Long-Term Safety and Efficacy of Botulinum Toxin A Treatment in Adolescent Patients with Axillary Bromhidrosis
AbstractBackgroundFor adolescent bromhidrosis, the long-term safety and efficacy of botulinum toxin type A (BTX-A) treatment are not clear to date.Patients and MethodsFrom June 2011 to July 2016, 62 adolescent patients with primary axillary bromhidrosis were recruited and 50  U of BTX-A was administered in each axilla. Repetitive injections were performed when the malodor returned.ResultsThe average follow-up was 2.64  years. There were no reported local or systemic adverse effects. After the first BTX-A injection, 61.3% of patients (38/62) maintained the duration of more than 4 weeks. Of these patients, 21 ...
Source: Aesthetic Plastic Surgery - January 17, 2018 Category: Cosmetic Surgery Source Type: research

Loading of the Condylar Cartilage Can Rescue the Effects of Botox on TMJ
AbstractThe purpose of this study is to evaluate whether the effects of botulinum neurotoxin (botox) injection into the masseter in the mandibular condylar cartilage (MCC) and subchondral bone could be rescued by compressive loading of the temporomandibular joint (TMJ). Twenty-four 6-week-old female mice (C57BL/6J) were used. Mice were divided in three groups: (1) Botox (n = 8); (2) Botox plus loading (n = 8); (3) Pure control (n = 8). Bone labels (3 and 1 day before sacrifice) and the proliferation marker EdU (2 and 1 day before sacrifice) were intraperitoneally injected...
Source: Calcified Tissue International - January 11, 2018 Category: Orthopaedics Source Type: research

Analysis of a 15-years' experience in including shoulder muscles, when treating upper-limb spasticity post-stroke with botulinum toxin type A.
Abstract Background Botulinum toxin type-A (BoNTA) is a recognized treatment for upper limb spasticity (ULS) after stroke, but there aren't many studies analyzing its effect in shoulder muscles. Objective To evaluate the efficacy of BoNTA injections for ULS, when shoulder muscles are included. Methods A cross-sectional study. Data from clinical forms of outpatients, treated at a Rehabilitation Center (2001-2016). Analyzes: goals of treatment; demographic characteristics/goal; treatment success, using Goal Attainment Scaling. Results Eighty-six stroke-patients, submitted to 547 BoNTA treatment sessions. The most in...
Source: Topics in Stroke Rehabilitation - January 11, 2018 Category: Neurology Authors: Carvalho MP, Pinto D, Gorayeb M, Jacinto J Tags: Top Stroke Rehabil Source Type: research

Early molecular response and microanatomical changes in the masseter muscle and mandibular head after botulinum toxin intervention in adult mice.
CONCLUSIONS: Our results show that masseter muscle paralysis induced by BoNTA leads to significant microanatomical changes by day 14, preceded by molecular changes as early as 2 d in bone, and 7 d in muscle. Therefore, masseter muscle atrophy and subchondral bone loss detected at 14 d are preceded by molecular responses that occur during the first week after BoNTA intervention. PMID: 29289710 [PubMed - as supplied by publisher] (Source: Annals of Anatomy)
Source: Annals of Anatomy - December 28, 2017 Category: Anatomy Authors: Balanta-Melo J, Toro-Ibacache V, Torres-Quintana MA, Kupczik K, Vega C, Morales C, Hernández-Moya N, Arias-Calderón M, Beato C, Buvinic S Tags: Ann Anat Source Type: research

A successful management of sever gummy smile using gingivectomy and botulinum toxin injection: A case report
Discussion and conclusion It is important to assess the patients’ esthetic expectations and show the possible therapeutic solutions that fit him. We revealed that BT is considered as one of the minimally invasive, quick and affordable modalities that can replace extensive surgical procedures for corrections of sever GS. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - December 16, 2017 Category: Surgery Source Type: research

