The Efficacy and Safety of Botulinum Toxin Injections in Preventing Postoperative Scars and Improving Scar Quality: A Systematic Review and Meta-Analysis
AbstractBackgroundScars exposed on the body surface lead to a large psychological burden on patients. However, no satisfactory scar treatments exist. Botulinum toxin type A is a neurotoxin that has been widely applied in the plastic and cosmetic surgery field. The purpose of this meta-analysis was to assess the efficacy and safety of botulinum toxin in scar management.MethodsPubMed, the Cochrane Library, EMBASE, MEDLINE, and Web of Science were searched for randomized controlled trials that evaluated the efficacy of botulinum toxin injections in preventing postoperative scars and improving scars quality and were published ...
Source: Aesthetic Plastic Surgery - March 5, 2021 Category: Cosmetic Surgery Source Type: research

Selective denervation of the corrugator supercilii muscle for the treatment of idiopatic trigeminal neuralgia purely paroxysmal distributed in the supraorbital and suprathrochlear dermatomes
AbstractIntroductionIdiopatic trigeminal neuralgia purely paroxysmal (ITNp) distributed in the supraorbital and suprathrochlear dermatomes (SSd), refractory to conventional treatments have been linked to the hyperactivity of the corrugator supercilii muscle (CSM). In these patients, the inactivation of the CSM via botulinum toxin type A (BTA) injections has been proven to be safe and effective in reducing migraine burden. The main limitation of BTA is the need of repetitive injections and relative high costs. Based on the study of the motor innervation of the CSM, we describe here an alternative approach to improve these t...
Source: The Journal of Headache and Pain - March 4, 2021 Category: Neurology Source Type: research

Exploring the Psychosocial Impact of Botulinum Toxin Type A Injections for Individuals With Oromandibular Dystonia: A Qualitative Study of Patients' Experiences
Conclusions Our results suggest that BoNT has a variable impact on domains related to quality of life, satisfaction with treatment, speech production, and communicative participation. This study adds novel information related to the psychosocial consequences of BoNT treatment in the management of OMD and builds on a literature that studies the consequences and experiences of living with OMD.PMID:33647215 | DOI:10.1044/2020_AJSLP-20-00124 (Source: American Journal of Speech-Language Pathology)
Source: American Journal of Speech-Language Pathology - March 1, 2021 Category: Speech-Language Pathology Authors: Allyson D Page Nada Elhayek Carolyn Baylor Scott Adams Mandar Jog Kathryn Yorkston Source Type: research

Surgical Management of the Ocular Surface in Neurotrophic Keratopathy: Amniotic Membrane, Conjunctival Grafts, Lid Surgery, and Neurotization
Conclusion: A variety of surgical options exist to manage neurotrophic keratopathy when medical treatments alone fail to resolve epitheliopathy. Ongoing protection and optimization of the ocular surface health remains crucial to prevent recurrent epithelial breakdown. (Source: Eye and Contact Lens: Science and Clinical Practice)
Source: Eye and Contact Lens: Science and Clinical Practice - February 24, 2021 Category: Opthalmology Tags: Review Article Source Type: research

The whole truth about botulinum toxin - a review.
Authors: Witmanowski H, Błochowiak K Abstract Treatment with botulinum toxin is widely viewed as safe, effective and largely devoid of serious side effects. There are two classes of Botox-related adverse events - transient and benign events, and potentially serious events. The aim of this study was to provide an overview of Botox-related side effects and advise potential management and preventive strategies. Benign side effects are well-localized, reversible and self-limited complications which develop within a few days of the injection, and they usually disappear without any treatment. The aesthetic and functiona...
Source: Advances in Dermatology and Allergology - February 21, 2021 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Antibiotic regimen and route of administration do not alter rates of urinary tract infection after intravesical botulinum toxin injection for overactive bladder
ConclusionsIn this cohort, no route of antibiotic administration was more effective in the prevention of UTI. Antibiotic prophylaxis did not lower the rate of post-procedural UTI compared to no antibiotics. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - February 16, 2021 Category: OBGYN Source Type: research

