first line of treatment; however, when first-line treatments fail, steroid injections can usually provide benefit. In some cases, HA or Botox may also be beneficial. US-guidance is increasing in hand injection and almost ubiquitously provides safer, more effective injections. Hand surgery remains the alternative for refractory pain. (Source: Pain and Therapy)
Source: Pain and Therapy - February 25, 2020 Category: Anesthesiology Source Type: research

Current management of refractory overactive bladder
AbstractOveractive bladder (OAB) is a common condition affecting one ‐sixth to one‐fifth of the global population. The treatment of refractory OAB remains a challenge for urologists. Current treatment options include the use of combination therapy with antimuscarinic agents and beta‐3 adrenoceptor agonists, and treating underlying curable disorders. Intravesica l botulinum toxin type A (BoNT‐A) injection, percutaneous tibial nerve stimulation, and sacral nerve stimulation are third‐line management therapies suggested by the American Urological Association/Society of Urodynamics, Female Pelvic Medicine& Urogen...
Source: LUTS: Lower Urinary Tract Symptoms - February 20, 2020 Category: Urology & Nephrology Authors: Li ‐Chen Chen, Hann‐Chorng Kuo Tags: REVIEW ARTICLE Source Type: research

What are the most commonly reported complications with cosmetic botulinum toxin type A treatments?
The purpose of this study was to determine the most commonly reported complications with cosmetic botulinum toxin type A (BTX-A) treatments. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - February 20, 2020 Category: ENT & OMF Authors: Kevin C. Lee, Alexander B. Pascal, Steven Halepas, Alia Koch Source Type: research

Ethics and aesthetics in injection treatments with Botox and Filler
. (Source: Journal of Women and Aging)
Source: Journal of Women and Aging - February 19, 2020 Category: International Medicine & Public Health Authors: Anna Abelsson Anna Willman Source Type: research

Botox jet spray may help extreme sweaters
Publication date: 15 February 2020Source: New Scientist, Volume 245, Issue 3269Author(s): Alice Klein (Source: New Scientist)
Source: New Scientist - February 15, 2020 Category: Science Source Type: research

Some people have extremely sweaty palms - but spraying Botox may help
Using high-pressure jet nozzles to fire liquid Botox into the skin could be a less painful alternative to injections to treat sweaty armpits and palms (Source: New Scientist - Health)
Source: New Scientist - Health - February 6, 2020 Category: Consumer Health News Source Type: research

Migraine Treatment
Migraine headaches affect more than 35 million Americans and are ranked the third-highest cause of disability worldwide, resulting in decreased quality of life and serious economic consequences. There are 4 types of migraine headaches: frontal, temporal, occipital, and rhinogenic. Each type has a well-described trigger site. Migraines headaches often are refractory to medical therapy and may respond well to botulinum toxin type A. Migraine surgery is another option to release trigger sites. A systematic review of the migraine surgery literature found an average success rate of 90%, with elimination or greater than 50% impr...
Source: Clinics in Plastic Surgery - February 6, 2020 Category: Cosmetic Surgery Authors: Danielle Olla, Justin Sawyer, Nicole Sommer, John B. Moore Source Type: research

Fibrodysplasia ossificans progressiva as a form of pseudodystonia
We describe potential mechanisms that can be responsible for the good outcome of BoNT/A therapy observed in our patient. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - January 31, 2020 Category: Neurology Authors: Jaros ław Dulski Tags: Correspondence Source Type: research

Correspondence: “Efficacy of electromotive drug administration in delivering botulinum toxin A in children with neuropathic detrusor overactivity - Outcomes of a pilot study”
In the study presented by Koh and colleagues, the authors performed an interesting investigation by comparing electromotive drug administration (EMDA) of botulinum toxin type A (BtA) with conventional intravesical BtA injection in children with neuropathic detrusor overactivity (NDO) [1]. Also, they compared two different BtA molecules, Botox ® vs. Dysport®. According to their experience, BtA/EMDA performed poorly when compared to conventional intravesical BtA injection. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - January 30, 2020 Category: Urology & Nephrology Authors: Behnam Nabavizadeh, Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Abdol-Mohammad Kajbafzadeh Tags: Letter to the Editor Source Type: research

