Effects of ultrasound-guided botulinum toxin type-A injections with a specific approach in spastic cerebral palsy
This study included 25 patients between 3 and 16 years of age who admitted to our clinic in 2017, were being followed in our clinic with a diagnosis of cerebral palsy, had BoNT-A injections due to lower extremity spasticity. The US-guided BoNT-A injections were administered into the spastic muscles using a specific approach according to innervation zones of muscle. Modified Ashworth Scale (MAS) and Gross Motor Functional Classification System (GMFCS) were assessed at the baseline, and 4 and 12 weeks after the BoNT-A i njections. Minimum and maximum ages of the patients were 45 and 192 months, and gender dist...
Source: Acta Neurologica Belgica - April 24, 2018 Category: Neurology Source Type: research

Effect of therapeutic exercise on knee osteoarthritis after intra-articular injection of botulinum toxin type A, hyaluronate or saline: A randomized controlled trial.
Authors: Bao X, Tan JW, Flyzik M, Ma XC, Liu H, Liu HY Abstract OBJECTIVE: To study the effect of therapeutic exercise on knee osteoarthritis after injection of botulinum toxin type A, hyaluronate or saline. METHODS: Sixty participants with knee osteoarthritis were randomly assigned to 3 groups: injection of saline (control) (group A), botulinum toxin type A (group B), or hyaluronate (group C). All participants received therapeutic exercise. Western Ontario and McMaster Universities Osteoarthritis Index questionnaire score, visual analogue scale pain scale, and Medical Outcomes Study 36-item Health Survey were ...
Source: Journal of Rehabilitation Medicine - April 19, 2018 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

054 Immunogenicity to botulinum neotoxins: Long term clinical relevance in aesthetic and therapeutic injections
Without any doubt, Botulinum Toxin is an amazing molecule with diverse clinical effects since the 1970S. The clinical use of Botulinum Toxin Type A and Type B (BONT-A and BONT-B) has revolutionized the practice of medicine over the past 30 years. The safety and effectiveness of injectable Botulinum Toxin have been well established in both aesthetic and medical indications. However to reach the desired endpoints and to maintain the efficacy, the frequency of injections is required. By increasing the numbers of patients without favorable therapeutic responses, a new concern has re-emerged on the immunoresistance and loss of ...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: M. Shiri, Z. Shiri, F. Bahrami, S. Shiri, G. Ebrahimi, H. Shiri, B. Shiri, M. Bahrami Tags: Adaptive and Auto-Immunity Source Type: research

333 Influence of social media on cosmetic procedure interest
Social media is increasingly cited in plastic surgeon surveys as a reason for undergoing cosmetic procedures, especially non-invasive procedures like onabotulinumtoxinA (Botox) and dermal fillers. We explored trends between social media usage and public interest in cosmetic procedures, as well as how these effects differ by procedure and by specialty (dermatology or plastic surgery). Google Trends was queried for search terms and compared with aggregate user data from Instagram and Facebook. Search terms were the brand names of medications, as these are how the general public knows the medications. (Source: Journal of Inve...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: C. Moreno, Z. Hopkins, A. Secrest Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

A comparative trial of ice application versus EMLA cream in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis.
Authors: Alsantali A Abstract Background: Botulinum toxin is a safe and effective therapy for palmar hyperhidrosis, but the associated pain from injections limits the usefulness of this method of treatment. Purpose: To evaluate the efficacy of Eutectic Mixture of Local Anesthetics (EMLA) cream versus ice application in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis. Methods: In this prospective study, 23 patients underwent palm Botox injections to treat their excessive sweating. In each patient, EMLA cream was applied to one palm and ice was applied directly before the inject...
Source: Clinical, Cosmetic and Investigational Dermatology - April 19, 2018 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A cost-effectiveness analysis of Onabotulinumtoxin A as first-line treatment for overactive bladder
AbstractIntroduction and hypothesisTo determine if Onabotulinumtoxin A (Botox ®) should be offered as a first-line therapy for the treatment of overactive bladder (OAB), even before prescribing anticholinergics.MethodsWe performed a cost-effectiveness analysis modeling the following clinical options: no treatment, non-selective anticholinergics, selective anticholinergics, and Botox ®. The model timeframe was 2 years to allow Botox® reinjection and discontinuation of anticholinergics. Multiple efficacy levels included response improvement by
Source: International Urogynecology Journal - April 18, 2018 Category: OBGYN Source Type: research