The One21 Technique: An Individualized Treatment for Glabellar Lines Based on Clinical and Anatomical Landmarks.
This study evaluates a customized assessment for the treatment of glabellar lines with Incobotulinumtoxin-A, leading to an individualized points distribution and dosage. Patients and Methods: A single-center, evaluator-blinded, therapeutic cohort study enrolled 130 women with moderate or severe glabellar wrinkles. They underwent Incobotulinumtoxin-A injection following the standard 5-point injection at the glabellar muscles (n = 65) or an individualized assessment and scheme treatment based on anatomical references of contraction, the One21 technique (n = 65). All the patients were photographed under maximum contractio...
Source: Clinical, Cosmetic and Investigational Dermatology - February 11, 2021 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

To evaluate the effect and longevity of Botulinum toxin type A (Botox®) in the management of gummy smile – A longitudinal study upto 4 years follow-up
Publication date: Available online 10 February 2021Source: Journal of Oral Biology and Craniofacial ResearchAuthor(s): Athreya Rajagopal, Manoj Goyal, Sagrika Shukla, Neeti Mittal (Source: Journal of Oral Biology and Craniofacial Research)
Source: Journal of Oral Biology and Craniofacial Research - February 11, 2021 Category: Dentistry Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Botulinum Toxin Type-A for the Treatment of Excessive Gingival Display on Smiling
CONCLUSION: From the study, it was inferred that botulinum toxin was effective in eliminating gummy smile along with noticeable decrease in the nasolabial fold despite for the effect lasting only about 24 weeks.CLINICAL SIGNIFICANCE: A nonsurgical method of correction of gummy smiles when compared to surgical intervention is readily accepted by patients. Botulinum toxin type-A for gummy smiles is an effective, conservative, and satisfactory technique.PMID:33568589 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - February 11, 2021 Category: Dentistry Authors: Jibin Skaria Nanditha Hegde Pradeep P George Tony Michael Joseph Sebastian Source Type: research

Beyond botulinum neurotoxin A for chemodenervation of the bladder
Purpose of review Botulinum neurotoxin A (BoNT/A), or Botox, is a popular option for overactive bladder (OAB) and neurogenic bladder (NGB) with or without incontinence. This review aims to discuss the clinical outcomes of BoNT in adult and pediatric bladder conditions, and introduces the potential benefit of novel, engineered neurotoxins beyond BoNT/A. Recent findings A large volume of evidence supports the use of Botox for OAB (to reduce urgency, frequency and incontinence episodes), and for NGB (to decrease incontinence and improve bladder capacity and detrusor pressures). Botox is now also Food & Drug Adm...
Source: Current Opinion in Urology - February 4, 2021 Category: Urology & Nephrology Tags: SPECIAL COMMENTARIES Source Type: research

Profiling gene expression reveals insights into pulmonary response to aerosolized botulinum toxin type A exposure in mice
This study investigated the global transcriptional profile of lung tissues after botulism inhalation. A mice model of inhaled botulism was established using intratracheal exposure to aerosolized BoNT/A and described through histological examination and flow cytometry. Transcriptomic analysis revealed that genes related to acute inflammatory responses were upregulated at 12 ‐h postexposure. Increased expression of multiple anti‐inflammatory marker genes and decreased expression of pro‐inflammatory marker genes were observed at 48‐ to 72‐h postexposure, underscoring a transcriptional shift toward a pro‐reparative...
Source: Journal of Applied Toxicology - February 3, 2021 Category: Toxicology Authors: Duo Su, Changjiao Gan, Zhouguang Jiao, Mengyun Deng, Sha Li, Yingjiao Ju, Yefeng Qiu, Lingfei Hu, Bo Gao, Dongsheng Zhou, Yuee Zhao, Huiying Yang Tags: RESEARCH ARTICLE Source Type: research

