Adsorption and leaching of β-blockers in fluvo-aquic and black soil: Behavior characteristic and enantiomer selectivity
In this study, the adsorption and leaching behaviors of β-blockers in fluvo-aquic soil and black soil were investigated. The adsorption of β-blockers was fit well by the Freundlich adsorption isotherm (R2 > 0.913) and the adsorption affinity of β-blockers decreased in the following order: propranolol (logarithm of Freundlich adsorption coefficient log Kf = 1.46-2.55) > atenolol (log Kf = 0.53-1.04) > sotalol (log Kf = 0.32-1.01). An increase in ionic strength and dissolved organic matter (DOM) inhibited their soil adsorption. Ionic change is the main driving force for adsorption. Besides, hydrophobic partitioni...
Source: Environmental Research - August 12, 2022 Category: Environmental Health Authors: Jiayao Xu Yu Wang Hongwen Sun Weiwei Zhang Source Type: research
Adsorption and leaching of β-blockers in fluvo-aquic and black soil: Behavior characteristic and enantiomer selectivity
In this study, the adsorption and leaching behaviors of β-blockers in fluvo-aquic soil and black soil were investigated. The adsorption of β-blockers was fit well by the Freundlich adsorption isotherm (R2 > 0.913) and the adsorption affinity of β-blockers decreased in the following order: propranolol (logarithm of Freundlich adsorption coefficient log Kf = 1.46-2.55) > atenolol (log Kf = 0.53-1.04) > sotalol (log Kf = 0.32-1.01). An increase in ionic strength and dissolved organic matter (DOM) inhibited their soil adsorption. Ionic change is the main driving force for adsorption. Besides, hydrophobic partitioni...
Source: Environmental Research - August 12, 2022 Category: Environmental Health Authors: Jiayao Xu Yu Wang Hongwen Sun Weiwei Zhang Source Type: research
[ASAP] Free Nitrous Acid Inhibits Atenolol Removal during the Sidestream Partial Nitritation Process through Regulating Microbial-Induced Metabolic Types
Environmental Science& TechnologyDOI: 10.1021/acs.est.1c08845 (Source: Environmental Science and Technology)
Source: Environmental Science and Technology - July 28, 2022 Category: Environmental Health Authors: managing.editor at est.acs.org (American Chemical Society) Source Type: research
Dissecting the role of cell signaling versus CD8 < sup > + < /sup > T cell modulation in propranolol antitumor activity
J Mol Med (Berl). 2022 Jul 27. doi: 10.1007/s00109-022-02238-8. Online ahead of print.ABSTRACTPreclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor (β-AR) blocker propranolol have revealed both cell signaling and immune function pathway effects. Intertumoral studies were performed using propranolol, a β1-AR selective agent (atenolol), and a β2-AR selective agent (ICI 118,551) in a preclinical in vivo model, as a step to dissect the contribution of cell signaling and CD8+ immunological effects on anticancer activity. We found that repression of β2-AR but not β1-AR si...
Source: Molecular Medicine - July 27, 2022 Category: Molecular Biology Authors: Wei Li Jielin Wan Cuiyu Chen Chengfang Zhou Ping Liao Qian Hu Jiali Hu Yang Wang Yu Zhang Cong Peng Yuanfei Huang Weihua Huang Wei Zhang Howard L Mcleod Yijing He Source Type: research
Dissecting the role of cell signaling versus CD8 < sup > + < /sup > T cell modulation in propranolol antitumor activity
J Mol Med (Berl). 2022 Jul 27. doi: 10.1007/s00109-022-02238-8. Online ahead of print.ABSTRACTPreclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor (β-AR) blocker propranolol have revealed both cell signaling and immune function pathway effects. Intertumoral studies were performed using propranolol, a β1-AR selective agent (atenolol), and a β2-AR selective agent (ICI 118,551) in a preclinical in vivo model, as a step to dissect the contribution of cell signaling and CD8+ immunological effects on anticancer activity. We found that repression of β2-AR but not β1-AR si...
Source: Cancer Control - July 27, 2022 Category: Cancer & Oncology Authors: Wei Li Jielin Wan Cuiyu Chen Chengfang Zhou Ping Liao Qian Hu Jiali Hu Yang Wang Yu Zhang Cong Peng Yuanfei Huang Weihua Huang Wei Zhang Howard L Mcleod Yijing He Source Type: research
Dissecting the role of cell signaling versus CD8 < sup > + < /sup > T cell modulation in propranolol antitumor activity
J Mol Med (Berl). 2022 Jul 27. doi: 10.1007/s00109-022-02238-8. Online ahead of print.ABSTRACTPreclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor (β-AR) blocker propranolol have revealed both cell signaling and immune function pathway effects. Intertumoral studies were performed using propranolol, a β1-AR selective agent (atenolol), and a β2-AR selective agent (ICI 118,551) in a preclinical in vivo model, as a step to dissect the contribution of cell signaling and CD8+ immunological effects on anticancer activity. We found that repression of β2-AR but not β1-AR si...
