ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice
In conclusion, our results demonstrate that LPS administration increases neutrophils infiltration into the CNS, activates immune cells and produces ETs that directly impair neuromuscular function. Prevention of ETs formation by β1-adrenergic blockers partly restores this function and could be a good target in order to reduce adverse effects in severe inflammation such as sepsis but also in other motor related pathologies linked to ETs production. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Dermato-Venereologica - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Derm Venereol A... - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Dermato-Venereologica - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Derm Venereol A... - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Dermato-Venereologica - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers
Acta Derm Venereol. 2023 Aug 30;103:adv5286. doi: 10.2340/actadv.v103.5286.ABSTRACTParents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of the infantile haemangioma, the beta-blocker treatment, and the infant. The study included 103 children aged 6-12 years, treated with beta-blockers (propranolol or atenolol) for infantile haemangioma during infancy (age at treatment initiation ≤1 year) for ≥6 months. Dermatologists and parents scored the ...
Source: Acta Derm Venereol A... - August 31, 2023 Category: Dermatology Authors: Mireille M Hermans Suzanne G M A Pasmans Marlies De Graaf Avi ël Ragamin Elodie J Mendels Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Corstiaan C Breugem Renske Schappin Source Type: research