Botched Botox Injections: A Transatlantic Epidemic
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 1, 2021 Category: Cosmetic Surgery Tags: Viewpoints Source Type: research

Visualizing the Pharmacologic Preconditioning Effect of Botulinum Toxin Type A by Infrared Thermography in a Rat Pedicled Perforator Island Flap Model
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 1, 2021 Category: Cosmetic Surgery Tags: Letters Source Type: research

Reply: Visualizing the Pharmacologic Preconditioning Effect of Botulinum Toxin Type A by Infrared Thermography in a Rat Pedicled Perforator Island Flap Model
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 1, 2021 Category: Cosmetic Surgery Tags: Letters Source Type: research

A Novel Technique to Reduce Pain from Intradermal Injection of Botulinum Toxin Type A
Source: Plastic and Reconstructive Surgery Global Open - February 1, 2021 Category: Cosmetic Surgery Tags: Viewpoint Source Type: research

Botulinum toxin A improves psychological distress in patients with hemifacial spasm
This study aimed at assessing mental health in patients with hemifacial spasm (HFS) and determined the effect of botulinum toxin type A (BTX-A) on psychological distress in patients with HFS.MethodsNinety-five HFS patients and 95 age- and sex-matched healthy controls were enrolled. Symptom checklist-90 (SCL-90) scores were used to measure psychological distress in HFS patients and healthy controls. The mental health status of HFS patients was also evaluated by SCL-90, before and after the injection of BTX-A. Moreover, for those patients with abnormal mental health, efficacy outcomes after treatment with BTX-A were compared...
Source: Acta Neurologica Belgica - January 29, 2021 Category: Neurology Source Type: research

Combination therapy with Repetitive Facilitative Exercise Program and Botulinum Toxin Type A to improve motor function for the upper-limb spastic paresis in Chronic Stroke: A Randomized Controlled Trial
To promote recovery from a paretic upper limb after stroke, various rehabilitation approaches have been effective.1 Regardless of the kind of training, a previous neurophysiological study suggests that repeating identical movements is important for motor relearning.2 In accordance with that observation, Kawahira3 developed the repetitive facilitative exercise (RFE) program, which combines repetitive volitional flexion and extension movements with modified traditional neurofacilitation approaches. (Source: Journal of Hand Therapy)
Source: Journal of Hand Therapy - January 26, 2021 Category: Rehabilitation Authors: Akihiko Hokazono, Seiji Etoh, Jonoshita Yuiko, Kazumi Kawahira, Megumi Shimodozono Source Type: research

Signal detection of botulinum toxin type A (BoNT/A) using the Korea Adverse Event Reporting System Database, 1999  - 2016.
CONCLUSION: The number of AE reports after BTX has increased, the majority of which were from females. Safety signals such as "medicine ineffective" and "concentration impaired" may be due to increasing off-label use, which warrants long-term surveillance, especially among females after BTX injection. PMID: 33480840 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - January 24, 2021 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Argireline: needle-free botox as analytical challenge.
Abstract Argireline-containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect. Therefore, it is used as a  safe needle-free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatography and tandem mass spectrometry (RP-HPLC-MS and MS/MS). The analysis revealed the presence of argireline and its oxidized form in several dif...
Source: Chemistry and Biodiversity - January 22, 2021 Category: Biochemistry Authors: Kluczyk A, Ludwiczak J, Modzel M, Kuczer M, Cebrat M, Biernat M, Bachor R Tags: Chem Biodivers Source Type: research

