Intercostal Nerve Transfer in Management of Biceps and Triceps Cocontraction in Spontaneously Recovered Obstetric Brachial Plexus Palsy
Conclusions Intercostal nerves transfer to MCN for management of biceps, and triceps cocontraction in spontaneously recovered obstetric brachial plexus injury is a good option with minimal morbidity and high success rate. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - September 17, 2019 Category: Cosmetic Surgery Tags: Peripheral Nerve Surgery and Research Source Type: research

Horizontal animation deformity as unusual complication of neurotoxin modulation of the gummy smile
Injections of botulinum toxin type A represent the most common nonsurgical cosmetic treatment worldwide. The authors report a case of dynamic horizontal wrinkling in the upper lip that appeared after botulinum toxin type A injections to treat gummy smile associated with nasal alar base reduction, in a 28-year-old woman. The anatomic features and pathogenic mechanism underlying this unusual complication are analyzed and discussed. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - September 10, 2019 Category: Dermatology Source Type: research

Botulinum toxin type A suppresses pro-fibrotic effects via the JNK signaling pathway in hypertrophic scar fibroblasts
In this study, human scar fibroblasts were cultured and stimulated with botulinum toxin type A, and the changes in fibroblast proliferation, migration, and protein expression of pro-fibrotic factors were evaluated with colorimetric, scratch, and enzyme-linked immunosorbent assays and western blotting, respectively. Botulinum toxin type A treatment decreased the proliferation and migration of human scar fibroblasts compared with those of untreated controls. Protein expression levels of pro-fibrotic factors (transforming growth factor β1, interleukin-6, and connective tissue growth factor) were also inhibited by botulin...
Source: Archives of Dermatological Research - September 9, 2019 Category: Dermatology Source Type: research

How satisfied are cervical dystonia patients after 3  years of botulinum toxin type A treatment? Results from a prospective, long-term observational study
ConclusionsDespite objective clinical improvements over 3  years, subject satisfaction with symptom control remained relatively constant, indicating that factors other than symptom control also play a role in patient satisfaction. (Source: Journal of Neurology)
Source: Journal of Neurology - September 9, 2019 Category: Neurology Source Type: research

Botulinum toxin type A for painful temporomandibular disorders: systematic review and meta-analysis
Painful temporomandibular disorders are chronic conditions that can have a negative impact on the quality of life and well-being of affected individuals. It is frequently associated with dysfunction of the masticatory muscles due to specific or non-specific temporomandibular disorders. Potential risk factors for painful temporomandibular disorders include trauma, dental malocclusion, excessive masticatory system loading, hypermobility, parafunctional habits and anatomical, psychosocial and/or systemic disorders. (Source: The Journal of Pain)
Source: The Journal of Pain - September 9, 2019 Category: Materials Science Authors: Daniel Machado, Ana Luiza Cabrera Martimbianco, Sandra Kalil Bussadori, Rafael Leite Pacheco, Rachel Riera, Elaine Marc ílio Santos Tags: Review Article Source Type: research

Optimisation of botulinum toxin type a treatment for the management of Raynaud ’s phenomenon using a dorsal approach: a prospective case series
This study aimed to determine the effect of Btx-A injected via a dorsal approach.MethodForty patients received 100  units of Btx-A, injected across both hands via a dorsal approach. Each patient had a baseline, 6- and 12-week hand assessment and thermographic image (FLIR E60bx) performed for the study.ResultsEighty-eight percent of patients reported an improvement in symptoms including reduction in pain, improved colour change with reduced swelling and edema at 6  weeks. Of these patients, 80% reported an improvement in cold intolerance with a reduction in the frequency and severity of Raynaud’s attacks. Th...
Source: Clinical Rheumatology - September 3, 2019 Category: Rheumatology Source Type: research

