Betrayed by bile: bile acids help norovirus sneak into cells
(Baylor College of Medicine) Human noroviruses, the leading viral cause of foodborne illness and acute diarrhea around the world, infect cells of the small intestine by piggybacking on a normal cellular process called endocytosis that cells use to acquire materials from their environment. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 31, 2019 Category: Infectious Diseases Source Type: news
Medtech in a Minute: FTC Blocks a Big Deal, Boston Scientific Scores a Win for Patient Safety, and More
FTC Blocks Illumina-PacBio Deal
The Federal Trade Commission is challenging the $1.2 billion-merger between Illumina and PacificBio (PacBio). The agency says Illumina is seeking to unlawfully maintain its monopoly in the U.S. market for next-generation DNA sequencing systems by extinguishing PacBio as a nascent competitive threat.
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Fully Disposable Duodenoscope Is a Win for Patient Safety
Boston Scientific snagged FDA clearance to sell its Exalt-D single-use duodenoscope in the United States to provide visualization and access to the upper gastrointestinal (GI) t...
Source: MDDI - December 21, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Source Type: news
Boston Scientific Wins FDA Clearance for the World & #039;s First Fully Disposable Duodenoscope
Contamination on duodenoscopes after reprocessing continues to be a major concern in the United States, but a recent FDA clearance represents a major step toward combating the problem.
Boston Scientific snagged clearance to sell its Exalt-D single-use duodenoscope in the United States to provide visualization and access to the upper gastrointestinal (GI) tract to treat bile duct disorders and other upper GI problems. The Exalt-D is the first fully disposable duodenoscope to reach the market. The company is planning a limited U.S. market release of the device during the first quarter of 2...
Source: MDDI - December 13, 2019 Category: Medical Devices Tags: Business Regulatory and Compliance Source Type: news
FDA Approves First Disposable Duodenoscope, Reducing Infection Risk
FRIDAY, Dec. 13, 2019 -- Improperly cleaned duodenoscopes -- a type of endoscope used to diagnose illness in the pancreas and bile ducts -- have been linked to hundreds of cases of severe, sometimes fatal, infections in patients.
Now, U.S. Food and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 13, 2019 Category: General Medicine Source Type: news
Gallbladder and Biliary Disease | Medscape Gallbladder and Biliary Disease | Medscape
Biliary disease encompasses a wide spectrum of disorders caused by abnormalities in bile composition, biliary anatomy, or function. The liver determines the chemical composition of bile, and this may be subsequently modified by the gallbladder and biliary epithelium. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 31, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news
iRhom2 inhibits bile duct obstruction-induced liver fibrosis
Chronic liver disease can induce prolonged activation of hepatic stellate cells, which may result in liver fibrosis. Inactive rhomboid protein 2 (iRhom2) is required for the maturation of A disintegrin and metalloprotease 17 (ADAM17, also called TACE), which is responsible for the cleavage of membrane-bound tumor necrosis factor–α (TNF-α) and its receptors (TNFRs). Here, using the murine bile duct ligation (BDL) model, we showed that the abundance of iRhom2 and activation of ADAM17 increased during liver fibrosis. Consistent with this, concentrations of ADAM17 substrates were increased in plasma samples f...
Source: Signal Transduction Knowledge Environment - October 28, 2019 Category: Science Authors: Sundaram, B., Behnke, K., Belancic, A., Al-Salihi, M. A., Thabet, Y., Polz, R., Pellegrino, R., Zhuang, Y., Shinde, P. V., Xu, H. C., Vasilevska, J., Longerich, T., Herebian, D., Mayatepek, E., Bock, H. H., May, P., Kordes, C., Aghaeepour, N., Mak, T. W., Tags: STKE Research Articles Source Type: news
Grail Stays at Forefront of Liquid Biopsy Conversation with New Results
Newly-released data is putting Grail back in the forefront of the liquid biopsy conversation. The Menlo Park, CA-based company announced data validating the performance of its investigational multi-cancer early detection blood test for the first time in an independent cohort of participants.
The validation data is coming from both the Circulating Cell-Free Genome Atlas (CCGA) study. Data show Grail’s liquid biopsy test was shown to detect more than 20 cancer types across all stages with a single, very low false-positive rate. Grail will present the results at an American Society of Clinical Oncology Break...
Source: MDDI - October 11, 2019 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news
Our union are at the forefront of fighting the far-right
Our union has always been at the forefront of fighting the hatred of the far right in our communities – that’s why we’re proud supporters of HOPE not hate. So I’m delighted to have become a patron of the HOPE education action fund.
