Therapeutic Effectiveness of Needle Injection Versus Needle-Free Jet Injector System for Botulinum Toxin Type a in Palmar Hyperhidrosis
CONCLUSIONS: When the trigger of the pressurized needle-free injector device is activated, the gas powered driving pressure propels BTX-A through an orifice (0.13 mm) about four times narrower than a 30 G needle at very high speed. As most pain occurs during the needle prick itself, the advantage of a small orifice coupled with high-speed penetration of BTX-A through the pressurized device results in reduced pain during administration. The needle-free direct administration system administers the injectate under the skin without a visible needle.PMID:37537972 | DOI:10.1177/12034754231191062 (Source: Hand Surgery)
Source: Hand Surgery - August 4, 2023 Category: Surgery Authors: Hitomi Watanabe Yuichiro Ohshima Daisuke Watanabe Source Type: research
Therapeutic Effectiveness of Needle Injection Versus Needle-Free Jet Injector System for Botulinum Toxin Type a in Palmar Hyperhidrosis
CONCLUSIONS: When the trigger of the pressurized needle-free injector device is activated, the gas powered driving pressure propels BTX-A through an orifice (0.13 mm) about four times narrower than a 30 G needle at very high speed. As most pain occurs during the needle prick itself, the advantage of a small orifice coupled with high-speed penetration of BTX-A through the pressurized device results in reduced pain during administration. The needle-free direct administration system administers the injectate under the skin without a visible needle.PMID:37537972 | DOI:10.1177/12034754231191062 (Source: Hand Surgery)
Source: Hand Surgery - August 4, 2023 Category: Surgery Authors: Hitomi Watanabe Yuichiro Ohshima Daisuke Watanabe Source Type: research
Effects of botulinum toxin type A in Meige's syndrome
Background: Meige ’s syndrome (MS) is a type of facial dystonia characterized by the simultaneous occurrence of blepharospasm and oromandibular dystonia. It was first described in 1910, by dr. Henri Meige, a French neurologist. Since then, MS physiopathology was not completely identified. It is known that genetic f actors, as well as environmental triggers, are involved in changes in the dopaminergic system modulation, causing hyperactivation of certain regions of the nervous system, such as the hypothalamus and basal ganglia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: A. Duarte, H.A. Ghizoni Teive Source Type: research
Botulinum toxin type a for blepharospasm
Background: Blepharospasm is a type of focal dystonia, characterized by involuntary contraction of eyelids, leading to bilateral eye closure or persistent blinking. Although there is currently no cure, botulinum toxin type A (BTA) has been used as a choice treatment since the eighties. The aim of our study was to quantify the symptoms improvement after BTA application. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - August 1, 2023 Category: Neurology Authors: A. Duarte, H.A. Ghizoni Teive Source Type: research
Rivastigmine ameliorates botulinum-induced hippocampal damage and spatial memory impairment in male rats
Neurotoxicology. 2023 Jul 26:S0161-813X(23)00100-6. doi: 10.1016/j.neuro.2023.07.004. Online ahead of print.ABSTRACTBotulinum toxin (Botox) is widely used in beauty industry and its long-term consequences can be a matter of concern. The hippocampal cholinergic system plays a significant role in memory and learning that could be affected by Botulinum toxin. However, to date, the effect of Botox on memory system has been controversial. This survey aimed to examine the effects of Botox on spatial memory, and biochemical and histological parameters of the hippocampus in male rats by using Rivastigmine (R) as a cholinesterase i...
Source: Neurotoxicology - July 28, 2023 Category: Neurology Authors: Keyvan Mehri Zohreh Zavvari Oskuye Ehsan Nassireslami Esmail Karami Mohammad Reza Parvizi Source Type: research
Rivastigmine ameliorates botulinum-induced hippocampal damage and spatial memory impairment in male rats
Neurotoxicology. 2023 Jul 26:S0161-813X(23)00100-6. doi: 10.1016/j.neuro.2023.07.004. Online ahead of print.ABSTRACTBotulinum toxin (Botox) is widely used in beauty industry and its long-term consequences can be a matter of concern. The hippocampal cholinergic system plays a significant role in memory and learning that could be affected by Botulinum toxin. However, to date, the effect of Botox on memory system has been controversial. This survey aimed to examine the effects of Botox on spatial memory, and biochemical and histological parameters of the hippocampus in male rats by using Rivastigmine (R) as a cholinesterase i...
Source: Neurotoxicology - July 28, 2023 Category: Neurology Authors: Keyvan Mehri Zohreh Zavvari Oskuye Ehsan Nassireslami Esmail Karami Mohammad Reza Parvizi Source Type: research
Treatment of cervical dystonia with Botox (onabotulinumtoxinA): Development, insights, and impact
Medicine (Baltimore). 2023 Jul 1;102(S1):e32403. doi: 10.1097/MD.0000000000032403.ABSTRACTCervical dystonia (CD), the most common focal dystonia encountered in neurologic practice, is a chronic disorder in which the muscles of the neck involuntarily contract and cause abnormal postures and movements of the head, neck, and shoulders. Treatment of CD prior to botulinum toxin was unsatisfactory, as existing therapies often did not improve symptoms. The use of botulinum toxin for CD grew out of its success in treating blepharospasm, another type of focal dystonia. On the basis of results from a double-blind, placebo-controlled...
Source: Pain Physician - July 27, 2023 Category: Anesthesiology Authors: Joseph Jankovic Joseph Tsui Mitchell F Brin Source Type: research
Treatment of cervical dystonia with Botox (onabotulinumtoxinA): Development, insights, and impact
Medicine (Baltimore). 2023 Jul 1;102(S1):e32403. doi: 10.1097/MD.0000000000032403.ABSTRACTCervical dystonia (CD), the most common focal dystonia encountered in neurologic practice, is a chronic disorder in which the muscles of the neck involuntarily contract and cause abnormal postures and movements of the head, neck, and shoulders. Treatment of CD prior to botulinum toxin was unsatisfactory, as existing therapies often did not improve symptoms. The use of botulinum toxin for CD grew out of its success in treating blepharospasm, another type of focal dystonia. On the basis of results from a double-blind, placebo-controlled...
Source: Pain Physician - July 27, 2023 Category: Anesthesiology Authors: Joseph Jankovic Joseph Tsui Mitchell F Brin Source Type: research
The effect of botulinum toxin type a in patients with essential blepharospasm
Acta Clin Croat. 2022 Nov;61(3):379-385. doi: 10.20471/acc.2022.61.03.02.ABSTRACTThe aim of this study was to determine the effect of botulinum toxin type A and satisfaction in patients with essential blepharospasm. The study included 12 subjects suffering from essential blepharospasm who received therapy with botulinum toxin type A injections. Respondents were given a Blepharospasm Disability Index (BSDI) survey before and three weeks after the procedure with questions related to quality of life. They were also given a Jankovic Rating Scale with questions related to the severity and frequency of symptoms. The overall leve...
Source: Acta Clinica Croatica - July 26, 2023 Category: General Medicine Authors: Klara Ga ćina Mladen Le šin Dean Saraj čev Nina Rotim Source Type: research