Efficacy of Botulinum Toxin in Treating Asian Indian Patients with Masseter Hypertrophy: A 4-Year Follow-Up Study
Background: Asian Indians usually have wide lower faces because of masseter hypertrophy. The authors evaluated the efficacy of botulinum toxin type A in long-term management of bilateral masseter hypertrophy in Asian Indian patients. Methods: Fifty patients were enrolled in the study and injected with 30 U of botulinum toxin type A to each side of the face, at baseline. Based on masseter muscle thickness and response to the injections, 25 patients underwent a second injection session at week 12, and the other 25 patients underwent additional third sessions, at week 24 after the first injection, respectively. Standardi...
Source: Plastic and Reconstructive Surgery - August 29, 2019 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research

Anti-cancer Potential of Captopril and Botulinum Toxin Type-A and Associated p53 Gene Apototic ...
Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic effect of captopril and BTX-A was determined using MTT assay against colon (HCT116) and prostate cancer (DU145) cells compared to their effect on normal vero cells. Anti-proliferation assay and anti-metastatic effect were carried out u...
Source: Iranian Journal of Pharmaceutical Research - August 23, 2019 Category: Drugs & Pharmacology Source Type: research

Battling neuropathic scar pain with botulinum toxin
We present a patient with refractory neuropathic pain in a normotrophic spread-scar treated with the injection of BTA. A 47-year-old Caucasian female with a history of invasive melanoma of the left upper arm presented with pain in her excision scar. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Treatment of postherpetic neuralgia with botulinum toxin type A
Background: Postherpetic neuralgia (PHN) is a neuropathic pain syndrome persisting or resuming after resolution of the herpes zoster (HZ) inflammatory rash. There is no consensus on best treatment, options for which are primarily pharmacologic and aimed at pain management (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Decrease in the therapeutic effect among botulinum toxin type A agents: Analysis of the FDA Adverse Event Report System Database
Background: Published literature comparing BoNT-A agents for antibody formation, resistance, and loss of effect is lacking. IncobotulinumtoxinA is the only botulinum toxin type A (BoNT-A) agent that has removed unnecessary proteins, leaving just the 150 kDa active component. The aim of this study was to assess the BoNT-A agents for decreased therapeutic effect. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Botulinum Toxin Type A Injections as an Effective Treatment of Refractory Multiple Sclerosis-Related Trigeminal Pain - A Case Report.
PMID: 31424566 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - August 19, 2019 Category: Neurology Authors: Calejo M, Salgado P, Moreira B, Correia C, Barros J Tags: Headache Source Type: research

Horizontal animation deformity as unusual complication of neurotoxin modulation of the gummy smile.
Abstract Injections of botulinum toxin type A represent the most common nonsurgical cosmetic treatment worldwide. The authors report a case of dynamic horizontal wrinkling in the upper lip that appeared after botulinum toxin type A injections to treat gummy smile associated with nasal alar base reduction, in a 28-year-old woman. The anatomic features and pathogenic mechanism underlying this unusual complication are analyzed and discussed. PMID: 31553868 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Chen G, Oranges CM, Giordano S, Huang R, Wang W Tags: Dermatol Online J Source Type: research

Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects?
ConclusionsIt can be concluded that BoNT-A treatment is well tolerated, since minor adverse effects were the most frequently reported; however, it is recommended that future studies aim to assess the safety and possible adverse effects of multiples applications or high doses of this treatment.Clinical relevanceBoNT-A has been increasingly diffused in dentistry, being used for the management of masticatory myofascial pain and trigeminal neuralgia. Nonetheless, there is no consensus about its efficacy and adverse effects that could occur when this treatment is applied. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - August 14, 2019 Category: Dentistry Source Type: research

Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review.
CONCLUSION: BoNT-A therapy is a safe and effective method of treating trigeminal neuralgia. PMID: 31397877 [PubMed - as supplied by publisher] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - August 9, 2019 Category: Neurology Authors: Ostrowski H, Roszak J, Komisarek O Tags: Neurol Neurochir Pol Source Type: research