Botulinum toxin type A and gabapentin attenuate postoperative pain and NK1 receptor internalization in rats
Publication date: June 2018 Source:Neurochemistry International, Volume 116 Author(s): Xueyang Li, Ruijuan Guo, Yuqing Sun, Huili Li, Danxu Ma, Chen Zhang, Yun Guan, Junfa Li, Yun Wang Treatment of postoperative pain remains a challenge in clinic. Botulinum toxin type A (BoNT/A) and gabapentin regulate the release of neurotransmitters from primary afferent neurons, but their effects of on postoperative pain are not clear. In the current study, using pain behavioral tests, Western blot analysis, and immunocytochemistry, we examined whether BoNT/A, alone or in combination with intrathecal gabapentin, inhibited pain hypersen...
Source: Neurochemistry International - April 14, 2018 Category: Neuroscience Source Type: research

[Foster Modification of Full Tendon Transposition of Vertical Rectus Muscles for Sixth Nerve Palsy].
CONCLUSIONS: Full tendon transposition of vertical rectus muscles, augmented with lateral posterior fixation suture is a safe and effective treatment method for abducens nerve palsy and in most cases recession of the medial rectus can be avoided. Upgaze and downgaze are affected very slightly. Diverse studies have shown that the risk of anterior segment ischemia is low. PMID: 29642261 [PubMed - as supplied by publisher] (Source: Klinische Monatsblatter fur Augenheilkunde)
Source: Klinische Monatsblatter fur Augenheilkunde - April 13, 2018 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

Management of spasticity with onabotulinumtoxinA: practical guidance based on the italian real-life post-stroke spasticity survey.
Authors: Sandrini G, Baricich A, Cisari C, Paolucci S, Smania N, Picelli A Abstract The present paper provides practical guidance on the management of adult spasticity with OnabotulinumtoxinA. Advisory Board members reviewed the available evidence and discussed their personal experiences in order to address the unmet needs in the management of spasticity with botulinum toxin type A identified by the recent Italian Real-Life Post-Stroke Spasticity Survey. Stroke patients should be referred to spasticity services that have adequate facilities and multidisciplinary teams with the necessary training, competence and exp...
Source: Functional Neurology - April 12, 2018 Category: Neurology Tags: Funct Neurol Source Type: research

Towards an in vitro fibrogenesis model of human vocal fold scarring
ConclusionBased on the principles of MMC we could successfully establish a laryngeal fibrogenesis model employing hVFF. Our finding of dose-dependent HGF effects is important before going into clinical trials in humans and has never been shown before. Our model provides a novel option to screen various potential antifibrotic compounds under standardized conditions in a short time. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - April 10, 2018 Category: ENT & OMF Source Type: research

Investigational procedures in benign prostatic hypertrophy
Purpose of review As benign prostatic hypertrophy (BPH) becomes a more common disease, there has been a dramatic rise in the number of investigational procedures being developed to manage it. We seek to present an overview of the most recently developed treatments and present clinical data related to application wherever available. Recent findings As a greater number of treatments become available for BPH, improved diagnostic testing could prove beneficial in helping guide patient selection. Efforts are underway to identify serum biomarkers associated with BPH as well as new classifications strategies, specifically wi...
Source: Current Opinion in Urology - April 4, 2018 Category: Urology & Nephrology Tags: Review Source Type: research

