Assessing the immediate impact of botulinum toxin injection on impedance of spastic muscle
Since the 1980s, Botulinum toxin type A (BoNT-A) has been widely used in the management of spasticity caused by stroke, spinal cord injury, or cerebral palsy [1 –5]. The underlying mechanisms of BoNT-A is that it can effectively block the release of acetylcholine from the nerve endings, thus producing a progressive paralysis of the muscle [1,6]. Subsequent to the intramuscular BoNT-A injection, alterations in the physiological and mechanical properties of muscle have been reported in histological, mechanical, and medical imaging studies [7–11]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - February 4, 2017 Category: Biomedical Engineering Authors: Xiaoyan Li, Henry Shin, Le Li, Elaine Magat, Sheng Li, Ping Zhou Tags: Technical note Source Type: research

Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis
Introduction Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A (OnaBotA; Botox Allergan, Dublin, Ireland) is a highly effective option for these patients. The local effects of OnaBotA are well understood, but not much is known of its afferent/sensory effects while treating the end organ. Ou...
Source: BMJ Open - February 3, 2017 Category: Journals (General) Authors: Elizondo, R. A., Karmonik, C., Boone, T. B., Khavari, R. Tags: Open access, Neurology, Radiology and imaging, Research methods, Urology, Obgyn Protocol Source Type: research

Anatomical relationships of the procerus with the nasal ala and the nasal muscles: transverse part of the nasalis and levator labii superioris alaeque nasi
ConclusionThis study has yielded crucial data for understanding the anatomical relationships and functions of the procerus in relation to the nose. They will be helpful when designing effective therapies involving botulinum toxin type A, performing various types of rhinoplasty and facial surgeries, and in electromyography analyses. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - January 28, 2017 Category: Anatomy Source Type: research

Topical Review: Potential Use of Botulinum Toxin in the Management of Painful Posttraumatic Trigeminal Neuropathy.
Authors: Moreau N, Dieb W, Descroix V, Svensson P, Ernberg M, Boucher Y Abstract Painful posttraumatic trigeminal neuropathy (PPTTN) is a chronic condition that is difficult to endure and has a poorly understood pathophysiology. Treatment options are limited and often unsatisfactory due to insufficient efficacy and significant adverse effects. Botulinum toxin type A (BTX-A), initially used in the management of pathologically sustained or twisting muscular contractions, has recently been advocated for treatment of neuropathic pain. Its action is not limited to the blockage of acetylcholine release at the neuromuscul...
Source: Journal of Orofacial Pain - January 25, 2017 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Preoperative progressive pneumoperitoneum and botulinum toxin type A in patients with large incisional hernia
AbstractPurposeCombination of preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) has not been previously reported in the management of large incisional hernia (LIH).MethodsObservational study of 45 consecutive patients with LIH between June 2010 and July 2014. The diameters of the hernia sac, the volumes of the incisional hernia (VIH) and the abdominal cavity (VAC), and the VIH/VAC ratio were measured before and after PPP and BT using abdominal CT scan data. We indicated the combination of both techniques when the volume of the incisional hernia (VIH)/volume of the abdominal cavity (VAC) ratio ...
Source: Hernia - January 25, 2017 Category: Sports Medicine Source Type: research

Treatment of the first bite syndrome.
, Gómez J, Llorente JL Abstract First bite syndrome is a potential complication of surgery involving the infratemporal fossa, deep lobe of the parotid gland and parapharyngeal space. It is described as an acute and intense pain in the parotid region caused with the first bite of each meal. It is related to damage to sympathetic innervation of the parotid gland. Parasympathetic hyperactivation is believed to stimulate an exaggerated myoepithelial cell contraction causing pain. Usual analgesic treatments have poor results. Botulinum toxin type A causes parasympathetic nerve paralysis of the parotid gland and ...
Source: Acta Otorrinolaringologica Espanola - January 21, 2017 Category: ENT & OMF Authors: Costales-Marcos M, López Álvarez F, Fernández-Vañes L, Gómez J, Llorente JL Tags: Acta Otorrinolaringol Esp Source Type: research

