Poster 138: The Use and Safety of Intramuscular Midazolam During In-Office Neurolysis/Botox Injection Procedures for Pediatric Patients
Mariam Mian: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Mariam Mian, Nadia O. Alwasiah Source Type: research

Poster 137: Incidence and Safety of Botulinum Toxin Type A Injections for Pediatric Patient with Cerebral Palsy
Denesh Ratnasingam: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Denesh Ratnasingam, Emily McGhee, Ashley K. Sherman, Matthew J. McLaughlin Source Type: research

Poster 78: Examining the Role of Botulinum Toxin on Functional Outcomes in an Inpatient Setting (Preliminary Results)
Aaron Hanyu-Deutmeyer: My spouse/partner has a relationship with Allergan-Speakers bureau, My spouse/partner has a relationship with Allergan-provided Botox for injection (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Aaron A. Hanyu-Deutmeyer, Michael Fitzgerald, Anjum Sayyad Source Type: research

Botulinum neurotoxin injection for the treatment of epiphora in nasolacrimal duct obstruction.
CONCLUSION: Patients with epiphora can be treated effectively with BoNT/A to reduce lacrimal secretion of the principal lacrimal gland in its palpebral portion. Ninety percent of the patients were very satisfied, with few side effects (ptosis or mild diplopia lasting from 3 days to 3 weeks). More studies are needed to delineate which types of epiphora can be treated with BoNT/A. PMID: 28847443 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - August 31, 2017 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

The Role of Botulinum Toxin A in Treatment of Temporomandibular Joint Disorders: A Review
In this study, online databases including Scopus, Medline, Ebsco, Cochrane, EMBASE, and Google scholar were searched for the keywords “pterygoid muscle” and “Onabotulinumtoxin A”.Twenty-four articles were eligible to be enrolled in the study. In 4 interventional studies and 20 descriptive studies, BTX-A was used for the treatment of TMDs. The dosage and number of injections were different in each study; however, the injection methods were relatively similar. Regardless of the type, number of injections, and dosage, injection of BTX-A in lateral pterygoid seems effective in reducing the click sound a...
Source: Journal of Dentistry, Shiraz University of Medical Sciences - August 26, 2017 Category: Dentistry Source Type: research

Urge Incontinence: Updates in Non-pharmacologic Treatments
AbstractPurpose of reviewThe aim of this manuscript is to provide an overview of the recent literature on non-pharmacologic therapies for urgency urinary incontinence (UUI), specifically focusing on treatments for adult women who suffer from UUI in the setting of idiopathic overactive bladder syndrome (OAB).Recent findingsThis review describes recent studies examining the efficacy of biofeedback-assisted pelvic muscle therapy, the effect of bariatric surgery on urinary incontinence, alternative approaches for tibial and transcutaneous nerve stimulation, sacral neuromodulation as compared to botulinum toxin type A, and 5-ye...
Source: Current Obstetrics and Gynecology Reports - August 26, 2017 Category: OBGYN Source Type: research

Intraprostatic botulinum toxin type “A” injection in patients with benign prostatic hyperplasia and unsatisfactory response to medical therapy: A randomized, double‐blind, controlled trial using urodynamic evaluation
AimsThe injection of botulinum neurotoxin A (BTA) into the prostate represents a minimally invasive treatment in patients with lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia (BPH). We evaluated the effectiveness of BTA in treating patients with BPH unresponsive to combined medical therapy (CMT), using urodynamic investigations. MethodsThis is a randomized, placebo‐controlled, double blind trial. Twenty consecutive patients were randomly assigned to receive intraprostatic BTA injection (n = 10) or saline solution (SS) (n = 10). Patients in the intervention group ...
Source: Neurourology and Urodynamics - August 25, 2017 Category: Urology & Nephrology Authors: Angelo Totaro, Francesco Pinto, Dario Pugliese, Matteo Vittori, Marco Racioppi, Nazario Foschi, Pier Francesco Bassi, Emilio Sacco Tags: ORIGINAL CLINICAL ARTICLE Source Type: research