Botulinum toxin type A for the treatment of localized recalcitrant chronic pruritus
To the Editor: Localized chronic pruritus is a common condition that significantly affects health-related quality of life. A variety of diseases result in localized chronic itch, which can be broadly classified as dermatologic, neuropathic, or psychogenic in nature. For patients with chronic pruritus that is refractory to conventional therapy, the burden of disease is substantial. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - December 12, 2017 Category: Dermatology Authors: Emily Boozalis, Mary Sheu, Jacqueline Selph, Shawn G. Kwatra Tags: Research letter Source Type: research

Botulinum toxin type A therapy for cervical dystonia.
CONCLUSIONS: We have moderate certainty in the evidence that a single BtA treatment session is associated with a significant and clinically relevant reduction of cervical dystonia-specific impairment, including severity, disability, and pain, and that it is well tolerated, when compared with placebo. There is also moderate certainty in the evidence that people treated with BtA are at an increased risk of developing adverse events, most notably dysphagia and diffuse weakness. There are no data from RCTs evaluating the effectiveness and safety of repeated BtA injection cycles. There is no evidence from RCTs to allow us to dr...
Source: Cochrane Database of Systematic Reviews - December 12, 2017 Category: General Medicine Authors: Castelão M, Marques RE, Duarte GS, Rodrigues FB, Ferreira J, Sampaio C, Moore AP, Costa J Tags: Cochrane Database Syst Rev Source Type: research

External Rotation Predicts Outcomes After Closed Glenohumeral Joint Reduction With Botulinum Toxin Type A in Brachial Plexus Birth Palsy
Background: Few studies have investigated outcomes after adjunct botulinum toxin type A (BTX-A) injections into the shoulder internal rotator muscles during shoulder closed reduction and spica cast immobilization in children with brachial plexus birth palsy. The purpose of this study was to report success rates after treatment and identify pretreatment predictors of success. Methods: Children with brachial plexus birth palsy who underwent closed glenohumeral joint reduction with BTX-A and casting were included. Minimum follow-up was 1 year. Included patients did not receive concomitant shoulder surgery nor undergo mic...
Source: Journal of Pediatric Orthopaedics - December 9, 2017 Category: Orthopaedics Tags: Upper Extremity - Trauma Source Type: research

Intravesical Electromotive Botulinum Toxin Type “A” Administration for Management of Urinary Incontinence Secondary to Neuropathic Detrusor Overactivity in Children: Long-Term Follow-up
To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) “Dysport®” administration in myelomeningocele (MMC) patients who had urinary incontinence due to neuropathic detrusor overactivity (NDO). (Source: Urology)
Source: Urology - December 8, 2017 Category: Urology & Nephrology Authors: Seyedeh-Sanam Ladi-Seyedian, Lida Sharifi-Rad, Abdol-Mohammad Kajbafzadeh Tags: Pediatric Urology Source Type: research

Intravesical Electromotive Botulinum Toxin Type “A” Administration for Management of Urinary Incontinence Secondary to Neuropathic Detrusor Overactivity in Children: Long-term Follow-up
To investigate the long-term efficacy and success rate of intravesical electromotive botulinum toxin type A (BoNTA) “Dysport” administration in patients with myelomeningocele who had urinary incontinence due to neuropathic detrusor overactivity (NDO). (Source: Urology)
Source: Urology - December 8, 2017 Category: Urology & Nephrology Authors: Seyedeh-Sanam Ladi-Seyedian, Lida Sharifi-Rad, Abdol-Mohammad Kajbafzadeh Tags: Pediatric Urology Source Type: research

