Steffanie Strathdee: ‘Phages have evolved to become perfect predators of bacteria’

In 2015, the scientist ’s husband was almost killed by an antibiotic-resistant superbug, until she found a cure that is now saving othersInfectious disease epidemiologist Steffanie Strathdee ’s husband survived a deadly antibiotic-resistant bacterial infection thanks to her suggestion of using an unconventional cure popular in the former Soviet Union: fighting the bug with a virus. Now the global health expert at the University of California, San Diego, she has, along with her husband , Tom Patterson, who is also a scientist at the institution, written an account of their nine month ordeal –The Perfect Predator: A Scientists ’s Race to Save Her Husband from a Deadly Superbug.What was the superbugyour husband got, and howdid he contract it?It is calledAcinetobacter baumanniibut nicknamed Iraqibacter because many wounded service members who have returned from the Middle East were infected with it. It was once a wimpy bacteria – mundane and harmless – but its superpower is its ability to acquire antibiotic-resistant genes. It nowtops the World Health Organization ’s list of the 12 mostly deadly superbugs to human health. It has infiltrated clinics and hospitals all around the world and sticks to hospital linens. Tom likely picked it up in Egypt while we were vacationing there in late 2015 – sequencing later showed it was an Egyptian strain. He came down in Egypt with what turned out to be acute pancreatitis, caused by a gallstone b...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Antibiotics Biology Science Books Society Source Type: news

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Publication date: Available online 15 July 2019Source: Carbohydrate PolymersAuthor(s): Osama M. Sharaf, Mamdouh S. Al-Gamal, Gamal A. Ibrahim, Nadia M. Dabiza, Salem S. Salem, Mohamed F. El-ssayad, Ahmed M. YoussefAbstractThis research attempted to inspect the contribution of lactic acid bacteria (LAB) with nanoparticle application in antimicrobial enhancement. Seven lactic acid cultures-free supernatants (CFSs) in both free and nanoparticles-loaded states were examined against seven foodborne microorganisms. Lactobacillus helveticus followed by Lactobacillus Plantarum possessed considerable antimicrobial activity. Headspa...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In conclusion, we have designed a set of new LL-37 peptides with varying antimicrobial activities, opening the door to potential topical treatment of infections involving different drug-resistant pathogens.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Condition:   Pancreatitis Relapsing Intervention:   Drug: Simvastatin 40mg Sponsors:   Enrique de-Madaria;   Instituto de Salud Carlos III Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions This systematic review identified a clinically relevant risk of new-onset DM after CP diagnosis. Therefore, patients should be informed of the risk of DM and monitored.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
Conclusions Cystic fibrosis or CFTR-RD can present as ARP/CP. Complete diagnostic testing for CFTR-RD in patients with ARP/CP will broaden treatment options and help to identify comorbid illness.
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research
No abstract available
Source: Pancreas - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Pancreas - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Pancreas - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
When Thomas Patterson woke up from a two-month coma in March 2016, he learned two things he couldn’t believe: Donald Trump was soon to become the Republican nominee for president, and his wife, Steffanie Strathdee, had saved him from dying of an antibiotic-resistant superbug by injecting him with viruses harvested from sewage. It took a lot of convincing for him to accept these weren’t just more hallucinations. Patterson and Strathdee met while serving on a National Institutes of Health grant review panel almost 16 years ago. Strathdee doesn’t usually find review panels a riveting experience, but when she...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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