Intraprostatic botulinum toxin type “A” injection in patients with benign prostatic hyperplasia and unsatisfactory response to medical therapy: A randomized, double‐blind, controlled trial using urodynamic evaluation
Neurourology and Urodynamics, EarlyView. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - August 25, 2017 Category: Urology & Nephrology Source Type: research

Botulinum toxin in parkinsonism: The when, how, and which for botulinum toxin injections.
Abstract The aim of this article is to provide a review of the use of injections of botulinum toxin in the management of selected symptoms and signs of Parkinson's disease and other forms of parkinsonism. Sialorrhea is defined as inability to control oral secretions, resulting in excessive saliva in the oropharynx. There is a high level of evidence for the treatment of sialorrhea in parkinsonism with injections of different forms of botulinum toxin type A as well as botulinum toxin type B. Tremor can be improved by the use of botulinum toxin injections but improved tremor control often leads to concomitant motor w...
Source: Toxicon - August 23, 2017 Category: Toxicology Authors: Cardoso F Tags: Toxicon Source Type: research

Overactive bladder treatment: application of methylene blue to improve the injection technique of onabotulinum toxin A.
CONCLUSIONS: Applying a coloured solution of BTX-A significantly facilitates observation of the procedure and assessment of drug distribution. There are no pharmaceutical interactions between MB and BTX-A. PMID: 28816073 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - August 19, 2017 Category: Urology & Nephrology Tags: Scand J Urol Source Type: research

First Urology Simulation Boot Camp in the United Kingdom
Conclusion This first UK Urology Simulation Boot Camp has demonstrated feasibility and effectiveness in enhancing trainee’s experience. Given these positive feedbacks there is a good reason to expect that future courses will improve the overall skills of a new urology trainee. (Source: African Journal of Urology)
Source: African Journal of Urology - August 17, 2017 Category: Urology & Nephrology Source Type: research

What is the true catheterization rate after intravesical onabotulinumtoxinA injection?
AbstractIntroduction and hypothesisA known side effect of intravesical onabotulinumtoxinA (Botox ®) injection for overactive bladder (OAB) is urinary retention requiring clean intermittent catheterization (CIC), the fear of which deters patients from choosing this therapy. In clinical practice, patients with an elevated postvoid residual (PVR) are often managed by observation only, providing t hey do not have subjective complaints or contraindications. We sought to determine the true rate of urinary retention requiring CIC in clinical practice.MethodsA retrospective review was performed over a 3-year period of patients...
Source: International Urogynecology Journal - August 14, 2017 Category: OBGYN Source Type: research

Single-dose botulinum toxin type a compared with repeated-dose for treatment of trigeminal neuralgia: a pilot study
ConclusionsThe single- and repeated-dosing BTX-A regimens were largely comparable in efficacy and safety. This study suggests that repeated dosing has no advantage over single dosing of BTX-A for TN. Dosing should be adjusted for the individual patient. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - August 10, 2017 Category: Neurology Source Type: research

von Brunn's Nests and Follicular Cystitis Following Intradetrusor OnabotulinumtoxinA Injections for Overactive Bladder
Publication date: September 2017 Source:Urology Case Reports, Volume 14 Author(s): Silpa Nekkanti, Andrew Doering, Debra L. Zynger, Andrew F. Hundley A 67-year-old female with refractory OAB was treated with intradetrusor Botox. She subsequently developed multiple papillary bladder lesions with tissue biopsy showing Von Brunn's nests. Von Brunn’s nests are benign bladder lesions similar in appearance to a rare urothelial tumor called Nested Variant of Urothelial Carcinoma (NVUC). It is critical that patients with these findings undergo evaluation to rule out the presence of carcinoma. This finding suggests the possi...
Source: Urology Case Reports - August 9, 2017 Category: Urology & Nephrology Source Type: research

Non-surgical treatment for eyelid retraction in thyroid eye disease (TED).
;o CA Abstract Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. The aim of this review is to describe the non-surgical modalities currently available for treatment of eyelid malposition in TED. The authors hav...
Source: The British Journal of Ophthalmology - August 9, 2017 Category: Opthalmology Authors: Grisolia ABD, Couso RC, Matayoshi S, Douglas RS, Briceño CA Tags: Br J Ophthalmol Source Type: research