Factors in the Efficacy, Safety, and Impact on Quality of Life for Treatment of Drooling with Botulinum Toxin Type A in Patients with Cerebral Palsy
Objective: To assess the efficacy and safety of botulinum toxin A (BoNT-A) injected in both submandibular and parotid versus only in parotid glands as a treatment for drooling in patients with spastic and dyskinetic cerebral palsy (CP), including an assessment of impact on quality of life (QoL) based on items from the International Classification of Functioning, Disability, and Health (ICF) core set. Design: Forty patients with CP 18 years or older (mean, 21.8 years) participated in a prospective, single-center, randomized controlled interventional study. All participants were classified as Gross Motor Function Classifica...
Source: American Journal of Physical Medicine and Rehabilitation - January 19, 2017 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Facial Contouring With Fillers, Neuromodulators, and Lipolysis to Achieve a Natural Look in Patients With Facial Fullness.
CONCLUSION: Use of HA-based fillers, neuromodulators (botulinum toxin), and injectable lipolytics are well-tolerated and are effective nonsurgical modalities to achieve facial recontouring for slimming of the face. J Drugs Dermatol. 2016;15(12):1536-1542. PMID: 28095576 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 19, 2017 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

[Botox ® treatments - still not reimbursed by insurance?]
[Botox® treatments - still not reimbursed by insurance?] Urologe A. 2017 Jan 13;: Authors: Ackermann KH PMID: 28084494 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - January 13, 2017 Category: Urology & Nephrology Authors: Ackermann KH Tags: Urologe A Source Type: research

[Neurogenic detrusor overactivity and onabotulinumtoxin A (Botox( ®)) : Is perioperative antbiotic prophylaxis unnecessary?]
[Neurogenic detrusor overactivity and onabotulinumtoxin A (Botox(®)) : Is perioperative antbiotic prophylaxis unnecessary?] Urologe A. 2017 Jan 09;: Authors: Kaufmann A PMID: 28070606 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - January 9, 2017 Category: Urology & Nephrology Authors: Kaufmann A Tags: Urologe A Source Type: research

Subcutaneous Botulinum Toxin Injection for Post-Thoracotomy Pain Syndrome in Palliative Care: A Case Report.
Abstract Post-thoracotomy pain syndrome (PTPS) is a traumatic neuropathy that can affect as many as 50% of patients undergoing thoracotomy. Patients are often refractory to conservative management and may require multiple analgesics for adequate pain control. Botulinum toxin, derived from Clostridium botulinum, has many uses in treating conditions involving spasticity, dystonia, chronic migraine, and a variety of pain disorders including neuropathies. Botulinum toxin type A injections may provide an alternative or adjunct to improve symptom management in patients with PTPS. PMID: 28641445 [PubMed - as supplie...
Source: The American Journal of Hospice and Palliative Care - January 1, 2017 Category: Palliative Care Authors: Rashid S, Fields AR, Baumrucker SJ Tags: Am J Hosp Palliat Care Source Type: research

Botox as an adjunct to lip repositioning for the management of excessive gingival display in the presence of hypermobility of upper lip and vertical maxillary excess
Conclusion: For patients desiring a less invasive alternative to orthognathic surgery, the mucosalrepositioned flap is a viable alternative. Moreover, Botox is a useful adjunct to enhance the estheticsand improve patient satisfaction where surgery alone may prove inadequately in moderate VME.Key Words: Botox, gum, smiling, lip, repositioning (Source: Dental Research Journal)
Source: Dental Research Journal - December 19, 2016 Category: Dentistry Source Type: research

Applicability of botulinum toxin type A in paediatric neurogenic bladder management
Purpose of review: The purpose of this article is to provide an overview about the applicability of botulinum toxin type A (BTX-A) in paediatric neurogenic bladder based on the recently published literature combined with hypothetical notes and future perspectives. Recent findings: The indications, clinical outcomes, urodynamic outcome parameters and cost-effectiveness are presented from recent publications. Also, alternative routes of application of BTX-A in the bladder are discussed as well as the influence of BTX-A on conservative and invasive treatment. Summary: Intradetrusor BTX-A injections for neurogenic bladder dy...
Source: Current Opinion in Urology - December 2, 2016 Category: Urology & Nephrology Tags: PEDIATRIC UROLOGY: Edited by David A. Diamond and Tom de Jong Source Type: research

