A case report on fatal intoxication by tapentadol: study of distribution and metabolism - Carelli C, Freni F, Moretti M, Vignali C, Ballardini M, Morini L.
We report a case in which a tapentadol acute intoxication was suspected as the cause of death of a 39-year-old man: approximately two days after death, cardiac and femoral blood, as well as urine, bile, gastric content and chest hair, were collected during... (Source: SafetyLit)
Source: SafetyLit - May 20, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Norfolk and Norwich Hospital: 'Serious concerns' over three operations
The removal of a bile duct is one of three procedures by the same surgeon under investigation. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 27, 2021 Category: Consumer Health News Source Type: news

Crohn's disease may be caused by immune signaling failure
(Scripps Research Institute) Scientists find that T cells in the small intestine prevent bile acid-driven stress and inflammation. The work highlights a completely new direction in Crohn's disease research, and potentially, its treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 7, 2021 Category: International Medicine & Public Health Source Type: news

Bile and Potatoes, 1921
One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis. (Source: The Scientist)
Source: The Scientist - April 1, 2021 Category: Science Tags: Foundations Magazine Issue Source Type: news

Europe Approves Pemigatinib for Bile Duct Cancer Europe Approves Pemigatinib for Bile Duct Cancer
The oral targeted therapy is for the treatment of locally advanced or metastatic cholangiocarcinoma.International Approvals (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 31, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news

Mirum Pharmaceuticals Announces FDA Acceptance of New Drug Application and Priority Review for Maralixibat in Alagille Syndrome
FOSTER CITY, Calif.--(BUSINESS WIRE)--Mar. 29, 2021-- Mirum Pharmaceuticals, Inc. (Nasdaq: MIRM) announced today that its New Drug Application (NDA) for maralixibat, an oral apical sodium dependent bile acid transporter (ASBT) inhibitor... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 29, 2021 Category: Drugs & Pharmacology Source Type: news

Study estimates rising global burden of gallbladder and biliary tract cancer
(Wiley) Although cancers that occur in the gallbladder or bile ducts are rare, their rates are increasing. A recent study provides details on the burden of gallbladder and biliary tract cancer (GBTC) across 195 countries and territories from 1990 to 2017. The findings are published early online inCANCER, a peer-reviewed journal of the American Cancer Society. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 22, 2021 Category: International Medicine & Public Health Source Type: news

Mayo Clinic Q & amp;A podcast: Hidden gallbladder and bile duct cancers
The gallbladder is a small, pear-shaped organ that sits just beneath the liver, on the right side of the abdomen. Slender tubes that carry bile fluid also are also located in that area. Because of the relatively hidden nature of the gallbladder and bile ducts, cancers can grow without being detected. Late detection can mean [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 22, 2021 Category: Databases & Libraries Source Type: news

Lab-grown ‘mini-bile ducts’ by scientists at Cambridge university used to repair human livers in regenerative medicine first
Scientists have used a technique to grow bile duct organoids – often referred to as ‘mini-organs’ – in the lab and shown that these can... (Source: Reuters: Health)
Source: Reuters: Health - February 20, 2021 Category: Consumer Health News Source Type: news

Organoids Repair Bile Ducts
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally. (Source: The Scientist)
Source: The Scientist - February 18, 2021 Category: Science Tags: News & Opinion Source Type: news

Organoids regenerate human bile ducts
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Kelly, P. N. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and resume their in vivo signatures when transplanted back in the biliary tree. We then utilize a model of cell engraftment in human livers undergoing ex vivo normothermic perfusion to...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., Mahbubani, K., Canu, G., Gieseck, R., Berntsen, N. L., Mulcahy, V. L., Crick, K., Fear, C., Robinson, S., Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 16, 2021 Category: Cancer & Oncology Tags: Gastroenterology, Hepatology, Oncology, News, Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
TUESDAY, Feb. 16, 2021 -- Most people aren ' t aware of the signs of gallbladder or bile duct cancer, but the Rutgers Cancer Institute of New Jersey says they should be. The gallbladder is a small organ connected to the liver by bile ducts. Its job... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 16, 2021 Category: General Medicine Source Type: news

Know the Signs of Rare But Deadly Gall Bladder, Bile Duct Cancers
Title: Know the Signs of Rare But Deadly Gall Bladder, Bile Duct CancersCategory: Health NewsCreated: 2/16/2021 12:00:00 AMLast Editorial Review: 2/16/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - February 16, 2021 Category: Cancer & Oncology Source Type: news