Determinants of botulinum toxin discontinuation in multiple sclerosis: a retrospective study
AbstractThe purpose of the present study was to investigate the long-term persistence to treatment with botulinum toxin type A (BoNT-A) for multiple sclerosis (MS)-related spasticity and the determinants of BoNT-A discontinuation in daily clinical setting. We retrospectively collected data of patients who started BoNT-A injections and underwent regular follow-up visits. Determinants of BoNT-A discontinuation were explored in a time-to-event Cox regression analysis which included as independent variables a large set of demographic and clinical characteristics. A total of 185 patients started BoNT-A injections from 2002 to 2...
Source: Neurological Sciences - August 1, 2017 Category: Neurology Source Type: research

Botulinum Toxin Injections Into the Lateral Cricoarytenoid Muscles for Vocal Process Granuloma
Contact granulomas are benign, exophytic inflammatory lesions of the larynx that typically arise on or near the vocal process of the arytenoid cartilage. The most common management options include voice therapy and antireflux pharmacotherapy, intralesional steroid injections, botulinum toxin injections, and surgical excision. In-office Botox injection into the lateral cricoarytenoid (LCA) muscle can be effective even for recurrent granulomas. (Source: Journal of Voice)
Source: Journal of Voice - August 1, 2017 Category: ENT & OMF Authors: Q. Pham, R. Campbell, J. Mattioni, R. Sataloff Source Type: research

The Effect of Intragastric Administration of Botulinum Toxin Type A on Reducing Adiposity in a Rat Model of Obesity Using Micro-CT and Histological Examinations.
Authors: Park JS, Zheng HM, Kim JM, Kim CS, Jeong S, Lee DH Abstract Background/Aims: Botulinum toxin type A (BTX), a long-acting inhibitor of muscular contraction in both striated and smooth muscles, is responsible for gastric motility. The aim of this study was to investigate the effects of an endoscopic intragastric BTX injection on weight loss, body fat accumulation, and gastric emptying time. Methods: The BTX group consisted of 15 obese rats in which 20 U of BTX were injected into the gastric antrum. The saline group consisted of 15 obese rats injected with 20 U of saline, and the control group included 10...
Source: Gut and Liver - July 30, 2017 Category: Gastroenterology Tags: Gut Liver Source Type: research

Modification of Chin Projection and Aesthetics With Botox Injection
This case series report evaluates the use of onabotulinumtoxinA for improving chin aesthetics in patients with an underprojected bony chin and a high-riding hyperactive mentalis muscle. (Source: JAMA Facial Plastic Surgery)
Source: JAMA Facial Plastic Surgery - July 27, 2017 Category: Cosmetic Surgery Source Type: research

Use of botulinum toxin type a in temporomandibular disorder
In conclusion, the use of botulinum toxin in patients with temporomandibular disorder should be considered as a viable therapeutic option.RESUMO A desordem temporomandibular pode ser definida como um conjunto de dist úrbios que envolvem os músculos mastigatórios, a articulação temporomandibular e estruturas associadas. Atualmente entre 40 a 75% da população apresenta algum sinal de desordem temporomandibular, sendo o mais frequente a dor, principalmente localizada nos músculos da mastigação e na regiã o pré-auricular. O caso clínico ...
Source: RGO - Revista Gaucha de Odontologia - July 24, 2017 Category: Dentistry Source Type: research

Botox and Thumb MCP Radial Collateral Ligament Reconstruction
We report the use of botulinum toxin to aid in the treatment of chronic radial collateral ligament insufficiency of the thumb. Case Description Treatment included autograft tendon reconstruction and cast immobilization. Six weeks postoperatively, prior to hand therapy, the patient underwent an ultrasound-guided botulinum neurotoxin A injection into the adductor pollicis muscle to negate its deforming forces on the reconstruction. The patient made an excellent recovery and 1 year postoperatively was pain free and had a stable radial collateral ligament (RCL) upon examination. Literature Review The o...
Source: Journal of Wrist Surgery - July 24, 2017 Category: Orthopaedics Authors: Cates, Robert A. Brault, Jeffrey S. Kakar, Sanjeev Tags: Case Report Source Type: research