Combination of Mesenchymal Stem Cell-Conditioned Medium and Botulinum Toxin Type A for Treating Human Hypertrophic Scars
Both mesenchymal stem cell-conditioned medium (MSCs CM) and Botox have demonstrated therapeutic effects for hypertrophic scar (HS). It is unclear if a synergistic effect occurs when these treatments are used in combination. We aimed to investigate therapeutic effects of MSCs CM and Botox alone compared with a combined regimen on HS. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - August 8, 2019 Category: Cosmetic Surgery Authors: Ching-Hsuan Hu, YI-Wen Tseng, Chien-Wei Lee, Chih-Yung Chiou, Shiow-Shuh Chuang, Jui-Yung Yang, Oscar K. Lee Source Type: research

[Dose and efficacy of botulinum toxin in pediatric patients with spasticity].
CONCLUSION: The application of botulinum toxin type A was effective for the treatment of spasticity in the pediatric population. PMID: 31364149 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - August 2, 2019 Category: Neurology Authors: Alcocer-Gamboa MA, Ojeda-Manzano A, Baqueiro-Gongora LJ, Denis-Alcocer LE, Hattori-Hara M, Pacheco-Guemez A Tags: Rev Neurol Source Type: research

Clinical trial to evaluate the efficacy of botulinum toxin type A injection for reducing scars in patients with forehead laceration: A double-blinded, randomized controlled study
Conclusion: Improvement of aesthetic, functional, and emotional aspect of the scar formation in the groups treated with BoNTA was illustrated. The application of BoNTA may be expanded to prevent hypertrophic scar after trauma, burns, or operations. (Source: Medicine)
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

The effects on the mandibular condyle of Botox injection into the masseter are not transient
ConclusionsThe effects on the MCC and subchondral bone of Botox injection into the masseter muscle persisted for 8 weeks after injection and were not considered to be transient. (Source: American Journal of Orthodontics and Dentofacial Orthopedics)
Source: American Journal of Orthodontics and Dentofacial Orthopedics - August 1, 2019 Category: Dentistry Source Type: research

Botulinum Toxin in the Management of Children with Cerebral Palsy
AbstractDuring the past 25  years, botulinum toxin type A (BoNT-A) has become the most widely used medical intervention in children with cerebral palsy. In this review we consider the gaps in our knowledge in the use of BoNT-A and reasons why muscle morphology and function in children with cerebral palsy are impaired. We review limitations in our knowledge regarding the mechanisms underlying the development of contractures and the difficulty in preventing them. It is clear from this review that injection of BoNT-A in the large muscles of both the upper and lower limbs of child...
Source: Pediatric Drugs - August 1, 2019 Category: Pediatrics Source Type: research

Protective Effect of Botulinum Toxin against Ultraviolet-Induced Skin Pigmentation
Background: Hyperpigmentation following ultraviolet irradiation has cosmetic concerns. Botulinum toxin type A can favorably affect skin pigmentation. However, the mechanism of skin pigmentation is unclear. Methods: In vitro, human epidermal melanocytes were co-cultured with human keratinocytes. After cells were treated with botulinum toxin type A, cell morphology, proliferation, and dendricity were analyzed, and immunofluorescence, tyrosinase activity, and melanin contents were determined. To evaluate the effect of botulinum toxin type A on ultraviolet B–irradiated mouse skin, ultraviolet B alone was applied to ...
Source: Plastic and Reconstructive Surgery - July 26, 2019 Category: Cosmetic Surgery Tags: Experimental Source Type: research

Post-mastectomy pain syndrome after mamma reduction plasty, an unusual case report
We report PMPS in a 39-year-old patient after revision operation of breast reduction surgery. Postoperatively, the patient showed symptoms of severe persistent pain, swelling, cutaneous temperature changes, and hyperhidrosis in the affected breast. Subcutaneous infiltration with triamcinolone acetonide and prilocaine only relieved the symptoms temporarily. Botox injections did not relieve her symptoms of sweating either. Two intercostal nerve branches were identified with ultrasonography and dissected in general anesthesia. This procedure relieved her symptoms. Surgeons should consider CRPS and PMPS as differential diagnos...
Source: European Journal of Plastic Surgery - July 25, 2019 Category: Cosmetic Surgery Source Type: research