In vitro and in vivo Assessment of Silver Nanoparticles against Clostridium botulinum type A botulinum.
CONCLUSION: These results, while open to future improvements, represent a preliminary step towards the satisfactory control of BoNT/A by silver nanoparticles for human protection against the challenges bioterrorism threat. Further study in this area will be promising enough to elucidate the underlying mechanism for detoxifying BoNT/A by silver nanoparticles. PMID: 29623844 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - April 3, 2018 Category: Drugs & Pharmacology Authors: Aminianfar M, Parvardeh S, Soleimani M Tags: Curr Drug Discov Technol Source Type: research

Pd32-06 patients have poor compliance with repeat onabotulinumtoxin a injections for overactive bladder
We report the outcomes of Botox injection at our institution and evaluate factors which correlate with continuation of maintenance Botox injection. (Source: The Journal of Urology)
Source: The Journal of Urology - April 1, 2018 Category: Urology & Nephrology Authors: Justina Tam, Anh Nguyen, Chris Du, Qingjie Wang, Michael Hung, Steven Weissbart, Jason Kim Tags: Urodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy II Source Type: research

Efficacy And Non Invasive Treatment Of Sialorrhea In The Goldenhar Syndrome.
Authors: Marvulli R, Gallo GA, Mastromauro L, Fiore P, Ianieri G, Megna M Abstract Goldenhar syndrome (ocular-auricular-vertebral syndrome), a rare congenital condition arising from defects in the first and second brachial arches, consists in clinical variety of features ranging from facial abnormalities, ear-eye abnormalities, vertebral defects and congenital heart problems and severe obstructive sleep apnea. Due to craniofacial abnormalities, patients presents mechanical obstructive phenomena and sialorrhea that cause prone position, language's fastening, use of nasopharyngeal cannulas and tracheal intubation. In...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 30, 2018 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Botulinum Toxin Type A Treatment Combined with Intensive Rehabilitation for Gait Poststroke: A Preliminary Study
To examine the effects of botulinum toxin type A (BoNT-A) treatment combined with intensive rehabilitation for gait compared with intensive rehabilitation alone in patients with chronic stroke. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2018 Category: Neurology Authors: Yuki Uchiyama, Tetsuo Koyama, Yosuke Wada, Masashi Katsutani, Norihiko Kodama, Kazuhisa Domen Source Type: research

Botox and Thumb MCP Radial Collateral Ligament Reconstruction.
We report the use of botulinum toxin to aid in the treatment of chronic radial collateral ligament insufficiency of the thumb. Case Description  Treatment included autograft tendon reconstruction and cast immobilization. Six weeks postoperatively, prior to hand therapy, the patient underwent an ultrasound-guided botulinum neurotoxin A injection into the adductor pollicis muscle to negate its deforming forces on the reconstruction. The patient made an excellent recovery and 1 year postoperatively was pain free and had a stable radial collateral ligament (RCL) upon examination. Literature Review  The outcome...
Source: Hand Surgery - March 28, 2018 Category: Surgery Authors: Cates RA, Brault JS, Kakar S Tags: J Wrist Surg Source Type: research

Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations
Conclusion Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.RESUMO Manifesta ções motoras e não motoras são comuns e incapacitantes nas paraparesias espásticas hereditárias (PEH). Toxina botulínica do tipo A (TB-A) é considerada eficaz no tratamento da espasticidade e pode melhorar a marcha nesses pacientes. Pouco se sabe sobre os efeitos da TB-A sobre sintomas não- motores. Objetivo avaliar a eficácia da TB-A sobre manifestações motoras e não-motoras nas PEH. M&ea...
Source: Arquivos de Neuro-Psiquiatria - March 27, 2018 Category: Neurology Source Type: research

Phenol versus botulinum toxin a injection in ambulatory cerebral palsy spastic diplegia: A comparative study
Nitesh Gonnade, Vaibhav Lokhande, Mohammed Ajij, Anil Gaur, Kamalakant ShuklaJournal of Pediatric Neurosciences 2017 12(4):338-343The aim of this study is to compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in the management of lower limb spasticity and to measure improvement in gross motor functional outcome in children with cerebral palsy (CP). This is a hospital-based prospective, noncontrolled randomized study that took place in a tertiary care center. A total of 61 ambulatory children with CP spastic diplegia, aged from 4 to 10 years, were randomly divided into two groups and inc...
Source: Journal of Pediatric Neurosciences - March 26, 2018 Category: Neuroscience Authors: Nitesh Gonnade Vaibhav Lokhande Mohammed Ajij Anil Gaur Kamalakant Shukla Source Type: research