Botulinum toxin A for patients with orofacial dystonia: prospective, observational, single-centre study
The objective of this study was to demonstrate the efficacy of intramuscular botulinum toxin type A (BTX-A) as a method of controlling the symptoms of focal facial dystonia. A prospective, longitudinal, observational, pre –post (case-series) single-centre study was conducted over a period of 3 months, involving 30 patients with focal dystonia. The patients were enrolled on a first-come, first-served basis. For all patients, the abnormal movements were evaluated using the Abnormal Involuntary Movement Scale (AIMS). (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - December 2, 2017 Category: ENT & OMF Authors: G. Ruiz-de-Le ón-Hernández, R.-M. Díaz-Sánchez, D. Torres-Lagares, E. Hernández-Pacheco, M. González-Martín, M.-A. Serrera-Figallo Tags: Clinical Paper Source Type: research

A case of mandibular condylar resorption following Botulinum Toxin A injection
Introduction: Botulinum Toxin (Botox) is a commonly used treatment modality for hypertonic muscles of mastication in Temporomandibular Joint Disorder (TMD). Although animal models exist, there are limited human studies which demonstrate condylar resorption as a consequence of repeated use of Botox in the masticatory muscles. This case report illustrates how a patient has experienced bone resorption of the condyle following this treatment. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2017 Category: ENT & OMF Authors: Jeyan Aziz, Danyal Awal, Peter Ayliffe Tags: P296 Source Type: research

YouTube Videos on Botulinum Toxin A for Wrinkles: A Useful Resource for Patient Education
CONCLUSION: The large number of useful videos, high reliability, and the wide range of content covered suggests that those who search for antiwrinkle BTX videos on YouTube are likely to view high-quality content. This suggests that YouTube may be a good source of videos to recommend for patients interested in BTX. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - November 29, 2017 Category: Dermatology Tags: Original Article Source Type: research

Botulinum Toxin Type A Injections as Monotherapy for Upper Limb Essential Tremor Using Kinematics.
Abstract BACKGROUND: There is a significant need for a targeted therapy for essential tremor (ET), as medications have not been developed specifically for ET, and the ones prescribed are often not well-tolerated, so that many patients remain untreated. Recent work has shown that, unlike previous experience, kinematically guided individualized botulinum toxin type A (BoNT-A) injections provide benefit along with minimal weakness. Ours is the first long-term (96-week) safety and efficacy study of BoNT-A as monotherapy for ET using kinematically driven injection parameters. METHODS: Ten ET patients were administ...
Source: The Canadian Journal of Neurological Sciences - November 21, 2017 Category: Neurology Authors: Samotus O, Kumar N, Rizek P, Jog M Tags: Can J Neurol Sci Source Type: research

Botox more effective than topiramate for chronic migraine prevention
New research suggested botox had greater tolerability compared with topiramate against chronic migraine (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - November 20, 2017 Category: Drugs & Pharmacology Source Type: research

Patient Registry of Spasticity Care World: Data Analysis Based on Physician Experience
Objective The aim of the study was to report physician experience–based “real-world” treatment patterns with botulinum toxin type A in patients with stroke and traumatic brain injury. Design A prospective, multicenter, international observational registry design was used. Results Six hundred twenty-seven participants with stroke and 132 participants with traumatic brain injury were assessed and treated by 17 more experienced physicians and 12 less experienced physicians. Due to the limited usage of abobotulinumtoxinA Dysport and incobotulinumtoxinA Xeomin, data were reported on onabotulinumtoxinA ...
Source: American Journal of Physical Medicine and Rehabilitation - November 18, 2017 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Modification of Chin Projection and Aesthetics With Botox Injection
This case series report evaluates the use of onabotulinumtoxinA for improving chin aesthetics in patients with an underprojected bony chin and a high-riding hyperactive mentalis muscle. (Source: JAMA Facial Plastic Surgery)
Source: JAMA Facial Plastic Surgery - November 17, 2017 Category: Cosmetic Surgery Source Type: research

