Ulcerative colitis: bacteria findings raise hopes for new treatment
Sufferers found to have low levels of gut microbes that convert bile acids into other substancesHopes of developing a new treatment for ulcerative colitis have been raised by research suggesting the condition may be linked to low levels of certain bacteria in the gut.Ulcerative colitis is a long-term condition in whichthe colon becomes inflamed. Accordingto the NHS, it is thought to be an autoimmune disease and affects one in every 420 people in the UK. Sufferers need to empty their bowels frequently, develop ulcers in their colon and have recurring bouts of diarrhoea with blood and pus in the faeces.Continue reading... (S...
Source: Guardian Unlimited Science - February 25, 2020 Category: Science Authors: Nicola Davis Tags: Digestive disorders Science Health & wellbeing Life and style Society Source Type: news

Bile duct cancer treatment potential boost from tailored medication -- study
(University of Birmingham) Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

'Genetic rewiring' drives cancer's drug resistance
(Institute of Cancer Research) Tiny RNA molecule rewires signalling network in bile duct cancer. Drugs to block RNA could overcome cancer's drug resistance. Findings announced to coincide with Bile Duct Cancer Awareness Day. Results could be applicable in other cancer types and have wider benefit. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Wild melancholy: on the historical plausibility of a black bile theory of blood madness, or h æmatomania - Verplaetse J.
Nineteenth-century art historian John Addington Symonds coined the term h æmatomania (blood madness) for the extremely bloodthirsty behaviour of a number of disturbed rulers like Ibrahim II of Ifriqiya (850-902) and Ezzelino da Romano (1194-1259). A... (Source: SafetyLit)
Source: SafetyLit - January 27, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Study suggests new strategy for treating advanced, progressing bile duct cancer
(Ohio State University Wexner Medical Center) A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) shows how resistance to a promising targeted drug develops in patients with a rare, lethal cancer of the bile ducts called cholangiocarcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 14, 2020 Category: Cancer & Oncology Source Type: news

Epistane, an anabolic steroid used for recreational purposes, causes cholestasis with elevated levels of cholic acid conjugates, by upregulating bile acid synthesis (CYP8B1) and cross-talking with nuclear receptors in human hepatocytes - Petrov PD, Fern ández-Murga L, Conde I, Martínez-Sena T, Guzmán C, Castell JV, Jover R.
Anabolic-androgenic steroids are testosterone derivatives, used by body-builders to increase muscle mass. Epistane (EPI) is an orally administered 17 α-alkylated testosterone derivative with 2a-3a epithio ring. We identified four individuals who, after EPI... (Source: SafetyLit)
Source: SafetyLit - January 4, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Versatile bile acids
(Harvard Medical School) Could bile acids -- the fat-dissolving juices churned out by the liver and gallbladder -- also play a role in immunity and inflammation?The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 3, 2020 Category: International Medicine & Public Health Source Type: news

Betrayed by bile: bile acids help norovirus sneak into cells
(Baylor College of Medicine) Human noroviruses, the leading viral cause of foodborne illness and acute diarrhea around the world, infect cells of the small intestine by piggybacking on a normal cellular process called endocytosis that cells use to acquire materials from their environment. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 31, 2019 Category: Infectious Diseases Source Type: news

Medtech in a Minute: FTC Blocks a Big Deal, Boston Scientific Scores a Win for Patient Safety, and More
FTC Blocks Illumina-PacBio Deal The Federal Trade Commission is challenging the $1.2 billion-merger between Illumina and PacificBio (PacBio). The agency says Illumina is seeking to unlawfully maintain its monopoly in the U.S. market for next-generation DNA sequencing systems by extinguishing PacBio as a nascent competitive threat.   Fully Disposable Duodenoscope Is a Win for Patient Safety Boston Scientific snagged FDA clearance to sell its Exalt-D single-use duodenoscope in the United States to provide visualization and access to the upper gastrointestinal (GI) t...
Source: MDDI - December 21, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Source Type: news