Effect of the masseter muscle injection of botulinum toxin A on the mandibular bone growth of developmental rats
The objective of this study was to evaluate the influence of masticatory muscle injection of botulinum toxin type A (BTX-A) on the growth of the mandibular bone in vivo. (Source: Maxillofacial Plastic and Reconstructive Surgery)
Source: Maxillofacial Plastic and Reconstructive Surgery - March 25, 2018 Category: ENT & OMF Authors: Hyun Seok, Seong-Gon Kim, Min-Keun Kim, Insan Jang and Janghoon Ahn Tags: Research Source Type: research

Efficacy and possible mechanisms of Botulinum Toxin type A on hypertrophic scarring
Journal of Cosmetic Dermatology, EarlyView. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - March 23, 2018 Category: Dermatology Source Type: research

Personalized botulinum toxin type A therapy for cervical dystonia based on kinematic guidance
ConclusionClinical judgement guided by kinematic analysis of CD biomechanics can result in faster optimal muscle selections and minimize use of higher BoNT-A doses as compared to visual determination, thereby achieving comparable and potentially better treatment outcomes. (Source: Journal of Neurology)
Source: Journal of Neurology - March 20, 2018 Category: Neurology Source Type: research

Effect of Hemifacial Spasm on Intraocular Pressure Measurement.
Conclusions: Contractions in facial muscles may not lead to significant increase in IOP in HFS patients. This result may help clinical decision making in the treatment of glaucoma patients with HFS. This trial is registered with NCT03390803. PMID: 29545951 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - March 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Non-surgical rhinoplasty using filler, Botox, and thread remodeling: Retro analysis of 332 cases
. (Source: Journal of Cosmetic and Laser Therapy)
Source: Journal of Cosmetic and Laser Therapy - March 15, 2018 Category: Laser Surgery Authors: Yasser Helmy Source Type: research

Do signs of an effusion of the temporomandibular joint on magnetic resonance imaging correlate with signs and symptoms of temporomandibular joint disease?
Publication date: February 2018 Source:British Journal of Oral and Maxillofacial Surgery, Volume 56, Issue 2 Author(s): N. Thomas, D.E. Harper, S. Aronovich Effusions are common among patients with disorders of the temporomandibular joint (TMJ), but publications are limited and results inconsistent about the correlation between them and important clinical variables, in particular severity of pain and degenerative disease. We organised a retrospective study of patients who presented for the evaluation and management of arthralgia of the TMJ and myofascial pain at the University of Michigan between 2011 and 2014. Inclusion ...
Source: British Journal of Oral and Maxillofacial Surgery - March 10, 2018 Category: ENT & OMF Source Type: research

Functional outcomes following ultrasound-guided botulinum toxin type A injections to reduce spastic equinovarus in adult post-stroke patients.
R, Ersoy Y Abstract OBJECTIVE: The aim of this study is to identify the effect on spasticity and walking of US-guided botulinum toxin type A (BoNT-A) injections administered to improve equinovarus walking pattern commonly observed in patients after stroke. MATERIAL AND METHOD: Twenty-three patients with post-stroke spastic equinovarus deformity were recruited. The US-guided BoNT-A injections were administered into the spastic muscles (including gastrocnemius; GK, soleus; S and tibialis posterior; TP) using a specific approach, and all of the patients were enrolled in rehabilitation programmes after the injec...
Source: Toxicon - March 9, 2018 Category: Toxicology Authors: Aktürk S, Büyükavcı R, Ersoy Y Tags: Toxicon Source Type: research