Efficacy and safety of lasmiditan in patients using concomitant migraine preventive medications: findings from SAMURAI and SPARTAN, two randomized phase 3 trials
AbstractObjectiveTo study the efficacy and safety of lasmiditan for acute treatment of migraine in patients using migraine preventive medications.BackgroundWhile lasmiditan has been proven to be an effective acute treatment for migraine, its effectiveness has not been examined when used concurrently with migraine preventives.MethodsSAMURAI and SPARTAN were similarly designed, double-blind, phase 3, placebo-controlled studies of patients 18  years or older with 3 to 8 migraine attacks per month. Patients were randomized to treat a migraine attack with oral lasmiditan 50 mg (SPARTAN only), 100 mg, 200&th...
Source: The Journal of Headache and Pain - July 24, 2019 Category: Neurology Source Type: research

Botulinum Toxin Type A for refractory trigeminal neuralgia in older patients: a better therapeutic effect
(Source: Journal of Pain Research)
Source: Journal of Pain Research - July 17, 2019 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research

Real-world effectiveness of onabotulinumtoxinA treatment for the prevention of headaches in adults with chronic migraine in Australia: a retrospective study
This study reviewed the medical records of adults with inadequately controlled CM from 7 private neurology practices in Australia who, beginning in March 2014, received PBS-subsidized onabotulinumtoxinA per product labelling for the first time. The primary effectiveness measure was the percentage of patients achieving a response defined by 50% or greater reduction in headache days from baseline after 2 treatment cycles. Additional data were recorded in the case report form when available and included demographics, clinical characteristics, headache severity and frequency, Headache Impact Test (HIT-6) score, medication use,...
Source: The Journal of Headache and Pain - July 15, 2019 Category: Neurology Source Type: research

Botulinum toxin type A injection increases range of motion in hip, knee and ankle joint contractures of children with cerebral palsy.
CONCLUSION: Botulinum toxin type A injection increases ROM in hip, knee and ankle joint contractures in CP. Although age, gender and functional level may influence the clinical outcomes, pre-treatment level of contracture is the main determinant in improvement in ROM at post-injection. PMID: 31291865 [PubMed - in process] (Source: Eklem Hastaliklari ve Cerrahisi)
Source: Eklem Hastaliklari ve Cerrahisi - July 13, 2019 Category: Orthopaedics Tags: Eklem Hastalik Cerrahisi Source Type: research

Ultrasonographic Analyses of the Forehead Region for Injectable Treatments
This study applied ultrasonography with the aim of providing guidelines for predicting the layered structure and soft-tissue thickness of the forehead. We performed ultrasound scanning at 7 facial landmarks in 40 Korean adults. Allowing for the error range, the minimum depth from the skin to exclude the muscle layer was 2.3 mm, and the maximum depth from the skin to include the muscle layer was 2.8 mm. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - July 13, 2019 Category: Radiology Authors: You-Jin Choi, Kang-Woo Lee, Young-Chun Gil, Kyung-Seok Hu, Hee-Jin Kim Tags: Original Contribution Source Type: research

Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)): Part B
ConclusionGuidelines are recommendations based on best available evidence intended to help the surgeon to improve the quality of his daily work. However, science is a continuously evolving process, and as such guidelines should be updated about every 3 years. For a comprehensive reference, however, it is suggested to read both the initially guidelines published in 2014 together with the update. Moreover, the presented update includes also techniques which were not known 3 years before. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - July 10, 2019 Category: Surgery Source Type: research