Surgical aspect of blepharospasm treatment: a case report.
SURGICAL ASPECT OF BLEPHAROSPASM TREATMENT: A CASE REPORT. Acta Clin Croat. 2020 Jun;59(2):377-381 Authors: Dinjar K, Zubčić V, Kopić A, Kopić V, Popić B, Holik D Abstract Blepharospasm is an idiopathic condition characterized by involuntary eyelid closure mainly caused by bilateral tonic-clonic contractions of the orbicularis oculi muscle. It results in patient inability to open their eyes, thus significantly impairing their ability to perform activities of daily living. First-line treatment for blepharospasm are primarily botulinum toxin type A injections. However, surgical procedure as a treatm...
Source: Acta Clinica Croatica - January 21, 2021 Category: General Medicine Tags: Acta Clin Croat Source Type: research

Correction to: The Positive Effects of a Calorie-Restricting High-Protein Diet Combined with Intragastric Botulinum Toxin Type A Application Among Morbidly Obese Patients: A Prospective, Observational Analysis of Eighty-Seven Grade 2 Obese Patients
A Correction to this paper has been published:https://doi.org/10.1007/s11695-020-04597-y (Source: Obesity Surgery)
Source: Obesity Surgery - January 21, 2021 Category: Surgery Source Type: research

Botulinum Toxin A: A Review of Potential Uses in Treatment of Female Urogenital and Pelvic Floor Disorders.
Conclusion: The efficacy of botulinum toxin A for treating pelvic pain, voiding dysfunction, muscle pain and dysfunction, and certain colorectal-related pain issues shows promise but requires additional rigorous evaluation. PMID: 33408578 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - January 8, 2021 Category: General Medicine Tags: Ochsner J Source Type: research

Fractional CO 2 laser-assisted Botulinum toxin type A delivery for the treatment of primary palmar hyperhidrosis
AbstractIntradermal injections of botulinum toxin type A (BTX-A) have been used successfully to treat patients with primary palmoplantar hyperhidrosis (PPH). However, problems with local injections of BTX-A for palmar hyperhidrosis include injection pain and reduced palmar muscle strength. This case series describes three patients with PPH. Patients were followed up for 3  months and assessed using the minor iodine starch test and the visual analog scale (VAS). Over two sessions within a 2-week interval, all patients received treatment on one palm, while the other palm served as the untreated control. Treated palms re...
Source: Lasers in Medical Science - January 5, 2021 Category: Laser Surgery Source Type: research

Botulinum Toxin Type A as a Tool for Correcting Capsular Contracture after Reconstructive Breast Surgery
Source: Plastic and Reconstructive Surgery Global Open - January 1, 2021 Category: Cosmetic Surgery Tags: Breast: Case Report Source Type: research

GSE141815 MiRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular gland [miRNA-Seq]
Conclusions: Our study describes the miRNA and mRNA expression profiles and functional network after injection of BTXA into submandibular gland. These findings explore the mechanism of BTXA in inhibiting salivary secretion, and probably provide a new idea for the clinical application.Key words: miRNA-mRNA, BTXA, submandibular gland (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research

GSE141819 MiRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular gland [microarray]
Conclusions: Our study describes the miRNA and mRNA expression profiles and functional network after injection of BTXA into submandibular gland. These findings explore the mechanism of BTXA in inhibiting salivary secretion, and probably provide a new idea for the clinical application.Key words: miRNA-mRNA, BTXA, submandibular gland (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research

GSE141824 MiRNA-mRNA expression profiles and functional network after injection of botulinum toxin type A into submandibular gland
Series Type : Expression profiling by array ; Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research

DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Efficacy Results From SAKURA 3, a Large, Open-Label, Phase 3 Safety Study
CONCLUSION DaxibotulinumtoxinA for Injection efficacy was highly consistent across treatment cycles. These results confirm the previously observed efficacy rates and duration of response. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 29, 2020 Category: Dermatology Tags: Original Article Source Type: research

Botox and Financial Conflicts of Interest
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - December 29, 2020 Category: Cosmetic Surgery Tags: Viewpoints Source Type: research