Navigated retrograde endoscopic myotomy (REM) for the treatment of therapy ‐resistant achalasia
ConclusionREM makes the proximal esophagus accessible for endoscopic myotomy. Potential indication for REM is motility disorders in the proximal esophagus and therapy failure after POEM. Esophageal motility disorders (EMD) involving the proximal esophagus are difficult to treat, because of inaccessibility for instrumentation Retrograde Endoscopic Myotomy (REM) was developed to treat EMD affecting the proximal esophagus and was performed with real‐time anatomical orientation based on prior computerized tomography and high‐resolution manometry REM was a safe and effective minimally invasive approach for myotomy of t...
Source: Neurogastroenterology and Motility - November 16, 2017 Category: Gastroenterology Authors: K. D. Pham, R. F. Havre, T. Lang ø, E. F. Hofstad, G. A. Tangen, R. Mårvik, T. Pham, O. H. Gilja, J. G. Hatlebakk, A. Viste Tags: ORIGINAL ARTICLE Source Type: research

Influence of the neural microenvironment on prostate cancer
ConclusionNerves play a role in the homeostasis of normal epithelial tissues and are involved in prostate cancer tumor survival. This study confirms that interactions between human cancer and nerves are essential to disease progression. This work may make a major impact in general cancer treatment strategies, as nerve/cancer interactions are likely important in other cancers as well. Targeting the neural microenvironment may represent a therapeutic approach for the treatment of human prostate cancer. (Source: The Prostate)
Source: The Prostate - November 13, 2017 Category: Urology & Nephrology Authors: Christian Coarfa, Diego Florentin, NagiReddy Putluri, Yi Ding, Jason Au, Dandan He, Ahmed Ragheb, Anna Frolov, George Michailidis, MinJae Lee, Dov Kadmon, Brian Miles, Christopher Smith, Michael Ittmann, David Rowley, Arun Sreekumar, Chad J. Creighton, Gu Tags: ORIGINAL ARTICLE Source Type: research

Role of central versus peripheral opioid system in antinociceptive and anti ‐inflammatory effect of botulinum toxin type A in trigeminal region
ConclusionsMorphine acts on pain in trigeminal region both peripherally and centrally, whereas the effect on dural plasma protein extravasation seems to be only centrally mediated. However, the interaction of BT‐A with endogenous opioid system, with consequent inhibition of nociceptive transmission as well as the DNI, occurs primarily centrally. SignificanceBotulinum toxin type A (BT‐A)'s axonal transport and potential transcytosis suggest that its antinociceptive effect might involve diverse neurotransmitters at different sites of trigeminal system. Here we discovered that the reduction in pain and accompanying DNI in...
Source: European Journal of Pain - November 13, 2017 Category: Anesthesiology Authors: V. Drinovac Vlah, B. Filipovi ć, L. Bach‐Rojecky, Z. Lacković Tags: Original Article Source Type: research

81. The florence spinal unit experience in the treatment of chronic pelvic pain with Botulinum toxin
Chronic pelvic pain (CPP) is a common disorder, more frequent in women, causing significant morbidity. CPP is difficult to diagnose and resist traditional treatment modalities. In the last years, it has been showed botulinum toxin type A (BTX-A) is effective in treating pain, above all if it is associated to muscular spasm. Some studies suggest that BTX-A blocks peripheral sensitization and, indirectly, reduces central sensitization.We studied 28 patients, aged 32 –87years, who had more than 2years of CPP, mono/bilateral, who differed from one another in pain area/intensity. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 11, 2017 Category: Neuroscience Authors: G. de Scisciolo, R. Caramelli, A. Cassardo, C. Martinelli, G. Del Popolo Source Type: research

A survey of the current practice of intramuscular Botulinum toxin injections for hemiplegic shoulder pain in the UK.
CONCLUSIONS: Current UK practice of Botulinum Toxin type A injections for hemiplegic shoulder pain associated with spasticity is highly variable. There are large gaps between current practice and available evidence with regards to muscle selection and doses used. A number of areas for further investigation have been identified to progress current understanding of this intervention. Implications for rehabilitation There are wide variations in practice for this complex intervention and clinicians should consider that their individual decision-making could be based on their own beliefs rather than available evidence. Pectoral...
Source: Disability and Rehabilitation - November 10, 2017 Category: Rehabilitation Authors: Holmes RJ, Connell LA Tags: Disabil Rehabil Source Type: research