Aesthetic Applications of Botulinum Toxin A in Asians: An International, Multidisciplinary, Pan-Asian Consensus
Source: Plastic and Reconstructive Surgery Global Open - December 1, 2016 Category: Cosmetic Surgery Tags: Original Article Source Type: research

Anatomical Regional Targeted (ART) BOTOX Injection Technique: A Novel Paradigm for Migraines and Chronic Headaches
Source: Plastic and Reconstructive Surgery Global Open - December 1, 2016 Category: Cosmetic Surgery Tags: Ideas and Innovations Source Type: research

Restriction of Postoperative Joint Loading in a Murine Model of Anterior Cruciate Ligament Reconstruction: Botulinum Toxin Paralysis and External Fixation
This study introduces a robust research tool to allow control of postoperative joint loading in animal models such as ACL reconstruction, permitting study of the effects of mechanical load on the biologic aspects of tendon-to-bone healing. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Knee Surgery)
Source: Journal of Knee Surgery - December 1, 2016 Category: Orthopaedics Authors: Lebaschi, Amir Deng, Xiang-Hua Coleman, Nathan W. Camp, Christopher L. Zong, Jianchun Carbone, Andrew Carballo, Camila B. Cong, Guang-Ting Album, Zoe M. Rodeo, Scott A. Tags: Original Article Source Type: research

An audit of the efficacy of Botulinum toxin for myofascial pain
We undertook a prospective audit of the efficacy of botox use for myofascial pain in the face. Inclusion criteria were age over 16, diagnosis of myofascial pain only (ie no joint component), failed conservative measures, and attended follow upat 3 and 6 months. Outcome measures were pain score (recorded on a visual analogue pain chart) and maximal interincisal opening (MIO). We used an evidence based gold standard of a 50% reduction in pain score and 17% increase in MIO.The first cycle included eight patients, patents were given25 units of botulinum toxin into the masseter muscles, with a further 50u. (Source: The British ...
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2016 Category: ENT & OMF Authors: Stephanie Milne, Lachlan Carter, Tamsin Cooper Tags: P173 Source Type: research

Can botox and hyaluronic acid fillers really improve a patient's psychological well-being?
This study aims to look into whether Botox and filler treatments can improve quality of life. So far, these treatments have been praised for being safer and quicker alternatives to surgery, but they have not been commended as to how well they can improve a patient's confidence and psychological well being. Patients who had received facial injections of Botox and hyaluronic acid fillers were retrospectively interviewed regarding their treatment satisfaction. (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2016 Category: ENT & OMF Authors: Meera Chauhan, Ibraz Siddique, Ricardo Mohammed-Ali Tags: P224 Source Type: research

Management of parotid sialocoeles with USS guided BOTOX injections
Introduction: The management of parotid sialocoeles has developed during the years. Surgical management for such a benign condition can be considered overtreatment considering the risks. Not doing anything can also be unwelcomed by the patient. USS guided Botox injection offers a good alternative with minimal risks and good outcomes (Source: The British Journal of Oral and Maxillofacial Surgery)
Source: The British Journal of Oral and Maxillofacial Surgery - December 1, 2016 Category: ENT & OMF Authors: Konstantinos Tzanidakis, Catherine Moss, Colin Liew, Simon Morley Tags: P240 Source Type: research

Clinical outcomes of Botox injections for chronic temporomandibular disorders: do we understand how Botox works on muscle, pain, and the brain?
The main objective of this retrospective review was to analyze the clinical outcomes following the use of botulinum toxin (onabotulinumtoxinA, Botox) injections to relieve the symptoms of chronic temporomandibular disorders (TMD). Seventy-one patients with a diagnosis of TMD (according to the RDC/TMD international consortium) associated with or without bruxism and refractory to conventional treatment (e.g. oral appliances, physiotherapy, etc.) received Botox injections into the temporalis and masseter muscles. (Source: International Journal of Oral and Maxillofacial Surgery)
Source: International Journal of Oral and Maxillofacial Surgery - November 28, 2016 Category: ENT & OMF Authors: S.T. Connelly, J. Myung, R. Gupta, G.M. Tartaglia, A. Gizdulich, J. Yang, R. Silva Tags: Clinical Paper Source Type: research