Functional popliteal artery entrapment syndrome: use of ultrasound guided Botox injection as a non-surgical treatment option
ConclusionsUltrasound-guided BTX-A injection represents a viable alternative to surgery in the treatment of functional PAES. Further study will help determine the optimum dose and frequency of injection to prevent recurrence of symptoms. (Source: Skeletal Radiology)
Source: Skeletal Radiology - July 20, 2017 Category: Radiology Source Type: research

Benefits and Risks of Non-Approved Injection Regimens for Botulinum Toxins in Spasticity
AbstractSpasticity with muscle paresis and loss of dexterity is a common feature of upper motor neuron syndrome due to injuries or the pyramidal tract in several neurological conditions. Botulinum toxin type A has been considered the gold standard treatment for spasticity and movement disorders, with efficacy, reversibility, and low prevalence of complications. During the last 30  years, thousands of studies of its use have been performed, but few guidelines are available. Therefore, there is great variability in both the doses and intervals of administration and the approaches taken by clinicians with considerable ex...
Source: Drugs - July 19, 2017 Category: Drugs & Pharmacology Source Type: research

The management of paediatric neurogenic bladder: an approach in a resource-poor setting.
CONCLUSION: Children with neurogenic bladder in resource-poor settings should have early bladder management to preserve renal function and provide social continence. PMID: 28714784 [PubMed - as supplied by publisher] (Source: Paediatrics and international child health)
Source: Paediatrics and international child health - July 18, 2017 Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research

Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice
Publication date: 1 September 2017 Source:Neuroscience, Volume 358 Author(s): Ivica Matak, Valéria Tékus, Kata Bölcskei, Zdravko Lacković, Zsuzsanna Helyes The antinociceptive action of botulinum toxin type A (BoNT/A) has been demonstrated in behavioral animal studies and clinical settings. It was shown that this effect is associated with toxin activity in CNS, however, the mechanism is not fully understood. Substance P (SP) is one of the dominant neurotransmitters in primary afferent neurons transmitting pain and itch. Thus, here we examined association of SP-mediated transmission and BoNT/A antinocic...
Source: Neuroscience - July 18, 2017 Category: Neuroscience Source Type: research

Evaluation of botulinum toxin type A effectiveness in preventing postoperative intraperitoneal adhesions.
In this study, we aimed to evaluate the effectiveness of local application of botulinum toxin type A (BoNT-A) in various dosages on the prevention of intra-abdominal adhesions in rats with experimental intra-abdominal adhesions. METHODS: Forty Wistar Albino female rats were randomly separated into 4 groups. The 4 groups were determined as follows: Control (group 1, n = 10); Sham (group 2, n = 10); 10-µg/kg low-dose BoNT-A (group 3, n = 10) and 30-µg/kg high-dose BoNT-A (group 4, n = 10). Subserosal injuries were created on the caecum of all rats. Laparotomy was performed on the fifth day. Adhesion scores, h...
Source: Annals of Surgical Treatment and Research - July 16, 2017 Category: Surgery Tags: Ann Surg Treat Res Source Type: research

A novel anesthetic technique for palmar botulinum toxin injection
Botulinum toxin type A effectively treats persistent palmar hyperhidrosis, but treatment-associated pain limits utility.1 Topical anesthesia, ethyl chloride spray, and cold packs have shown limited success. Deep-wrist nerve blocks that target the median and ulnar nerves are effective but carry risks of vessel puncture, impaired hand dexterity, and needle-related nerve trauma. Because patients typically need repeated injections at regular intervals, the compounded risks make deep nerve blocks even less attractive. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - July 13, 2017 Category: Dermatology Authors: Stephanie T. Le, Cody Hanson, Anand N. Rajpara, Deede Y. Liu, Daniel J. Aires Tags: JAAD Online Source Type: research