Intravesical Electromotive Botulinum Toxin Type A (Dysport ®) Administration in Children with Myelomeningocele
Electromotive drug administration (EMDA) presents a minimally-invasive method of intravesical instillation of therapeutic agents without the need for general anesthesia 1. It employs a combination of iontophoresis, electrophoresis, and electroporation to deliver drugs into deep tissue layers using an electrical current created between two electrodes 2. This video shows feasibility of botulinum toxin type A (BoNTA) EMDA in myelomeningocele (MMC) children with urinary incontinence secondary to neuropathic detrusor overactivity. (Source: Urology)
Source: Urology - July 9, 2019 Category: Urology & Nephrology Authors: Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Behnam Nabavizadeh, Maryam Alijani, Abdol-Mohammad Kajbafzadeh Tags: Video Article Source Type: research

Intravesical Electromotive Botulinum Toxin Type A (Dysport) Administration in Children With Myelomeningocele
Electromotive drug administration (EMDA) presents a minimally invasive method of intravesical instillation of therapeutic agents without the need for general anesthesia.1 It employs a combination of iontophoresis, electrophoresis, and electroporation to deliver drugs into deep tissue layers using an electrical current created between 2 electrodes.2 This video shows feasibility of botulinum toxin type A (BoNTA) EMDA in myelomeningocele children with urinary incontinence secondary to neuropathic detrusor overactivity. (Source: Urology)
Source: Urology - July 9, 2019 Category: Urology & Nephrology Authors: Lida Sharifi-Rad, Seyedeh-Sanam Ladi-Seyedian, Behnam Nabavizadeh, Maryam Alijani, Abdol-Mohammad Kajbafzadeh Tags: “Show Me How” Video Source Type: research

Efficacy and safety of botulinum toxin a injection into urethral sphincter for underactive bladder
The aim of this retrospective study was to evaluate the clinical efficacy and safety of botulinum toxin type A (BTX-A) injection into the urethral sphincter to treat patients with underactive bladder (UAB). (Source: BMC Urology)
Source: BMC Urology - July 5, 2019 Category: Urology & Nephrology Authors: Guoqing Chen, Limin Liao and Fei Zhang Tags: Research article Source Type: research

Botulinum Toxin type A interrupts autophagic flux of submandibular gland.
This study was carried out to explore the association between BTXA injection and autophagy in rat SMG. Western blotting and immunofluorescence were used to detect the expression and distribution of light chain 3 (LC3) in rat SMG. MTS was used to detect the toxicity of BTXA on rat SMG-C6 cell line. GFP-LC3 and Lyso-Tracker Red fluorescence probe were used to assess the levels of autophagosomes and lysosome fusion and the effect of BTXA on autophagic flux in SMG-C6. Western blotting and immunofluorescence results showed that BTXA temporarily increased autophagosomes in rat SMG. MTS results showed that BTXA exerted its toxici...
Source: Bioscience Reports - July 4, 2019 Category: Biomedical Science Authors: Xie S, Xu H, Shan XF, Cai ZG Tags: Biosci Rep Source Type: research

Comparison of the Efficacies of Dry Needling and Botox Methods in the Treatment of Myofascial Pain Syndrome Affecting the Temporomandibular Joint
Conclusion: The authors suggest that abobotulinum toxin-A injection and dry needling yield satisfactory therapeutic outcomes regarding pain relief and restoration of function in patients with MPS involving TMJ. Further multicentric, randomized, controlled trials on larger series are warranted to obtain more accurate and reliable information. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - July 1, 2019 Category: Surgery Tags: Clinical Studies Source Type: research

Botulinum Toxin in the Management of Children with Cerebral Palsy
AbstractDuring the past 25  years, botulinum toxin type A (BoNT-A) has become the most widely used medical intervention in children with cerebral palsy. In this review we consider the gaps in our knowledge in the use of BoNT-A and reasons why muscle morphology and function in children with cerebral palsy are impaired. We rev iew limitations in our knowledge regarding the mechanisms underlying the development of contractures and the difficulty in preventing them. It is clear from this review that injection of BoNT-A in the large muscles of both the upper and lower limbs of children with cerebral palsy will result in a ...
Source: Pediatric Drugs - July 1, 2019 Category: Pediatrics Source Type: research