Correspondence: Efficacy of electromotive drug administration in delivering botulinum toxin A in children with neuropathic detrusor overactivity – outcomes of a pilot study
In the study presented by Koh et  al [1], the authors performed an interesting investigation by comparing electromotive drug administration (EMDA) of botulinum toxin type A (BtA) with conventional intravesical BtA injection in children with neuropathic detrusor overactivity (NDO). In addition, they compared two different BtA molec ules, Botox® vs. Dysport®. According to their experience, BtA/EMDA performed poorly when compared with conventional intravesical BtA injection. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - January 30, 2020 Category: Urology & Nephrology Authors: Behnam Nabavizadeh, Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Abdol-Mohammad Kajbafzadeh Tags: Letter to the Editor Source Type: research

Mechanical Micronization of Lipoaspirates for the Treatment of Horizontal Neck Lines
Conclusion: SVF gel is an effective treatment for horizontal neck wrinkles, particularly in patients with type III and IV wrinkles. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - January 29, 2020 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Cost-Effectiveness of Long-Term, Targeted OnabotulinumtoxinA versus Peripheral Trigger Site Deactivation Surgery for the Treatment of Refractory Migraine Headaches
Conclusions: Based on this model, peripheral trigger site deactivation surgery is the more cost-effective option for treating refractory migraine headaches requiring treatment beyond 6.75 years. The model reveals that peripheral trigger-site deactivation surgery is more effective and less costly than long-term, targeted botulinum toxin type A over the course of a patient’s lifetime. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - January 29, 2020 Category: Cosmetic Surgery Tags: Reconstructive: Head and Neck: Original Articles Source Type: research

Botox and Dermal Fillers
For the general dentist, the use of BTA and dermal fillers confers the ability to exert control over the soft tissues surrounding the mouth to better create a harmonious smile. The injection of BTA and fillers into the facial musculature and dermis requires a level of finesse to achieve the desired outcomes. A sound understanding of the mechanisms of action and the ability to manage potential complications are also necessary, because the dentist administering BTA and dermal fillers must be competent to the same level as other providers who have traditionally been the gatekeepers of such agents. (Source: Dental Clinics of North America)
Source: Dental Clinics of North America - January 17, 2020 Category: Dentistry Authors: David Sheen, Earl Clarkson Source Type: research

A comparative study between intradermal botulinum toxin A and fractional microneedle radiofrequency (FMR) for the treatment of primary axillary hyperhidrosis
This study was a randomized, intraindividual split-side comparative study. Twenty female subjects clinically diagnosed of primary axillary hyperhidrosis were enrolled. All subjects randomly assigned to receive either FMR device on one side of axilla or 50  units of intradermal botulinum toxin A on contralateral side of axilla. Treatment with FMR device was scheduled for 2 sessions for 4 weeks apart. After treatment, mean Hyperhidrosis Disease Severity Score (HDSS) of both groups revealed remarkably better reduction from the baseline (p 
Source: Lasers in Medical Science - January 14, 2020 Category: Laser Surgery Source Type: research

Botulinum toxin type A for spastic cerebral palsy: Is it time to change praxis?
Authors: Colovic H, Dimitrijevic L, Stankovic I, Radovic-Janosevic D, Zlatanovic D PMID: 31922204 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - January 12, 2020 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Effect Of Botulinum Toxin Type-A In Spasticity And Functional Outcome Of Upper Limbs In Cerebral Palsy
ConclusionI.m. BTX-A injected using anatomical landmarks had significant improvement in both clinical and functional outcome measures. We noticed significant improvement in MACS and COPM at 6 months despite return of local spasticity. It is safe and effective for spasticity of upper limbs in cerebral palsy and capable of improving function without major side effects. MACS & COPM are easy to use, less time consuming & easily adjusted to local needs. Randomized control trials with long follow up are required in future with special focus on dosing and timing, scoring system for functional outcome as per regional needs...
Source: Journal of Clinical Orthopaedics and Trauma - January 9, 2020 Category: Orthopaedics Source Type: research