Boston Scientific Wins FDA Clearance for the World & #039;s First Fully Disposable Duodenoscope
Contamination on duodenoscopes after reprocessing continues to be a major concern in the United States, but a recent FDA clearance represents a major step toward combating the problem. Boston Scientific snagged clearance to sell its Exalt-D single-use duodenoscope in the United States to provide visualization and access to the upper gastrointestinal (GI) tract to treat bile duct disorders and other upper GI problems. The Exalt-D is the first fully disposable duodenoscope to reach the market. The company is planning a limited U.S. market release of the device during the first quarter of 2...
Source: MDDI - December 13, 2019 Category: Medical Devices Tags: Business Regulatory and Compliance Source Type: news

FDA Approves First Disposable Duodenoscope, Reducing Infection Risk
FRIDAY, Dec. 13, 2019 -- Improperly cleaned duodenoscopes -- a type of endoscope used to diagnose illness in the pancreas and bile ducts -- have been linked to hundreds of cases of severe, sometimes fatal, infections in patients. Now, U.S. Food and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 13, 2019 Category: General Medicine Source Type: news

Gallbladder and Biliary Disease | Medscape Gallbladder and Biliary Disease | Medscape
Biliary disease encompasses a wide spectrum of disorders caused by abnormalities in bile composition, biliary anatomy, or function. The liver determines the chemical composition of bile, and this may be subsequently modified by the gallbladder and biliary epithelium. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 31, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news

iRhom2 inhibits bile duct obstruction-induced liver fibrosis
Chronic liver disease can induce prolonged activation of hepatic stellate cells, which may result in liver fibrosis. Inactive rhomboid protein 2 (iRhom2) is required for the maturation of A disintegrin and metalloprotease 17 (ADAM17, also called TACE), which is responsible for the cleavage of membrane-bound tumor necrosis factor–α (TNF-α) and its receptors (TNFRs). Here, using the murine bile duct ligation (BDL) model, we showed that the abundance of iRhom2 and activation of ADAM17 increased during liver fibrosis. Consistent with this, concentrations of ADAM17 substrates were increased in plasma samples f...
Source: Signal Transduction Knowledge Environment - October 28, 2019 Category: Science Authors: Sundaram, B., Behnke, K., Belancic, A., Al-Salihi, M. A., Thabet, Y., Polz, R., Pellegrino, R., Zhuang, Y., Shinde, P. V., Xu, H. C., Vasilevska, J., Longerich, T., Herebian, D., Mayatepek, E., Bock, H. H., May, P., Kordes, C., Aghaeepour, N., Mak, T. W., Tags: STKE Research Articles Source Type: news

Grail Stays at Forefront of Liquid Biopsy Conversation with New Results
Newly-released data is putting Grail back in the forefront of the liquid biopsy conversation. The Menlo Park, CA-based company announced data validating the performance of its investigational multi-cancer early detection blood test for the first time in an independent cohort of participants. The validation data is coming from both the Circulating Cell-Free Genome Atlas (CCGA) study. Data show Grail’s liquid biopsy test was shown to detect more than 20 cancer types across all stages with a single, very low false-positive rate. Grail will present the results at an American Society of Clinical Oncology Break...
Source: MDDI - October 11, 2019 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news

Our union are at the forefront of fighting the far-right
Our union has always been at the forefront of fighting the hatred of the far right in our communities – that’s why we’re proud supporters of HOPE not hate. So I’m delighted to have become a patron of the HOPE education action fund. Taking the fight against that hate into our schools is vital. Working with young people to challenge far-right radicalisation is more important than ever, because we know they are being targeted by far right groups. Young people are being exposed to the bile and toxic lies of the fascists more than ever, but these days their approach is more insidious and subtle. Social media is a force ...
Source: UNISON Health care news - October 4, 2019 Category: UK Health Authors: Rachael Henry Tags: General secretary's blog hope not hate Source Type: news