Taking the fight against that hate into our schools is vital. Working with young people to challenge far-right radicalisation is more important than ever, because we know they are being targeted by far right groups. Young people are being exposed to the bile and toxic lies of the fascists more than ever, but these days their approach is more insidious and subtle. Social media is a force ...
Source: UNISON Health care news - October 4, 2019 Category: UK Health Authors: Rachael Henry Tags: General secretary's blog hope not hate Source Type: news
Our union is at the forefront of fighting the far right
Our union has always been at the forefront of fighting the hatred of the far right in our communities – that’s why we’re proud supporters of HOPE not hate. So I’m delighted to have become a patron of the HOPE education action fund.
Taking the fight against that hate into our schools is vital. Working with young people to challenge far-right radicalisation is more important than ever, because we know they are being targeted by far right groups.
Young people are being exposed to the bile and toxic lies of the fascists more than ever, but these days their approach is more insidious and subtle. Social media is a force ...
Source: UNISON Health care news - October 4, 2019 Category: UK Health Authors: Rachael Henry Tags: General secretary's blog hope not hate Source Type: news
Prognostic Value of Intraoperative Bile Spillage in Gallbladder Adenocarcinoma
Intraoperative bile spillage might serve as a prognostic tool for gall bladder cancer. (Source: CancerNetwork)
Source: CancerNetwork - October 3, 2019 Category: Cancer & Oncology Authors: Leanne Marcello, MS Source Type: news
FDA Is Still Trying to Tackle the Dirty Duodenoscope Problem
In April FDA reported that postmarket surveillance studies indicated higher-than-expected levels of contamination on duodenoscopes after reprocessing. Now, FDA is recommending that healthcare facilities either use fully disposable duodenoscopes or ones with disposable endcaps when they become available. Disposable designs simplify or eliminate the need for reprocessing, which may reduce between-patient duodenoscope contamination as compared to reusable, or fixed endcaps, the agency said.
Duodenoscopes are the flexible, lighted tubes that are threaded through the mouth, throat, and stomach into the t...
Source: MDDI - August 29, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news
Many of the deadliest cancers receive the least amount of research funding
(Northwestern University) Many of the deadliest or most common cancers get the least amount of nonprofit research funding, reports a new Northwestern Medicine study. 'Embarrassing' or stigmatized cancers, like lung and liver, are underfunded. Colon, endometrial, liver and bile duct, cervical, ovarian, pancreatic and lung cancers were all poorly funded compared to how common they are and how many deaths they cause, the study found. In contrast, breast cancer, leukemia, lymphoma and pediatric cancers were all well-funded, respective to their impact on society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 18, 2019 Category: Cancer & Oncology Source Type: news
Medical News Today: What is bile acid malabsorption?
Bile acid malabsorption is a condition in which the body does not reabsorb enough bile acid, leading to diarrhea and other gastrointestinal symptoms. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 15, 2019 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news
CDx Diagnostics Founder and CSO Shares Company ’s Journey
CDx Diagnostics is on a mission to provide clinicians with tests and tools to preempt cancer through enhanced detection of precancerous cellular changes. The Suffern, NY-based company accomplishes this goal with WATS3, a diagnostic platform that synthesizes computer imaging, artificial intelligence, molecular biology and three-dimensional cytopathology to detect precancerous change earlier and more reliably than prior methods.
MD+DI caught up with the company’s founder and CSO to discuss the evolution of the company and where it goes from here.
MD+DI: Let’s talk a little bit about CDx D...
Source: MDDI - June 21, 2019 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news
Steffanie Strathdee: ‘Phages have evolved to become perfect predators of bacteria’
In 2015, the scientist ’s husband was almost killed by an antibiotic-resistant superbug, until she found a cure that is now saving othersInfectious disease epidemiologist Steffanie Strathdee ’s husband survived a deadly antibiotic-resistant bacterial infection thanks to her suggestion of using an unconventional cure popular in the former Soviet Union: fighting the bug with a virus. Now the global health expert at the University of California, San Diego, she has, along with her husband , Tom Patterson, who is also a scientist at the institution, written an account of their nine month ordeal –The Perfect Predator: A Sc...
Source: Guardian Unlimited Science - June 16, 2019 Category: Science Authors: Zo ë Corbyn Tags: Medical research Antibiotics Biology Science Books Society Source Type: news