Efficacy of Intra-Articular Botulinum Toxin in Osteoarticular Joint Pain: A Meta-Analysis of Randomized Controlled Trials
This study was conducted with the aim of evaluating the efficacy of intra-articular injections of botulinum toxin type A (BT-A) into the painful joint diseases through a systematic review of the literature and a meta-analysis of controlled randomized trials. Intra-articular therapies (corticosteroids, hyaluronic acid) have limited efficacy and run a risk of toxicity in patients with joint pain. New therapeutic options are needed to treat painful osteoarticular disease. Methods: We searched via Pubmed, American College of Rheumatology, and European League Against Rheumatism congresses, and gray literature for the studies...
Source: The Clinical Journal of Pain - March 8, 2018 Category: Anesthesiology Tags: Review Article Source Type: research

Intra-Detrusor Injections of Botulinum Toxin Type a in Children with Spina Bifida: a Multicenter Study
To assess the effectiveness of Intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida. (Source: Urology)
Source: Urology - March 6, 2018 Category: Urology & Nephrology Authors: Juliette Hascoet, Benoit Peyronnet, V éronique Forin, Maximilien Baron, Grégoire Capon, Thomas Prudhomme, Clément Allenet, Simon Tournier, Charlotte Maurin, Jean-Nicolas Cornu, Ourdia Bouali, Matthieu Peycelon, Alexis Arnaud, Mariette Renaux-Petel, Agn Tags: Pediatric Urology Source Type: research

Botulinum toxin type a affects the transcriptome of cell cultures derived from muscle biopsies of controls and spastic patients.
Abstract Botulin toxin (BTX) is widely used for treating skeletal muscle spasticity. Experimental reports on BTX treatment were mainly focused on the neuromuscular junction, while relatively little is known about toxin effects on the muscle cell itself. We investigated possible impact of BTX type A on skeletal muscle cell transcriptome by microarray analysis in muscle-derived cell cultures (fibroblasts, myoblasts and myotubes) from controls and spastic patients, and results were then validated at transcript and protein level. BTX-A treatment of control cells induced major changes in the myogenic component of the t...
Source: Toxicology in Vitro - March 6, 2018 Category: Toxicology Authors: Zanotti S, Kapetis D, Gibertini S, Salerno F, Ciusani E, Colombo C, Gronchi A, Morandi L, Mantegazza R, Molteni F, Mora M Tags: Toxicol In Vitro Source Type: research

Intradetrusor Injections of Botulinum Toxin Type A in Children With Spina Bifida: A Multicenter Study
To assess the effectiveness of intradetrusor injections of botulinum toxin type A (IDBTX-A) in children with spina bifida. (Source: Urology)
Source: Urology - March 6, 2018 Category: Urology & Nephrology Authors: Juliette Hascoet, Benoit Peyronnet, V éronique Forin, Maximilien Baron, Grégoire Capon, Thomas Prudhomme, Clément Allenet, Simon Tournier, Charlotte Maurin, Jean-Nicolas Cornu, Ourdia Bouali, Matthieu Peycelon, Alexis Arnaud, Mariette Renaux-Petel, Agn Tags: Pediatric Urology Source Type: research

Effect of botulinum toxin type A treatment in children with cerebral palsy: Sequential physical changes for 3  months after the injection
This study investigated the sequential physical changes after botulinum toxin type A (BTX-A) injected in children with cerebral palsy. (Source: Brain and Development)
Source: Brain and Development - March 3, 2018 Category: Neurology Authors: Mayumi Matsuda, Kazuhide Tomita, Arito Yozu, Tomohiro Nakayama, Jyunko Nakayama, Haruka Ohguro, Nobuaki Iwasaki Tags: Original article Source Type: research

The Effects of Botulinum Toxin Injections on Plantar Flexor Spasticity in Different Phases After Stroke: A Secondary Analysis From a Double-Blind, Randomized Trial
There are no guidelines on the ideal time to inject botulinum toxin type A (BT-A) for lower leg spasticity in stroke patients. An early injection may produce unwanted weakness, interfering with gait recovery. (Source: PM and R)
Source: PM and R - March 3, 2018 Category: Rehabilitation Authors: Hyun-Mi Oh, Geun-Young Park, Young Min Choi, Hyung Jung Koo, Yongjun Jang, Sun Im Tags: Original Research Source Type: research

