AI singles out high-risk prostate cancer on mpMRI
Working with radiomics data on multiparametric MRI (mpMRI) scans, an artificial...Read more on AuntMinnie.comRelated Reading: Advanced imaging offers insight into targeted therapies AI can predict breast cancer molecular subtypes on MRI AI can differentiate glioblastoma, brain metastasis CT radiomics improves management of bile duct cancer Faster MRI protocol avoids unneeded prostate biopsies (Source: Headlines)
Source: Headlines - February 8, 2019 Category: Radiology Source Type: news

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation
In cancer patients, metastasis of tumors to sentinel lymph nodes (LNs) predicts disease progression and often guides treatment decisions. The mechanisms underlying tumor LN metastasis are poorly understood. By using comparative transcriptomics and metabolomics analyses of primary and LN-metastatic tumors in mice, we found that LN metastasis requires that tumor cells undergo a metabolic shift toward fatty acid oxidation (FAO). Transcriptional coactivator yes-associated protein (YAP) is selectively activated in LN-metastatic tumors, leading to the up-regulation of genes in the FAO signaling pathway. Pharmacological inhibitio...
Source: ScienceNOW - February 7, 2019 Category: Science Authors: Lee, C.-k., Jeong, S.-h., Jang, C., Bae, H., Kim, Y. H., Park, I., Kim, S. K., Koh, G. Y. Tags: Medicine, Diseases reports Source Type: news

Gene-editing tool CRISPR/Cas9 shown to limit impact of certain parasitic diseases
(George Washington University) For the first time, researchers at the George Washington University have successfully used the gene-editing tool CRISPR/Cas9 to limit the impact of parasitic worms responsible for schistosomiasis and for liver fluke infection, which can cause a diverse spectrum of human disease including bile duct cancer.   (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 15, 2019 Category: Cancer & Oncology Source Type: news

Rupture of the common bile duct due to blunt trauma, presenting difficulty in diagnosis - Ishida T, Hayashi E, Tojima Y, Sakakibara M.
We present a case of a 19-year-old young woman with rupture of the common bile duct due to... (Source: SafetyLit)
Source: SafetyLit - December 25, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Could You Have Silent Gallstones?
FRIDAY, Dec. 14, 2018 -- As many as 20 million Americans have gallstones. Most don ' t have any symptoms, but not all will escape a gallstone attack. The gallbladder is a small organ in the upper right abdomen. It ' s a reservoir for bile, the fluid... (Source: - Daily MedNews)
Source: - Daily MedNews - December 14, 2018 Category: General Medicine Source Type: news

Going viral: New cells for norovirus production in the lab
(Osaka University) Human norovirus is a major cause of infections that can be particularly dangerous to children and elderly people. Here, an Osaka University-led research team found that human induced pluripotent stem cell-derived intestinal epithelial cells allowed for efficient growth of human norovirus in the laboratory, without requiring human tissue or bile. This method raises fewer practical and ethical issues than conventional systems and should prove useful for industrial applications such as testing new potential vaccines. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 10, 2018 Category: Infectious Diseases Source Type: news

Zimbabwe: Botched Surgery Costs Hospital U.S.$27 000
[The Herald] Negligence by doctors at Parirenyatwa Group of Hospitals which resulted in a patient suffering a bile leak has proved costly after the High Court ordered the public institution to pay damages amounting to US$27 890 in expenses plus R252 546. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 28, 2018 Category: African Health Source Type: news

MS Linked to Alterations in Bile Acid Metabolism MS Linked to Alterations in Bile Acid Metabolism
Abnormalities of these cholesterol metabolites in both children and adults with MS, along with encouraging preclinical findings, have spurred a clinical trial to assess supplementation therapy.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 31, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

CT radiomics improves management of bile duct cancer
Researchers from China have developed a radiomics model that can determine...Read more on AuntMinnie.comRelated Reading: Radiomics helps distinguish lung cancer nodules on CT AIUM: Can deep learning classify liver fibrosis on US? AI, radiomics help distinguish lung nodules on CT scans MRI, radiomics help diagnose, discern ADHD subtypes AAPM: Radiomics helps fine-tune radiation therapy dose (Source: Headlines)
Source: Headlines - October 19, 2018 Category: Radiology Source Type: news

UAB center dedicated to pancreas and bile duct diseases established
UAB has established a new program to treat diseases of the pancreas and bile ducts. The new Pancreatobiliary Disease Center within the UAB School of Medicine plans to link medical professionals from across UAB Medicine involved in managing pancreatobiliary diseases, which includes pancreatic and gallbladder cancer, cysts, bile duct injuries and bile duct injures. “While malign ancies of the pancreas and bile duct present their own unique challenges to treatment, so do the litany of benign diseases… (Source: Health Care:Physician Practices headlines)
Source: Health Care:Physician Practices headlines - October 8, 2018 Category: American Health Authors: Tyler Patchen Source Type: news

Silicone Materials for Long-term Medical Implants: Innovate for the Future
By Feifei Lin, Ph.D., Business Development Manager, Healthcare, Elkem Silicones USA Corp. With the growth of the aging population, the number of age-related diseases has increased. Every year millions of patients sustained or improved their lives through surgical procedures involving implanted medical devices. Implants such as orthopedics, pacemakers, cardiovascular stents, defibrillators, neural prosthetics or combinational devices like drug-eluting stents have become an indispensable part of modern medicine. Long-term implantable devices used to improve and sustain life are highly regulated by regulatory bodies around th...
Source: Mass Device - October 5, 2018 Category: Medical Devices Authors: MassDevice Tags: Sponsored Content Source Type: news

Study links BAP1 protein to tumor suppression in kidney, eye, bile duct and mesothelioma cancers
(University of Texas M. D. Anderson Cancer Center) Researchers at The University of Texas MD Anderson Cancer Center have shown how BRCA-associated protein 1 (BAP1) serves as a tumor suppressor gene in kidney, eye, bile duct, mesothelioma and other cancers by regulating a form of cell death called ferroptosis, opening up a potential new area of therapy research. Findings from the study, led by Boyi Gan, Ph.D., associate professor, Department of Experimental Radiation Oncology, were published in the Sept. 10 online issue of Nature Cell Biology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 10, 2018 Category: Cancer & Oncology Source Type: news

Which Technique Is Best for Gallstones/Biliary Duct Calculi? Which Technique Is Best for Gallstones/Biliary Duct Calculi?
Dr Lowenfels comments on a study that examines the efficacy and safety of four techniques for removing stones in the bile duct and gallbladder.Medscape General Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 6, 2018 Category: Consumer Health News Tags: General Surgery Viewpoint Source Type: news

GW Researcher investigating link between parasitic infection and bile duct cancer
(George Washington University) Paul Brindley, Ph.D., at the GW School of Medicine and Health Sciences, has received more than $1.7 million from the National Cancer Institute at the National Institutes of Health to investigate the cellular and molecular links between liver fluke infection and bile duct cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 5, 2018 Category: International Medicine & Public Health Source Type: news

Investigators find that bile acids reduce cocaine reward
(Vanderbilt University Medical Center) Bile acids -- gut compounds that aid in the digestion of dietary fats -- reduce the desire for cocaine, according to a new study by researchers at Vanderbilt University Medical Center and the University of Alabama at Birmingham. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 31, 2018 Category: International Medicine & Public Health Source Type: news