A prospective study investigating gross motor function of children with cerebral palsy and GMFCS level II after long-term Botulinum toxin type A use
The aim of this study is to contribute to the knowledge base on the long-term outcomes of evidence-based medical interventions used to improve gross motor function in children and adolescents with Cerebral Palsy. (Source: BMC Pediatrics)
Source: BMC Pediatrics - January 6, 2020 Category: Pediatrics Authors: Jane Valentine, Sue-Anne Davidson, Natasha Bear, Eve Blair, Lisa Paterson, Roslyn Ward, David Forbes and Catherine Elliott Tags: Research article Source Type: research

Five-year follow-up of patients treated with intra-dermal botulinum toxin for axillary hyperhidrosis
AbstractBackgroundAxillary hyperhidrosis is a common complaint affecting 5% of the general population. It can significantly impact quality of life (QOL) and may be extremely debilitating. Administration of intra-dermal botulinum toxin type-A (Botox) has been proven to be effective in managing axillary hyperhidrosis; however, to date, no long-term data has assessed its efficacy.AimWe aim to assess long-term (> 5 years) QOL outcomes in this patient cohort.MethodsIn this single-centre series, all patients attending for axillary botox, with five or more years of follow-up, were prospectively included. QOL was assessed in al...
Source: Irish Journal of Medical Science - January 3, 2020 Category: General Medicine Source Type: research

Neurotoxin Impurities: A Review of Threats to Efficacy
Source: Plastic and Reconstructive Surgery Global Open - January 1, 2020 Category: Cosmetic Surgery Tags: Special Topic Source Type: research

The efficacy of intra dermal injections of botulinum toxin in management of enlarged facial pores and seborrhea: A split face controlled study.
Authors: Sayed KS, Hegazy R, Gawdat HI, Mounir R, Ahmed MM, Nouredin Mohammed F, Allam R, Fahim A Abstract Background: Enlarged facial pores are becoming a matter of cosmetic concern. Injections of (botulinum toxin type A) have an increasing popularity among cosmetic procedures.Objective: To determine the efficacy and safety of intradermal injection of botulinum toxin in treatment of excess sebum secretion and enlarged facial pores .Materials and methods: This split face controlled pilot study was conducted on 20 patients with enlarged facial pores and seborrhea. One cheek was treated by intradermal injection of bo...
Source: Journal of Dermatological Treatment - December 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

The Use of Botulinum Toxin Type A in the Healing of Thyroidectomy Wounds: A Randomized, Prospective, Placebo-Controlled Study
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - December 24, 2019 Category: Cosmetic Surgery Tags: Letters Source Type: research

Appropriate Timing of Early Postoperative Botulinum Toxin Type A Injection for Thyroidectomy Scar Management: A Split-Scar Study: Correction
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - December 24, 2019 Category: Cosmetic Surgery Tags: Corrections Source Type: research

DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from Each of Two Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Studies (SAKURA 1 and SAKURA 2)
Background: DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A formulation in clinical development. A phase 2 dose-ranging study identified an optimal dose and demonstrated efficacy with a median duration of 24 weeks. Methods: In two phase 3, multicenter, randomized, double-blind, placebo-controlled studies (SAKURA 1 and SAKURA 2), subjects with moderate or severe glabellar lines at maximum frown were assigned randomly to receive placebo or 40 U of DAXI. Glabellar lines were evaluated at least every 4 weeks for at least 24 weeks until severity returned to baseline (≤36 weeks). Results: Ov...
Source: Plastic and Reconstructive Surgery - December 24, 2019 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Botulinum Toxin A Salvage of Ischemic Hand Trauma
Summary: Posttraumatic hand injuries from crush injury, infusion, or iatrogenic vascular cannulation can cause ischemic finger damage that can progress to necrosis and digital amputation. Botulinum toxin type A (Botox) improves blood flow in chronic vasospastic disorders of the hand. Botox’s efficacy in salvaging ischemic loss in digits in acute traumatic and iatrogenic injury has not been previously reported. From February of 2015 to December of 2016, 11 patients at a Level I trauma center (West Virginia University) presented to the hand surgery service with early ischemic injury and vascular compromise to hand an...
Source: Plastic and Reconstructive Surgery - December 24, 2019 Category: Cosmetic Surgery Tags: Hand/Peripheral Nerve: Ideas and Innovations Source Type: research