Preoperative Preparation of “Loss of Domain” Hernia. Progressive Pneumoperitoneum and Botulinum Toxin Type A
Publication date: Available online 10 July 2017 Source:Cirugía Española (English Edition) Author(s): José Bueno-Lledó, Antonio Torregrosa Gallud, Raquel Jiménez Rosellón, Fernando Carbonell Tatay, Providencia García Pastor, Santiago Bonafé Diana, José Iserte Hernández Preoperative progressive pneumoperitoneum and botulinum toxin type A are useful tools in the preparation of patients with loss of domain hernias. Both procedures are complementary in the surgical repair, especially with the use of prosthetic techniques without tension, that allow a integra...
Source: Cirugia Espanola - July 10, 2017 Category: Surgery Source Type: research

The Italian real-life post-stroke spasticity survey: unmet needs in the management of spasticity with botulinum toxin type A.
Authors: Picelli A, Baricich A, Cisari C, Paolucci S, Smania N, Sandrini G Abstract The present national survey seeking to identify unmet needs in the management of spasticity with botulinum toxin type A focused on the use of OnabotulinumoxinA, since this is the brand with the widest range of licensed indications in Italy. Physicians from twenty-four Italian neurorehabilitation units compiled a questionnaire about "real-life" post-stroke spasticity management. OnabotulinumtoxinA was reported to be used in the following average doses: upper limb 316.7 ± 79.1 units; lower limb 327.8 ± 152.3; u...
Source: Functional Neurology - July 7, 2017 Category: Neurology Tags: Funct Neurol Source Type: research

Clinical practice of BOTOX( ®) treatment for overactive bladder syndrome in Sweden: an assessment of resource use and external validity.
CONCLUSIONS: Patient characteristics in the real world were similar to those in the clinical trials, showing a high degree of external validity. Treatment intervals were longer in the real world than in clinical trials, indicating that treatment cost could be lower when patients are treated as observed in real-world clinical practice. PMID: 28678587 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - July 7, 2017 Category: Urology & Nephrology Tags: Scand J Urol Source Type: research

Botolinum toxin in rhinitis: Literature review and posterior nasal injection in allergic rhinitis
ConclusionBased on our review of current literature, BTX shows clear efficacy on symptoms of both intrinsic and allergic rhinitis, with a good safety profile. Single‐dose posterior nasal injection demonstrates good efficacy and duration of action, with moderate discomfort. Level of Evidence4. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - July 6, 2017 Category: ENT & OMF Authors: Edward Zhiyong Zhang, Sophocles Tan, Ian Loh Tags: Allergy/Rhinology Source Type: research

The Role of Endoscopic Intra-Gastric Botulinum Toxin-A for Obesity Treatment
AbstractObesity prevalence has been increasing with devastating health and economic consequences. Botulinum toxin type A (BTX-A), a neurotoxin, is used clinically for conditions characterized by prolonged muscular contraction. Its inhibitory effects on gastric smooth muscles, in theory, make it a potential agent for obesity treatment through delayed gastric emptying and increased satiety. This review aims to examine the evidence for the use of endoscopic BTX-A injection for treating obesity. The literature search identified 60 articles with 11 primary studies as relevant for the scope of the review. Several studies have be...
Source: Obesity Surgery - July 6, 2017 Category: Surgery Source Type: research

Esotropia following botulinum toxin type A injection for facial wrinkles
. (Source: Journal of Cosmetic and Laser Therapy)
Source: Journal of Cosmetic and Laser Therapy - July 6, 2017 Category: Laser Surgery Authors: Soo-Keun Lee Hee Jin Jun Source Type: research

Trends and demographic characteristics of Saudi cosmetic surgery patients.
Conclusion: There is a possible positive correlation between gender and undergoing cosmetic procedure. Laser hair removal, botox, liposuction, filler, and scar revision are common among females, while rhinoplasty is a common procedure among males. PMID: 28674720 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - July 6, 2017 Category: Middle East Health Tags: Saudi Med J Source Type: research

