MGMT promoter methylation in 1p19q-intact gliomas
ConclusionsThis ancillary analysis supports conclusions from the CATNON trial for adjuvant TMZ as standard-of-care for anaplastic astrocytomas (IDH-mutant and 1p19q-intact), irrespective ofMGMT status. Determining the optimal strategy for diffuse gliomas that are IDH-wildtype will be particularly important.MGMT promoter methylation should be considered as a stratification factor in future clinical trials for these patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 20, 2023 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 43: Congenital Tumors & mdash;Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers, Vol. 16, Pages 43: Congenital Tumors—Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers doi: 10.3390/cancers16010043
Authors:
Kwasniewicz
Wieczorek-Pastusiak
Romaniuk-Doroszewska
Bekiesinska-Figatowska
Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were ...
Source: Cancers - December 20, 2023 Category: Cancer & Oncology Authors: Kwasniewicz Wieczorek-Pastusiak Romaniuk-Doroszewska Bekiesinska-Figatowska Tags: Article Source Type: research
A rare case of subependymal giant cell astrocytoma presenting with spontaneous intratumoral hemorrhage
We present a similar case of SEGA with spontaneous intratumoral hemorrhage in a 35-year-old male with cutaneous manifestations of tuberous sclerosis complex and acute onset headache with convulsion.PMID:38102901 | DOI:10.4103/jcrt.JCRT_1288_20 (Source: Cell Research)
Source: Cell Research - December 16, 2023 Category: Cytology Authors: Sarang Gotecha Prashant Punia Chhabra Shobhit Ashish Chugh Megha Kotecha Source Type: research
Individualized discrimination of tumor progression from treatment-related changes in different types of adult-type diffuse gliomas using [11C]methionine PET
ConclusionThis work confirms that MET PET has varying diagnostic performances in distinguishing TP from TRCs within three types of adult-type diffuse gliomas, and highlights its high diagnostic accuracy inIDH-mutant and 1p/19q-codeleted oligodendroglioma and potential prognostic value forIDH-mutant gliomas, particularlyIDH-mutant astrocytoma. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 14, 2023 Category: Cancer & Oncology Source Type: research
Fluorescence-guided resection of intradural spinal tumors: a systematic review and meta-analysis
AbstractIntradural spinal tumors present significant challenges due to involvement of critical motor and sensory tracts. Achieving maximal resection while preserving functional tissue is therefore crucial. Fluorescence-guided surgery aims to improve resection accuracy and is well studied for brain tumors, but its efficacy has not been fully assessed for spinal tumors. This meta-analysis aims to delineate the efficacy of fluorescence guidance in intradural spinal tumor resection. The authors performed a systematic review in four databases. We included studies that have utilized fluorescence agents, 5-aminolevulinic acid (...
Source: Neurosurgical Review - December 12, 2023 Category: Neurosurgery Source Type: research
Imaging of supratentorial intraventricular masses in children: a pictorial review —part 2
ConclusionThe WHO CNS5 introduces notable changes, emphasizing the vital importance of molecular diagnostics in classifying pediatric central nervous system tumors. These foundational shifts have significant potential to impact management strategies and, as a result, the outcomes of intraventricular masses in children. (Source: Neuroradiology)
Source: Neuroradiology - December 12, 2023 Category: Radiology Source Type: research
Spinal Cord Tumors: A Review of Demographic Characteristics and Treatment Follow-Up of Patients in Isfahan City, Iran
CONCLUSION: The results may contribute to improve the pre-operative planning, optimization, and monitoring of the patient's recovery after the operation.PMID:38073727 | PMC:PMC10699237 | DOI:10.4103/abr.abr_168_23 (Source: Adv Data)
Source: Adv Data - December 11, 2023 Category: Epidemiology Authors: Mehdi Mahmoodkhani Majid Rezvani Majid Aliyari Mehdi Shafiei Donya S Tehrani Source Type: research
A new subtype of diffuse midline glioma, H3 K27 and BRAF/FGFR1 co-altered: a clinico-radiological and histomolecular characterisation
In conclusion,DMG, H3 K27 and BRAF/FGFR1 co-altered represent a new subtype of DMG with distinct genotype/phenotype characteristics, which deserve further attention with respect to trial interpretation and patient management. (Source: Acta Neuropathologica)
Source: Acta Neuropathologica - December 8, 2023 Category: Neurology Source Type: research
5-aminolevulinic acid-guided endoscopic biopsy with violet light-emitting diode flashlight in malignant glioma: Technical note
CONCLUSION: This technique of neuroendoscopic biopsy guided by 5-ALA PDD fluorescence with a violet LED flashlight may allow a safe and accurate diagnosis of deep-seated malignant gliomas.PMID:38053712 | PMC:PMC10695459 | DOI:10.25259/SNI_204_2023 (Source: Surgical Neurology International)
Source: Surgical Neurology International - December 6, 2023 Category: Neurosurgery Authors: Michiharu Yoshida Susumu Yamaguchi Keisuke Iwasaki Mitsuto Iwanaga Source Type: research