The Efficacy of Drug Injection in the Treatment of Pathological Scar: A Network Meta-analysis
ConclusionIn the injection treatment of pathological scar, we recommend the combined injection of two drugs, especially botulinum toxin type A combined with corticosteroids. The effective treatment of botulinum toxin type A combined with corticosteroids in the treatment of pathological scar is as follows: Patients were treated once monthly with intralesional injection of TAC (0.1  ml/cm3) mixed with botulinum toxin type A (2.5  IU/cm3) for a total of 3 treatments. However, there are still limitations in this network meta-analysis, and its conclusion still needs to be further confirmed by more randomized controlle...
Source: Aesthetic Plastic Surgery - December 18, 2019 Category: Cosmetic Surgery Source Type: research

Consensus of the Hellenic Headache Society on the diagnosis and treatment of migraine
AbstractMore than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-experts. On behalf of the Hellenic Headache Society, we report here a consensus on the diagnosis and treatment of adult migraine that is based on the recent guidelines of the European Headache Federation, on the principles of Good Clinical Practice and on the Greek regulatory affairs. The purposes are three-fold: (1) to increase awareness for migraine in Greece; (2) to support Greek practitioners who are treating mi...
Source: The Journal of Headache and Pain - December 13, 2019 Category: Neurology Source Type: research

Intramural Injection of Botulinum Toxin A in Surgical Treatment of a Long Gap Esophageal Atresia —Rat Model
Conclusion We found that BTX-A exerts a positive effect on stretch characteristics of esophageal tissue in rats at 2 U/kg via four-injection delivery and 24-hour waiting period. This study suggests that BTX-A might improve anastomotic healing. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - December 13, 2019 Category: Surgery Authors: Pike, Ashton Hideki Zvara, Peter Antulov, Marijana Rincic Schr øder, Henrik Daa Hejboel, Eva Kildall Rasmussen, Lars Qvist, Niels Elleb æk, Mark Bremholm Tags: Original Article Source Type: research

Botulinum toxin type a for first bite syndrome - a case report
Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Rachael Harlow, Lachlan Carter (Source: British Journal of Oral and Maxillofacial Surgery)
Source: British Journal of Oral and Maxillofacial Surgery - December 12, 2019 Category: ENT & OMF Source Type: research

Characteristics of tear abnormalities associated with benign essential blepharospasm and amelioration by means of botulinum toxin type A treatment
ConclusionTear abnormalities seen in BEB correspond to short BUT-type dry eye (DE), subclassified into decreased wettability DE in view of FBUPs. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - December 10, 2019 Category: Opthalmology Source Type: research

Treatment of symptomatic epiblepharon with Botulinum toxin type A in patients under 2years of age.
CONCLUSIONS: The present study provides evidence that a pretarsal BoNT-A injection is an effective and safe treatment for the correction of symptomatic epiblepharon in patients younger than 2 years of age. PMID: 31806264 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Source: Archivos de la Sociedad Espanola de Oftalmologia - December 8, 2019 Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research

Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review
Conclusions: There are a variety of management strategies available for fEGJOO and some patients may not require any intervention. However, among 4 potential approaches aimed at disrupting lower esophageal sphincter hypertonicity, the largest existing evidence base supports either a therapeutic challenge of Botox injection or watchful waiting. Ultimately, these data indicate the need for further study with controlled trials to identify a definitive approach. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - December 7, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

OnabotulinumtoxinA for the treatment of major depressive disorder: a phase 2 randomized, double-blind, placebo-controlled trial in adult females
This 24-week double-blind placebo-controlled multicenter randomized phase 2 trial evaluated efficacy and safety of onabotulinumtoxinA (onabotA; BOTOX) vs. placebo for major depressive disorder (MDD) [NCT02116361]. Primary endpoint was the change in Montgomery-Åsberg Depression Rating Scale (MADRS); secondary endpoints were Clinical Global Impressions-Severity and 17-item Hamilton Depression Rating Scale at week 6. A total of 255 adult females were treated. OnabotA 30 U approached significance compared to placebo on MADRS (mixed-effect model repeated measures least-squares mean difference: −3.7; P = 0.053) and r...
Source: International Clinical Psychopharmacology - December 3, 2019 Category: Psychiatry Tags: Original Articles Source Type: research

