Intraarticular botulinum toxin type A versus corticosteroid or hyaluronic acid for painful knee osteoarthritis: A meta-analysis of head-to-head randomized controlled trials
Toxicon. 2024 Feb 22:107656. doi: 10.1016/j.toxicon.2024.107656. Online ahead of print.ABSTRACTIntraarticular botulinum toxin type A (BTA) has been shown to be effective for painful knee osteoarthritis (KOA), while the efficacy and safety of intraarticular BTA compared to corticosteroid and hyaluronic acid (HA) remains unknown. A meta-analysis was performed to compare. A search was conducted in Medline (PubMed), CENTER (Cochrane Library), Embase (Ovid), Web of Science, Wanfang, and CNKI to find head-to-head randomized controlled trials (RCTs) directly compare the efficacy and safety between intraarticular BTA and intraarti...
Source: Toxicon - February 24, 2024 Category: Toxicology Authors: Yinan Yang Guozheng Li Yuping Su Source Type: research
Intradetrusor Botox Injection and Augmentation Cystoplasty Trends Among Spina Bifida Patients at US Freestanding Children ’s Hospitals
Intra-detrusor botulinum toxin (Botox) injection is a minimally invasive alternative to augmentation cystoplasty in patients with refractory neurogenic bladder. Botox was first used for neurogenic bladder children two decades ago. However, there are no existing guidelines on indications or use among patients with spina bifida. Furthermore, there are little data regarding its use relative to bladder augmentation and patient volume on a national scale. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - February 16, 2024 Category: Urology & Nephrology Authors: Ranveer Vasdev, Kenneth Softness, Dylan Cahill, John Panagides, Tanya Logvinenko, Rachel Saunders, Stuart Bauer, Carlos Estrada, Hsin-Hsiao Scott Wang Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
The efficacy and safety of botulinum toxin epicardial fat injection to prevent postoperative atrial fibrillation in patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials
CONCLUSION: There was no difference between the epicardial fat injection of BTX versus placebo for preventing POAF.PMID:38343481 | PMC:PMC10857451 | DOI:10.1080/08998280.2023.2299205 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - February 12, 2024 Category: Universities & Medical Training Authors: Mohamed Abuelazm Othman Saleh Soumya Kambalapalli Majd M Albarakat Ibrahim Gowaily Abdelrahman Mahmoud Basel Abdelazeem Source Type: research
Botulinum toxin type a blocks aquaporin 5 trafficking by decreasing synaptosomal-associated protein 23 in submandibular acinar cells
In this study, SNAP23 was predominantly localized to the plasma membrane of acinar cells in the rat submandibular gland (SMG) and colocalized with AQP5 at the apical membrane of acinar cells. In stable GFP-AQP5-transfected SMG-C6 cells, the acetylcholine receptor agonist carbachol (CCh) induced trafficking of AQP5 from intracellular vesicles to the apical membrane. Furthermore, SNAP23 knockdown by siRNA significantly inhibited CCh-induced AQP5 trafficking, whereas this inhibitory effect was reversed by SNAP23 re-expression, indicating that SNAP23 was essential in AQP5 trafficking. More importantly, BoNT/A inhibited salivar...
Source: Experimental Cell Research - February 2, 2024 Category: Cytology Authors: Hui Xu Huabing Ge Zhigang Cai Source Type: research
Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis
In conclusion, BTXA exhibited an antiapoptotic effect on DHT-induced DPC injury via the circ_0135062/miR-506-3p/Bax axis.Level of Evidence II This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - January 29, 2024 Category: Cosmetic Surgery Source Type: research
Successful Treatment of Schwartz-Jampel Syndrome with Botulinum Toxin Type A
In this report, we describe a male patient with SJS type 1A. Trio whole-exome sequencing identified a pathogenic mutation (NM_001291860.1: c.10897C>T; p.Arg3633Ter) and variants of unknown significance (NM_001291860.2: c.413+10G>T). The patient experienced difficulty in opening his eyes and mouth, which significantly limited his daily activities. Botulinum toxin A injection was administered and demonstrated significant clinical improvement after the treatment. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - January 28, 2024 Category: Dermatology Source Type: research
Does prior treatment not affect the clinical success of peroral endoscopic myotomy and lead to reduced procedure time?