BTX-A has notable effects contradicting some treatment aims in the rat triceps surae compartment, which are not confined to the muscles injected
Botulinum toxin type-A (BTX-A) is widely used in treating gastrocnemius medial (GM) and lateral (GL) muscles in cerebral palsy to improve joint motion. However, recent animal experiments indicate inferior BTX-A effects beyond the injected muscle. The goal was to test the following hypotheses in a rat model. (1) BTX-A injected into the GM and GL does not spread into the soleus (SOL), and muscles exposed show (2) a wider length range of force exertion (Lrange), (3) reduced passive forces and (4) no intermuscular interaction effects. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - November 6, 2017 Category: Biomedical Science Authors: Can A. Yucesoy, Filiz Ate ş Source Type: research

Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone.
CONCLUSION: These recommendations depart from traditional consensus documents by providing detailed incobotulinumtoxinA injection protocols for the forehead based on the major parameters that differ between patients, including muscular anatomy, size, and tone. It is expected that the use of this document will lead to more satisfactory, natural, and individualized aesthetic outcomes for patients. PMID: 29089780 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - November 3, 2017 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Progress on Botulinum Toxin Type A-Induced Pain Relief in the Field of Plastics
Conclusion: The results suggest that BTX-A may induce postoperative pain associated with plastic surgeries relief. But the available data of outcome assessment involved in this review are inconsistent and failed to meet methodological rigor. And pain alleviations are influenced by many factors. So further randomized controlled clinical trials with large sample sizes are needed to support this practice, determine standard usage methods, and establish corresponding specification systems. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - November 1, 2017 Category: Surgery Tags: Clinical Studies Source Type: research

Lower Face Rejuvenation with Injections: Botox, Juvederm, and Kybella for Marionette Lines and Jowls
Source: Plastic and Reconstructive Surgery Global Open - November 1, 2017 Category: Cosmetic Surgery Tags: Case Report Source Type: research

Dynamic Model of Applied Facial Anatomy with Emphasis on Teaching of Botulinum Toxin A
Source: Plastic and Reconstructive Surgery Global Open - November 1, 2017 Category: Cosmetic Surgery Tags: Original Article Source Type: research

Therapeutic Plasma Exchange in a rare case myasthenic crisis after Botox injection.
CONCLUSIONS: Clinical symptoms of myasthenia gravis and systemic Botox effects are very similar. This should be taken into consideration during medical history taking. The injection of high doses of Botox (more than 200 units in every injection) or boostering within less than one month is dangerous. (Botox BCC2024). Systemic side effects can be treated using TPE to lower the circulating dose of Botox. PMID: 29096852 [PubMed - in process] (Source: Atherosclerosis Supplements)
Source: Atherosclerosis Supplements - November 1, 2017 Category: Cardiology Authors: Chegini A Tags: Atheroscler Suppl Source Type: research

Before Botox, There Was Botulism
Introduction: Botulism, a consequence of botulinum toxin produced by Clostridium botulinum can present with fever, nausea and facial weakness spreading to the limbs. Ultimately it can lead to respiratory failure. Diagnosis often requires tissue samples, requiring the expertise of surgeons. (Source: International Journal of Surgery)
Source: International Journal of Surgery - November 1, 2017 Category: Surgery Authors: R. Rollett, K. Medjoub, S. Mcintosh, S. Sexton, T. Athanasopoulos Source Type: research

