Quantitative analysis of the illegal addition of Atenolol in Panax notoginseng based on NIR-MIR spectral data fusion and calibration transfer
RSC Adv. 2024 Apr 17;14(18):12428-12437. doi: 10.1039/d3ra08183d. eCollection 2024 Apr 16.ABSTRACTTo address the issue of the common illegal addition of Atenolol in Panax notoginseng, we propose an approach that realizes multivariate calibration transfer between different particle sizes based on near-infrared (NIR) and mid-infrared (MIR) spectral data fusion. To achieve high prediction accuracy, we construct three data fusion schemes (full-spectrum fusion, feature-level fusion, and decision-level fusion) that combine NIR and MIR spectral data. Among three data fusion schemes, the feature-level fusion based on the UVE-SPA-P...
Source: Adv Data - April 18, 2024 Category: Epidemiology Authors: Jie Du Zhengwei Huang Chun Li Ling Jiang Source Type: research
Environmental risk assessment of selected pharmaceuticals in hospital wastewater in nothern vietnam
This study investigated the occurrence of selected pharmaceuticals in influent and effluent of wastewater treatment plants of 12 hospitals in Hanoi and 3 northern cities of Vietnam during dry and rainy seasons. In addition, environmental risk of pharmaceuticals in both hospital influents and effluents were evaluated based on risk quotients (RQs). Nine selected pharmaceutical compounds including sulfamethoxazole (SMX), naproxen (NPX), diclofenac (DCF), ibuprofen (IBU), acetaminophen (ACT), carbamazepine (CBM), iopromide (IOP), atenolol (ATN), and caffeine (CAF) were frequently detected in most influent and effluent wastewat...
Source: Chemosphere - April 12, 2024 Category: Chemistry Authors: Anh T P Hoang Manh Cuong Do Kyoung-Woong Kim Source Type: research
Ex vivo Gut-Hepato-Biliary organ perfusion model to characterize oral absorption, gut-wall metabolism, pre-systemic hepatic metabolism and biliary excretion; application to midazolam
Eur J Pharm Sci. 2024 Apr 2:106760. doi: 10.1016/j.ejps.2024.106760. Online ahead of print.ABSTRACTTo date, characterization of the first-pass effect of orally administered drugs consisting of local intestinal absorption and metabolism, portal vein transport and hepatobiliary processes remains challenging. Aim of this study was to explore the applicability of a porcine ex-vivo perfusion model to study oral absorption, gut-hepatobiliary metabolism and biliary excretion of midazolam. Slaughterhouse procured porcine en bloc organs (n=4), were perfused via the aorta and portal vein. After 120min of perfusion, midazolam, atenol...
Source: European Journal of Pharmaceutical Sciences - April 4, 2024 Category: Drugs & Pharmacology Authors: L J Stevens E van de Steeg J B Doppenberg I P J Alwayn C A J Knibbe J Dubbeld Source Type: research
Ex vivo Gut-Hepato-Biliary organ perfusion model to characterize oral absorption, gut-wall metabolism, pre-systemic hepatic metabolism and biliary excretion; application to midazolam
Eur J Pharm Sci. 2024 Apr 2:106760. doi: 10.1016/j.ejps.2024.106760. Online ahead of print.ABSTRACTTo date, characterization of the first-pass effect of orally administered drugs consisting of local intestinal absorption and metabolism, portal vein transport and hepatobiliary processes remains challenging. Aim of this study was to explore the applicability of a porcine ex-vivo perfusion model to study oral absorption, gut-hepatobiliary metabolism and biliary excretion of midazolam. Slaughterhouse procured porcine en bloc organs (n=4), were perfused via the aorta and portal vein. After 120min of perfusion, midazolam, atenol...
Source: European Journal of Pharmaceutical Sciences - April 4, 2024 Category: Drugs & Pharmacology Authors: L J Stevens E van de Steeg J B Doppenberg I P J Alwayn C A J Knibbe J Dubbeld Source Type: research
Molecules, Vol. 29, Pages 1598: 3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers & rsquo; Absolute Configuration
Molecules, Vol. 29, Pages 1598: 3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration
Molecules doi: 10.3390/molecules29071598
Authors:
Rosa Sparaco
Pierfrancesco Cinque
Antonia Scognamiglio
Angela Corvino
Giuseppe Caliendo
Ferdinando Fiorino
Elisa Magli
Elisa Perissutti
Vincenzo Santagada
Beatrice Severino
Paolo Luciano
Marcello Casertano
Anna Aiello
Gustavo Yuri Martins Viegas
Gilberto De Nucci
Francesco Frecentese
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolo...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Rosa Sparaco Pierfrancesco Cinque Antonia Scognamiglio Angela Corvino Giuseppe Caliendo Ferdinando Fiorino Elisa Magli Elisa Perissutti Vincenzo Santagada Beatrice Severino Paolo Luciano Marcello Casertano Anna Aiello Gustavo Yuri Martins Viegas Gilberto Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1480: Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method
This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L−1 of iomeprol, 48.8 μg L−1 of iopromide, 29.9 μg L−1 of gabapentin, 42.0 μg L−1 of caffeine and 82.5 μg L−1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed hi...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Lucia Molnarova Tatana Halesova Daniela Tomesova Marta Vaclavikova Zuzana Bosakova Tags: Article Source Type: research
The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic
ConclusionsThese results indicate that information from the peripheral and central adrenergic system does not play a major role in the construction of the subjective emotion. (Source: Psychopharmacology)
Source: Psychopharmacology - March 1, 2024 Category: Psychiatry Source Type: research
Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices
Biol Pharm Bull. 2024;47(1):72-78. doi: 10.1248/bpb.b23-00490.ABSTRACTWe recently reported that the gastrointestinal (GI) fluid volume is influenced by the solution osmolality, and proposed that this effect may play a role in beverage-drug interactions. Here, we investigated whether osmolality-dependent fluid secretion can explain the difference in the magnitudes of fruit juice-drug interactions depending on the type of fruit juice (grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ)). The osmolality of GFJ, OJ, and AJ used in this study was found to be 552, 686, and 749 mOsm/kg, respectively. Measurements of i...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Miyuki Takemura Katsuhisa Inoue Ikumi Tamai Yoshiyuki Shirasaka Source Type: research
Magnitude of Fruit Juice-Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices
Biol Pharm Bull. 2024;47(1):72-78. doi: 10.1248/bpb.b23-00490.ABSTRACTWe recently reported that the gastrointestinal (GI) fluid volume is influenced by the solution osmolality, and proposed that this effect may play a role in beverage-drug interactions. Here, we investigated whether osmolality-dependent fluid secretion can explain the difference in the magnitudes of fruit juice-drug interactions depending on the type of fruit juice (grapefruit juice (GFJ), orange juice (OJ), and apple juice (AJ)). The osmolality of GFJ, OJ, and AJ used in this study was found to be 552, 686, and 749 mOsm/kg, respectively. Measurements of i...
Source: Biological and Pharmaceutical Bulletin - January 3, 2024 Category: Drugs & Pharmacology Authors: Miyuki Takemura Katsuhisa Inoue Ikumi Tamai Yoshiyuki Shirasaka Source Type: research