We read with great interest the article by Kadiyala et al,1 who conducted a study to compare clinical success and procedural times between treatment-naïve and treatment-refractory patients with achalasia and other esophageal motility disorders during peroral endoscopic myotomy (POEM). Finally, they concluded that prior treatment, including Botox inje ctions, pneumatic dilation (PD), and laparoscopic Heller myotomy (LHM), did not negatively affect clinical success or lead to reduced procedure time. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 17, 2024 Category: Gastroenterology Authors: Han Zhang, Huang Zhong, Zhong Huang, Xiaowei Tang Tags: Letter to the Editor Source Type: research
A Phase III Clinical Study of the Efficacy and Safety of Botulinum Toxin Type A (MASPORT) with DYSPORT for the Treatment of Glabellar Lines
ConclusionAbobotulinum toxin A [MASPORT] is equally safe and effective as commercial product [DYSPORT] for the treatment of glabellar lines with the dose of 50 units, up to 120 days.Level of Evidence IThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266. (Source: Aesthetic Plastic Surgery)
Source: Aesthetic Plastic Surgery - January 17, 2024 Category: Cosmetic Surgery Source Type: research
Intrathecal Baclofen Infusion-Botulinum Toxin Combined Treatment Efficacy in the Management of Spasticity due to Cerebral Palsy
CONCLUSION: This study demonstrated the efficacy and safety of intrathecal baclofen infusion and botulinum toxin combined treatment in the management of spasticity, pain, quality of life, and selfcare in CP patients.PMID:38213169 | DOI:10.2174/0118715273250973230919121808 (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - January 12, 2024 Category: Drugs & Pharmacology Authors: Riccardo Marvulli Giuseppa Lagioia Giancarlo Ianieri Lucrezia Dell'Olio Alessandra Zonno Mariagrazia Riccardi Rosa Bianca Sinisi Laura Belinda Rizzo Giacomo Far ì Marisa Megna Maurizio Ranieri Source Type: research
Optimized Patient Outcomes With the Novel Modality of Corrective Chemical Peel and Neurotoxin on Same-Day Treatment
Conclusion: This study confirmed the safety of the same-day combination. The efficacy of VI Peel & Botox same-day treatment was clinically proven by the improvements to Wrinkle Severity, Uniformity of Pigment, and Skin Tone via photographic matching. While perception studies indicated strong patient satisfaction with the combination. J Drugs Dermatol. 2024;23(1):1349-1354. doi:10.36849/JDD.7194R1.PMID:38206148 | DOI:10.36849/JDD.7194 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - January 11, 2024 Category: Dermatology Authors: Wendy E Roberts Nancy Miller Source Type: research
Preferably pre-empt pathological scars, or pick from a plethora of therapies
AbstractPathological scars, including keloids and hypertrophic scars, are best managed by preventative strategies, such as occlusive silicone dressings or gels, or pressure therapies. For established lesions, intralesional corticosteroids, particularly triamcinolone acetonide (TAC) are first-line therapies. Combining TAC with intralesional 5-fluorouracil or non-pharmacological options such as lasers is generally more effective than monotherapy and may be better tolerated. Other treatments include cryotherapy, botulinum toxin type A, and more novel therapies including anti-cancer and anti-inflammatory agents. Well-designed ...
Source: Drugs and Therapy Perspectives - January 8, 2024 Category: Drugs & Pharmacology Source Type: research
Prevention of component separation in complex abdominal wall surgery by Botox prehabilitation: a propensity-matched study
ConclusionThere is a tendency for decrease of necessity for CST by preoperatively administered BTA in patients with complex abdominal wall defects. Although small, as this study used propensity matched comparison, further exploration of BTA should be encouraged. (Source: Hernia)
Source: Hernia - January 3, 2024 Category: Sports Medicine Source Type: research