The efficacy of 2 formulations of botulinum toxin type A for masseter reduction: A split-face comparison study.
Authors: Wanitphakdeedecha R, Ungaksornpairote C, Kaewkes A, Sathaworawong A, Lektrakul N, Manuskiatti W Abstract BACKGROUND: Botulinum toxin type A (BTA) is now extensively used to address cosmetic concerns. OnabotulinumtoxinA (ONA, Botox; Allergan Inc., Irvine, CA) received FDA approval for upper face rejuvenation, including glabella frown lines and crow's-feet lines. The other off-label uses for lower face conditions have been utilized for contouring purposes, especially masseter hypertrophy. Recently, a new Daewoong BTA, (Nabota, NBT, Daewoong Pharmaceutical, Seoul, Korea), was recently introduced. OBJECTIV...
Source: Journal of Dermatological Treatment - November 27, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

An Experimental Study on Botulinum Toxin Type A for the Treatment of Excessive Secretion after Submandibular Gland Transplantation in Rabbits.
Conclusion. BTXA could effectively control excessive secretion after SMG transplantation in rabbits. PMID: 27840738 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 16, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Botulinum Toxin Injection for Treatment of Chronic Anal Fissure: Is There Any Dose-Dependent Efficiency? A Meta-Analysis
ConclusionsBT injection has been an accepted method for the management of CAF. Surprisingly, there is no dose-dependent efficiency, and the postoperative incontinence rate is not related to the BT dosage regardless the type of formulation of botulinum neurotoxin used. Moreover, no difference in healing rate has been observed in regard to the site and number of injections per session. (Source: World Journal of Surgery)
Source: World Journal of Surgery - November 11, 2016 Category: Surgery Source Type: research

Efficacy and safety of Botulinum Toxin type A for upper limb spasticity after stroke or traumatic brain injury: a systematic review with meta-analysis and trial sequential analysis.
CONCLUSIONS: As compared with placebo, Botulinum Toxin type A injections have beneficial effects with improved muscle tone and well-tolerated treatment for patients with upper limb spasticity post stroke or traumatic brain injury. PMID: 27834471 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
Source: European Journal of Physical and Rehabilitation Medicine - November 11, 2016 Category: Rehabilitation Authors: Dong Y, Wu T, Hu X, Wang T Tags: Eur J Phys Rehabil Med Source Type: research

Intra-articular injection of Botulinum toxin A reduces neurogenic inflammation in CFA-induced arthritic rat model.
Abstract Currently, administration of Botulinum toxin Type A (BoNT/A) to treat arthritic pain has promising efficacy in clinical research. However, the mechanisms underlying anti-neurogenic inflammation mediated by BoNT/A remains unclear. The aim of this study was to demonstrate the effectiveness in macro and micro levels and to explore the causal mechanism of BoNT/A. Wistar rats (n = 60) were injected with 50ul complete Freund's adjuvant (CFA) in the left ankle joint capsule to establish a model of chronic monoarthritis. Pain behaviour (Evoked pain assessment) and infrared thermal imaging testing were p...
Source: Toxicon - November 9, 2016 Category: Toxicology Authors: Li T, Wang L, Wang K, Chu X, Shen N, Fan C, Niu Z, Zhang X, Hu L Tags: Toxicon Source Type: research

Ultrasound-guided intrasphincteric botulinum toxin injection relieves obstructive defecation due to Hirschsprung's disease and internal anal sphincter achalasia
Chronic obstructive defecation can occur in patients with Hirschsprung Disease (HD) and internal anal sphincter (IAS) achalasia. Injection of Botulinum Toxin (BoTox) into the IAS can temporarily relieve obstructive defecation, but can be challenging when performed by tactile sense alone. We compared results of BoTox injections with and without ultrasound (US) guidance. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - November 8, 2016 Category: Surgery Authors: Joseph T. Church, Samir K. Gadepalli, Toghrul Talishinsky, Daniel H. Teitelbaum, Marcus D. Jarboe Source Type: research