The Efficacy of Botulinum Toxin Injection Site in Chronic Anal Fissure Healing
Conclusions: Even though there was no statistical difference in the long term healing rate between groups 1 and 2, choosing 6 and 12 o'clock alignments of internal sphincter muscle for botox injection is more advantageous than 3 and 9 o'clock alignments in terms of better postoperative pain and lower complication rate in the early period. (Source: Nigerian Journal of Clinical Practice)
Source: Nigerian Journal of Clinical Practice - December 23, 2020 Category: Rural Health Authors: U Sekmen M Paksoy Source Type: research

Sleeve Gastrectomy as a Novel Procedure for Gastroparesis.
Abstract BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has recently been considered for the surgical management of refractory gastroparesis. Our study aims to determine the efficacy of LSG as a new treatment modality for gastroparesis. METHODS: A multi-surgeon single institution retrospective chart review of patients who underwent LSG for refractory gastroparesis from September 2016-December 2017. Pre- and postoperative Patient Assessment of Upper Gastrointestinal Disorders-Symptoms Severity Index and/or Gastroparesis Cardinal Symptom Index (GCSI) questionnaires were reviewed. A telephone survey was condu...
Source: The American Surgeon - December 19, 2020 Category: Surgery Authors: Alicuben ET, Samaan JS, Houghton CC, Soffer E, Lipham JC, Samakar K Tags: Am Surg Source Type: research

Industry Payments by Allergan, Inc to Plastic Surgery and Related Specialties in 2018
In this study, we aimed to describe the quantity, type, and specific products associated with Allergan's payments to both plastic surgeons and physicians of other specialties. In 2018, Allergan paid a total of $48,484,163 in 397,225 payments to 90,386 physicians. Psychiatry and neurology received $11,867,861 in payments, the largest of any specialty, whereas internal medicine received the largest number of individual payments. Plastic surgeons made the most per physician ($3025). Most payments made to plastic surgeons were categorized as “gifts.” Payments made in relation to Botox were predominantly made to neu...
Source: Annals of Plastic Surgery - December 17, 2020 Category: Cosmetic Surgery Tags: Circumspectus Medicinae: Texts and Contexts Source Type: research

OnabotulinumtoxinA in Chronic Migraine: A Profile of Its Use
AbstractOnabotulinumtoxinA (Botox®; a formulation of botulinum toxin type A (BoNT/A)] is indicated for the prevention of headaches in adults with chronic migraine (CM) in numerous countries, including those of Europe. In clinical trials, intramuscular administration of BoNT/A (155 –195 units at 12-week intervals) to patients with CM was generally well tolerated and associated with sustained and clinically meaningful improvements in multiple assessments of headache symptoms, headache-related impact and/or disability and migraine-specific health-related quality of life over a period of 1 year (in the pivotal PREEMP...
Source: CNS Drugs - December 11, 2020 Category: Neurology Source Type: research

A clinical review of the use of Botulinum Toxin type A in managing central neuropathic pain in patients with spinal cord injury.
CONCLUSION: While early results are interesting, the quality and quantity of research published is not yet high enough to provide formal guidance on the use of BTX-A in treating central neuropathic pain in the spinal cord injury population. Further high-quality research is therefore recommended going forward. PMID: 33263489 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - December 4, 2020 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Efficacy and Safety of Botulinum Toxin vs. Placebo in Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Conclusions: The present meta-analysis provides evidence that BTX-A injections are associated with a statistically significant improvement in depressive symptoms. BTX-A injections are generally safe and may provide a new, alternative option for the treatment of depression. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - December 4, 2020 Category: Psychiatry Source Type: research

A risk-stratified approach toward safely resuming OnabotulinumtoxinA injections based on dosing and ambulatory status in pediatric patients with cerebral palsy during the Coronavirus pandemic of 2019 (COVID-19).
Authors: McLaughlin MJ, Fisher MT, Vadivelu S, Ramsey J, Ratnasingam D, McGhee E, Hartman K Abstract PURPOSE: After the onset of the Coronavirus pandemic of 2019-2020 (COVID-19), physicians who inject OnabotulinumtoxinA (BoNT-A) were left with determining risks and benefits in pediatric patients with cerebral palsy. Many of these patients have pre-existing conditions that make them more prone to COVID-19 symptoms, and this susceptibility potentially increases after BoNT-A injections. METHODS: A retrospective chart review of 500 patients identified 256 pediatric patients with cerebral palsy who received an intra...
Source: Journal of Pediatric Rehabilitation Medicine - December 2, 2020 Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research

