Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells
Primary liver tumors and liver metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators of antitumor immunity, and although the liver is exposed to gut bacteria, their role in antitumor surveillance of liver tumors is poorly understood. We found that altering commensal gut bacteria in mice induced a liver-selective antitumor effect, with an increase of hepatic CXCR6+ natural killer T (NKT) cells and heightened interferon- production upon antigen stimulation. In vivo functional studies showed that NKT cells mediated liver-selective tumor inhibition. NKT cell accum...
Source: ScienceNOW - May 24, 2018 Category: Science Authors: Ma, C., Han, M., Heinrich, B., Fu, Q., Zhang, Q., Sandhu, M., Agdashian, D., Terabe, M., Berzofsky, J. A., Fako, V., Ritz, T., Longerich, T., Theriot, C. M., McCulloch, J. A., Roy, S., Yuan, W., Thovarai, V., Sen, S. K., Ruchirawat, M., Korangy, F., Wang, Tags: Immunology, Online Only r-articles Source Type: news

Why are we living in an age of anger – is it because of the 50-year rage cycle?
From passive-aggressive notes on ambulance windscreens to bilious political discourse, it feels as though society is suddenly consumed by fury. What is to blame for this outpouring of aggression?A neighbourobjected to a young couple from Newcastle being naked in their own home. “We are sick of seeing big bums, big boobs and little willy,” was the core message of the note, crescendoing to: “We will report you both for indecent exposure.” It is such a small thing, banal, without consequence. It connects to no wider narrative and conveys nothing but the bubbling disco mfort of human beings living near each other. Yet ...
Source: Guardian Unlimited Science - May 16, 2018 Category: Science Authors: Zoe Williams Tags: Psychology Social media Digital media Social networking Science Source Type: news

Handful of walnuts a day may prevent heart disease and bowel cancer by encouraging 'good' bacteria
Researchers from the  University of Illinois found eating a third of a cup of walnuts for six weeks reduces the production of excess bile acids, as well as lowering 'bad' cholesterol levels. (Source: the Mail online | Health)
Source: the Mail online | Health - May 4, 2018 Category: Consumer Health News Source Type: news

'Rapid autopsy' races the clock to unlock mysteries of cancer
After Keith Beck died of bile duct cancer last year, family members said more than 900 people showed up to pay respects to the popular athletic director at the University of Findlay in northwestern Ohio. (Source: CNN.com - Health)
Source: CNN.com - Health - May 3, 2018 Category: Consumer Health News Source Type: news

'Rapid autopsy' to unlock mysteries of cancer
After Keith Beck died of bile duct cancer last year, family members said more than 900 people showed up to pay respects to the popular athletic director at the University of Findlay in northwestern Ohio. (Source: CNN.com - Health)
Source: CNN.com - Health - May 3, 2018 Category: Consumer Health News Source Type: news

How a New Kind of Autopsy Is Helping in the Fight Against Cancer
After Keith Beck died of bile duct cancer last year, family members said, more than 900 people showed up to pay respects to the popular athletic director at the University of Findlay in northwestern Ohio. Many were former students who recalled acts of kindness during Beck’s nearly 30-year career: $20 given to a kid who was broke, textbooks bought for a student whose parents were going through bankruptcy, a spot cleared to sleep on Beck’s living room floor. But few knew about Beck’s final gesture of generosity. The 59-year-old had agreed to a “rapid autopsy,” a procedure conducted within hours ...
Source: TIME: Health - April 24, 2018 Category: Consumer Health News Authors: JoNel Aleccia / Kaiser Health News Tags: Uncategorized Cancer healthytime Source Type: news

Novel Non-Bile FXR Agonist Promising in PBC Patients
(MedPage Today) -- Phase II trial interim analysis found dose-dependent response, good safety profile (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - April 16, 2018 Category: Gastroenterology Source Type: news