Analgesic Effect of Botulinum Toxin A in Myofascial Pain Syndrome Patients Previously Treated with Local Infiltration of Anesthetic and Steroids.
Authors: Cartagena-Sevilla J, García-Fernández MR, Vicente-Villena JP Abstract The purpose of this study was to evaluate the analgesic effect of botulinum toxin A (BoNTA) injections in patients with myofascial pain syndrome (MPS) who were previously treated with the local infiltration of anesthetic and steroids (LIAS). The study included a retrospective phase and a longitudinal open-label prospective phase, which were conducted on consecutive patients with MPS previously treated with the local infiltration of anesthetic (levobupivacaíne 0.25%) and steroids (triamcinolone 40 mg). Eligible patien...
Source: Journal of Pain and Palliative Care Pharmacotherapy - November 3, 2016 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

The Creator of Botox Never Cared about Wrinkles
He invented it to treat strabismus; it's now used for everything from migraines and chewing problems to drooling, hair loss and urinary incontinence -- Read more on ScientificAmerican.com (Source: Scientific American)
Source: Scientific American - November 3, 2016 Category: Science Authors: Chuck McCutcheon Tags: Health The Body Source Type: research

Is Botulinum Toxin Type A a Valuable Adjunct During Femoral Lengthening? A Randomized Trial.
CONCLUSIONS: Local injection of 200 IU BtX-A in the quadriceps muscles does not appear to reduce distraction-induced pain nor enhance ROM in the hip or knee during femoral lengthening. Additional studies are needed to evaluate the effect of larger doses or different injection methods. Based on our findings, we do not recommend routine use of botulinum injections during limb lengthening and believe any further use of this drug should only be in the context of a controlled trial. LEVEL OF EVIDENCE: Level II, therapeutic study. PMID: 27506971 [PubMed - in process] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - November 1, 2016 Category: Orthopaedics Authors: Park H, Shin S, Shin HS, Kim HW, Kim DW, Lee DH Tags: Clin Orthop Relat Res Source Type: research

The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats.
CONCLUSIONS:: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months. PMID: 27982258 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - November 1, 2016 Category: Surgery Authors: Camargo CP, Fernandes FA, Lee MH, Silva LC, Besteiro JM, Gemperli R Tags: Acta Cir Bras Source Type: research

Effect of Botulinum Toxin on Clonus
To conduct a systematic review of the literature that examined the effect of botulinum toxin type A on clonus. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - October 24, 2016 Category: Rehabilitation Authors: Vivekanand Thanikachalam, Chetan P. Phadke, Farooq Ismail, Chris Boulias Tags: Review article (Meta-analysis) Source Type: research

Impact of intravesical onabotulinumtoxinA on sexual function in women with OAB
AIMSUrgency urinary incontinence (UUI), and the symptoms of overactive bladder (OAB) have a negative impact on female sexual function. The aim of this study was to investigate the effect of intravesical onabotulinumtoxinA (Botox) injection on sexual function in women with OAB, using the multi domain Female Sexual Function Index (FSFI) questionnaire. METHODSSixty‐eight sexually active women with idiopathic OAB with at least one episode of UUI and ≥8 micturitions per 24 h were recruited. Patients completed the FSFI questionnaire before and 12 weeks after treatment with intravesical onabotulinumtoxinA injections. ...
Source: Neurourology and Urodynamics - October 4, 2016 Category: Urology & Nephrology Authors: Pawel Miotla, Rufus Cartwright, Katarzyna Skorupska, Michal Bogusiewicz, Ewa Markut ‐Miotla, Konrad Futyma, Tomasz Rechberger Tags: Original Clinical Article Source Type: research

The Effect of Intramural Botulinum Toxin Injections on the Elongation of the Piglet Oesophagus Is Time Dependent
Conclusion Elongation of the piglet esophagus was significantly improved with a 2-hour waiting period after BTX-A injection. Injections with BTX-A could be useful in oesophageal atresia, where primary anastomosis is not possible. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 3, 2016 Category: Surgery Authors: Dibbern, Christian Bakholdt Rose, Morten Elleb æk, Mark Bremholm Qvist, Niels Tags: Original Article Source Type: research

Botulinum Toxin Type-A (BoNT-A) Injections of the Corrugator Muscles for Aesthetics and Depression?
This article describes the origin of “facial feedback” by Charles Darwin nearly 150 years ago, as well as “emotional proprioception”—2 neuroanatomical concepts that help provide the scientific rationale behind the general influence facial muscles have on the emotional centers of the brain, and, specifically, how the corrugator muscles—involved with frowning—promote a gloomy mood. The journey researchers have taken to clinically qualify BoNT-A injections of the corrugator muscles—to inhibit frowning, and thereby mitigate depression—will also be highlighted so that aesthe...
Source: Plastic Surgical Nursing - October 1, 2016 Category: Nursing Tags: Departments: Aesthetic Department Source Type: research