Injectable DaxibotulinumtoxinA for the Treatment of Glabellar Lines: A Phase 2, Randomized, Dose-Ranging, Double-Blind, Multicenter Comparison With OnabotulinumtoxinA and Placebo
CONCLUSION: The 40U dose of daxibotulinumtoxinA was well tolerated (e.g., absence of ptosis) and had the most favorable risk: benefit profile. Compared with 20U onabotulinumtoxinA, it exhibited a significantly greater response rate and a significantly longer duration of response (median of 24 weeks vs 19 weeks; p = .030). (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - October 28, 2017 Category: Dermatology Tags: Original Articles Source Type: research

Effectiveness, Safety, and Predictors of Response to Botulinum Toxin Type A in Refractory Masticatory Myalgia: A Retrospective Study
Masticatory muscle pain disorders respond well to conservative therapy; however, in some patients the pain becomes refractory. Botulinum toxin type A (BoT-A) therapy has been shown to be an effective modality in the management of refractory headache disorders. Conversely, there are conflicting reports in the literature regarding the efficacy, safety, and predictors of therapeutic response to BoT-A therapy for management of refractory masticatory muscle pain. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - October 25, 2017 Category: ENT & OMF Authors: Shehryar N. Khawaja, Steven J. Scrivani, Nicole Holland, David A. Keith Tags: Anesthesia/facial pain Source Type: research

Efficacy of botulinum toxin in treating myofascial pain and occlusal force characteristics of masticatory muscles in bruxism
Conclusion: Results from the present study supported the efficacy of BTX-A to reduce myofascial pain symptoms in bruxers, and effective in reducing the occlusal force. (Source: Indian Journal of Dental Research)
Source: Indian Journal of Dental Research - October 25, 2017 Category: Dentistry Authors: Varsha A Jadhao Nitin Lokhande Shweta G Habbu Sagar Sewane Shailesh Dongare Neha Goyal Source Type: research

Tenth case of bilateral hemifacial spasm treated by microvascular decompression: Review of the pathophysiology.
CONCLUSIONS: We believe that bilateral MVD is the best approach in cases of BHFS. PMID: 29026661 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - October 16, 2017 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Comparison of Safety and Efficacy of Botox and Neuronox in the Management of Benign Essential Blepharospasm: A Split-face Study.
Authors: Sane S, Ali MJ, Naik M Abstract PURPOSE: To compare the efficacy and safety of Botox and Neuronox in the management of benign essential blepharospasm (BEB). METHODS: We performed a triple-masked, randomized control study to compare Botox and Neuronox in 48 eyes of 24 patients with BEB. All 24 patients randomly received Botox or Neuronox in the periorbital region in a masked, randomized split-face manner, keeping the injection sites and doses uniform. The toxin preparation, injection, and clinical evaluations were done by three independent observers. Objective outcome measures included improvement in th...
Source: Korean Journal of Ophthalmology : KJO - October 14, 2017 Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research

Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules.
Abstract Synaptotagmin 1 (Syt1) is the Ca(2+) sensor protein with an essential role in neurotransmitter release. Since the wrinkle formation is due to the excessive muscle fiber stimulation in the face, a helpful stratagem to diminish the wrinkle line intenseness is to weaken the innervating neuron activity through Syt1 inhibition which is one of the possible therapeutic strategies against wrinkles. Recently, experimental evidence showed that botox-like peptides, which are typically used as SNARE modulators, may inhibit Syt1. In this work, we applied molecular modeling to (1) characterize the structural framework ...
Source: Molecular and Cellular Biochemistry - October 10, 2017 Category: Biochemistry Authors: Wongrattanakamon P, Nimmanpipug P, Sirithunyalug B, Jiranusornkul S Tags: Mol Cell Biochem Source Type: research

Efficacy of Bladder Hydrodistension Under Combined General and Spinal Anesthesia in Patients with Interstitial Cystitis with and Without the Addition of Botulinum Toxin Injection Into the Pelvic Floor Muscles: a Prospective Trial
Study Objective: To determine the efficacy of bladder hydrodistension (BOD) in patients with interstitial cystitis (IC) and botulinum toxin injection (botox) into the pelvic floor muscles (PFM) for pelvic floor tension myalgia (PFTM). To examine the number of patients with underlying endometriosis. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 7, 2017 Category: OBGYN Authors: N. Mehandru, M. Hibner, M. Castellanos, N. Desai, J.R. Wilson Source Type: research

