QT shortening: a proarrhythmic safety surrogate measure or an inappropriate indicator of it?
CONCLUSIONS: From a regulatory perspective one cannot refute the possibility of a clinically relevant risk from QT shortening through the current testing requirements. Lack of further investigations into any potential morphological changes to the AP, or APD90 shortening beyond a specified threshold in our opinion does not fully exclude the possibility of proarrhythmic effects of active substances.PMID:35621140 | DOI:10.1080/03007995.2022.2083401 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - May 27, 2022 Category: Research Authors: Amy Tanti Benjamin Micallef Janis Vella Szijj Anthony Serracino-Inglott John-Joseph Borg Source Type: research
Can β-blockers influence regular daily physical activity?
Background:
In hypertension, β-blockers have a high rate of nonadherence to treatment likely because of fatigue.
Methods:
We evaluate daily physical activity and maximal exercise performance in 56 patients with hypertension (grades I–II), with and without β-blockers (bisoprolol 10 mg or atenolol 100 mg) added to standard treatment; 48 patients completed the study. Study tests were performed after 8 weeks of antihypertensive therapy without β blockers and after the following 8 weeks with β-blockers.
Results:
No significant differences between β-blockers were observed. At office measurement, ...
Source: Journal of Hypertension - May 26, 2022 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research
Pulmonary vein Doppler flow in a patient with fatigue and dyspnoea
Clinical introduction A woman in her 80s with a medical history of uncontrolled hypertension, hyperlipidaemia and diet-controlled pre-diabetes presented to a primary care physician’s office with fatigue and dyspnoea on exertion of 2–3 months’ duration. The patient reported no chest pain, paroxysmal dyspnoea or orthopnoea. Medications included atenolol 50 mg once a day. Blood pressure in the clinic was 158/75 mm Hg. An echocardiogram was performed. Question Which of the following explains the pulmonary vein pulsed wave Doppler flow signal, as shown in figure 1? Figure 1Pulsed wave Doppler of the pulmonary ...
Source: Heart - May 25, 2022 Category: Cardiology Authors: Devgun, J. K., Nasser, T., Lee, J. Tags: Image challenges Source Type: research
Oral atenolol versus propranolol in the treatment of infantile hemangioma: A systematic review and meta-analysis
Conclusion: The present meta-analysis provides evidence that atenolol has got a comparable efficacy and better safety profile with propranolol (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - May 12, 2022 Category: Surgery Authors: Swapnil Annasaheb Pattanshetti Vidya M Mahalmani Phulen Sarma Hardeep Kaur Md Mokkaram Ali Muneer Abas Malik Nitin James Peters Manisha Prajapat Subodh Kumar Bikash Medhi Ram Samujh Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine
Anal Chim Acta. 2022 May 22;1208:339829. doi: 10.1016/j.aca.2022.339829. Epub 2022 Apr 11.ABSTRACTIn sample preparation, simultaneous extraction of analytes of very different polarity from biological matrixes represents a challenge. In this work, verapamil hydrochloride (VRP), amitriptyline (AMP), tyramine (TYR), atenolol (ATN), metopropol (MTP) and nortriptyline (NRP) were used as basic model analytes and simultaneously extracted from urine samples by liquid-phase microextraction (LPME) in a microfluidic device. The model analytes (target compounds) were pharmaceuticals with 0.4 < log P < 5. Different organic solven...
Source: Analytica Chimica Acta - May 7, 2022 Category: Chemistry Authors: Elia Santigosa Stig Pedersen-Bjergaard Pablo Gim énez-Gómez Mar ía Muñoz Mar ía Ramos-Payán Source Type: research
Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma
This study evaluated the difference in long-term aesthetic outcomes between infantile haemangiomas treated with either propranolol or atenolol, including the perspective of physicians, parents, and children. Children, aged ≥6 years, treated with propranolol or atenolol for infantile haemangioma during infancy, participated in this 2-centre cross-sectional study. The primary endpoint was change in appearance of the infantile haemangioma from pre-treatment to follow-up, using a physician-rated visual analogue scale (VAS). Secondary outcomes were the Patient Observer Scar Assessment Scale (physician- and parent-rated) and a...
Source: Acta Dermato-Venereologica - May 4, 2022 Category: Dermatology Authors: Mireille M Hermans Corstiaan C Breugem Renske Schappin Emma Jonge Poerink Elodie J Mendels Avi ël Ragamin Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Suzanne G M A Pasmans Marlies De Gra Source Type: research
Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma
This study evaluated the difference in long-term aesthetic outcomes between infantile haemangiomas treated with either propranolol or atenolol, including the perspective of physicians, parents, and children. Children, aged ≥6 years, treated with propranolol or atenolol for infantile haemangioma during infancy, participated in this 2-centre cross-sectional study. The primary endpoint was change in appearance of the infantile haemangioma from pre-treatment to follow-up, using a physician-rated visual analogue scale (VAS). Secondary outcomes were the Patient Observer Scar Assessment Scale (physician- and parent-rated) and a...
Source: Acta Derm Venereol A... - May 4, 2022 Category: Dermatology Authors: Mireille M Hermans Corstiaan C Breugem Renske Schappin Emma Jonge Poerink Elodie J Mendels Avi ël Ragamin Johannes M P J Breur Hester R Langeveld Martine F Raphael Peter C J De Laat Saskia N De Wildt Andr é B Rietman Suzanne G M A Pasmans Marlies De Gra Source Type: research