Advancements and Refinement in Facial Neuromodulators
This article provides a stepwise approach to treat dynamic facial rhytides with neuromodulators, including indications, facial analysis, preparation and injection technique, post-procedure care, and complications. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - September 29, 2016 Category: Cosmetic Surgery Tags: Cosmetic: Video Source Type: research

Long-Term Loss of Function in Rat Skeletal Muscle After a Single Botox Injection
To determine the extent to which muscle functional properties recover in rat skeletal muscles after nearly the entire rat lifetime. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 27, 2016 Category: Rehabilitation Authors: Richard Lieber Source Type: research

ICF-WHO Model to Describe Goal Characteristics Among Individuals with Spasticity Receiving Botulinum Injections
Goal Attainment Scale (GAS) is used to assess functional gains in response to treatment. Specific characteristics of functional goals set by individuals receiving botulinum toxin type-A (BoNTA) injections for spasticity management are unknown. The primary objective of this study was to describe the characteristics of goals set by patients prior to BoNTA injections using The International Classification of Functioning, Disability and Health (ICF) developed by the World Health Organization and determine whether the pattern of spasticity distribution affects the type of goal(s) set. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 27, 2016 Category: Rehabilitation Authors: Chetan Phadke, Shannon Reid, Ayako Sasaki, Kevin Choi, Jaclyn Peters, Elizabeth Chapman, Andrew Tri, Farooq Ismail, Chris Boulias Source Type: research

Delayed Antitoxin Treatment of Two Adult Patients with Botulism after Cosmetic Injection of Botulinum Type A Toxin
Injection of botulinum toxin type A for cosmetic purposes is common. It is believed to be safe, but adverse reactions have been reported, including dysphagia, generalized paralysis, respiratory depression, and death caused by focal injection of the toxin. Early administration of antitoxin in patients with adverse reactions is the mainstay of management, but the time window for its clinical efficacy is not well defined. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - September 26, 2016 Category: Emergency Medicine Authors: Kit-Ling Fan, Yan-Li Wang, Gary Chu, Ling-Pong Leung Tags: Selected Topics: Toxicology Source Type: research

Iatrogenic Thenar Eminence Atrophy After Botox A Injection for Secondary Raynaud Phenomenon
No abstract available (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - September 24, 2016 Category: Rheumatology Tags: Letters to the Editor Source Type: research

Treatment with Botulinum Toxin Type A in Infants with Refractory Congenital Muscular Torticollis: A 10-Year Retrospective Study.
Publication date: September 2016 Source:PM&R, Volume 8, Issue 9, Supplement Author(s): Clarice N. Sinn, Robert J. Rinaldi (Source: PMandR)
Source: PMandR - September 24, 2016 Category: Rehabilitation Source Type: research

[Patient information before bladder wall injection of botulinum toxin A (Botox( ®)): Which essential items? Results of Delphi consensus from GENULF experts].
CONCLUSION: We identified accurate items considered as essential for preoperative information to patients before bladder wall injection of botulinum toxin A (Botox(®)) by a Delphi method recommended by HAS. LEVEL OF EVIDENCE: 4. PMID: 27647649 [PubMed - as supplied by publisher] (Source: Progres en Urologie)
Source: Progres en Urologie - September 22, 2016 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

Comparison between Steroid and Two Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia: A Randomized, Double-blind, Active Drug-controlled Pilot Study
To compare the effects of two different injection sites of low doses of botulinum toxin type A with steroid in treating lateral epicondylalgia. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 22, 2016 Category: Rehabilitation Authors: Yao-Hong Guo, Ta-Shen Kuan, Kuan-Lin Chen, Wei-Chih Lien, Pei-Chun Hsieh, I-Chieh Hsieh, Szu-Hao Chiu, Yu-Ching Lin Source Type: research