Current Treatment Options for Bilateral Vocal Fold Paralysis: A State-of-the-Art Review.
Authors: Li Y, Garrett G, Zealear D Abstract Vocal fold paralysis (BVFP) refers to neurological causes of reduced or absent movement of one or both vocal folds. Bilateral BVFP is characterized by inspiratory dyspnea due to narrowing of the airway at the glottic level with both vocal folds assuming a paramedian position. The primary objective of intervention for BVFP is to relieve patients' dyspnea. Common clinical options for management include tracheostomy, arytenoidectomy and cordotomy. Other options that have been used with varying success include reinnervation techniques and botulinum toxin (Botox) injections i...
Source: Clinical and Experimental Otorhinolaryngology - July 4, 2017 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Selfie culture not to blame for rise of botox
Publication date: 1 July 2017 Source:New Scientist, Volume 235, Issue 3132 Author(s): Clare Wilson (Source: New Scientist)
Source: New Scientist - July 1, 2017 Category: Science Source Type: research

Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model
Background: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. Methods: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D). These specimens were implanted into the backs of nude mice after intralesional injection from each group and were observed fo...
Source: Plastic and Reconstructive Surgery - June 30, 2017 Category: Cosmetic Surgery Tags: Experimental: Original Articles Source Type: research

Declarative Title: Botulinum toxin A might be an alternative or adjunct therapy for the treatment of trigeminal and postherpetic neuralgia
Publication date: Available online 29 June 2017 Source:Journal of Evidence Based Dental Practice Author(s): Ya-Wei Chen, Sung-Kiang Chuang Article Title and Bibliographic Information The efficacy of botulinum toxin for the treatment of trigeminal and postherpetic neuralgia: a systematic review with meta-analyses. Shackleton T, Ram S, Black M, Ryder J, Clark GT, Enciso R. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122(1):61-71. Reviewer(s) Name and Contact Information Ya-Wei Chen, DDS, Sung-Kiang Chuang, DMD, MD, DMSc Purpose/Question Does botulinum toxin type A (BoTN-A) contribute to pain intensity reduction in trige...
Source: Journal of Evidence Based Dental Practice - June 29, 2017 Category: Dentistry Source Type: research

Achalasia: It ’s Not All About the Lower Esophageal Sphincter
Question: A 66-year-old man with cirrhosis secondary to hepatitis C (complicated with development of esophageal varices) and achalasia (diagnosed in 1980s, failed Botox injections, pneumatic dilatation, calcium channel blockers, and now status post  percutaneous endoscopic gastrostomy tube placement for feedings) presented as a referral for evaluation and management of achalasia. He was deemed to be a very high-risk surgical myotomy candidate owing to cirrhosis and signs of portal hypotension (platelets of 55,000 and International Normalized Ratio of 1.4). (Source: Gastroenterology)
Source: Gastroenterology - June 29, 2017 Category: Gastroenterology Authors: Dhyanesh A. Patel, William E. Gibson, Michael F. Vaezi Tags: Electronic Clinical Challenges and Images in GI Source Type: research

IncobotulinumtoxinA for Aesthetic Indications: A Systematic Review of Prospective Comparative Trials
CONCLUSION: The weight of the evidence from comparative clinical trials indicates that incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA have similar efficacy for aesthetic applications. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - June 27, 2017 Category: Dermatology Tags: Original Article Source Type: research

Management of refractory idiopathic overactive bladder: intradetrusor injection of botulinum toxin type A versus posterior tibial nerve stimulation.
CONCLUSIONS: Intradetrusor injection of BTX-A and PTNS are both effective to manage refractory idiopathic OAB. BTX-A is more effective than PTNS and is also durable, minimally invasive, reversible, and safe, but it also has more side effects. PMID: 28646940 [PubMed - in process] (Source: Canadian Journal of Urology)
Source: Canadian Journal of Urology - June 26, 2017 Category: Urology & Nephrology Tags: Can J Urol Source Type: research

First case of anaphylaxis after botulinum toxin type A injection
We report a case of anaphylaxis induced by intramuscular BTA injection into the masseter muscles of a 35‐year‐old woman. She had previously received injections of the identical BTA product into the same muscles without incident. However, during the reported procedure, symptoms suggestive of angio‐oedema and anaphylaxis developed about 5 min after BTA injection. Intramuscular epinephrine was used to manage the reaction. Following this, the patient was found to have an elevated total serum IgE level. We could not perform testing with BTA because of the risk of triggering another episode of anaphylaxis; however, in...
Source: Clinical And Experimental Dermatology - June 22, 2017 Category: Dermatology Authors: I. J. Moon, S. E. Chang, S. D. Kim Tags: Concise report Source Type: research

