Single-cell Sequence Analysis Combined with Multiple Machine Learning to Identify Markers in Sepsis Patients: LILRA5
AbstractSepsis
is a disease with a very high mortality rate, mainly involving an immune-dysregulated response due to bacterial infection. Most studies are currently limited to the whole blood transcriptome level; however, at the single cell level, there is still a great deal unknown about specific cell subsets and disease markers. We obtained 29 peripheral blood single-cell sequencing data, including 66,283 cells from 10 confirmed samples of sepsis infection and 19 healthy samples. Cells related to the sepsis phenotype were identified and characterized by the “scissor” method. The regulatory relationships of sepsis-...
Source: Inflammation - March 15, 2023 Category: Allergy & Immunology Source Type: research
Pediatric Heart Network Trial of Losartan vs. Atenolol in Children and Young Adults with Marfan Syndrome: Impact on Prescription Practices
AbstractThe Pediatric Heart Network (PHN) trial showed similar efficacy of β-blockers (BB) and angiotensin receptor blockers (ARB) for aortic root dilation in Marfan syndrome, but the impact on prescription practices is unknown. We hypothesized BB and ARB prescriptions would increase after the trial results were published (2014). Prescription data (2007–2016) were obtai ned from outpatient encounters (IBM Marketscan) for Marfan syndrome patients (6 months–25 years old). Excluding 2014 as a washout period, we analyzed two intervals: 2007–2013 and 2015–2016. Medication categories included BB, ARB, angiotensin conv...
Source: Pediatric Cardiology - March 1, 2023 Category: Cardiology Source Type: research
IJERPH, Vol. 20, Pages 4285: Exposure of the Gestating Mother to Sympathetic Stress Modifies the Cardiovascular Function of the Progeny in Male Rats
Conclusion: These data suggest permanent changes to the heart’s adrenergic response after rat progeny were stressed in the uterus. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - February 28, 2023 Category: Environmental Health Authors: Beatriz Piquer Diandra Olmos Andrea Flores Rafael Barra Gabriela Bahamondes Guillermo Diaz-Araya Hernan E. Lara Tags: Article Source Type: research
Pediatric Heart Network Trial of Losartan vs. Atenolol in Children and Young Adults with Marfan Syndrome: Impact on Prescription Practices
AbstractThe Pediatric Heart Network (PHN) trial showed similar efficacy of β-blockers (BB) and angiotensin receptor blockers (ARB) for aortic root dilation in Marfan syndrome, but the impact on prescription practices is unknown. We hypothesized BB and ARB prescriptions would increase after the trial results were published (2014). Prescription data (2007–2016) were obtai ned from outpatient encounters (IBM Marketscan) for Marfan syndrome patients (6 months–25 years old). Excluding 2014 as a washout period, we analyzed two intervals: 2007–2013 and 2015–2016. Medication categories included BB, ARB, angiotensin conv...
Source: Pediatric Cardiology - February 23, 2023 Category: Cardiology Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
α/β- and β-Blocker Exposure in Pregnancy and the Risk of Neonatal Hypoglycemia and Small for Gestational Age
CONCLUSIONS: Carvedilol administration during pregnancy was associated with neonatal hypoglycemia; however, it did not occur in a time- or dose-dependent manner. Routine monitoring of blood glucose levels in newborns exposed to α/β- and β-blockers is essential.PMID:36823100 | DOI:10.1253/circj.CJ-22-0647 (Source: Circulation Journal)
Source: Circulation Journal - February 23, 2023 Category: Cardiology Authors: Kana Kubota Kei Inai Eriko Shimada Tokuko Shinohara Source Type: research
Molecules, Vol. 28, Pages 1184: Development of Capillary Zone Electrophoresis Method for the Simultaneous Separation and Quantification of Metformin and Pioglitazone in Dosage Forms; and Comparison with HPLC Method
O. Alnajjar
A capillary zone electrophoretic (CZE) method was developed, validated, and applied for the assay of metformin (MET) and pioglitazone (PIO) in pharmaceutical formulations. The optimum running buffer composition was found to be 75 mmol/L phosphate buffer containing 30% acetonitrile (ACN) at pH 4.0. The optimum instrumental conditions were found to be injection time, 10 s; applied voltage, 25 kV; hydrodynamic injection pressure, 0.5 psi for 10 sec, capillary temperature, 25 °C; and the detection wavelength, 210 nm. The quantifications were calculated based on the ratio of the peak areas of analyte...
Source: Molecules - January 25, 2023 Category: Chemistry Authors: Maymonah K.I. AlThikrallah Abubakr M. Idris Abdalla Ahmed Elbashir Rafea E.E. Elgorashe Alyah Buzid Ahmed O. Alnajjar Tags: Article Source Type: research
Burden of and factors associated with poor quality antibiotic, antimalarial, antihypertensive and antidiabetic medicines in Malawi
by Francis Kachidza Chiumia, Happy Magwaza Nyirongo, Elizabeth Kampira, Adamson Sinjani Muula, Felix Khuluza
ObjectiveTo assess the prevalence and factors associated with substandard and falsified (SF) medicines among antibiotic, antimalarial, antihypertensive and antidiabetic medicines in Malawi. MethodsWe conducted a cross-sectional study in 23 public, faith-based and private health facilities in Zomba, Machinga and Nsanje districts. We analyzed oral medicine samples of commonly used medicines among antibiotics, antimalarial, antihypertensive and antidiabetics in accordance with Malawi Essential Medicines List and local ...
