β-blockers as the First Line of Treatment for Hypertension Management
J Assoc Physicians India. 2023 Sep;71(9):95-100. doi: 10.59556/japi.71.0341.ABSTRACTβ-adrenergic blocker group of medicines has been traditionally used to control high blood pressure since propranolol was discovered by Sir James Black almost 50 years ago. They were the drug of choice in hypertension (HTN) associated with ischemic heart disease, tachyarrhythmias including atrial fibrillation (AF), and anxiety. Congestive cardiac failure was a relative contraindication, but with major advances in science, it became an absolute indication. However, with the advent of newer antihypertensives, especially calcium channel blocke...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Saumitra Ray Saboo Banshi Joshi Shashank Tiwaskar Mangesh Bansal Sandeep Kamal Kumar Nath Baishali Source Type: research
Removal of Pharmaceutical Compounds and Toxicology Study in Wastewater using Malaysian Fungal Ganoderma lucidum
Chemosphere. 2024 Apr 30:142209. doi: 10.1016/j.chemosphere.2024.142209. Online ahead of print.ABSTRACTElevated usage of pharmaceutical products leads to the accumulation of emerging contaminants in sewage. In the current work, Ganoderma lucidum (GL) was used to remove pharmaceutical compounds (PCs), proposed as a tertiary method in sewage treatment plants (STPs). The PCs consisted of a group of painkillers (ketoprofen, diclofenac, and dexamethasone), psychiatrists (carbamazepine, venlafaxine, and citalopram), beta-blockers (atenolol, metoprolol, and propranolol), and anti-hypertensives (losartan and valsartan). The perfor...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Zarimah Mohd Hanafiah Wan Hanna Melini Wan Mohtar Wan Abd Al Qadr Imad Wan-Mohtar Aziza Sultana Bithi Rosiah Rohani Antonius Indarto Zaher Mundher Yaseen Suraya Sharil Teh Sabariah Binti Abdul Manan Source Type: research
Removal of Pharmaceutical Compounds and Toxicology Study in Wastewater using Malaysian Fungal Ganoderma lucidum
Chemosphere. 2024 Apr 30:142209. doi: 10.1016/j.chemosphere.2024.142209. Online ahead of print.ABSTRACTElevated usage of pharmaceutical products leads to the accumulation of emerging contaminants in sewage. In the current work, Ganoderma lucidum (GL) was used to remove pharmaceutical compounds (PCs), proposed as a tertiary method in sewage treatment plants (STPs). The PCs consisted of a group of painkillers (ketoprofen, diclofenac, and dexamethasone), psychiatrists (carbamazepine, venlafaxine, and citalopram), beta-blockers (atenolol, metoprolol, and propranolol), and anti-hypertensives (losartan and valsartan). The perfor...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Zarimah Mohd Hanafiah Wan Hanna Melini Wan Mohtar Wan Abd Al Qadr Imad Wan-Mohtar Aziza Sultana Bithi Rosiah Rohani Antonius Indarto Zaher Mundher Yaseen Suraya Sharil Teh Sabariah Binti Abdul Manan Source Type: research
Removal of Pharmaceutical Compounds and Toxicology Study in Wastewater using Malaysian Fungal Ganoderma lucidum
Chemosphere. 2024 Apr 30:142209. doi: 10.1016/j.chemosphere.2024.142209. Online ahead of print.ABSTRACTElevated usage of pharmaceutical products leads to the accumulation of emerging contaminants in sewage. In the current work, Ganoderma lucidum (GL) was used to remove pharmaceutical compounds (PCs), proposed as a tertiary method in sewage treatment plants (STPs). The PCs consisted of a group of painkillers (ketoprofen, diclofenac, and dexamethasone), psychiatrists (carbamazepine, venlafaxine, and citalopram), beta-blockers (atenolol, metoprolol, and propranolol), and anti-hypertensives (losartan and valsartan). The perfor...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Zarimah Mohd Hanafiah Wan Hanna Melini Wan Mohtar Wan Abd Al Qadr Imad Wan-Mohtar Aziza Sultana Bithi Rosiah Rohani Antonius Indarto Zaher Mundher Yaseen Suraya Sharil Teh Sabariah Binti Abdul Manan Source Type: research
Removal of Pharmaceutical Compounds and Toxicology Study in Wastewater using Malaysian Fungal Ganoderma lucidum
Chemosphere. 2024 Apr 30:142209. doi: 10.1016/j.chemosphere.2024.142209. Online ahead of print.ABSTRACTElevated usage of pharmaceutical products leads to the accumulation of emerging contaminants in sewage. In the current work, Ganoderma lucidum (GL) was used to remove pharmaceutical compounds (PCs), proposed as a tertiary method in sewage treatment plants (STPs). The PCs consisted of a group of painkillers (ketoprofen, diclofenac, and dexamethasone), psychiatrists (carbamazepine, venlafaxine, and citalopram), beta-blockers (atenolol, metoprolol, and propranolol), and anti-hypertensives (losartan and valsartan). The perfor...
Source: Chemosphere - May 2, 2024 Category: Chemistry Authors: Zarimah Mohd Hanafiah Wan Hanna Melini Wan Mohtar Wan Abd Al Qadr Imad Wan-Mohtar Aziza Sultana Bithi Rosiah Rohani Antonius Indarto Zaher Mundher Yaseen Suraya Sharil Teh Sabariah Binti Abdul Manan Source Type: research
Novel predictive approaches for drug-induced convulsions in non-human primates using machine learning and heart rate variability analysis
J Toxicol Sci. 2024;49(5):231-240. doi: 10.2131/jts.49.231.ABSTRACTDrug-induced convulsions are a major challenge to drug development because of the lack of reliable biomarkers. Using machine learning, our previous research indicated the potential use of an index derived from heart rate variability (HRV) analysis in non-human primates as a biomarker for convulsions induced by GABAA receptor antagonists. The present study aimed to explore the application of this methodology to other convulsants and evaluate its specificity by testing non-convulsants that affect the autonomic nervous system. Telemetry-implanted males were ad...
Source: Journal of Toxicological Sciences - May 1, 2024 Category: Toxicology Authors: Kazuhiro Kuga Motohiro Shiotani Kentaro Hori Hiroshi Mizuno Yusaku Matsushita Harushige Ozaki Kohei Hayashi Takatomi Kubo Manabu Kano Source Type: research
Quantitative analysis of the illegal addition of Atenolol in Panax notoginseng based on NIR-MIR spectral data fusion and calibration transfer
RSC Adv. 2024 Apr 17;14(18):12428-12437. doi: 10.1039/d3ra08183d. eCollection 2024 Apr 16.ABSTRACTTo address the issue of the common illegal addition of Atenolol in Panax notoginseng, we propose an approach that realizes multivariate calibration transfer between different particle sizes based on near-infrared (NIR) and mid-infrared (MIR) spectral data fusion. To achieve high prediction accuracy, we construct three data fusion schemes (full-spectrum fusion, feature-level fusion, and decision-level fusion) that combine NIR and MIR spectral data. Among three data fusion schemes, the feature-level fusion based on the UVE-SPA-P...
Source: Adv Data - April 18, 2024 Category: Epidemiology Authors: Jie Du Zhengwei Huang Chun Li Ling Jiang Source Type: research