Effect of botulinum toxin type A treatment in children with cerebral palsy: Sequential physical changes for 3  months after the injection
This study investigated the sequential physical changes after botulinum toxin type A (BTX-A) injected in children with cerebral palsy. (Source: Brain and Development)
Source: Brain and Development - March 3, 2018 Category: Neurology Authors: Mayumi Matsuda, Kazuhide Tomita, Arito Yozu, Tomohiro Nakayama, Jyunko Nakayama, Haruka Ohguro, Nobuaki Iwasaki Tags: Original article Source Type: research

Botox ®: A 22 year experience
(Source: Operative Techniques in Oculoplastic, Orbital and Reconstructive Surgery)
Source: Operative Techniques in Oculoplastic, Orbital and Reconstructive Surgery - March 2, 2018 Category: Surgery Authors: Bosniak, Stephen Cantisano-Zilkha, Marian Source Type: research

Indications and limitations of cosmetic botulinum toxin type A
(Source: Operative Techniques in Oculoplastic, Orbital and Reconstructive Surgery)
Source: Operative Techniques in Oculoplastic, Orbital and Reconstructive Surgery - March 2, 2018 Category: Surgery Authors: Moriarty, Kate Coleman Source Type: research

Surgical Management of Migraine Headache
Migraine surgery has been recently reported as an alternative to medical management to provide long-term relief in migraine sufferers. A prospective study was designed wherein patients diagnosed with migraine were screened for surgery by injecting botulinum toxin type A at the primary trigger site. Surgery consisted of corrugator supercilii muscle resection to decompress supra-trochlear and supra-orbital nerves with avulsion of zygomaticotemporal branch of trigeminal nerve. Using pre and postsurgery questionnaires, information regarding the degree of reduction of migraines with regard to severity and frequency; and surgica...
Source: Journal of Craniofacial Surgery - March 1, 2018 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 28, 2018 Category: Cosmetic Surgery Tags: Letters Source Type: research

Reply: Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model
No abstract available (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 28, 2018 Category: Cosmetic Surgery Tags: Letters Source Type: research

Effects of Botulinum Toxin on Improving Facial Surgical Scars: A Prospective, Split-Scar, Double-Blind, Randomized Controlled Trial
Conclusion: This study demonstrates that early postsurgical botulinum toxin injections can produce better, narrower, and flatter facial surgical scars. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - February 28, 2018 Category: Cosmetic Surgery Tags: Cosmetic: Ideas and Innovations Source Type: research

[Myths and evidence on the use of botulinum toxin: neuropharmacology and dystonia].
CONCLUSION: This review does not pretend to be a guide, but rather a tool for continuous training of residents and specialists in neurology, about different specific areas of the management of BTA. PMID: 29480513 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - February 27, 2018 Category: Neurology Authors: Garcia-Ruiz PJ, Sanz-Cartagena P, Martinez-Castrillo JC, Ares-Pensado B, Aviles-Olmos I, Blazquez-Estrada M, Fanjul-Arbos S, Garcia-Caldentey J, Gazulla J, Gutierrez-Garcia J, Huete-Anton B, Lucas-Rodenas C, Luquin MR, Martinez-Torres I, Medialdea-Natera Tags: Rev Neurol Source Type: research

Botulinum toxin type A relieves sternocleidomastoid muscle fibrosis in congenital muscular torticollis.
In conclusion, our results suggested that BTA could be a promising agent against SCM fibrosis in CMT through regulating fibroblast and inhibiting myofibroblast differentiation. PMID: 29447964 [PubMed - as supplied by publisher] (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - February 12, 2018 Category: Biochemistry Authors: Jiang B, Zu W, Xu J, Xiong Z, Zhang Y, Gao S, Ge S, Zhang L Tags: Int J Biol Macromol Source Type: research