Source: PLoS One - December 27, 2022 Category: Biomedical Science Authors: Francis Kachidza Chiumia Source Type: research
Long-term neurocognitive functioning of children treated with propranolol or atenolol for infantile hemangioma
Conclusions: Long-term neurocognitive functioning did not differ between children treated with propranolol and those treated with atenolol for IH. Overall, propranolol and atenolol appear to be safe treatments for IH regarding long-term neurocognitive functioning. The substantially lower CPI scores in males wa rrant further investigation.Trial registration: Netherlands Trial Register, NL7703https://www.trialregister.nl/trial/7703What is Known:• Infants with infantile hemangioma are effectively treated with propranolol or atenolol.• Parents and professionals are concerned about long-term neurocognitive effects.Wha...
Source: European Journal of Pediatrics - December 7, 2022 Category: Pediatrics Source Type: research
Exploration of < em > Cassia fistula < /em > L. seed mucilage into floating drug delivery system
Nat Prod Res. 2022 Oct 29:1-6. doi: 10.1080/14786419.2022.2140154. Online ahead of print.ABSTRACTThe aim of the present study was to explore Cassia fistula L. seed mucilage as a natural polymer in controlled release floating drug delivery system. First, seed mucilage was extracted and evaluated for phytochemical screening, solubility studies, swelling index, viscosity and surface tension. Then, Atenolol floating systems were prepared with and without the C. fistula L. seed mucilage by direct compression method. Phytochemical screening resulted from the presence of secondary metabolite carbohydrates, glycosides, flavonoids ...
Source: Natural Product Research - October 29, 2022 Category: Biochemistry Authors: Dinanath T Gaikwad Sayali J Patil Suresh G Killedar Source Type: research
Exploration of < em > Cassia fistula < /em > L. seed mucilage into floating drug delivery system
Nat Prod Res. 2022 Oct 29:1-6. doi: 10.1080/14786419.2022.2140154. Online ahead of print.ABSTRACTThe aim of the present study was to explore Cassia fistula L. seed mucilage as a natural polymer in controlled release floating drug delivery system. First, seed mucilage was extracted and evaluated for phytochemical screening, solubility studies, swelling index, viscosity and surface tension. Then, Atenolol floating systems were prepared with and without the C. fistula L. seed mucilage by direct compression method. Phytochemical screening resulted from the presence of secondary metabolite carbohydrates, glycosides, flavonoids ...
Source: Natural Product Research - October 29, 2022 Category: Biochemistry Authors: Dinanath T Gaikwad Sayali J Patil Suresh G Killedar Source Type: research
Atenolol treatment does not affect behavioral outcomes in pediatric patients with infantile hemangiomas: a case-control cohort study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - September 21, 2022 Category: Dermatology Authors: Fareed Sabbah, Ilan Shamir, Lidia V. Gabis, Ayelet Ollech, Meirav Shaham, Aviv Barzilai, Sharon Baum, Orit Krispin, Tamar Peleg, Dan Ben Amitai, Shoshana Greenberger Source Type: research
Molecules, Vol. 27, Pages 6199: Synthesis, Molecular Docking, and Preclinical Evaluation of a New Succinimide Derivative for Cardioprotective, Hepatoprotective and Lipid-Lowering Effects
In conclusion, the histological and biochemical results showed that the test compound (Comp-1) had prominent cardioprotective, hepatoprotective, and lipolytic effects against 5-FU-induced toxicity in the subjected animal model. (Source: Molecules)
Source: Molecules - September 21, 2022 Category: Chemistry Authors: Muhammad Imran Qayyum Sami Ullah Umer Rashid Abdul Sadiq Obaidullah Mater H. Mahnashi Osama M. Alshehri Mohammed M. Jalal Khalid J. Alzahrani Ibrahim F. Halawani Tags: Article Source Type: research
Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro
CONCLUSION: Our data suggest that autophagy may be ascribed among the mechanisms of action of β-blockers suggesting new mechanistic insights on the potential therapeutic application of this class of drugs in pathologic conditions involving uncontrolled angiogenesis.PMID:36103993 | DOI:10.1016/j.vph.2022.107110 (Source: Vascular Pharmacology)
Source: Vascular Pharmacology - September 14, 2022 Category: Drugs & Pharmacology Authors: Bruno Lorusso Giuseppe Cerasoli Angela Falco Caterina Frati Gallia Graiani Denise Madeddu Antonella Nogara Emilia Corradini Giovanni Roti Elisa Cerretani Andrea Gherli Mariafrancesca Caputi Letizia Gnetti Francesco Paolo Pilato Federico Quaini Costanza La Source Type: research