Botulinum toxin type a usage for preoperative treatment for dental implants placed in maxillary arches for full ‐arch restoration of patients with bruxism
(Source: Clinical Oral Implants Research)
Source: Clinical Oral Implants Research - October 4, 2017 Category: Dentistry Tags: ABSTRACTS Source Type: research

Anatomical Relationship of the Inferior Bundle of the Incisivus Labii Inferioris With the Depressor Labii Inferioris and the Platysma
Abstract: The current study examined the inferior bundle of the incisivus labii inferioris muscle (ILI) and its morphologic and spatial relationships with regard to the depressor labii inferioris muscle (DLI) and the platysma. Incisivus labii inferioris muscles and their inferior bundles were investigated in 50 specimens from embalmed Korean adult cadavers. The inferior bundle of the ILI was divided from the originating fibers of the ILI, and it was present in all specimens (100%). The inferior bundle of the ILI could be distinguished into the transverse and inferolateral slips according to their courses and locations. The...
Source: Journal of Craniofacial Surgery - October 1, 2017 Category: Surgery Tags: Anatomical Studies Source Type: research

Value of botulinum toxin injections preceding a comprehensive rehabilitation period for children with spastic cerebral palsy: a cost-effectiveness study.
CONCLUSION: The addition of botulinum toxin type A to intensive physiotherapy did not improve the effectiveness of rehabilitation for ambulatory children with spastic cerebral palsy and was also not cost-effective. Thus botulinum toxin is not recommended for use in improving gross motor function, activity levels or health-related quality-of-life in this cerebral palsy age- and severity-subgroup. PMID: 28949368 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - September 29, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Gastrointestinal: Hepatic abscess after botulinum toxin type —A therapy for achalasia
(Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - September 26, 2017 Category: Gastroenterology Authors: H Giles, A Ross, RB Gearry Tags: Education and Imaging Source Type: research

Effectiveness, Safety, and Predictors of Response to Botulinum Toxin Type A in Refractory Masticatory Myalgia: A Retrospective Study
Temporomandibular disorders (TMD) are defined as a subgroup of craniofacial musculoskeletal and neuromuscular disorders. They are broadly sub-divided into temporomandibular joint disorders and masticatory muscle disorders. Common manifestations of masticatory muscle disorders in TMD consist of pain, persistent, recurring, or chronic in nature, which is often associated with limitation of range of mandibular motion. Masticatory muscle pain disorders respond well to conservative therapy. However, in some patients the pain may become refractory [1]. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 25, 2017 Category: ENT & OMF Authors: S.N. Khawaja, S.J. Scrivani, N. Holland, D.A. Keith Tags: Oral Abstract Track One: Reconstruction, TMJ Source Type: research

The Effect and Mechanism of Botulinum Toxin Type A For Knee Osteoarthritis Through Ultrasound
To study the effect and mechanism of botulinum toxin type A (BoNT-A) injection in patients with refractory knee osteoarthritis through ultrasound. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 24, 2017 Category: Rehabilitation Authors: Xiao Bao, Howe Liu, Hao Liu, Jiewen Tan, Ying Long Source Type: research

Effect of Ultrasound-Guided Injection Of Botulinum Toxin Type A for Shoulder Pain On Post-Stroke Patients
To study the effect of ultrasound-guided injection of botulinum toxin type A for shoulder pain on patients with stroke. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 24, 2017 Category: Rehabilitation Authors: Xiao Bao, Howe Liu, Hao Liu, Jiewen Tan, Ying Long, Myles Quiben Source Type: research

Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency.
Abstract Botulinum toxin type A is a causative agent of human botulism. Due to high toxicity and ease of production it is classified by the Centres for Disease Control and Prevention as a category A bioterrorism agent. The same serotype, BoNT/A, is also the most widely used in pharmaceutical preparations for treatment of a diverse range of neuromuscular disorders. Traditionally, animals are used to confirm the presence and activity of toxin and to establish neutralizing capabilities of countermeasures in toxin neutralization tests. Cell based assays for BoNT/A have been reported as the most viable alternative to a...
Source: Journal of Immunological Methods - September 21, 2017 Category: Allergy & Immunology Authors: Yadirgi G, Stickings P, Rajagopal S, Liu Y, Sesardic D Tags: J Immunol Methods Source Type: research

CEVL interactive – it is feasible for Pediatric Urology fellows to create pediatric urological surgical plans: a case study of Botox endoscopic injection
Effectively and efficiently performing pediatric urological surgeries requires the pediatric urologist to ‘team’ with the entire operating room (OR) staff. Yet there are no existing methods with which to assure that the members of this team have working knowledge of the specific procedures they are expected to perform. Traditionally, surgeon training has relied on immersive clinical operative experi ence. Such real-time training may be supplemented with review of video clips, if available. Similarly, circulating nurses and surgical technicians typically train together under the supervision of the nursing staff,...
Source: Journal of Pediatric Urology - September 18, 2017 Category: Urology & Nephrology Authors: G.O. Huang, M. Maizels, C.J. Koh, D.D. Tu, P. Meade Tags: CEVL Source Type: research

Editorial comment
I think that the CEVL tool is an excellent representation of the Botox injection technique for providers, trainees, and OR staff. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - September 18, 2017 Category: Urology & Nephrology Authors: Patricio C. Gargollo Tags: Editorial Source Type: research

[Botulinum toxin: An important complement for facial rejuvenation surgery].
Abstract The improved understanding of the functional anatomy of the face and of the action of the botulinum toxin A leads us to determine a new injection procedure which consequently decreases the risk of eyebrow and eyelid ptosis and increases the toxin's injection possibilities and efficiencies. With less units of toxin, the technique herein described proposes to be more efficient on more muscles: variable toxin injections concentration adapted to each injected muscle are used. Thanks to a new procedure in the upper face, toxin A injection can be quite close to an endoscopic surgical action. In addition, intere...
Source: Annales de Chirurgie Plastique et Esthetique - September 18, 2017 Category: Cosmetic Surgery Authors: Le Louarn C Tags: Ann Chir Plast Esthet Source Type: research

Cosmetic Practitioners Take Huge Risks Purchasing and Administering Illegal Botulinum Toxin Drug Products.
Authors: Bradshaw S Abstract In their article "Importing Injectables" in the September 2014 issue of the Journal of Drugs in Dermatology, Dr. Kenneth Beer and Karen Rothschild highlighted the possible harm to patients and practitioners from the use of unapproved botulinum toxin products - eg, Botox, Dysport, Xeomin, and Myobloc - and other cosmetic prescription drug products purchased from foreign or unlicensed suppliers.1 In the intervening years, the accuracy of their critique has been repeatedly demonstrated, as the dangers to patients' health, as well as to cosmetic practitioners' liberty, has only in...
Source: Journal of Drugs in Dermatology - September 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Mild to Moderate Dysphagia Following Very Low-dose Abobotulinumtoxin A for Platysmal Bands.
We present a case of mild to moderate dysphagia in a patient after very low doses of Abobutulinumtoxin (60 units, equivalent to 20 units of Onabotulinumtoxin using a 3:1 conversion ratio). We speculate that the adverse effects noted may be due to several possibilities, such as diffusion, injection technique, or intravascular injection. Thus, although botulinum toxin-A is generally considered a safe off-label treatment for vertical platysma bands, readers should still be aware of the possible side-effects even with low dose use, as supported by our case report of mild to moderate dysphagia with relatively conservative doses...
Source: Journal of Drugs in Dermatology - September 17, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research