Comparison Between Steroid and 2 Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia: A Randomized, Double-Blind, Active Drug-Controlled Pilot Study
To compare the effects of 2 different injection sites of low doses of botulinum toxin type A with steroid in treating lateral epicondylalgia. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 22, 2016 Category: Rehabilitation Authors: Yao-Hong Guo, Ta-Shen Kuan, Kuan-Lin Chen, Wei-Chih Lien, Pei-Chun Hsieh, I-Chieh Hsieh, Szu-Hao Chiu, Yu-Ching Lin Tags: Original research Source Type: research

Onabotulinumtoxin-A treatment in Greek patients with chronic migraine
AbstractBackgroundChronic migraine is a disabling condition, with limited treatment options. We conducted an open label, single arm, prospective clinical trial, to assess the efficacy and safety of onabotulinumtoxin-A in Greek patients with chronic migraine. Since recent evidence suggests that a meaningful clinical response may be delayed until after a third onabotulinumtoxin-A administration, we aimed at assessing outcomes at this time point.MethodsA total of 119 patients with CM, scheduled to be treated with Onabotulinumtoxin-A (Botox ®) every 3 months, according to the approved indication and standard clinical ...
Source: The Journal of Headache and Pain - September 17, 2016 Category: Neurology Source Type: research

CORR Insights( ®): Is Botulinum Toxin Type A a Valuable Adjunct During Femoral Lengthening? A Randomized Trial.
CORR Insights(®): Is Botulinum Toxin Type A a Valuable Adjunct During Femoral Lengthening? A Randomized Trial. Clin Orthop Relat Res. 2016 Sep 14; Authors: Green SA PMID: 27637614 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - September 14, 2016 Category: Orthopaedics Authors: Green SA Tags: Clin Orthop Relat Res Source Type: research

Effective local anesthesia for onabotulinumtoxin A injections to treat hyperhidrosis associated with traumatic amputation.
CONCLUSIONS: We suggest using ice in combination with a topical anesthetic as an effective method for pain control that avoids general anesthesia in treating amputation-associated hyperhidrosis. PMID: 27617615 [PubMed - as supplied by publisher] (Source: Dermatol Online J)
Source: Dermatol Online J - September 13, 2016 Category: Dermatology Authors: Shi LL, Sargen MR, Chen SC, Arbiser JL, Pollack BP Tags: Dermatol Online J Source Type: research

Efficacy and Safety of IncobotulinumtoxinA in Asian Subjects: A Pooled Analysis of Clinical Trials in the Treatment of Glabellar Frown Lines.
CONCLUSIONS: Compared with non-Asians, a trend towards slightly higher responses was observed in Asians at maximum frown. There were no clinically relevant differences in the safety of incobotulinumtoxinA when administered to Asian and non-Asian subjects. J Drugs Dermatol. 2016;15(9):1084-1087. PMID: 27602970 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - September 9, 2016 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

New Clinical Analysis and Device for Botox Injections
Conclusions: Facial BT grid analysis lines allow an individualized treatment improving the long-term results. Juvapen permits a less painful injection. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - September 1, 2016 Category: Surgery Tags: Clinical Studies Source Type: research

Thyroarytenoid Botulinum Toxin Type A Injection for Refractory Chronic Cough
This case series describes self-reported outcomes and complications of patients with refractory chronic cough treated with bilateral electromyography-guided thyroarytenoid botulinum toxin type A injection. (Source: JAMA Otolaryngology - Head and Neck Surgery)
Source: JAMA Otolaryngology - Head and Neck Surgery - September 1, 2016 Category: ENT & OMF Source Type: research

Protocols for Diagnosis and Treatment of Medically Jaded Patients
The use of botulinum toxin injection as a new treatment for chronic (neurogenic) cough is new and novel. In an article by Sasieta and colleagues in this issue ofJAMA Otolaryngology —Head& Neck Surgery, 22 patients whose chronic coughing had been repeatedly evaluated and treated for many years without benefit received 31 distinct injections of very large doses of botulinum toxin type A (BtxA) into each thyroarytenoid muscle. In this retrospective study, response to treatment was assessed via telephone follow-up using patient self-reporting of percent improvement of cough at 1 and 2 months. The primary outcome of t...
Source: JAMA Otolaryngology - Head and Neck Surgery - September 1, 2016 Category: ENT & OMF Source Type: research