Macroplastique and Botox are superior to Macroplastique alone in the management of neurogenic vesicoureteric reflux in spinal cord injury population with presumed healthy bladders.
CONCLUSION: The combination of BTX-A and Macroplastique is more effective that Macroplastique alone in the management of secondary VUR in SCI patients with presumed healthy bladders. PMID: 29412074 [PubMed - as supplied by publisher] (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - February 8, 2018 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Evaluating the functional outcomes of ultrasound-guided botulinum toxin type A injections using the Euro-musculus approach for upper limb spasticity treatment in post-stroke patients; an observational study.
Abstract BACKGROUND: Ultrasound-guided botulinum toxin type A injection is an effective treatment for spasticity. Euro-musculus spasticity approach is a new method for administering injections to the correct point of the correct muscle. The clinical outcomes of this practical approach is not yet available in the literature. AIM: The purpose of this study was to evaluate the effects on spasticity and the functional outcomes of ultrasound guided botulinum toxin type A injections via the Euro-musculus spasticity approach to treat upper limb spasticity in post-stroke patients. DESIGN: An observational study....
Source: European Journal of Physical and Rehabilitation Medicine - February 7, 2018 Category: Rehabilitation Authors: Buyukavci R, Akturk S, Ersoy Y Tags: Eur J Phys Rehabil Med Source Type: research

Botulinum Toxin Type A: Assessing The Effects on The Brain Stem
ConclusionIt was concluded that Botulinum toxin type A application did not trigger apoptosis in stem cell tissues.No Level AssignedThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - February 6, 2018 Category: Cosmetic Surgery Source Type: research

Do signs of an effusion of the temporomandibular joint on magnetic resonance imaging correlate with signs and symptoms of temporomandibular joint disease?
Effusions are common among patients with disorders of the temporomandibular joint (TMJ), but publications are limited and results inconsistent about the correlation between them and important clinical variables, in particular severity of pain and degenerative disease. We organised a retrospective study of patients who presented for the evaluation and management of arthralgia of the TMJ and myofascial pain at the University of Michigan between 2011 and 2014. Inclusion criteria were: patients who had pain that was primarily arthrogenous, and coexisting myogenous pain, who had had initial non-surgical treatment, and arthrosco...
Source: The British Journal of Oral and Maxillofacial Surgery - February 4, 2018 Category: ENT & OMF Authors: N. Thomas, D.E. Harper, S. Aronovich Source Type: research

The effectiveness of Clostridium botulinum toxin A (Dysport ®, AbobotulinumtoxinA) in the management of temporomandibular dysfunction (TMD) and a small number of other maxillofacial conditions; an open cohort study
ConclusionsOur findings suggest Dysport® is a safe, well‐tolerated and effective treatment for TMD and Masseteric hypertrophy. (Source: Oral Surgery)
Source: Oral Surgery - February 1, 2018 Category: ENT & OMF Authors: S. White, B. Ahmed, A. Ondhia Tags: Original Article Source Type: research

Long-term Efficacy of Botulinum Neurotoxin-A Treatment for Essential Blepharospasm.
Authors: Lee S, Park S, Lew H Abstract PURPOSE: In the present study, we investigated the treatment efficacy and clinical outcomes of botulinum neurotoxin-A (BoNT-A) administered for longer than 5 years to patients with essential blepharospasm. METHODS: We retrospectively reviewed 19 patients (male : female = 8 : 11) diagnosed with essential blepharospasm between March 2006 and July 2016 who underwent BoNT-A injections for over 5 years and were followed. Efficacy of 297 injections of Botox (n = 162), Meditoxin (n = 75), Hugel-tox (n = 40), or Dysport (n = 20) was based on the symptom improvement score at the fi...
Source: Korean Journal of Ophthalmology : KJO - January 30, 2018 Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research

Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
ConclusionsWhen sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever. (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 30, 2018 Category: Neurology Source Type: research