Plant toxins linked to biliary atresia in newborn animals
Plant toxin causes changes that resemble biliary atresia, a liver disease that affects newborns and causes the bile ducts to become inflamed and scarred. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

FDA Cracks Down on Duodenoscope Manufacturers Again
FDA doesn't like it when manufacturers ignore the agency's orders, as all three companies that make duodenoscope should probably have figured out by now. The company said it issued warning letters Friday to Olmpus, Pentax, and Fujifilm for failing to comply with post-market surveillance requirements to assess the effectiveness of reprocessing the devices. As part of an ongoing effort to prevent patient infections associated with the transmission of bacteria from contaminated duodenoscopes, FDA in 2015 ordered these manufacturers to conduct a post-market surveillance study to determine whether healthcare facilities were abl...
Source: MDDI - March 10, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news

Liver study offers insights into hard-to-treat diseases
(University of Edinburgh) A key cell process that could cause damage to bile ducts and help explain some liver diseases has been identified by scientists. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2018 Category: International Medicine & Public Health Source Type: news

Polyganics liver and pancreas sealant wins FDA breakthrough designation
Polyganics said today it won FDA breakthrough device designation for its Liver and Pancreas Sealant Patch designed to prevent fluid leakage after hepato-pancreato-biliary procedures. The Dutch company’s Liver and Pancreas Sealant Patch is made from a proprietary bioresorbable polymer designed to seal-off the surgically treated tissue during the critical healing period. “There is a clear need for a device that can effectively control the leakage of fluids in HPB surgery, that can be applied easily and can seal and withstand the enzymatic action and acid substances such as bile and pancreatic fluids. If an effec...
Source: Mass Device - March 8, 2018 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regulatory/Compliance Surgical Wound Care Polyganics Source Type: news

Building better bile ducts
(Source: ScienceNOW)
Source: ScienceNOW - March 8, 2018 Category: Science Authors: Sampaziotis, F. Tags: essays Source Type: news

Boston Sci Whets M & amp;A Appetite with EMcision Buy
Boston Scientific could be very busy with M&A this year. During the Marlborough, MA-based company’s most recent earnings call, CEO Michael Mahoney hinted at the possibility of potential acquisitions. “We do have a pretty active M&A appetite,” Mahoney said, according to a transcript from Seeking Alpha. "So, I think you'll see us be active with tuck-in acquisitions to strengthen our category leadership strategy." On Monday, Boston Scientific backed up its CEO’s words and revealed it would strengthen its endoscopy offerings with the acquisition of London – based EMcision, for an undisclosed sum. With the EM...
Source: MDDI - March 5, 2018 Category: Medical Devices Authors: Omar Ford Tags: Medical Device Business Source Type: news

Medical News Today: Why am I vomiting green or yellow bile?
Throwing up bile, a yellow or greenish liquid, can happen for many reasons. Some of the causes may be serious and require urgent medical attention. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2018 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

For one early adopter, CAR T therapy means 18 months cancer-free and counting
For as long as he can remember, Josh Feldman has eagerly embraced the latest technology.Decades ago, his family was the first one on the block with a VCR. Years later, when television went hi-def, he acquired a big-screen TV and signed up for HD service.So after he was diagnosed with lymphoma, it was only natural that Feldman was driven to join clinical trials for a promising new treatment. He would become one of the first UCLA Health patients to receive CAR T therapy. When nothing else worked, the treatment beat back cancer and filled his life with new hope.“Years ago, while doing my own reading after my diagnosis, I le...
Source: UCLA Newsroom: Health Sciences - February 14, 2018 Category: Universities & Medical Training Source Type: news

Bile Duct Cancer (Cholangiocarcinoma)
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 2, 2018 Category: General Medicine Source Type: news

Bile acids fire up fat burning
(Ecole Polytechnique F é d é rale de Lausanne) EPFL scientists have discovered a novel role for bile acids: converting energy-storing white fat depots into energy-expending beige fat. The study is published in Nature Communications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 16, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: What you should know about the HIDA scan
The HIDA scan is used to view the liver, gallbladder, bile ducts, and small intestine. Included are details on side effects and why it is done. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 3, 2018 Category: Consumer Health News Tags: Radiology / Nuclear Medicine Source Type: news

RedHill teams with Mayo Clinic, MD Anderson on new cancer trial
Tel-Aviv, Israel-based RedHill Biopharma (Nasdaq: RDHL) – which is continuing to build up its U.S. commercial operations based in Raleigh – is teaming with the Mayo Clinic and The University of Texas MD Anderson Cancer Center on a new cancer trial. The new Phase IIa study is for YELIVA – a product candidate RedHill acquired from Apogee Biotechnolo gy back in 2015 – for the treatment of cholangiocarcinoma, or bile duct cancer. It will enroll patients at Mayo Clinic campuses in both Arizona… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - December 28, 2017 Category: Pharmaceuticals Authors: Jennifer Henderson Source Type: news

Medical News Today: Biliary colic: Causes and treatment
Biliary colic can happen when a gallstone blocks a bile duct, causing intense stomach pain. It is also known as a gallstone attack or gallbladder attack. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 27, 2017 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

CD4 T cells, xenobiotic transporters, and metabolites in inflammatory bowel diseases
(Osaka University) Few studies have investigated the interaction between intestinal T cells with metabolites. Researchers have now shown in mice CD4+ T effector (Teff) cells upregulate the protein Mdr1 in the ileum to maintain homeostasis in the presence of the metabolite bile acid. Mice lacking Mdr1 display mucosal dysfunction and induce Crohn's disease-like ileitis. Their findings suggest that T cell adaptation to enterohepatic bile acid circulation in the ileum safeguards intestinal homeostasis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 26, 2017 Category: International Medicine & Public Health Source Type: news

What is DIOS?
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - December 18, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news