First-in-human clinical trial of new targeted therapy drug reports promising responses for multiple
(University of Texas M. D. Anderson Cancer Center) A phase I, first-in-human study led by The University of Texas MD Anderson Cancer Center reveals for the first time, an investigational drug that is effective and safe for patients with cancers caused by an alteration in the receptor tyrosine kinase known as RET. The drug appears to be promising as a potential therapy for RET-driven cancers, such as medullary and papillary thyroid, non-small cell lung, colorectal and bile duct cancers, which have been historically difficult to treat. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2018 Category: Cancer & Oncology Source Type: news

The Medical Device Behind the Discovery of a New Human Structure
What on Earth is this thing? That is the question David Carr-Locke, MD, and his colleagues asked when they discovered a microanatomical network of interconnected spaces, filled with fluid and lined by collagen with a unique arrangement, that appears to be present throughout the body. Whether or not this network is actually a newly discovered human organ is debatable. What is clear, however, is that this discovery is very widespread throughout the body and contains a lot of fluid, said Carr-Locke, clinical director of the Center for Advanced Digestive Care at Weill Cornell Medical College and New York Presbyterian Hospita...
Source: MDDI - April 13, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Imaging Source Type: news

How Intestinal Bacteria Affects Blood Sugar and Lipid Levels
Influence of changes in intestinal bacteria on sugar and lipid metabolism finds secondary bile acids produced by the bacteria can influence blood glucose and lipid concentrations and parts of their molecular mechanisms (Source: Disabled World)
Source: Disabled World - April 10, 2018 Category: Disability Tags: Digestive Disorders Source Type: news

Duodenum May Help Fight Metabolic Disease (CME/CE)
(MedPage Today) -- Manipulating duodenal features from bile acids to neurons may offer new insight into obesity and type 2 diabetes (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 6, 2018 Category: Cardiology Source Type: news

Scientists Have Discovered a New Organ in the Human Body
It’s not a second stomach or a mini-brain. But scientists have discovered an important new organ that may play a critical role in how many tissues and other organs do their jobs, as well as in some diseases like cancer. In a study published in Scientific Reports, a New York University-led team of researchers describe the interstitium, which is a series of connected, fluid-filled spaces found under skin as well as throughout the gut, lungs, blood vessels and muscles. The bubble wrap-like network only became visible when the pathologists used a new laser endoscope, called a confocal laser endomicroscope, that allowed ...
Source: TIME: Health - March 27, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized health healthytime medicine Source Type: news

Scientists Have Discovered a New Organ in the Human Body. What is the Interstitium?
It’s not a second stomach or a mini-brain. But scientists have discovered an important new organ that may play a critical role in how many tissues and other organs do their jobs, as well as in some diseases like cancer. In a study published in Scientific Reports, a New York University-led team of researchers describe the interstitium, which is a series of connected, fluid-filled spaces found under skin as well as throughout the gut, lungs, blood vessels and muscles. The bubble wrap-like network only became visible when the pathologists used a new laser endoscope, called a confocal laser endomicroscope, that allowed ...
Source: TIME: Health - March 27, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized health healthytime medicine Source Type: news

Fitness Trackers, Virtual Coaching Helps Patients Stay Fit After Cardiac Rehab
Treatment TermsCardiac prevention and cardiac rehabilitation Author Sarah Avery Overview Heart patients typically do well during cardiac rehab programs but tend to lose momentum once the formal gym-based regimens end. Duke Health researchers wanted to know if something could be done to change that result. Their small study found a follow-up program that uses wearable fitness trackers and virtual sessions with a health coach helped heart patients sustain lifestyle improvements after their cardiac rehab program ended. Content Blocks Header Mobile Health Helps Maintain Fitness Gains Content" The benefits of a ...
Source: dukehealth.org: Duke Health News - March 19, 2018 Category: Consumer Health News Authors: efh7 at duke.edu Source Type: news

Redirecting the flow of bile to the distal small intestine could provide metabolic health benefits similar to bariatric surgery
Study suggests surgical diversion of bile to the ileum results in many of the health benefits of RYGB, without the risks linked to dramatic GI tract changes. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news