Comparative Pharmacodynamics Study of 3 Different Botulinum Toxin Type A Preparations in Mice
CONCLUSION CBoNT displays the same efficacy as OBoNT as shown by their comparable chemodenervation and local paretic effects, and demonstrates superior efficacy and duration of action compared with IBoNT. Likewise, CBoNT has comparable DAS potency to OBoNT and is superior to IBoNT. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 1, 2020 Category: Dermatology Tags: Original Article Source Type: research

Piriformis syndrome: pain response outcomes following CT-guided injection and incremental value of botulinum toxin injection.
In this study, we hypothesize that a CT-guided injection with botulinum toxin is more effective in providing pain relief than a CT-guided injection without Botox. METHODS: Overall, 97 consecutive patients with piriformis syndrome presented for a CT-guided injection of the piriformis muscle and perineural injection of the sciatic nerve. After the injection, the patients received a visual analog scale pain log to record their pain level until the follow-up appointment. P values of less than 0.2 were considered as confounder and adjusted by inverse probability of treatment weighting (IPTW) via propensity score. The effec...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - November 30, 2020 Category: Radiology Authors: Yan K, Xi Y, Hlis R, Chhabra A Tags: Diagn Interv Radiol Source Type: research

15033 Evaluation of QM1114, a novel ready-to-use liquid botulinum toxin, in esthetic treatment of glabellar lines
The objective of this study was to evaluate efficacy and safety of 3 doses of QM1114 in esthetic treatment of glabellar lines (GLs). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Gary Monheit, Mark Nestor, Joel L. Cohen, Mitchel P. Goldman, Michael H. Gold, Elizabeth Tichy, Leonard Swinyer, Matthew Meckfessel Source Type: research

Botulinum Toxin Type A for the Treatment of Post-traumatic Headache: A Randomized, Placebo-Controlled, Cross-over Study.
This study sought to determine whether treatment with BoNT/A improved symptoms of PTH in military veterans. MATERIALS AND METHODS: Forty subjects with PTH were randomized to receive treatment of either BoNT/A or a saline placebo. Sixteen weeks post-treatment or at return to baseline headache severity, subjects were crossed over to receive treatment with the other medication than previously treated with in the first session. Subjects recorded number of headaches, number of headache days, and headache pain severity in daily diaries. Outcome measures included change in the weekly number of headaches, number of headache da...
Source: Military Medicine - November 27, 2020 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Functional acute acquired comitant esotropia: clinical characteristics and efficacy of single Botulinum toxin type A injection
To examine the clinical features of acute acquired comitant esotropia (AACE) and to evaluate the clinical effectiveness of a single injection of botulinum toxin type A (BTXA) on binocular visual function (BVF). (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - November 25, 2020 Category: Opthalmology Authors: Luyao Tong, Xiaoning Yu, Xiajing Tang, Yidong Zhang, Sifan Zheng and Zhaohui Sun Tags: Research article Source Type: research

Intraoperative Botulinum Toxin Chemodenervation and Analgesia in Abdominal Wall Reconstruction.
Conclusions. Chemodenervation was the only factor associated with reduced opioid usage compared to a standard group using multimodality analgesia. The role of muscular pain in laparotomy is likely underappreciated and understudied. Intraoperative selective muscular chemodenervation may play a significant role in recovery from abdominal surgery and requires further study. PMID: 33234030 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - November 24, 2020 Category: Surgery Authors: Blaha L, Chouliaras K, White A, McNatt S, Westcott C Tags: Surg Innov Source Type: research