Botulinum Toxin in the Management of Children with Cerebral Palsy.
Abstract During the past 25 years, botulinum toxin type A (BoNT-A) has become the most widely used medical intervention in children with cerebral palsy. In this review we consider the gaps in our knowledge in the use of BoNT-A and reasons why muscle morphology and function in children with cerebral palsy are impaired. We review limitations in our knowledge regarding the mechanisms underlying the development of contractures and the difficulty in preventing them. It is clear from this review that injection of BoNT-A in the large muscles of both the upper and lower limbs of children with cerebral palsy will resu...
Source: Paediatric Drugs - July 1, 2019 Category: Pediatrics Authors: Multani I, Manji J, Hastings-Ison T, Khot A, Graham K Tags: Paediatr Drugs Source Type: research

[Botulinum toxin treatment in children with cerebral palsy].
Conclusion: Our study strengthens the observation that botox treatment of the spastic calf muscle together with plaster casting can result in improved ankle dorsiflexion. Multilevel botox treatment can improve lower limb joints range of motion, however, gait pattern remains unchanged. The administration of botulinum toxin with respect to the guidelines has no major adverse effects. Further studies are needed to clarify the observed beneficial associate effects of the toxin. Orv Hetil. 2019; 160(28): 1105-1111. PMID: 31280598 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - July 1, 2019 Category: General Medicine Authors: Terebessy T, Domos G, Hevér D, Horváth N, Kiss S, Szőke G Tags: Orv Hetil Source Type: research

Efficacy of botulinum toxin in the treatment of bruxism: Systematic review.
CONCLUSION: Infiltrations with BTX-A are a safe and effective treatment for patients with bruxism, so its use is justified in daily clinical practice, especially in patients diagnosed with severe bruxism. PMID: 31246937 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - June 29, 2019 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Botuloscope: 1-year follow-up of upper limb post-stroke spasticity treated with botulinum toxin
Publication date: Available online 20 June 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Philippe Marque, Angelique Denis, David Gasq, Emmanuelle Chaleat-Valayer, Alain Yelnik, Cyrille Colin, Botuloscope Group, Dominic PérennouAbstractBackgroundBotuloscope is a cohort study supported by a French public grant and aiming to evaluate a 1-year treatment of the post-stroke spastic upper limb with botulinum toxin type A (BoNT-A) in terms of individual satisfaction with respect to personalized goals and quality of life.MethodsThis was an open-label prospective, multicentric study (11 French centres) ...
Source: Annals of Physical and Rehabilitation Medicine - June 25, 2019 Category: Rehabilitation Source Type: research

Botuloscope: 1-year follow-up of upper-limb post-stroke spasticity treated with botulinum toxin
Publication date: Available online 20 June 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Philippe Marque, Angelique Denis, David Gasq, Emmanuelle Chaleat-Valayer, Alain Yelnik, Cyrille Colin, Botuloscope Group, Dominic PérennouAbstractBackground. Botuloscope is a cohort study supported by a French public grant and aiming to evaluate 1-year treatment of the post-stroke spastic upper limb with botulinum toxin type A (BoNT-A) in terms of individual satisfaction with respect to personalized goals and quality of life.Methods. This was an open-label prospective, multicentric study (11 French centres...
Source: Annals of Physical and Rehabilitation Medicine - June 22, 2019 Category: Rehabilitation Source Type: research

Electrical stimulation of antagonist muscles after botulinum toxin type A for post-stroke spastic equinus foot. A randomized single-blind pilot study
Publication date: Available online 19 June 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Alessio Baricich, Alessandro Picelli, Stefano Carda, Nicola Smania, Carlo Cisari, Andrea Santamato, Alessandro de Sire, Marco InvernizziAbstractBackground. Botulinum toxin type A (BoNT-A) injection is an effective treatment for lower-limb spasticity and should be offered as first-line treatment for focal manifestations. Although its possible role has been hypothesized, the efficacy of electrical stimulation (ES) of antagonists of the injected muscles for improving clinical outcome after BoNT-A injection remains t...
Source: Annals of Physical and Rehabilitation Medicine - June 21, 2019 Category: Rehabilitation Source Type: research