Gastric Per Oral Pyloromyotomy for Post-Vagotomy-Induced Gastroparesis Following Esophagectomy
ConclusionsGPOP status post-esophagectomy presented multiple challenges: difficulty maintaining field of view and insufflation, establishing tension and counter tension for the mucosotomy, and a limited working space. With care and patience, endoscopists trained to perform POEM may apply their skillset to help a large population of patients suffering with post-esophagectomy gastroparesis. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - December 2, 2019 Category: Surgery Source Type: research

Is BOTOX ® able to improve your Pain and Quality of life? Can this be measured?
Introduction Aetiology of TMD is multifactorial; symptoms may be of intra articular, myofascial or mixed aetiology leading to varied management. BOTOX ® may benefit symptoms of myofascial pain although a systematic review of RCT's was inconclusive. Currently all our TMD patients have psychological assessment using IMPARTS (Integrating mental and physical: research training and services). A package of questionnaire's scoring pain (BPI), anxiety (G AD-7), depression (PHQ9) and oral function (OHIP-14) is given to patients suffering from TMD. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2019 Category: ENT & OMF Authors: Hanna Strang, Salim Miskry, Kathleen Fan Tags: P210 Source Type: research

Botulinum toxin type a for first bite syndrome - a case report
Introduction: First bite syndrome (FBS) – a condition first described in 1986 by Haubrich, is a condition typified as intense, often neuralgic pain in the parotid gland on the first bite of food, that decreases in severity with each further bite1-4. The condition most commonly occurs following surgery to the parotid gland, within the pa rapharyngeal or infratemporal space. Adenervation injury can result in hypersensitivity of the sympathetic fibres that supply the myoepithelial cells of the parotid4. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2019 Category: ENT & OMF Authors: Rachael Harlow, Lachlan Carter Tags: P194 Source Type: research

Anti-cancer Potential of Captopril and Botulinum Toxin Type-A and Associated p53 Gene Apototic ...
Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic effect of captopril and BTX-A was determined using MTT assay against colon (HCT116) and prostate cancer (DU145) cells compared to their effect on normal vero cells. Anti-proliferation assay and anti-metastatic effect were carried out u...
Source: Iranian Journal of Pharmaceutical Research - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase  3 studies (SAKURA 1 and SAKURA 2)
DaxibotulinumtoxinA for Injection (DAXI) is a novel botulinum toxin type A in clinical development. Phase 2 data have shown it offers a more prolonged duration of response than onabotulinumtoxinA. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 29, 2019 Category: Dermatology Authors: Vince Bertucci, Nowell Solish, Joely Kaufman-Janette, Steve Yoelin, Ava Shamban, Joel Schlessinger, Daniel Snyder, Conor Gallagher, Yan Liu, Gill Shears, Roman G. Rubio Tags: Original article Source Type: research

Interrater Reliability of the Modified Ashworth Scale with Standardized Movement Speeds: A Pilot Study.
Conclusion: Using consistent movement velocity, novice evaluators were able to score spasticity with reasonable interrater reliability when assessing the wrist flexors but not the ankle plantar flexors. PMID: 31762545 [PubMed] (Source: Physiotherapy Canada)
Source: Physiotherapy Canada - November 27, 2019 Category: Physiotherapy Authors: Zurawski E, Behm K, Dunlap C, Koo J, Ismail F, Boulias C, Reid S, Phadke CP Tags: Physiother Can Source Type: research

The Use of Botulinum Toxin Type A in the Healing of Thyroidectomy Wounds: A Randomized, Prospective, Placebo-Controlled Study
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - November 27, 2019 Category: Cosmetic Surgery Tags: Letters Source Type: research