Source: Molecular Medicine - July 27, 2022 Category: Molecular Biology Authors: Wei Li Jielin Wan Cuiyu Chen Chengfang Zhou Ping Liao Qian Hu Jiali Hu Yang Wang Yu Zhang Cong Peng Yuanfei Huang Weihua Huang Wei Zhang Howard L Mcleod Yijing He Source Type: research
Dissecting the role of cell signaling versus CD8+ T cell modulation in propranolol antitumor activity
AbstractPreclinical and early clinical mechanistic studies of antitumor activity from the beta-adrenergic receptor ( β-AR) blocker propranolol have revealed both cell signaling and immune function pathway effects. Intertumoral studies were performed using propranolol, a β1-AR selective agent (atenolol), and a β2-AR selective agent (ICI 118,551) in a preclinical in vivo model, as a step to dissect the contribution of cell signaling and CD8+ immunological effects on anticancer activity. We found that repression of β2-AR but not β1-AR signaling selectively suppressed cell viability and inhibited xenograft growth in vivo....
Source: Journal of Molecular Medicine - July 27, 2022 Category: Molecular Biology Source Type: research
Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats
In conclusion, this study has identified phytochemical constituents, in particular juglone, as a potential cardioprotective agent.PMID:35877444 | DOI:10.3390/cimb44070220 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 25, 2022 Category: Molecular Biology Authors: Taseer Ahmad Taous Khan Tahira Tabassum Yahya S Alqahtani Mater H Mahnashi Bandar A Alyami Ali O Alqarni Mohammed Y Alasmary Sultan A Almedhesh Abdul Jabbar Shah Source Type: research
Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats
In conclusion, this study has identified phytochemical constituents, in particular juglone, as a potential cardioprotective agent.PMID:35877444 | DOI:10.3390/cimb44070220 (Source: Mol Biol Cell)
Source: Mol Biol Cell - July 25, 2022 Category: Molecular Biology Authors: Taseer Ahmad Taous Khan Tahira Tabassum Yahya S Alqahtani Mater H Mahnashi Bandar A Alyami Ali O Alqarni Mohammed Y Alasmary Sultan A Almedhesh Abdul Jabbar Shah Source Type: research
Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats
In conclusion, this study has identified phytochemical constituents, in particular juglone, as a potential cardioprotective agent.PMID:35877444 | PMC:PMC9319353 | DOI:10.3390/cimb44070220 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - July 25, 2022 Category: Molecular Biology Authors: Taseer Ahmad Taous Khan Tahira Tabassum Yahya S Alqahtani Mater H Mahnashi Bandar A Alyami Ali O Alqarni Mohammed Y Alasmary Sultan A Almedhesh Abdul Jabbar Shah Source Type: research
Juglone from Walnut Produces Cardioprotective Effects against Isoproterenol-Induced Myocardial Injury in SD Rats
In conclusion, this study has identified phytochemical constituents, in particular juglone, as a potential cardioprotective agent.PMID:35877444 | PMC:PMC9319353 | DOI:10.3390/cimb44070220 (Source: Mol Biol Cell)
Source: Mol Biol Cell - July 25, 2022 Category: Molecular Biology Authors: Taseer Ahmad Taous Khan Tahira Tabassum Yahya S Alqahtani Mater H Mahnashi Bandar A Alyami Ali O Alqarni Mohammed Y Alasmary Sultan A Almedhesh Abdul Jabbar Shah Source Type: research
Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway
ConclusionThe present study suggests that implementation of a drug interaction database providing recommendations on non-interacting drug alternatives contributes to reduced co-prescribing of drug combinations associated with potentially serious adverse effects. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - July 25, 2022 Category: Drugs & Pharmacology Source Type: research
An ultra-sensitive laccase/polyaziridine-bismuth selenide nanoplates modified GCE for detection of atenolol in pharmaceuticals and urine samples
Bioelectrochemistry. 2022 Jul 16;147:108212. doi: 10.1016/j.bioelechem.2022.108212. Online ahead of print.ABSTRACTThe analysis of β-blockers in pharmaceutical, biological and environmental samples has gained much interest due to their wide applications. The aim of this study was to develop an enzyme-based biosensor using hexagonal-shaped low-dimensional Bi2Se3 NPs decorated with laccase through polyaziridine (PAZ) modified glassy carbon electrode (Lac/PAZ-Bi2Se3 NPs/GCE). Surface properties were examined using SEM, TEM, EDX, XRD, XPS, FTIR, UV-Visible, and zeta potential. Electrochemical studies were performed with cyclic...
Source: Bioelectrochemistry - July 23, 2022 Category: Biochemistry Authors: Ayyappa Bathinapatla Govinda Gorle Suvardhan Kanchi Reddy Prasad Puthalapattu Yong Chien Ling Source Type: research