Can Botox Offer Help Women With Vaginismus? A Systematic Review and Meta-Analysis
. (Source: International Journal of Sexual Health)
Source: International Journal of Sexual Health - June 19, 2019 Category: Sexual Medicine Authors: Atefeh Velayati Shahideh Jahanian Sadatmahalleh Saeideh Ziaei Anoshirvan Kazemnejad Source Type: research

Comment on "Botulinum toxin type-A as an alternative treatment for gummy smile: a case report".
Comment on "Botulinum toxin type-A as an alternative treatment for gummy smile: a case report". Dermatol Online J. 2019 Jun 15;25(6): Authors: Pedron IG Abstract Currently, the search for esthetic excellence has become the main objective in the facial treatment. The gummy smile is one of the complaints from the patients, since this situation may influence their self-esteem and social relationship. The development of new techniques, such as the application of botulinum toxin, may be a conservative therapeutic option in the treatment of gummy smile. The purpose of this letter is to comment som...
Source: Dermatol Online J - June 15, 2019 Category: Dermatology Authors: Pedron IG Tags: Dermatol Online J Source Type: research

Hip Adductor Intramuscular Nerve Distribution Pattern of Children: A Guide for BTX-A Treatment to Muscle Spasticity in Cerebral Palsy
This study is the first to systematically investigate the intramuscular nerve distribution pattern in the hip adductors. The results indicated that the best targets for BTX-A injection, when treating spasticity, are the dense regions of terminal nerves described above. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - June 14, 2019 Category: Neurology Source Type: research

Comparison of Intralesional Triamcinolone Acetonide, Botulinum toxin type A, and Their Combination for the Treatment of Keloid lesions.
Conclusion: Combined injection of intralesional steroids with BTX-A appears to be superior to either therapy alone and offer the best benefit of safer and more efficacious response with lesser side effects. PMID: 31184533 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - June 13, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Botulinum toxin type A in chronic neuropathic pain in refractory leprosy
Conclusion: BoNT-A proved to be a good therapeutic option in relieving pain with improved quality of life for these patients.RESUMO A dor neurop ática é uma síndrome crônica que é difícil de tratar e freqüentemente afeta pacientes com hanseníase. O tratamento recomendado inclui o uso de drogas analgésicas, codeína, antidepressivos tricíclicos, neurolépticos, anticonvulsivantes e talidomida, mas sem consenso sobre dose uniforme e resultados plenamente satisfatórios. Objetivo: Busca-se analisar a efetividade da toxina botulínica ti...
Source: Arquivos de Neuro-Psiquiatria - June 10, 2019 Category: Neurology Source Type: research

Botulinum toxin type A reduces the expression of transient receptor potential melastatin 3 and transient receptor potential vanilloid type 4 in the trigeminal subnucleus caudalis of a rat model of trigeminal neuralgia
This study was designed to investigate the expression of transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid type 4 (TRPV4) in the trigeminal spinal subnucleus caudalis of a rat model of trigeminal neuralgia (TN). The influence of botulinum toxin type A (BTX-A) on the expression of these channels was also explored. In this study, a model was established involving chronic constriction injury to the infraorbital nerve (ION-CCI), inducing TN. To explore the effects of BTX-A and whether it was dose related, rats were divided randomly into four groups: a control group, an ION-CCI group, ...
Source: NeuroReport - June 8, 2019 Category: Neurology Tags: DEGENERATION AND REPAIR Source Type: research

Expression of a degradation ‐resistant β‐catenin mutant in osteocytes protects the skeleton from mechanodeprivation‐induced bone wasting
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Whitney A. Bullock, April Hoggatt, Daniel J. Horan, Karl Lewis, Hiroki Yokota, Steven Hann, Matthew L. Warman, Aimy Sebastian, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling Tags: ORIGINAL ARTICLE Source Type: research