Don ’t blame Instagram for the rise of botox and lip fillers
A new report rightly suggests that non-surgical cosmetic procedures need tighter regulation, but stumbles by blaming selfies and social media for their popularity (Source: New Scientist - Health)
Source: New Scientist - Health - June 22, 2017 Category: Consumer Health News Source Type: research

Re: Cost-Effectiveness Analysis of Anticholinergics versus Botox for Urgency Urinary Incontinence: Results from the Anticholinergic versus Botox Comparison Randomized Trial
A. G. Visco, H. Zyczynski, L. Brubaker, I. Nygaard, X. Xu, E. S. Lukacz, M. F. Paraiso, J. Greer, D. D. Rahn, S. F. Meikle and A. A. Honeycutt (Source: The Journal of Urology)
Source: The Journal of Urology - June 19, 2017 Category: Urology & Nephrology Authors: Alan J. Wein Tags: Urological Survey Source Type: research

Recovery of rat muscle size but not function more than 1 year after a single botulinum toxin injection
ConclusionsThe data demonstrate that, after a single BT‐A injection, although gross muscle morphology recovered over a 12‐month time period, loss of contractile function did not recover. Muscle Nerve, 2017 (Source: Muscle and Nerve)
Source: Muscle and Nerve - June 15, 2017 Category: Internal Medicine Authors: Samuel R. Ward, Viviane B. Minamoto, Kentaro P. Suzuki, Jonah B. Hulst, Shannon N. Bremner, Richard L. Lieber Tags: Basic Science Research Article Source Type: research

Posture-Dependent Dysphagia After Botulinum Toxin Type A Injection at Sternocleidomastoid in a Patient With Athetoid Cerebral Palsy.
We report a unique case of posture-dependent dysphagia due to preactivation of the suprahyoid and infrahyoid muscles to compensate for impaired head stabilization by the weakened sternocleidomastoid muscle while swallowing. This case suggests a possible mechanism of dysphagia in patients with athetoid cerebral palsy. PMID: 28604409 [PubMed - as supplied by publisher] (Source: Physica Medica)
Source: Physica Medica - June 9, 2017 Category: Physics Authors: Chang WK, Kim K, Seo HG, Leigh JH, Bang MS Tags: Am J Phys Med Rehabil Source Type: research

The effect of botulinum toxin A (Botox) injections used to treat limb spasticity on speech patterns in children with dysarthria and cerebral palsy: A report of two cases.
This report presents results of longitudinal speech evaluation of two children with CP given injections of Btx-A for treatment of limb spasticity. Speech evaluations were accomplished at baseline (date of injections) and 4- and 10-weeks post-injections. Improvements in production of consonants, loudness control, and syllables produced per breath were found. Parental survey also suggested improvements in subjects' speech production and willingness to speak outside the testing situation. Future larger studies are warranted to assess the nature of the changes observed related to Btx-A. PMID: 28582880 [PubMed - in process]...
Source: Journal of Pediatric Rehabilitation Medicine - June 8, 2017 Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research

Side effects and potential risk factors of botulinum toxin type A intramuscular injections in knee flexion contractures of hemophiliacs.
Authors: Rodriguez-Merchan EC, De la Corte-Rodriguez H Abstract INTRODUCTION: Knee flexion contracture (KFC) is a common complication of recurrent hemarthrosis in children and young adults with hemophilia. If the KFC is not prevented (by means of primary prophylaxis) and treated properly and early (be means of physical medicine and rehabilitation) it will become fixed. Areas covered: The aim of this article is to review the potential role of botulinum toxin type A (BTX-A) intramuscular injections for the treatment of KFC in people with hemophilia (PWH). Expert commentary: Although two recent reports have mentioned ...
Source: Expert Review of Hematology - June 8, 2017 Category: Hematology Tags: Expert Rev Hematol Source Type: research